Clinical trials of new and novel therapeutic agents

World Journal of Surgery

Volumn 20, Issue 4, 1996, Pages 493-498

  Baue, Arthur E ^a   Durham, Rodney M ^a   Mazuski, John E ^a  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

21 [4 [2,6 BIS(1 PYRROLIDINYL) 4 PYRIMIDINYL] 1 PIPERAZINYL]PREGNA 1,4,9(11) TRIENE 3,20 DIONE; 21 AMINOSTEROID; ACETYLCYSTEINE; ADENOSINE TRIPHOSPHATE MAGNESIUM; ALBIFYLLINE; ALLOPURINOL; ALPHA INTERMEDIN; ALPHA TOCOPHEROL; ANTIINFLAMMATORY AGENT; ANTIOXIDANT; ANTITHROMBIN III; APROTININ; ASCORBIC ACID; CORTICOTROPIN RELEASING FACTOR; GLUCAN; GLUTATHIONE; GROWTH FACTOR; HUMAN GROWTH HORMONE; HYDROCORTISONE; HYPERTONIC SOLUTION; INOTROPIC AGENT; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 6 RECEPTOR; KETOCONAZOLE; NITRIC OXIDE DONOR; PENTOXIFYLLINE; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR; TUMOR NECROSIS FACTOR ANTIBODY; UNINDEXED DRUG;

ADULT RESPIRATORY DISTRESS SYNDROME; ASSISTED CIRCULATION; ASSISTED VENTILATION; CLINICAL TRIAL; HUMAN; INFECTION PREVENTION; INFLAMMATION; INTENSIVE CARE; KIDNEY FAILURE; LUNG CIRCULATION; MULTIPLE ORGAN FAILURE; NONHUMAN; PATIENT MONITORING; REPERFUSION INJURY; RESUSCITATION; REVIEW; SEPTIC SHOCK;

ANTITHROMBIN III; CLINICAL TRIALS; COMBINED MODALITY THERAPY; CRITICAL CARE; GLUCAGON; GROWTH SUBSTANCES; HUMANS; INFLAMMATION MEDIATORS; KETOCONAZOLE; LIFE SUPPORT CARE; MULTIPLE ORGAN FAILURE; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; TREATMENT OUTCOME;

EID: 0029922413     PISSN: 03642313     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002689900078     Document Type: Review

References (42)

