메뉴 건너뛰기




Volumn 41, Issue 4, 1996, Pages 809-815

Tauroursodeoxycholic Acid for Treatment of Primary Biliary Cirrhosis: A Dose-Response Study

Author keywords

Bile acids; Chronic cholestasis; Primary biliary cirrhosis; Tauroursodeoxycholic acid

Indexed keywords

HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIVER ENZYME; TAUROURSODEOXYCHOLIC ACID;

EID: 0029922431     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02213140     Document Type: Article
Times cited : (41)

References (46)
  • 1
    • 0025790578 scopus 로고
    • Conjugates of ursodeoxycholate protect against cytotoxicity of more hydrophobic bile salts: In vitro studies in rat hepatocytes and human erythrocytes
    • Heuman DM, Pandak WM, Hylemon PB, Vlahcevic ZR: Conjugates of ursodeoxycholate protect against cytotoxicity of more hydrophobic bile salts: In vitro studies in rat hepatocytes and human erythrocytes. Hepatology 14:920-426, 1991
    • (1991) Hepatology , vol.14 , pp. 920-1426
    • Heuman, D.M.1    Pandak, W.M.2    Hylemon, P.B.3    Vlahcevic, Z.R.4
  • 2
    • 0026086134 scopus 로고
    • Conjugates of ursodeoxycholate protect against cholestasis and hepatocellular necrosis caused by more hydrophobic bile salts. in vivo studies in the rat
    • Heuman DM, Mills AS, McCall J, Hylemon PB, Pandak WM, Vlahcevic ZR: Conjugates of ursodeoxycholate protect against cholestasis and hepatocellular necrosis caused by more hydrophobic bile salts. In vivo studies in the rat. Gastroenterology 100:203-211, 1991
    • (1991) Gastroenterology , vol.100 , pp. 203-211
    • Heuman, D.M.1    Mills, A.S.2    McCall, J.3    Hylemon, P.B.4    Pandak, W.M.5    Vlahcevic, Z.R.6
  • 3
    • 0026442917 scopus 로고
    • Microtubule-independent choleresis and anti-cholestatic action of tauroursodeoxycholate in colchicine treated rat liver
    • Nakai T, Katagiri K, Hoshino N, Hayakawa T, Ohiwa T: Microtubule-independent choleresis and anti-cholestatic action of tauroursodeoxycholate in colchicine treated rat liver. Biochem J 288:613-617, 1992
    • (1992) Biochem J , vol.288 , pp. 613-617
    • Nakai, T.1    Katagiri, K.2    Hoshino, N.3    Hayakawa, T.4    Ohiwa, T.5
  • 4
    • 0027371595 scopus 로고
    • Taurine conjugate of ursodeoxycholate plays a major role in the hepatoprotective effect against cholestasis induced by taurochenodeoxycholate in rats
    • Tsukahara K, Kanai S, Ohta M, Kitani K: Taurine conjugate of ursodeoxycholate plays a major role in the hepatoprotective effect against cholestasis induced by taurochenodeoxycholate in rats. Liver 13:262-269, 1993
    • (1993) Liver , vol.13 , pp. 262-269
    • Tsukahara, K.1    Kanai, S.2    Ohta, M.3    Kitani, K.4
  • 5
    • 26544449607 scopus 로고
    • Hepatoprotection in ethinylestradiol-treated rats is provided by tauroursodeoxycholic acid, but not by ursodeoxycholic acid
    • abstract
    • Azer SA, Stacey NH: Hepatoprotection in ethinylestradiol-treated rats is provided by tauroursodeoxycholic acid, but not by ursodeoxycholic acid. Hepatology 18:311A. 1993 (abstract)
    • (1993) Hepatology , vol.18
    • Azer, S.A.1    Stacey, N.H.2
  • 6
    • 0029098462 scopus 로고
    • Tauroursodeoxycholate increases rat liver ursodeoxycholate levels and limits lithocholale formation better than ursodeoxycholate
    • Rodrigues CMP, Kren BT, Steer CJ, Setchell KDR: Tauroursodeoxycholate increases rat liver ursodeoxycholate levels and limits lithocholale formation better than ursodeoxycholate. Gastroenterology 109:564-572, 1995
    • (1995) Gastroenterology , vol.109 , pp. 564-572
    • Rodrigues, C.M.P.1    Kren, B.T.2    Steer, C.J.3    Setchell, K.D.R.4
  • 7
    • 0020055254 scopus 로고
