Lectin-affinity electrophoresis for the detection of AFP microheterogeneities in patients with hepatocellular carcinoma

Anticancer Research

Volumn 16, Issue 1, 1996, Pages 305-310

  Zaninotto, M ^a   Ujka, F ^b   Lachin, M ^a   Bernardi, D ^a   Marafi, C ^c   Farinati, F ^c   Plebani, M ^a,b  

^a UNIVERSITY HOSPITAL OF PADOVA   (Italy)

^b Centro di Ricerca Biomedica   (Italy)

^c Cattedra Malattie Apparato Digerente   (Italy)

Author keywords

Fetoprotein; Benign liver diseases; Fucosylation index; Hepatocellular carcinoma; Lectin electrophoresis; Lens Culinaris agglutinm A; Tumor marker

Indexed keywords

ALPHA FETOPROTEIN;

ADULT; AGED; ARTICLE; CHRONIC LIVER DISEASE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; DIFFERENTIAL DIAGNOSIS; EARLY DIAGNOSIS; ELECTROPHORESIS; ENZYME IMMUNOASSAY; FEMALE; FUCOSYLATION; HUMAN; IMMUNOBLOTTING; LIVER CELL CARCINOMA; LIVER DISEASE; MALE; PRIORITY JOURNAL;

ADULT; AGED; AGED, 80 AND OVER; ALPHA-FETOPROTEINS; ANTIBODY AFFINITY; CARCINOMA, HEPATOCELLULAR; ELECTROPHORESIS; FEMALE; FUCOSE; HUMANS; IMMUNOBLOTTING; LECTINS; LIVER DISEASES; LIVER NEOPLASMS; MALE; MIDDLE AGED; PLANT LECTINS; ROC CURVE; SENSITIVITY AND SPECIFICITY;

EID: 0029922976     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Christiansen M, Ishiguro T, Hogdan C, Norgaard-Pedersen B: Alpha-fetoprotein. In: Up dating on tumor markers in tissues and in biological fluids (Ballestra AM, Tone GC, Bombardieri E, Gion M. Molina R eds). Torino, Minerva Medica, 1993, pp 245-269.
2. Taketa K: Alpha-fetoprotein: reevaluation in hepatology. Hepatology 12: 1420-1432, 1990.
3. Sato Y, Nakata K, Kato Y, Shima M, Ishii N, Koji T, Taketa K, Endo Y, Nagataki S: Early recognition of hepatocellular carcinoma based on altered profiles of alpba-fetoprotein. N Engl J Med 328: 1802-1806, 1993.
4. Yamashita K, Taketa K, Nishi S, Fukushima K, Ohkura T: Sugar chains of human cord serum alpha-fetoprotein: characteristics of N-linked sugar chains of glycoproteins produced in human liver and hepatocellular carcinomas. Cancer Res 53: 2970-2975, 1993.
5. Ohno M, Nishikawa A, Koretsu M, Taga H, Endo Y, Hada T, Higashino K, Taniguchi N: Enzymatic basis of sugar structures of alpha-fetoprotein in hepatoma and hepatoblastoma cell lines: correlation with activities of alpha 1-6 fucosyltransferase and N-acetylglucosaminyltransferases III and V. Int J Cancer 51: 315-317, 1992.
6. Tsuchida Y, Fukui M, Sakaguchi H, Ishiguro T: Analysis of lectin affinity immunoelectrophoretic profiles of serum alpha-fetoprotein from patients with yolk sac tumors and carcinomas of the gastrointestinal tract: correlation with molecular structures. Tumor Biol 10: 289-296, 1989.
7. Taketa K, Endo Y, Sekiya C, Tanikawa K, Koji T, Taga H, Satomura S, Matsuura S, Kawai T, Hirai H: A collaborative study for the evaluation of lectin-reactive alpha-fetoproteins in early detection of hepatocellular carcinoma. Cancer Res 53, 5419-5423, 1993.
8. Aoyagi Y, Suzuki Y, Isemura M, Soga K, Ozaki T, Ichida T, Inque K, Ichda F: Differential reactivity of alpha-fetoprotein with lectins and evaluation of its usefulness in the diagnosis of hepatocellular carcinoma. Gann 75: 809-815, 1984.
9. Kobayashi K, Sugimoto T, Makino H, Kumal M, Unoura M, Tanaka N, Kato Y, Hattori N: Screening methods for early detection of hepatocellular carcinoma. Hepatology 5: 1100-1105, 1985.
10. Tsuchida Y, Fukui M, Sakaguchi H, Ishiguro T: The ratio of fucosylation of alpha-fetoprotein in hepatoblastoma. Cancer 63: 2174-2176, 1989.
11. Aoyagi Y, Suzuki Y, Isemura M, Nomoto M, Sekine C, Igarashi K, Ichida F: The fucosylation index of alpha-fetoprotein and its usefulness in the early diagnosis of hepatocellular carcinoma. Cancer 61: 769-774, 1988.
12. Bionner-Kanellakopoulos P, Shimizu K, Satomura S, Matsuura S: New, highly sensitive, and specific differentiation method between hepatocellular carcinoma and benign liver diseases by using a lectin-affinity electrophoresis of α-letoprotein. Lab Med 17: 200, 1993.
13. Shimizu K, Taniichi T, Satomura S, Matsuura S, Taga H, Taketa K: Establishment of assay kits for the determination of microheterogeneities of alpha-fetoprotein using lectin-affinity electrophoresis. Clin Chim Acta 214: 3-12, 1993.
14. Gerhardt W, Olsson V A computer programme for graphical evaluation of test data from clinical studies. Progr Med Lab 4: 111-115, 1984
15. Gerhardt W, Keller H: Evaluation of test data from clinical studies. I. Terminology, graphic interpretations, diagnostic strategies and selection of sample group II. Critical review of the concepts of efficiency, receiver operating characteristic (ROC) and likelihood ratios. Scand J Clin Lab Invest 181 (Suppl.). 11-74, 1986.
16. Hanley JA, McNeil BJ: The meaning and use of the area under a receiver operating characteristic (ROC) curve. Radiology 143: 29-36, 1982.
17. Hanley JA, McNeil BJ: A method of comparing the area under receiver operating characteristic curves derived from the same cases. Radiology 148: 839-943, 1983.
18. Kerckaert JP, Bayard B, Biserte G. Microheterogeneity of rat, mouse and human α-fetoprotein as revealed by polyacrylamide gel electrophoresis and by crossed immuno-affinoelectrophoresis with different lectins. Biochim Biophis Acta 256: 6633-6640, 1981.
19. Aoyagi Y, Isemura M, Yosizawa Z, Suzuki Y, Sekine C, Ono T, Ichida F: Fucosylation of serum alpha-fetoprotein in patients with primary hepatocellular carcinoma. Biochim Biophisica Acta 830: 217-223, 1985.