Negative dromotropic effects of Class I antiarrhythmic drugs in anisotropic ventricular muscle

Cardiovascular Research

Volumn 31, Issue 4, 1996, Pages 640-650

  Iida, Masato ^a   Kodama, Itsuo ^a   Toyama, Junji ^a  

^a NAGOYA UNIVERSITY   (Japan)

Author keywords

anisotropy; anti arrhythmic drugs; conduction; rabbit, ventricle; sodium channel

Indexed keywords

ANTIARRHYTHMIC AGENT; APRINDINE; FLECAINIDE; QUINIDINE; SESAMODIL FUMARATE; SODIUM CHANNEL;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HEART ARRHYTHMIA; HEART VENTRICLE WALL; NONHUMAN; PRIORITY JOURNAL; RABBIT;

ACTION POTENTIALS; ANIMALS; ANTI-ARRHYTHMIA AGENTS; APRINDINE; CALCIUM CHANNEL BLOCKERS; DOSE-RESPONSE RELATIONSHIP, DRUG; FLECAINIDE; HEART CONDUCTION SYSTEM; MEMBRANE POTENTIALS; QUINIDINE; RABBITS; SODIUM CHANNELS; THIAZOLES;

EID: 0029922430     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/0008-6363(96)00010-7     Document Type: Article

References (39)

