메뉴 건너뛰기




Volumn 56, Issue 8, 1996, Pages 1805-1816

Factors influencing the pharmacokinetics, dosimetry, and diagnostic accuracy of radioimmunodetection and radioimmunotherapy of carcinoembryonic antigen-expressing tumors

Author keywords

[No Author keywords available]

Indexed keywords

CARCINOEMBRYONIC ANTIGEN; CARCINOEMBRYONIC ANTIGEN MONOCLONAL ANTIBODY;

EID: 0029922060     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (59)

References (69)
  • 1
    • 0018179330 scopus 로고
    • Use of radiolabeled antibodies to carcinembryonic antigen for the detection and localization of diverse cancers by external photoscanning
    • Goldenberg, D. M., DeLand, F. Kim, E., Bennett, S , Primus, F J., van Nagell, J. R., Estes, N., De Simone, P., and Rayburn, P Use of radiolabeled antibodies to carcinembryonic antigen for the detection and localization of diverse cancers by external photoscanning. N. Engl. J. Med., 298: 1384-1388, 1978
    • (1978) N. Engl. J. Med. , vol.298 , pp. 1384-1388
    • Goldenberg, D.M.1    DeLand, F.2    Kim, E.3    Bennett, S.4    Primus, F.J.5    Van Nagell, J.R.6    Estes, N.7    De Simone, P.8    Rayburn, P.9
  • 2
    • 0016756272 scopus 로고
    • Continuous cultures of fused cells secreting antibody of predefined specificity
    • Kohler, G., and Milstein, C. Continuous cultures of fused cells secreting antibody of predefined specificity. Nature (Lond.), 256. 495-499, 1975.
    • (1975) Nature (Lond.) , vol.256 , pp. 495-499
    • Kohler, G.1    Milstein, C.2
  • 10
    • 0028939731 scopus 로고
    • Circulating antigen: Bad or good for immunoscintigraphy?
    • Pimm, M. V Circulating antigen: bad or good for immunoscintigraphy? Nucl. Med. Biol., 22: 137-145, 1995.
    • (1995) Nucl. Med. Biol. , vol.22 , pp. 137-145
    • Pimm, M.V.1
  • 13
    • 0026548072 scopus 로고
    • Influence of antibody protein dose on therapeutic efficacy of radioiodinated antibodies in nude mice bearing GW-39 human tumor
    • Boerman, O. C , Sharkey, R M., Wong, G Y , Blumenthal, R D , Aninipot, R L., and Goldenberg, D M Influence of antibody protein dose on therapeutic efficacy of radioiodinated antibodies in nude mice bearing GW-39 human tumor. Cancer Immunol Immunother , 35: 127-134, 1992
    • (1992) Cancer Immunol Immunother , vol.35 , pp. 127-134
    • Boerman, O.C.1    Sharkey, R.M.2    Wong, G.Y.3    Blumenthal, R.D.4    Aninipot, R.L.5    Goldenberg, D.M.6
  • 15
    • 0026763061 scopus 로고
    • The presence of a concomitant bulky tumor can decrease the uptake and therapeutic efficacy of radiolabeled antibodies in small tumors
    • Boerman, O. C., Sharkey, R M , Blumenthal, R. D., Aninipot, R. L., and Goldenberg, D M The presence of a concomitant bulky tumor can decrease the uptake and therapeutic efficacy of radiolabeled antibodies in small tumors. Int J. Cancer, 51, 470-475, 1992.
    • (1992) Int J. Cancer , vol.51 , pp. 470-475
    • Boerman, O.C.1    Sharkey, R.M.2    Blumenthal, R.D.3    Aninipot, R.L.4    Goldenberg, D.M.5
  • 16
    • 0023188365 scopus 로고
    • Antibody protein dose and radioimmunodetection of GW-39 human colon tumor xenografts
    • Sharkey, R M., Primus, F J , and Goldenberg, D. M Antibody protein dose and radioimmunodetection of GW-39 human colon tumor xenografts Int. J. Cancer, 39: 611-617, 1987.
