Heparin induced thrombocytopenia

European Journal of Vascular and Endovascular Surgery

Volumn 11, Issue 3, 1996, Pages 260-269

  Dryjski, M ^a   Dryjski, H ^a  

^a UNIVERSITY AT BUFFALO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICOAGULANT AGENT; ANTITHROMBOCYTIC AGENT; HEPARIN;

CLINICAL FEATURE; HUMAN; LABORATORY DIAGNOSIS; PATHOGENESIS; PRIORITY JOURNAL; REVIEW; THROMBOCYTE AGGREGATION; THROMBOCYTOPENIA; THROMBOEMBOLISM;

EID: 0029921829     PISSN: 10785884     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1078-5884(96)80072-4     Document Type: Review

References (143)

1. Jaques LB Heparin-anionic polyelectrolyte drugs Pharmacol Rev 31 1980 99 166
2. Freedman MD Pharmacodynamics, clinical indications, and adverse effects of heparin J Clin Pharmacol 32 1992 584 596
3. Meuleman DG Hobbelen PMJ Van Deden G Moelker HCT A novel anti-thrombotic heparinoid (Org 10172) devoid of bleeding inducing capacity; a survey of its pharmacological properties in experimental animal models Thromb Res 27 1982 353 363
4. Jaques LB The effect of intravenous injection of heparin in the dog Am J Physiol 125 1939 98
5. Fidlar E Jaques LB The effect of commercial heparin on the platelet count J Lab Clin Med 33 1948 1410 1423
6. Weismann RE Tobin RW Arterial embolism occurring during systemic heparin therapy Arch Surg 76 1958 219 227
7. Roberts B Rosato FE Rosato EF Heparin a cause of arterial emboli? Surgery 55 1964 803 808
8. Rhodes GR Dixon RH Silver D Heparin induced thrombocytopenia with thrombotic and hemorrhagic manifestation Surg Gynecol Obstet 136 1973 409 416
9. Warkentin TE Kelton JG Heparin and platelets Hemat Oncology Clin North Amer 4 1990 243 264
10. Ansell J Deykin D Heparin-induced thrombocytopenia and recurrent thromboembolism Am J Hematol 8 1980 325 332
11. Ansell J Slepchuk N Jr Kumar R Lopez A Southard L Deykin D Heparin induced thrombocytopenia: a prospective study Thromb Hemost 43 1980 61 65
12. Eika C Godal HC Laake K Hamborg T Low incidence of thrombocytopenia during treatment with hog mucosa and beef lung heparin Scand J Haematol 25 1980 19 24
13. Chong BH Pitney WR Castaldi PA Heparin-induced thrombocytopenia: Association of thrombotic complications with heparin-dependent IgG antibody that induces thromboxane synthesis and platelets aggregation Lancet 2 1982 1246 1249
14. Howe SE Lynch DM An enzyme-linked immunosorbent assay for evaluation of thrombocytopenia induced by heparin J Lab Clin Med 105 1985 554 559
15. Cola C Ansell J Heparin induced thrombocytopenia and arterial thrombosis. Alternative therapies Am Heart J 119 1990 368 374
16. Kelton JG Sheridan D Brain H Powers PJ Turpie AG Carter CJ Clinical usefulness of testing for a heparin-dependent platelets-aggregating factor in patient with suspect heparin-associated thrombocytopenia J Lab Clin Med 103 1984 606 612
17. Powers PJ Kelton JG Carter CJ Studies on frequency of heparin-associated thrombocytopenia Thromb Res 33 1984 439 443
18. Nelson JC Lernere RG Golstein R Cagin NA Heparin induced thrombocytopenia Arch Intern Med 138 1978 548 552
19. Saffle JR Russo J Jr Dukes GE Jr Warden GD The effect of low-dose heparin therapy on serum platelet and transaminase levels J Surg Res 28 1980 297 305
20. Schwartz KA Royer G Kaufman DB Penner JA Complication of heparin administration in normal individuals Am J Hematol 19 1985 355 363
21. Silver D Kapsch D Tsoi E Heparin-induced thrombocytopenia, thrombosis and hemorrhage Ann Surg 198 1983 301 306
22. Walls JT Boley TM Curtis JJ Silver D Heparin induced thrombocytopenia in patients undergoing intra-aortic balloon pumping after open heart surgery ASAIO J 38 1992 M574 M576
23. Laster J Cirit D Walker N Silver D The heparin-induced thrombocytopenia. An update Surgery 102 1987 763 770
24. Schmitt BP Adelman B Heparin-associated thrombocytopenia: a critical review and pooled analysis Am J Med Sci 305 1993 208 215