    • The hydrophobic/hydrophilic balance of bile salts. Inverse correlation between reverse-phase high performance liquid chromatographic mobilities and micellar cholesterol-solubilizing capacities
    • Armstrong MJ, Carey MC: The hydrophobic/hydrophilic balance of bile salts. Inverse correlation between reverse-phase high performance liquid chromatographic mobilities and micellar cholesterol-solubilizing capacities. J Lipid Res 23:70-80, 1982
    • (1982) J Lipid Res , vol.23 , pp. 70-80
    • Armstrong, M.J.1    Carey, M.C.2
  • 8
    • 0022656312 scopus 로고
    • Bile acid-induced liver toxicity: Relation to the hydrophobic-hydrophilic balance of bile acids
    • Attili AF, Angelico M, Cantafora A, Alvaro D, Capocaccia L: Bile acid-induced liver toxicity: Relation to the hydrophobic-hydrophilic balance of bile acids. Med Hypotheses 19:57-69, 1986
    • (1986) Med Hypotheses , vol.19 , pp. 57-69
    • Attili, A.F.1    Angelico, M.2    Cantafora, A.3    Alvaro, D.4    Capocaccia, L.5
  • 9
    • 0023655896 scopus 로고
    • Ursodeoxycholic acid for primary biliary cirrhosis
    • Hofmann AF, Popper H: Ursodeoxycholic acid for primary biliary cirrhosis. Lancet 2:398-399, 1987
    • (1987) Lancet , vol.2 , pp. 398-399
    • Hofmann, A.F.1    Popper, H.2
  • 10
    • 0024318186 scopus 로고
    • Quantitative estimation of the hydrophobic-hydrophilic balance of mixed bile salt solutions
    • Heuman DM: Quantitative estimation of the hydrophobic-hydrophilic balance of mixed bile salt solutions. J Lipid Res 30:719-730, 1989
    • (1989) J Lipid Res , vol.30 , pp. 719-730
    • Heuman, D.M.1
  • 11
    • 0023125182 scopus 로고
    • Is ursodeoxycholic acid an effective treatment for primary biliary cirrhosis?
    • Poupon R, Chrétien Y, Poupon RE, Ballet F, Calmus Y, Darnis F: Is ursodeoxycholic acid an effective treatment for primary biliary cirrhosis? Lancet 1:834-836, 1987
    • (1987) Lancet , vol.1 , pp. 834-836
    • Poupon, R.1    Chrétien, Y.2    Poupon, R.E.3    Ballet, F.4    Calmus, Y.5    Darnis, F.6
  • 12
    • 0024464260 scopus 로고
    • Ursodeoxycholic acid in primary biliary cirrhosis: Results of a controlled double-blind trial
    • Leuschner U. Fischer H, Kurtz W, et al: Ursodeoxycholic acid in primary biliary cirrhosis: Results of a controlled double-blind trial. Gastroenterology 97:1268-1274, 1989
    • (1989) Gastroenterology , vol.97 , pp. 1268-1274
    • Leuschner, U.1    Fischer, H.2    Kurtz, W.3
  • 13
    • 0027309033 scopus 로고
    • Ursodeoxycholic acid for symptomatic primary biliary cirrhosis: Preliminary analysis of a double-blind multicentre trial
    • Battezzati PM, Podda M, Bianchi FB, et al: Ursodeoxycholic acid for symptomatic primary biliary cirrhosis: Preliminary analysis of a double-blind multicentre trial. J Hepatol 17:332-338, 1993
    • (1993) J Hepatol , vol.17 , pp. 332-338
    • Battezzati, P.M.1    Podda, M.2    Bianchi, F.B.3
  • 14
    • 0024997057 scopus 로고
    • Ursodeoxycholic acid for primary sclerosing cholangitis
    • Chazouillères O, Poupon R, Capron JP, et al: Ursodeoxycholic acid for primary sclerosing cholangitis. J Hepatol 11:120-123, 1990
    • (1990) J Hepatol , vol.11 , pp. 120-123
    • Chazouillères, O.1    Poupon, R.2    Capron, J.P.3
  • 15
    • 0026730984 scopus 로고
    • Ursodeoxycholic acid for treatment of primary sclerosing cholangitis: A placebo-controlled trial
    • Beuers U, Spengler U, Kruis W, et al: Ursodeoxycholic acid for treatment of primary sclerosing cholangitis: A placebo-controlled trial. Hepatology 16:707-714, 1992
    • (1992) Hepatology , vol.16 , pp. 707-714
    • Beuers, U.1    Spengler, U.2    Kruis, W.3
  • 16
    • 0024998297 scopus 로고