    • (1987) Int. J. Cancer , vol.39 , pp. 611-617
    • Sharkey, R.M.1    Primus, F.J.2    Goldenberg, D.M.3
  • 17
    • 0026100692 scopus 로고
    • Variables influencing tumor uptake of anti-melanoma monoclonal antibodies radioiodinated using para-iodobenzoyl (PIB) conjugate
    • Murray, J L , Mujoo, K., Wilmanns, C., Mansfield, P., Wilbur, D. S , and Rosenblum, M. G. Variables influencing tumor uptake of anti-melanoma monoclonal antibodies radioiodinated using para-iodobenzoyl (PIB) conjugate J Nucl Med , 32: 279-287, 1991
    • (1991) J Nucl Med , vol.32 , pp. 279-287
    • Murray, J.L.1    Mujoo, K.2    Wilmanns, C.3    Mansfield, P.4    Wilbur, D.S.5    Rosenblum, M.G.6
  • 18
    • 0023753181 scopus 로고
    • Improved tumor localization with increasing dose of indium-111-labeled anti-carcinoembryonic antigen monoclonal antibody ZCE-025 in metastatic colorectal cancer
    • Patt, Y. Z., Lamki, L. M., Haynie, T. P., Unger, M. W., Rosenblum, M. G., Shirkhoda, A , and Murray, J L Improved tumor localization with increasing dose of indium-111-labeled anti-carcinoembryonic antigen monoclonal antibody ZCE-025 in metastatic colorectal cancer. J Clin Oncol., 6 1220-1230, 1988
    • (1988) J Clin Oncol. , vol.6 , pp. 1220-1230
    • Patt, Y.Z.1    Lamki, L.M.2    Haynie, T.P.3    Unger, M.W.4    Rosenblum, M.G.5    Shirkhoda, A.6    Murray, J.L.7
  • 24
    • 0025373376 scopus 로고
    • Murine monoclonal antibodies against carcinoembryonic antigen: Immunological, pharmacokinetic, and targeting properties in humans
    • Sharkey, R. M., Goldenberg, D. M., Goldenberg, H., Lee, R E , Ballance, C., Pawlyk, D., Varga, D., and Hansen, H. J. Murine monoclonal antibodies against carcinoembryonic antigen: immunological, pharmacokinetic, and targeting properties in humans. Cancer Res., 50: 2823-2831, 1990.
    • (1990) Cancer Res. , vol.50 , pp. 2823-2831
    • Sharkey, R.M.1    Goldenberg, D.M.2    Goldenberg, H.3    Lee, R.E.4    Ballance, C.5    Pawlyk, D.6    Varga, D.7    Hansen, H.J.8
  • 26
    • 0021714270 scopus 로고
    • Carcinoembryonic antigen production, secretion, and kinetics in BALB/c mice and a nude mouse-human tumor model
    • Martin, K. W , and Halpern, S. E. Carcinoembryonic antigen production, secretion, and kinetics in BALB/c mice and a nude mouse-human tumor model. Cancer Res., 44: 5475-5481, 1984
    • (1984) Cancer Res. , vol.44 , pp. 5475-5481
    • Martin, K.W.1    Halpern, S.E.2
  • 27
    • 0025156771 scopus 로고
    • Human immune response to anti-carcinoembryonic antigen murine monoclonal antibodies
    • Losman, M. J., DeJager, R. L., Monestier, M., Sharkey, R. M., and Goldenberg, D. M. Human immune response to anti-carcinoembryonic antigen murine monoclonal antibodies. Cancer Res., 50 (Suppl.): 1055s-1058s, 1990.
    • (1990) Cancer Res. , vol.50 , Issue.SUPPL.
    • Losman, M.J.1    DeJager, R.L.2    Monestier, M.3    Sharkey, R.M.4    Goldenberg, D.M.5
  • 28
    • 1842350494 scopus 로고
    • Effect of human anti-mouse antibody (HAMA) on monoclonal antibody (Mab) biokinetics and biodistribution during a phase I/II radioimmunotherapy clinical trial
    • Ford, E H., Lee, R. E., Sharkey, R M., Alger, E. A., Horowitz, J. A , Hall, T. C , and Goldenberg, D. M. Effect of human anti-mouse antibody (HAMA) on monoclonal antibody (Mab) biokinetics and biodistribution during a phase I/II radioimmunotherapy clinical trial. J. Nucl. Med., 29: 761, 1988.