1. Wit AL, Dillon SM. Anisotropic reentry. In: Zipes DP, Jalife J, ed. Cardiac Electrophysiology. From Cell to Bedside. Philadelphia, PA: W.B. Saunders, 1990:353-363.
2. Spach MS, Josephson ME. Initiating reentry: the role of nonuniform anisotropy in small circuits. J Cardiovasc Electrophysiol 1994;5: 182-209.
3. Sicilian Gambit. Electrophysiological mechanisms for cardiac arrhythmias. In: Antiarrhythmic Therapy. A Pathophysiologic Approach. Armonk, NY: Futura, 1994:44-84.
4. foot, and propagation safety factor. Circ Res 1987;60:206-219.
5. Anno T, Hondeghem LM. Interactions of flecainide with guinea pig cardiac sodium channels. Importance of activation unblocking to the voltage dependence of recovery. Circ Res 1990;66:789-803.
6. Kodama I, Toyama J, Takanaka C, Yamada K. Block of activated and inactivated sodium channels by Class I antiarrhythmic drugs studied by using the maximum upstroke velocity (Vmax) of action potential in guinea-pig cardiac muscles. J Mol Cell Cardiol 1987;19:367-377.
7. Kodama I, Honjo H, Kamiya K, Toyama J. Two types of sodium channel block by Class I antiarrhythmic drugs studied by using Vmax of action potential in single ventricular myocytes. J Mol Cell Cardiol 1990;22:1-12.
8. Kodama I, Suzuki R, Maruyama K, Toyama J. Electrophysiological effects of SD-3212, a new antiarrhythmic agent with vasodilating action, on guinea pig ventricular cells. Br J Pharmacol 1995;114:503-509.
9. Osaka T, Kodama I, Tsuboi N, Toyama J, Yamada K. Effects of activation sequence and anisotropic cellular geometry on the repolarization phase of action potential of dog ventricular muscle. Circulation 1987;76:226-236.
10. Osaka T, Kodama I, Toyama J, Yamada K. Effects of bepridil on ventricular depolarization and repolarization of rabbit isolated hearts with particular reference to its possible proarrhythmic properties. Br J Pharmacol 1988:93:775-780.
11. Spach MS, Miller WT III, Miller-Jones E, Warren RB, Barr RC. Extracellular potentials related to intracellular action potentials during impulse conduction in anisotropic canine cardiac muscle. Circ Res 1979;45:188-204.
12. Spach MS, Miller WT III, Geselovitz DB, Barr RC, Kootsey JM, Johnson EA. The discontinuous nature of propagation in normal canine cardiac muscle. Circ Res 1981;48:39-54.
13. Spach MS, Kootsey JM, Sloan JD. Active modulation of electrical coupling between cardiac cells of the dog. A mechanism for transient and steady state variations in conduction velocity. Circ Res 1982;51:347-362.
14. + concentration and stimulation frequency. Jpn Cire J 1985;49:487-498.
15. Kadish AH, Spear JF, Levine JH, Moore N. The effects of procainamide on conduction in anisotropic canine ventricular myocardium. Circulation 1986;74:616-625.
16. Quinteiro RA, Biagetti MO, De Forteza E. Effects of lidocaine on Vmax and conduction velocity in uniform anisotropic canine ventricular muscle: possible role of its binding-rate constants. J Cardiovasc Pharmacol 1990;15:29-36.
17. Hoyt RH, Cohen ML, Saffitz JE. Distribution and three-dimensional structure of intercellular junctions in canine myocardium. Circ Res 1989;64:563-574.
18. Saffitz JE, Kanter HL, Green KG, Tolley TK, Beyer EC. Tissue-specific determinants of anisotropic conduction velocity in canine atrial and ventricular myocardium. Circ Res 1994;74:1065-1070.
19. Sommer JR, Scherer B. Geometry of cell and bundle appositions in cardiac muscle: light microscopy. Am J Physiol 1985;248:H792-803.
20. Spach MS, Dolber PC, Heidlage JF. Influence of the passive anisotropic properties of directional differences in propagation following modification of the sodium conductance in human atrial muscle. A model of reentry based on anisotropic discontinuous propagation. Circ Res 1988;62:811-832.
21. Spach MS, Heidlage JF, Darken ER, Hofer E, Raines KH, Starmer F. Cellular Vmax reflects both membrane properties and the load presented by adjoining cells. Am J Physiol 1992;263:H1855-1863.
22. Grant AO, Starmer F, Strauss HC. Antiarrhythmic drug action. Blockade of the inward sodium current. Circ Res 1984;55:427-439.
23. Campbell TJ. Subclassification of Class I antiarrhythmic drugs. In: Vaughan Williams EM, ed. Antiarrhythmic Drugs. Berlin: Springer-Verlag, 1989:165-172.
24. Kodama I, Honjo H, Kamiya K, Toyama J. Electropharmacology of OPC-88117, a new antiarrhythmic agent. Cardiovasc Drug Rev 1990;8:350-363.
25. Kodama I, Toyama J, Yamada K. Competitive inhibition of cardiac sodium channels by aprindine and lidocaine studied using a maximum upstroke velocity of action potential in guinea pig ventricular muscle. J Pharmacol Exp Ther 1987;241:1065-1071.
26. Hondeghem LM, Matsubara T. Quinidine blocks cardiac sodium channels during opening and slow inactivation in guinea pig papillary muscle. Br J Pharmacol 1988;93:311-318.
27. Spach MS, Kootsey JM. Relating the sodium current and conductance to the shape of transmembrane and extracellular potentials by simulation: effects of propagation boundaries. IEEE Trans Biomed Eng 1985;BME-32:743-755.
28. Bajaj AK, Kopelman HA, Wikswo JP Jr, Cassidy F, Woosley RL, Roden DM. Frequency-and orientation-dependent effects of mexiletine and quinidine on conduction in the intact dog heart. Circulation 1987;75:1065-1073.
29. Anderson KP, Walker R, Lux RL, Ershler PR, Menlove R, Williams MR, Krall R, Moddrelle D. Conduction velocity depression and drug-induced ventricular tachyarrhythmias. Effects of lidocaine in the intact canine heart. Circulation 1990;81:1024-1038.
30. Clarkson CW, Follmer CH, Ten Eick RE, Hondeghem LM, Yeh JZ. Evidence for two components of sodium channel block of lidocaine in isolated cardiac myocytes. Circ Res 1988;63:869-878.
31. Coromilas J, Saltman AE, Waldecker B, Dillon SM, Wit AL. Electrophysiological effects of flecainide on anisotropic conduction and reentry in infarcted canine hearts. Circulation 1995;91:2245-2263.
32. Ursell PC, Gardner PI, Albala A, Fenoglio JJ Jr, Wit AL. Structural and electrophysiological changes in the epicardial border zone of canine myocardial infarcts during infarct healing. Circ Res 1985;56:436-451.
33. Hodgkin AL, Huxley AF. A quantitative description of membrane current and its application to conduction and excitation in nerve. J Physiol (Lond) 1952;117:500-544.
34. McAllister RE, Noble D, Tsien RW. Reconstruction of the electrical activity of cardiac Purkinje fibers. J Physiol (Lond) 1975;251:1-59.
35. Beeler GW, Reuter H. Reconstruction of the action potential of ventricular myocardial fibers. J Physiol (Lond) 1977;268:177-210.
36. Ebihara L, Johnson EA. Fast sodium current in cardiac muscle: a quantitative description. Biophys J 1980;32:779-790.
37. Luo C, Rudy Y. A model of the ventricular cardiac action potential. Depolarization, repolarization, and their interaction. Circ Res 1991;68:1501-1526.
38. DiFrancesco D, Noble D. A model of cardiac electrical activity incorporating ionic pumps and concentration changes. Philos Trans R Soc Lond [Biol] 1985;307:353-398.
39. Alberts B, Bray D, Lewis J, Raff M, Roberts K, Watson JD. Molecular Biology of the Cell, 3rd Edition. New York, NY: Garland Publ. Co., 1994:512.