    • Effects of ursodeoxycholic acid therapy for liver disease associated with cystic fibrosis
    • Colombo C, Setchell KDR, Podda M, et al: Effects of ursodeoxycholic acid therapy for liver disease associated with cystic fibrosis. J Pediatr 117:482-489, 1990
    • (1990) J Pediatr , vol.117 , pp. 482-489
    • Colombo, C.1    Setchell, K.D.R.2    Podda, M.3
  • 17
    • 0025876404 scopus 로고
    • A multicenter controlled trial of ursodiol for the treatment of primary biliary cirrhosis
    • Poupon RE, Balkau B, Eschwège E, Poupon R, UDCA-PBC Study Group: A multicenter controlled trial of ursodiol for the treatment of primary biliary cirrhosis. N Engl J Med 325:1548-1554, 1991
    • (1991) N Engl J Med , vol.325 , pp. 1548-1554
    • Poupon, R.E.1    Balkau, B.2    Eschwège, E.3    Poupon, R.4
  • 19
    • 0028346255 scopus 로고
    • The Canadian multicenter double-blind randomized controlled trial of ursodeoxycholic acid in primary biliary cirrhosis
    • Heathcote EJL, Cauch-Dudek K, Walker V, et al: The Canadian multicenter double-blind randomized controlled trial of ursodeoxycholic acid in primary biliary cirrhosis. Hepatology 19:1149-1156, 1994
    • (1994) Hepatology , vol.19 , pp. 1149-1156
    • Heathcote, E.J.L.1    Cauch-Dudek, K.2    Walker, V.3
  • 20
    • 0028331716 scopus 로고
    • Ursodeoxycholic acid in the treatment of primary biliary cirrhosis
    • Lindor KD, Dickson ER, Baldus WP, et al: Ursodeoxycholic acid in the treatment of primary biliary cirrhosis. Gastroenterology 106:1284-1290, 1994
    • (1994) Gastroenterology , vol.106 , pp. 1284-1290
    • Lindor, K.D.1    Dickson, E.R.2    Baldus, W.P.3
  • 21
    • 0029127685 scopus 로고
    • A randomized, double-blind, placebo-controlled trial of ursodeoxycholic acid in primary biliary cirrhosis
    • Combes B, Carithers RL Jr, Maddrey WC, et al: A randomized, double-blind, placebo-controlled trial of ursodeoxycholic acid in primary biliary cirrhosis. Hepatology 22:759-766, 1995
    • (1995) Hepatology , vol.22 , pp. 759-766
    • Combes, B.1    Carithers Jr., R.L.2    Maddrey, W.C.3
  • 22
    • 0028294206 scopus 로고
    • Ursodiol for the long-term treatment of primary biliary cirrhosis
    • Poupon RE, Poupon R, Balkau B, UDCA-PBC Study Group: Ursodiol for the long-term treatment of primary biliary cirrhosis. N Engl J Med 330:1342-1347, 1994
    • (1994) N Engl J Med , vol.330 , pp. 1342-1347
    • Poupon, R.E.1    Poupon, R.2    Balkau, B.3
  • 23
    • 0020424887 scopus 로고
    • The effect of tauroursodeoxycholic acid and taurine supplementation on biliary bile acid composition
    • Batta AK, Salen G, Shefer S, Tint GS, Dayal B: The effect of tauroursodeoxycholic acid and taurine supplementation on biliary bile acid composition. Hepatology 2:811-816, 1982
    • (1982) Hepatology , vol.2 , pp. 811-816
    • Batta, A.K.1    Salen, G.2    Shefer, S.3    Tint, G.S.4    Dayal, B.5
  • 26
    • 0022490227 scopus 로고
    • Enterohepatic circulation in man: A simple method for the determination of duodenal bile acids
    • Vonk RJ, Kneepkens CMF, Havinga R, Kuipers F, Bijleveld CMA: Enterohepatic circulation in man: A simple method for the determination of duodenal bile acids. J Lipid Res 27:901-904, 1986
    • (1986) J Lipid Res , vol.27 , pp. 901-904
    • Vonk, R.J.1    Kneepkens, C.M.F.2    Havinga, R.3    Kuipers, F.4    Bijleveld, C.M.A.5
  • 27
    • 0023238801 scopus 로고
    • High-pressure liquid chromatographic analysis of conjugated bile acids in human bile: Simultaneous resolution of sulphated and unsulphated lithocholyl amidates and the common conjugated bile acids