    • (1988) J. Nucl. Med. , vol.29 , pp. 761
    • Ford, E.H.1    Lee, R.E.2    Sharkey, R.M.3    Alger, E.A.4    Horowitz, J.A.5    Hall, T.C.6    Goldenberg, D.M.7
  • 29
    • 0022852624 scopus 로고
    • Development of primary and secondary immune responses to mouse monoclonal antibodies used in the diagnosis and therapy of malignant neoplasms
    • Courtenay-Luck, N S , Epenetos, A. A., Moore, R., Larche, M , Pectasides, D., Dhokia, B , and Ritter, M A. Development of primary and secondary immune responses to mouse monoclonal antibodies used in the diagnosis and therapy of malignant neoplasms. Cancer Res., 46: 6489-6493, 1986.
    • (1986) Cancer Res. , vol.46 , pp. 6489-6493
    • Courtenay-Luck, N.S.1    Epenetos, A.A.2    Moore, R.3    Larche, M.4    Pectasides, D.5    Dhokia, B.6    Ritter, M.A.7
  • 30
    • 9244228689 scopus 로고
    • HAMA response to repeated administration of In-111 satumomab pendetide (OncoScint™). Frequency and patterns of development
    • Nabi, H. A , and Maroli, A. HAMA response to repeated administration of In-111 satumomab pendetide (OncoScint™). Frequency and patterns of development. Proc Am. Assoc. Cancer Res., 35. 218, 1994.
    • (1994) Proc Am. Assoc. Cancer Res. , vol.35 , pp. 218
    • Nabi, H.A.1    Maroli, A.2
  • 31
    • 0020701108 scopus 로고
    • Immunological heterogeneity of carcinoembryonic antigen: Antigenic determinants on carcinoembryonic antigen distinguished by monoclonal antibodies
    • Primus, F. J., Newell, K D , Blue, A , and Goldenberg, D M Immunological heterogeneity of carcinoembryonic antigen: antigenic determinants on carcinoembryonic antigen distinguished by monoclonal antibodies. Cancer Res., 43: 686-692, 1983
    • (1983) Cancer Res. , vol.43 , pp. 686-692
    • Primus, F.J.1    Newell, K.D.2    Blue, A.3    Goldenberg, D.M.4
  • 32
    • 0020699925 scopus 로고
    • Immunological heterogeneity of carcinoembryonic antigen: Immunohistochemical detection of carcinoembryonic antigen determinants in colonic tumors with monoclonal antibodies
    • Primus, F. J., Kuhns, W. J , and Goldenberg, D M. Immunological heterogeneity of carcinoembryonic antigen: immunohistochemical detection of carcinoembryonic antigen determinants in colonic tumors with monoclonal antibodies. Cancer Res., 43: 693-701, 1983
    • (1983) Cancer Res. , vol.43 , pp. 693-701
    • Primus, F.J.1    Kuhns, W.J.2    Goldenberg, D.M.3
  • 33
    • 0027198722 scopus 로고
    • Characterization of second-generation of second-generation monoclonal antibodies against carcinoembryonic antigen
    • Phila.
    • Hansen, H. J., Goldenberg, D M., Newman, E. S., Grebenau, R., and Sharkey, R. M. Characterization of second-generation of second-generation monoclonal antibodies against carcinoembryonic antigen. Cancer (Phila.), 71: 3478-3485, 1993.
    • (1993) Cancer , vol.71 , pp. 3478-3485
    • Hansen, H.J.1    Goldenberg, D.M.2    Newman, E.S.3    Grebenau, R.4    Sharkey, R.M.5
  • 36
    • 0025131586 scopus 로고
    • Murine monoclonal antibodies to colon-specific antigen-p
    • Gold, D. V., Nocera, M A., Stephens, R., and Goldenberg, D. M. Murine monoclonal antibodies to colon-specific antigen-p Cancer Res., 50: 6405-6409, 1990.