25. Ansell JE Price JM Shah S Beckner RR Heparin-induced thrombocytopenia. What is its real frequency? Chest 88 1985 878 882
26. AbuRahma AF Boland JP Witsberger T Diagnostic and therapeutic strategies of white clot syndrome Am J Surg 162 1991 175 179
27. Bell WR Tomasulo PA Alving BM Duffy TP Thrombocytopenia occurring during the administration of heparin: A prospective study in 52 patients Ann Intern Med 85 1976 155 160
28. Bell WR Royall RM Heparin-associated thrombocytopenia. A comparison of three heparin preparations N Eng J Med 303 1980 902 907
29. Cines DB Kaywin P Bina M Tomaski A Schreiber AD Heparin associated thrombocytopenia N Eng J Med 303 1980 788 795
30. Johansson RA Lazarus KH Henry DH Heparin induced thrombocytopenia: A prospective study Am J Hematol 17 1984 349 353
31. Green D Martin GJ Shoichet SH De Backer N Bomalski JS Lind RN Thrombocytopenia in prospective, randomized, double-blind trial of bovine and porcine heparin Am J Med Sci 288 1984 60 64
32. Cipolle BJ Rodvold KA Seifert R Clarens R Ramirez-Lassepas M Heparin associated thrombocytopenia: a prospective evaluation of 211 patients Ther Drug Monit 5 1983 205 211
33. Ramirez-Lassepas M Cipolle RJ Rodvold KA Heparin-induced thrombocytopenia in patients with cerebrovascular ischemic disease Neurology 34 1984 736 740
34. Warkentin TE Kelton JG Heparin-induced thrombocytopenia Prog Hemost Thromb 10 1991 1 34
35. Kapsch DN Adelstein EH Rhodes GR Silver D Heparin induced thrombocytopenia, thrombosis, and hemorrhage Surgery 86 1979 148 155
36. Murdoch IA Beattie RM Silver DM Heparin-induced thrombocytopenia in children Acta Paediatr 82 1993 495 497
37. Spadone D Clark F James E Laster J Hoch J silver D Heparin-induced thrombocytopenia in the newborn J Vasc Surg 15 1992 306 312
38. Castaman G Ruggeri M Girardello R Rodeghiero F An unusually prolonged case of heparin-induced thrombocytopenia and disseminated intravascular coagulation Haematologica 77 1992 174 176
39. Kappa JR Fisher CA Berkowitz HD Cottrell E Addonizio VP Jr Heparin-induced platelet activation in sixteen surgical patients. Diagnosis and management J Vasc Surg 5 1987 101 109
40. Phelan BK Heparin associated thrombosis without thrombocytopenia Ann Intern Med 99 1983 637 638
41. Van Der Weyden MB Hunt M McGrath K Delayed-onset heparin induced thrombocytopenia. A potentially malignant syndrome Med J Aust 2 1983 132 135
42. Benhamou AC Gruel Y Barsotti J The white clot syndrome or heparin associated thrombocytopenia and thrombosis (WCS or HATT) (26 cases) Int Angiol 4 1985 303 310
43. Boshkov LK Warkentin T Hayward CP Andrew M Kelton JK Heparin-induced thrombocytopenia and thrombosis: clinical and laboratory studies Br J Haematol 84 1993 322 328
44. Baird RA Convery FR Arterial thromboembolism in patients receiving systemic heparin therapy. A complication associated with heparin-induced thrombocytopenia J Bone Joint Surg 59A 1977 1061 1064
45. Rhodes GR Dixon RH Silver D Heparin induced thrombocytopenia: Eight cases with thrombotic-hemorrhagic complications Ann Surg 186 1977 752 758
46. Kapsch D Silver D Heparin induced thrombocytopenia with thrombosis and hemorrhage Arch Surg 116 1981 1423 1429
47. Klein HG Bell WR Disseminated intravascular coagulation during heparin therapy Ann Intern Med 80 1974 477 481
48. Babcock RB Dumper CW Scharfman WB Heparin-induced immune thrombocytopenia N Eng J Med 295 1976 237 241
49. White PW Sadd JR Nensel RE Thrombotic complication of heparin therapy. Including six cases of heparin-induced skin necrosis Ann Surg 190 1979 595 608
50. Platell CFE Tan EGC Hypersensivity reaction to heparin. Delayed onset thrombocytopenia and necrotizing skin lesions Aust NZ J Surg 56 1986 621 623
51. Mehta DP Yoder EL Appel J Bergsman KL Heparin-induced thrombocytopenia and thrombosis: Reversal with streptokinase. A case report and review of literature Am J Hematol 36 1991 275 279