    • Rossi SS, Converse JL, Hofmann AF: High-pressure liquid chromatographic analysis of conjugated bile acids in human bile: Simultaneous resolution of sulphated and unsulphated lithocholyl amidates and the common conjugated bile acids. J Lipid Res 28:589-595, 1987
    • (1987) J Lipid Res , vol.28 , pp. 589-595
    • Rossi, S.S.1    Converse, J.L.2    Hofmann, A.F.3
  • 28
    • 0019932716 scopus 로고
    • A rapid method for the quantitative extraction of bile acids and their conjugates from serum using commercially available reverse phase octadecylsilane bonded silica cartridge
    • Setchell KDR, Worthington J: A rapid method for the quantitative extraction of bile acids and their conjugates from serum using commercially available reverse phase octadecylsilane bonded silica cartridge. Clin Chim Acta 125:135-144, 1982
    • (1982) Clin Chim Acta , vol.125 , pp. 135-144
    • Setchell, K.D.R.1    Worthington, J.2
  • 31
    • 0024256157 scopus 로고
    • Chromatographic methods for bile acid analysis
    • Street JM, Setchell KDR: Chromatographic methods for bile acid analysis. Biomed Chromatogr 2:229-241, 1988
    • (1988) Biomed Chromatogr , vol.2 , pp. 229-241
    • Street, J.M.1    Setchell, K.D.R.2
  • 32
    • 1542637539 scopus 로고    scopus 로고
    • Metabolism of tauroursodeoxycholic acid given by mouth in patients with primary biliary cirrhosis
    • in press
    • Setchell KDR, Rodrigues C, Podda M, Crosignani A: Metabolism of tauroursodeoxycholic acid given by mouth in patients with primary biliary cirrhosis. Gut 1996 (in press)
    • (1996) Gut
    • Setchell, K.D.R.1    Rodrigues, C.2    Podda, M.3    Crosignani, A.4
  • 33
    • 0024834972 scopus 로고
    • Effect of different doses of ursodeoxycholic acid in chronic liver disease
    • Podda M, Ghezzi C, Battezzati PM, et al: Effect of different doses of ursodeoxycholic acid in chronic liver disease. Dig Dis Sci 34:595-65S, 1989
    • (1989) Dig Dis Sci , vol.34
    • Podda, M.1    Ghezzi, C.2    Battezzati, P.M.3
  • 34
    • 0026352217 scopus 로고
    • Changes in bile acid composition in patients with primary biliary cirrhosis induced by ursodeoxycholic acid administration
    • Crosignani A, Podda M, Battezzati PM, et al: Changes in bile acid composition in patients with primary biliary cirrhosis induced by ursodeoxycholic acid administration. Hepatology 14:1000-1007, 1991
    • (1991) Hepatology , vol.14 , pp. 1000-1007
    • Crosignani, A.1    Podda, M.2    Battezzati, P.M.3
  • 35
    • 0021910812 scopus 로고
    • Absorption of urso- and chenodeoxycholic acid and their taurine and glycine conjugates in rat jejunum, ileum, and colon
    • Walker S, Stiehl A, Raedsch R, Kloters P, Kommerell B: Absorption of urso- and chenodeoxycholic acid and their taurine and glycine conjugates in rat jejunum, ileum, and colon. Digestion 32:47-52, 1985
    • (1985) Digestion , vol.32 , pp. 47-52
    • Walker, S.1    Stiehl, A.2    Raedsch, R.3    Kloters, P.4    Kommerell, B.5
  • 36
    • 0021919474 scopus 로고
    • Intestinal absorption of ursodeoxycholic, glycoursodeoxycholic and tauroursodeoxycholic acids in rats
    • Ota M, Minami Y, Hoshita T: Intestinal absorption of ursodeoxycholic, glycoursodeoxycholic and tauroursodeoxycholic acids in rats. J Pharmacobio-Dyn 8:114-118, 1985
    • (1985) J Pharmacobio-Dyn , vol.8 , pp. 114-118
    • Ota, M.1    Minami, Y.2    Hoshita, T.3
  • 37
    • 0023860986 scopus 로고
    • Hepatic transport of bile acids in the isolated perfused rat liver. Structure-kinetic relationship
    • Poupon R, Chrétien Y, Parquet M, Ballet F, Rey C, Infante R: Hepatic transport of bile acids in the isolated perfused rat liver. Structure-kinetic relationship. Biochem Pharmacol 37:209-212, 1988