    • (1990) Cancer Res. , vol.50 , pp. 6405-6409
    • Gold, D.V.1    Nocera, M.A.2    Stephens, R.3    Goldenberg, D.M.4
  • 37
    • 0025975672 scopus 로고
    • Improved radioimmunotherapy of colorectal cancer xenografts using antibody mixtures against carcinoembryonic antigen and colon-specific antigen-p
    • Blumenthal, R. D., Kashi, R., Stephens, R., Sharkey, R. M., and Goldenberg, D. M. Improved radioimmunotherapy of colorectal cancer xenografts using antibody mixtures against carcinoembryonic antigen and colon-specific antigen-p. Cancer Immunol. Immunother , 32: 303-310, 1991
    • (1991) Cancer Immunol. Immunother , vol.32 , pp. 303-310
    • Blumenthal, R.D.1    Kashi, R.2    Stephens, R.3    Sharkey, R.M.4    Goldenberg, D.M.5
  • 39
    • 0025212647 scopus 로고
    • Evaluation of a remote radioiodination system for radioimmunotherapy
    • Weadock, K. S., Sharkey, R. M , Varga, D. C., and Goldenberg, D. M. Evaluation of a remote radioiodination system for radioimmunotherapy. J. Nucl. Med., 31: 508-511, 1990.
    • (1990) J. Nucl. Med. , vol.31 , pp. 508-511
    • Weadock, K.S.1    Sharkey, R.M.2    Varga, D.C.3    Goldenberg, D.M.4
  • 40
    • 0023846125 scopus 로고
    • "Sandwich"-type immunoassay for carcinoembryonic antigen in patients receiving murine monoclonal antibodies for diagnosis and management of cancer
    • Primus, F J , Kelley, E. A , Hansen, H. J , and Goldenberg, D. M. "Sandwich"-type immunoassay for carcinoembryonic antigen in patients receiving murine monoclonal antibodies for diagnosis and management of cancer. Clin Chem , 34: 261-264, 1988.
    • (1988) Clin Chem , vol.34 , pp. 261-264
    • Primus, F.J.1    Kelley, E.A.2    Hansen, H.J.3    Goldenberg, D.M.4
  • 42
    • 0021282561 scopus 로고
    • Absolute quantitation of radioactivity using the buildup factor
    • NY
    • Wu, R. K , and Siegel, J. A. Absolute quantitation of radioactivity using the buildup factor. Med. Phys. (NY), 11: 189-192, 1984.
    • (1984) Med. Phys. , vol.11 , pp. 189-192
    • Wu, R.K.1    Siegel, J.A.2
  • 46
    • 0003562303 scopus 로고
    • "S" absorbed dose per unit cumulative activity for selected radionuclides and organs
    • New York: Society of Nuclear Medicine
    • Snyder, W S., Ford, M. R., Warner, G G., and Watson, S B. "S" absorbed dose per unit cumulative activity for selected radionuclides and organs. Medical Internal Radiation Dose Pamphlet No. 11. New York: Society of Nuclear Medicine, 1976.
    • (1976) Medical Internal Radiation Dose Pamphlet No. 11
    • Snyder, W.S.1    Ford, M.R.2    Warner, G.G.3    Watson, S.B.4
  • 50
    • 0024232289 scopus 로고
    • Mechanisms of heterogenous distribution of monoclonal antibodies and other macromolecules in tumors: Significance of elevated interstitial pressure
    • Jain, R K , and Baxter, L. T. Mechanisms of heterogenous distribution of monoclonal antibodies and other macromolecules in tumors: significance of elevated interstitial pressure. Cancer Res., 48: 7022-7032, 1988.
    • (1988) Cancer Res. , vol.48 , pp. 7022-7032
    • Jain, R.K.1    Baxter, L.T.2
  • 51
    • 0023909330 scopus 로고
    • Determination of tumor blood flow: A review
    • Jain, R. K. Determination of tumor blood flow: a review Cancer Res., 48: 2641-2658, 1988.
    • (1988) Cancer Res. , vol.48 , pp. 2641-2658
    • Jain, R.K.1
  • 52
    • 0026425576 scopus 로고
    • An analysis of monoclonal antibody distribution in microscopic tumor nodules: Consequences of a "binding site barrier."