1. Baue, A.E.: Mechanisms, mediators and prevention of multiple organ failure. Jpn. J. Intern. Care Med. 17:86, 1993
2. Baue, A.E.: Multiple organ failure (MOF), multiple organ dysfunction syndrome (MODS) and the systemic inflammatory response syndrome (SIRS) - where do we stand? Shock 2:385, 1994
3. Baue, A.E.: Organ dysfunction (MODS), organ failure (MOF) and therapeutic conundrums in injured and septic patients. In Sepsis and Organ Failure (Vol. 2), A. Gullo, editor. Milan, Fogliazza Editore, 1994, pp. 9-39
4. Bickell, W.H., Wall, M.H., Jr., Pepe, P.E., et al.: Immediate versus delayed fluid resuscitation for hypertensive patients with penetrating injuries. N. Engl. J. Med. 331:1105, 1994
5. Jacobs, L.M.: Timing of fluid resuscitation in trauma. N. Engl. J. Med. 331:1153, 1994
6. Wall, M.J., Jr.. Granchi, T., Liscum, K., Aucar, J., Mattox, K.L.: Delayed versus immediate fluid resuscitation in patients with penetrating trauma-subgroup analysis. J. Trauma 39:173, 1995
7. Cheatham, M.L, Safcsak, K., Nelson, L.D.: Right ventricular end-diastolic volume index is superior to cardiac filling pressures in determining preload status. Contemp. Surg. 45:79, 1994
8. Vincent, J.L., Thirion, M., Brimioulle, S., et al.: Thermodilution measurement of right ventricular ejection fraction with a modified pulmonary artery catheter. Intens. Care Med. 12:33, 1986
9. Durham, R.M., Hernandez, K., Shapiro, M J., et al.: Right ventricular end diastolic volume as a measure of cardiac preload. Crit. Care Med. 21:520, 1993
10. Durham, R.M., Neunaber, K., Mazuski, J.E., Shapiro, M.J., Baue, A.E.: The use of oxygen consumption and delivery as endpoints for resuscitation in critically ill patients. J. Trauma 59:172, 1995
11. Younes, R.N., Ann, F., Ching, C., et al.: Prognosis following the administration of hypertonic/hyperoncotic solutions in hypovolemic patients. Shock 1:6, 1994
12. Watson, W.C., Owens, T., Prough, D.S., Kramer, G.C.: "Limited prehospital" resuscitation of hemorrhagic solutions and lactated Ringers. Shock 1:16, 1994
13. Hirasawa, H., Sugai, T., Ohtake, Y., et al.: Energy metabolism and nutritional support in anuric multiple organ failure patients. In Nutritional Support in Organ Failure, T. Tanaka, A. Tanaka, editors. Amsterdam, Elsevier, 1990, pp. 439-446
14. Coccia, M.T., Waxman, K., Soliman, M.H., et al.: Pentoxifylline improves survival following hemorrhagic shock. Crit. Care Med. 17:36, 1989
15. Burch, J.M., Ortiz, V.B., Richardson, R.J.: Abbreviated laparotomy and planned reoperation for critically injured patients. Ann. Surg. 215:476, 1992
16. Hirshberg, A., Wall, M.J., Jr., Mattox, K.L.: Planned reoperation for trauma: a two year experience with 124 consecutive patients. J. Trauma 37:365, 1994
17. Teichman, W., Wittman, D.H., Andreone, P.A.: Scheduled reoperation (etappenlavage) for diffuse peritonitis. Arch. Surg. 68:147, 1986
18. Widergreen, J.T., Battistella, F.D.: The open abdomen: treatment of intra-abdominal compartment syndrome. J. Trauma 37:158, 1994
19. Johnson, K.D., Cadambi, A., Seibert, B.: Incidence of adult respiratory distress syndrome in patients with multiple musculoskeletal injuries: effect of early operative stabilization. J. Trauma 25:375, 1985
20. Pape, H.C., Auf'mKolk, M., Paffrath, T., et al.: Primary intramedullary femur fracture fixation in multiple trauma patients with associated lung contusion - a cause of post-traumatic ARDS? J. Trauma 34:540, 1993
21. Pell, A.C.H., Hughes, D., Keating, J., Christie, J., Busuttil, A., Sutherland, G.R.: Brief report: fulminating fat embolism syndrome caused by paradoxical embolism through a patent foramen ovale. N. Engl. J. Med. 329:926, 1993
22. Babineau, T.J., Hackford, A., Kenler, A., et al.: A phase II multicenter, double-blind randomized, placebo-controlled study of three dosages of an immunomodulator (PGG-glucan) in high risk surgical patients. Arch. Surg. 129:1204, 1994
