In vivo administration of anti-murine CD3 monoclonal antibody induces selective, long-term anergy in CD8+ T cells

Transplantation

Volumn 61, Issue 5, 1996, Pages 798-803

  Woodle, E Steve ^a   Hussein, Shafi ^a   Bluestone, Jeffrey A ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 2; MONOCLONAL ANTIBODY CD3;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CLONAL ANERGY; CONTROLLED STUDY; GRAFT REJECTION; IMMUNOSUPPRESSIVE TREATMENT; LYMPHOCYTE SUBPOPULATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD3; ANTIGENS, CD44; CD8-POSITIVE T-LYMPHOCYTES; CRICETINAE; IMMUNE TOLERANCE; INTERLEUKIN-2; LYMPHOCYTE DEPLETION; LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; MALE; MICE; MICE, INBRED BALB C; RECEPTORS, INTERLEUKIN-2; THYMECTOMY;

EID: 0029922911     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-199603150-00021     Document Type: Article

References (9)

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5. 2 fragments are immunosuppressive in vivo without evoking either the strong humoral response or morbidity associated with whole mAb. Transplantation 1990; 49: 1117.
6. Hirsch R, Eckhaus M, Auchincloss H, Sachs DH, Bluestone JA. Effects of in vivo administration of anti-CD3 monoclonal antibody on T cell function in mice. I. Immunosuppression of transplantation responses. J Immunol 1988; 140: 3766.
7. Mackie JD, Pankewycz OG, Bastos MG, Kelley VE, Strom TB. Dose related mechanisms of immunosuppression by murine anti-CD3 monoclonal antibody in pancreatic islet cell transplantation and delayed-type hypersensitivity. Transplantation 1990; 49: 1150.
8. DeSilva DR, Urdayl KB, Jenkins MK. Clonal anergy is induced in vitro by T cell receptor occupancy in the absence of proliferation. J Immunol 1991; 147: 3261.
9. 2 fragments of anti-CD3 monoclonal antibody. J Immunol 1991; 147: 2088.