HFA-134a (1,1,1,2-tetrafluoroethane): Effects of inhalation exposure upon reproductive performance, development and maturation of rats

Human & Experimental Toxicology

Volumn 15, Issue 6, 1996, Pages 508-517

  Alexander, D J ^a   Libretto, S E ^a   Adams, M J ^a   Hughes, E W ^b  

^a GLAXOSMITHKLINE   (United Kingdom)

^b HUNTINGDON LIFE SCIENCES   (United Kingdom)

Author keywords

HFA 134a; inhalation; rats; reproductive toxicology

Indexed keywords

NORFLURANE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DEVELOPMENT; FEMALE; FERTILITY; GAMETOGENESIS; INHALATIONAL DRUG ADMINISTRATION; LACTATION; MALE; MATING; MATURATION; NONHUMAN; PREGNANCY; PRIORITY JOURNAL; RAT; REPRODUCTION; WEIGHT GAIN;

ANIMALS; FEMALE; FERTILITY; GROWTH; HALF-LIFE; HYDROCARBONS, FLUORINATED; MALE; PREGNANCY; RATS; TERATOGENS;

ANIMALIA;

EID: 0029922597     PISSN: 09603271     EISSN: None     Source Type: Journal    
DOI: 10.1177/096032719601500609     Document Type: Article

References (19)

1. Montreal Protocol on Substances that Deplete the Ozone Layer. Liaison Office of the United Nations Environmental Program. New York, 1989.
2. Molina MJ, Rowland FS Stratospheric sink for chlorofluoromethanes: chlorine atom-catalyzed destruction of ozone. Nature 1974; 249: 810-812.
3. Kontny MJ et al. Issues surrounding MDI formulation development with non-CFC propellants. Journal of Aerosol Medicine 1991; 4: 181-187.
4. Graepel P., Alexander DJ CFC replacements: Safety testing, approval for use in metered dose inhalers. Journal of Aerosol Medicine 1991; 4: 193 - 200.
5. Alexander DJ, Libretto SE An overview of the toxicology of HFA-134a (1,1,1,2-tetrafluoroethane). Human and Experimental Toxicology 1995; 14: 715-720.
6. Organisation for Economic Cooperation and Development (OECD) Guidelines for testing of chemicals. Guideline numbers: 401 - Acute inhalation toxicology, 12 May 1981; 412- Repeated dose inhalation toxicity 28 day or 14 day study, 12 May 1981; 453 - Combined chronic toxicity/carcinogenicity studies, 12 May 1981.
7. Jones BJ, Roberts DJ The quantitative measurement of motor inco-ordination in naive mice using an accelerating rota-rod. Journal of Pharmacy and Pharmacology 1968; 20: 302 - 304.
8. Marsden CA, King B. The use of Dopler shift radar to monitor physiological and drug induced activity patterns in the rat. Pharmacology, Biochemistry and Behaviour 1979; 10: 631-635.
9. Biel WC Early age differences in maze performance in the albino rat. Journal of Genetic Psychology 1940; 56: 439 - 453.
10. Dawson AB Note on the staining of cleared skeletal specimens with Alizarin red S. Stain Technology 1926; 1: 123-124.
11. Wilson JG Methods for administering agents and detecting malformations in experimental animals. In: Teratology: Principles and Techniques, Wilson JG, Warkany (eds,) pp. 262-277. Chicago: University of Chicago Press, 1965.
12. Salewski E. Farbmethode zum makroskopischen nachweis von implantationsstellen am uterus der ratte. Naunyn-Schmiedebergs Archives of Experimental Pathology and Pharmacology 1964; 247: 367.
13. Snedecor GW, Cochran WG Statistical Methods. Iowa: The Iowa State University Press, 6th ed.
14. Williams DA Williams’ test for comparing the effect of increasing doses of a substance with a zero dose. Biometrics 1971; 27: 103 - 117.
15. Williams DA Williams’ test for comparing the effect of increasing doses of a substance with a zero dose. Biometrics 1972; 28: 519 - 531.
16. Hollander M., Wolfe DA Non-parametric statistical methods. New York: J Wiley & Sons, 1973.
17. Fisher RA Statistical methods for research workers. Edinburgh: Oliver and Boyd, 1950.
18. Mantel N. Chi-squared tests with one degree of freedom: Extensions of the Mantel Haenszel procedure. Journal of the American Statistics Association 1963; 58: 690-700.
19. Shirley E. A non-parametric equivalent of Williams’ test for contrasting increasing dose levels of a treatment. Biometrics 1977; 33: 386-389.