    • (1988) Biochem Pharmacol , vol.37 , pp. 209-212
    • Poupon, R.1    Chrétien, Y.2    Parquet, M.3    Ballet, F.4    Rey, C.5    Infante, R.6
  • 38
    • 0024453032 scopus 로고
    • Uptake of bile acids by perfused rat liver: Evidence of structure-activity relationship
    • Aldini R, Roda A, Simioni P, Lenzi P, Roda E: Uptake of bile acids by perfused rat liver: Evidence of structure-activity relationship. Hepatology 10:840-845, 1989
    • (1989) Hepatology , vol.10 , pp. 840-845
    • Aldini, R.1    Roda, A.2    Simioni, P.3    Lenzi, P.4    Roda, E.5
  • 39
    • 0028084463 scopus 로고
    • Kinetics of hepatic bile acids handling in cholestatic liver disease: Effect of ursodeoxycholic acid
    • Jazrawi RP, de Caestecker JS, Goggin PM, et al: Kinetics of hepatic bile acids handling in cholestatic liver disease: Effect of ursodeoxycholic acid. Gastroenterology 106:134-142, 1994
    • (1994) Gastroenterology , vol.106 , pp. 134-142
    • Jazrawi, R.P.1    De Caestecker, J.S.2    Goggin, P.M.3
  • 40
    • 0027537002 scopus 로고
    • Cholesterol-lowering effect of ursodeoxycholic acid in patients with primary biliary cirrhosis
    • Poupon RE, Ouguerram K, Chrétien Y, et al: Cholesterol-lowering effect of ursodeoxycholic acid in patients with primary biliary cirrhosis. Hepatology 17:577-582, 1993
    • (1993) Hepatology , vol.17 , pp. 577-582
    • Poupon, R.E.1    Ouguerram, K.2    Chrétien, Y.3
  • 41
    • 0020318866 scopus 로고
    • Ursodeoxycholic acid in the treatment of cholesterol cholelithiasis
    • Bachrach WH, Hofmann AF: Ursodeoxycholic acid in the treatment of cholesterol cholelithiasis. Part I. Dig Dis Sci 27:737-761, 1982
    • (1982) Dig Dis Sci , vol.27 , Issue.1 PART , pp. 737-761
    • Bachrach, W.H.1    Hofmann, A.F.2
  • 42
    • 0019976525 scopus 로고
    • Ursodeoxycholic acid in the treatment of cholesterol cholelithiasis
    • Bachrach WH, Hofmann AF: Ursodeoxycholic acid in the treatment of cholesterol cholelithiasis. Part II. Dig Dis Sci 27:833-856, 1982
    • (1982) Dig Dis Sci , vol.27 , Issue.2 PART , pp. 833-856
    • Bachrach, W.H.1    Hofmann, A.F.2
  • 43
    • 0018833455 scopus 로고
    • Cholesterol absorption during bile acid feeding. Effect of ursodeoxycholic acid (UDCA) administration
    • Ponz de Leon M, Carulli N, Loria P, Ioria R, Zironi F: Cholesterol absorption during bile acid feeding. Effect of ursodeoxycholic acid (UDCA) administration. Gastroenterology 78:214-219, 1980
    • (1980) Gastroenterology , vol.78 , pp. 214-219
    • Ponz De Leon, M.1    Carulli, N.2    Loria, P.3    Ioria, R.4    Zironi, F.5
  • 44
    • 0024847339 scopus 로고
    • Structure-activity relationship studies on natural and synthetic bile acid analogs
    • Roda A, Grigolo B, Pellicciari R, Natalini B: Structure-activity relationship studies on natural and synthetic bile acid analogs. Dig Dis Sci 34:24S-35S, 1989
    • (1989) Dig Dis Sci , vol.34
    • Roda, A.1    Grigolo, B.2    Pellicciari, R.3    Natalini, B.4
  • 45
    • 0021192714 scopus 로고
    • Chemistry and enterohepatic circulation of bile acids
    • Hofmann AF: Chemistry and enterohepatic circulation of bile acids. Hepatology 4:4S-14S, 1984
    • (1984) Hepatology , vol.4
    • Hofmann, A.F.1
  • 46
    • 0021739393 scopus 로고
    • Physicochemical properties of bile acids and their relationship to biological properties: An over-view of the problem
    • Hofmann AF, Roda A: Physicochemical properties of bile acids and their relationship to biological properties: An over-view of the problem. J Lipid Res 25:1477-1489, 1984
    • (1984) J Lipid Res , vol.25 , pp. 1477-1489
    • Hofmann, A.F.1    Roda, A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.