23. Yu, M., Tomasa, G.: A double-blind, prospective, randomized trial of ketoconazole, a thromboxane synthetase inhibitor, in the prophylaxis of the adult respiratory distress syndrome. Crit. Care Med. 21:1635, 1994
24. Fourrier, F., Chopin, C.J.J., Runge, I., Caron, C., Goudermand, J.: Double-blind, placebo-controlled trial of antithrombin III concentrates in septic shock with disseminated intravascular coagulation. Chest 104:882, 1993
25. Ertel, W., Karres, I., Kremer, J.O., Kenney, J.S., Faist, E., Schildberg, F.W.: Transforming growth factor type β1 (TGF-β1) is a strong anti-inflammatory cytokine that inhibits transcription, translocation, and secretion of inflammatory mediators on different levels. Surg. Forum 44:105, 1993
26. Gross-Weege, W., Weiss, M., Wenning, M., Ohmann, C., Becher, H.: Phase II study of filgastrin (rhG-CSF) for prophylaxis and treatment of sepsis in surgical intensive care patients Curr. Opin. Surg. Infect. 2:40, 1994
27. Gennari, R., Alexander, J.W., Gianotti, L., Eaves-Pyles, T., Hartmann, S.: Granulocyte macrophage colony-stimulating factor improves survival in two models of gut-derived sepsis by improving gut barrier function and modulating bacteria clearance. Ann. Surg. 220: 68, 1994
28. Knox, J., Demling, R.H., Wilmore, D., Savraf, P., Santos, A.: Increased survival after major thermal injury - the effect of growth therapy in adults. J. Trauma 126:74, 1994
29. Gilpin, D.A., Barrow, R.E., Rutan, R.L., Broemeling, L., Herndon, D.N.: Recombinant human growth hormone accelerates wound healing in children with large cutaneous burns. Ann. Surg. 20:19, 1994
30. Cioffi, W.G., Gore, D.C., Rue, L.W., et al.: Insulin-like growth factor-1 lowers protein oxidation in patients with thermal injury. Ann. Surg. 230.310, 1994
31. Peterson, S.R., Holaday, N J., Jeevanandam, M.: Enhancement of protein synthesis efficiency in parenterally fed trauma victims by adjuvant recombinant human growth hormone. J. Trauma 36:726, 1994
32. Mustoe, T.A., Cutler, N.R., Allman, R.M., et al.: A phase 11 study to evaluate recombinant platelet-derived growth factor-BB in the treatment of stage 3 and 4 pressure ulcers. Arch. Surg. 129:213, 1994
33. 2-receptor for catecholamines. Arch. Surg. 129:1301, 1994
34. Marzi, I., Buhren, V., Schuttler, A., Trentz, O.: Value of superoxide dismutase for prevention of multiple organ failure after multiple trauma. J. Trauma 35:110, 1994
35. Harrison, P.M., Wendon, J.A., Gimson, A.E.S., Alexander, G.J.M., Williams, R.: Improvement by acetylcysteine of hemodynamics and oxygen transport in fulminant hepatic failure. N. Engl. J. Med. 324:1852, 1991
36. Rossaint, R., Falke, K.J., Lopez, F., et al.: Inhaled nitric oxide for the adult respiratory distress syndrome. N. Engl. J. Med. 34:540, 1993
37. Suter, P M., Domenighetti, G., Schaller, M.D., et al.: N-Acetylcysteine enhances recovery from acute lung injury in man: a randomized, double-blind, placebo-controlled clinical study. Chest 105:190, 1994
38. Abraham, E., Yoshihara, G.: Cardiorespiratory effects of pressure controlled inverse ratio ventilation in severe respiratory failure. Chest 96:1356, 1989
39. Banner, M.J., Kirby, R.R., Blanch, P.B., et al.: Decreased imposed work of the breathing apparatus to zero using pressure support ventilation. Crit. Care Med. 21:1333, 1993
40. Arnold, J.H., Hanson, J.H., Toro-Figuero, L.O., Gutiérrez, J., Berens, R.J., Anglin, D.L.: Prospective, randomized comparison of high-frequency oscillatory ventilation and conventional mechanical ventilation in pediatric respiratory failure. Crit. Care Med. 22:1530, 1994
41. Rodeberg, D.A., Housinger, T.A., Greenhalgh, D.G., Maschinot, N.E., Warden, G.D.: Improved ventilatory function in burn patients using volumetric diffusive respiration. J. Am. Coll. Surg. 179: 518, 1994
42. Lucas, C.E.: The renal response to acute injury and sepsis. Surg. Clin. North Am. 56:953, 1976