    • van Osdol, W., Fujimori, K., and Weinstein, J. N An analysis of monoclonal antibody distribution in microscopic tumor nodules: consequences of a "binding site barrier." Cancer Res., 51: 4776-4784, 1991.
    • (1991) Cancer Res. , vol.51 , pp. 4776-4784
    • Van Osdol, W.1    Fujimori, K.2    Weinstein, J.N.3
  • 53
    • 0026739369 scopus 로고
    • Micropharmacology of monoclonal antibodies in solid tumors: Direct experimental evidence for a binding site barrier
    • Juweid, M., Neumann, R., Paik, C., Perez-Bacete, M. J , Sato, J., van Osdol, W., and Weinstein, J. N. Micropharmacology of monoclonal antibodies in solid tumors: direct experimental evidence for a binding site barrier. Cancer Res., 52: 5144-5153, 1992.
    • (1992) Cancer Res. , vol.52 , pp. 5144-5153
    • Juweid, M.1    Neumann, R.2    Paik, C.3    Perez-Bacete, M.J.4    Sato, J.5    Van Osdol, W.6    Weinstein, J.N.7
  • 55
    • 0023701097 scopus 로고
    • Quantitative considerations supporting the irrelevance of circulating serum CEA for the immunoscintigraphic visualization of CEA expressing carcinomas
    • Bosslet, K., Steinstrasser, A., Schwarz, A., Harthus, H P., Luben, G., Kuhlmann, L., and Sedlacek, H. H. Quantitative considerations supporting the irrelevance of circulating serum CEA for the immunoscintigraphic visualization of CEA expressing carcinomas. Eur J. Nucl. Med , 14: 523-528, 1988.
    • (1988) Eur J. Nucl. Med , vol.14 , pp. 523-528
    • Bosslet, K.1    Steinstrasser, A.2    Schwarz, A.3    Harthus, H.P.4    Luben, G.5    Kuhlmann, L.6    Sedlacek, H.H.7
  • 56
    • 0025667380 scopus 로고
    • The structure, metabolism and function of the carcinoembryonic antigen gene family
    • Thomas, P , Toth, C. A., Saini, K. S , Jessup, J. M., and Steele, G. The structure, metabolism and function of the carcinoembryonic antigen gene family. Biochim Biophys. Acta, 1032: 177-189, 1990.
    • (1990) Biochim Biophys. Acta , vol.1032 , pp. 177-189
    • Thomas, P.1    Toth, C.A.2    Saini, K.S.3    Jessup, J.M.4    Steele, G.5
  • 57
    • 0016345593 scopus 로고
    • Altered metabolism of carcinoembryonic antigen in hamsters bearing GW-39 tumours
    • Primus, F. J , Hansen, H. J., and Goldenberg, D. M Altered metabolism of carcinoembryonic antigen in hamsters bearing GW-39 tumours. Nature (Lond.), 249: 837-838, 1974
    • (1974) Nature (Lond.) , vol.249 , pp. 837-838
    • Primus, F.J.1    Hansen, H.J.2    Goldenberg, D.M.3
  • 59
    • 0022633795 scopus 로고
    • The effect of tumor CEA content and tumor size in tissue uptake of indium 111-labeled anti-CEA monoclonal antibody
    • Phila.
    • Philben, V. J , Jakowatz, J G , Beatty, B. G., Vlahos, W. G., Paxton, R J., Williams, L. E., Shively, J. E., and Beatty, J. D. The effect of tumor CEA content and tumor size in tissue uptake of indium 111-labeled anti-CEA monoclonal antibody. Cancer (Phila.), 57: 571-576, 1986.
    • (1986) Cancer , vol.57 , pp. 571-576
    • Philben, V.J.1    Jakowatz, J.G.2    Beatty, B.G.3    Vlahos, W.G.4    Paxton, R.J.5    Williams, L.E.6    Shively, J.E.7    Beatty, J.D.8
  • 60
    • 0028269755 scopus 로고
    • A repertoire of monoclonal antibodies reveals extensive epitope heterogeneity in CEA purified from neoplasms originating from different organs
    • Hernando, J. J , von Kleist, S., and Grunert, F. A repertoire of monoclonal antibodies reveals extensive epitope heterogeneity in CEA purified from neoplasms originating from different organs. Int J. Cancer, 56: 655-661, 1994.
    • (1994) Int J. Cancer , vol.56 , pp. 655-661
    • Hernando, J.J.1    Von Kleist, S.2    Grunert, F.3
  • 61
    • 0020523938 scopus 로고
    • Isolation and structures of the oligosaccharide units of carcinoembryonic antigen
    • Chandrasekaran, E V., Davila, M. Nixon, D. W , Goldfarb, M., and Mendicino, J Isolation and structures of the oligosaccharide units of carcinoembryonic antigen. J. Biol Chem , 258: 7213-7222, 1983.
    • (1983) J. Biol Chem , vol.258 , pp. 7213-7222
    • Chandrasekaran, E.V.1    Davila, M.2    Nixon, D.W.3    Goldfarb, M.4    Mendicino, J.5
  • 62
    • 0026572279 scopus 로고
    • A predicted three-dimensional structure for the carcinoembryonic antigen (CEA)
    • Bates, P. A , Luo, J , and Sternberg, M J E A predicted three-dimensional structure for the carcinoembryonic antigen (CEA). FEBS Lett., 301: 207-214, 1992
    • (1992) FEBS Lett. , vol.301 , pp. 207-214
    • Bates, P.A.1    Luo, J.2    Sternberg, M.J.E.3
  • 63
    • 0017150285 scopus 로고
    • Heterogeneity of carcinoembryonic antigen: Implications on its role as a tumour marker substance
    • Rogers, G. T Heterogeneity of carcinoembryonic antigen: implications on its role as a tumour marker substance. Biochim Biophys. Acta, 458: 355-373, 1976.
    • (1976) Biochim Biophys. Acta , vol.458 , pp. 355-373
    • Rogers, G.T.1
  • 65
    • 0021835608 scopus 로고
    • Effect of heterogeneity of carcinoembryonic antigen on liver cell membrane binding and its kinetics of removal from circulation
    • Byrn, R A., Medrek, P , Thomas, P , Jeanloz, R W., and Zamchek, N Effect of heterogeneity of carcinoembryonic antigen on liver cell membrane binding and its kinetics of removal from circulation Cancer Res., 45: 3137-3142, 1985.
    • (1985) Cancer Res. , vol.45 , pp. 3137-3142
    • Byrn, R.A.1    Medrek, P.2    Thomas, P.3    Jeanloz, R.W.4    Zamchek, N.5
  • 66
    • 0028117662 scopus 로고
    • Beziehung zwischen Lebermelastasenvolumen und klinisch-chemischen Parametern
    • Schulz, G , Heckemann, R , and Bremer, K Beziehung zwischen Lebermelastasenvolumen und klinisch-chemischen Parametern. Tumordiagn Ther , 15: 197-202, 1994.
    • (1994) Tumordiagn Ther , vol.15 , pp. 197-202
    • Schulz, G.1    Heckemann, R.2    Bremer, K.3
  • 67
    • 9244221280 scopus 로고
    • Medical internal dosimetry for high-dose radionuclide therapies
    • D. M. Goldenberg (ed.), Boca Raton, FL: CRC Press, Inc.
    • Fisher, D. Medical internal dosimetry for high-dose radionuclide therapies. In: D. M. Goldenberg (ed.), Cancer Therapy with Radiolabeled Antibodies, pp. 7-19 Boca Raton, FL: CRC Press, Inc., 1995.
    • (1995) Cancer Therapy with Radiolabeled Antibodies , pp. 7-19
    • Fisher, D.1
  • 68
    • 0023635232 scopus 로고
    • Anti-antibody enhancement of iodine-131 anti-CEA radioimmunodetection in experimental and clinical studies
    • Goldenberg, D. M , Sharkey, R. M , and Ford, E Anti-antibody enhancement of iodine-131 anti-CEA radioimmunodetection in experimental and clinical studies J. Nucl Med., 28: 1604-1610, 1987.
    • (1987) J. Nucl Med. , vol.28 , pp. 1604-1610
    • Goldenberg, D.M.1    Sharkey, R.M.2    Ford, E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.