52. Cimo PL Moake JL Weinger RS Ben-Menachem Y Khalil KG Heparin-induced thrombocytopenia: Association with a platelet aggregating factor and arterial thromboses Am J Hematol 6 1979 125 133
53. Somers DL Sotolongo C Bertolatus JA White clot syndrome associated with renal failure J Am Soc Nephrol 4 1993 137 141
54. Towne JB Bernhard VM Hussey C Garancin JC White clot syndrome. Peripheral vascular complications of heparin therapy Arch Surg 114 1979 372 377
55. Delhumeau A Moreau X Chapotte C Houi N Bigorgne JC Heparin associated thrombocytopenia syndrome: an underestimated etiology of adrenal hemorrhage Intensive Care Med 19 1993 475 477
56. Leschi JP Goëau-Brissonnière O Coggia M Chiche L Heparin-related thrombocytopenia and adrenal hemorrhagic necrosis following aortic surgery Ann Vasc Surg 8 1994 506 508
57. Feng WC Singh AK Bert AA Sanofsky SJ Crowley JP Perioperative paraplegia and multiorgan failure from heparin-induced thrombocytopenia Ann Thorac Surg 55 1993 1555 1557
58. Makhoul RG Greenberg CS McCann RL Heparin-associated thrombocytopenia and thrombosis: A serious clinical problem and potential solution J Vasc Surg 4 1986 522 528
59. Battey PM Salem AA Venous gangrene associated with heparin-induced thrombocytopenia Surgery 97 1985 618 620
60. Sobel M Adelman B Szentpetery S Hoffman M Posner M Jenvey W Surgical management of heparin-associated thrombocytopenia J Vasc Surg 8 1988 395 401
61. Leroy J Leclerc MH Delahousse B Treatment of heparin-associated thrombocytopenia and thrombosis with low molecular weight-heparin. (CY 216) Sem Thromb Hemost 11 1985 326 329
62. Eichinger S Kyrle PA Brenner B Thrombocythopenia associated with low-molecular-weigh heparin (letter) Lancet 337 1991 1425 1426
63. Kikta MJ Keller MP Humphrey PW Silver D Can low molecular weight heparins and heparinoids be safely given to patients with heparin-induced thrombocytopenia syndrome? Surgery 114 1993 705 710
64. Follea G Hamandjian I Trzeciak MC Nedey C Streichenberger R Dechavanne M Pentosane polysulphate associated thrombocytopenia Thromb Res 42 1986 413 418
65. Greinacher A Michels I Schäfer M Kiefel V Mueller-Eckhardt C Heparin-associated thrombocytopenia in a patient treated with polysulphated chondroitin sulphate: evidence for immunological crossreactivity between heparin and polysulphated glycosaminoglycan Br J Haematol 81 1992 252 254
66. Chong BH Magnani HN Orgaran in heparin-induced thrombocytopenia Haemostasis 22 1992 85 91
67. Magnani HN Heparin induced thrombocytopenia (HIT): An overview of 230 patients treated with Orgaran (Org 10172) Thromb Haemost 70 1993 554 561
68. Bailey RT Jr Ursick JA Heim KL Hilleman DE Reich JW Heparin associated thrombocytopenia: a prospective comparison of bovine lung heparin, manufactured by a new process, and porcine intestine heparin Drug Intell Clin Pharm 20 1986 374 378
69. Phillips YY Copley JB Store RA Thrombocytopenia and low dose heparin South Med J 76 1983 526 528
70. Rao KA White GC Sherman L Colman R Lan G Ball AP Low incidence of thrombocytopenia with porcine mucosal heparin. A prospective multicentre study Arch Int Med 149 1989 1285 1288
71. Doty JR Alving BM McDonnell DE Ondra SL Heparin-associated thrombocytopenia in the neurosurgical patients Neurosurgery 19 1986 69 72
72. Rizzoni WE Miller K Rick M Lotze MT Heparin-induced thrombocytopenia and thromboembolism in the postoperative period Surgery 103 1988 470 476
73. Rama BN Haake RE Bander SJ Ghasem-Zadeh A Gorla C Heparin-flush associated thrombocytopenia-induced hemorrhage: A case report Nebr Med J 76 1991 392 394
74. Laster J Silver D Heparin-coated catheters and heparin induced thrombocytopenia J Vasc Surg 7 1988 667 672
75. Barker CF Rosato FE Roberts B Peripheral atrial embolism Surg Gynecol Obstet 123 1966 22 26
76. Zalcberg JR McGrath K Dauer R Wiley JS Heparin-induced thrombocytopenia with associated disseminated intravascular coagulation (letter) Br J Haematol 54 1983 655 657
77. Van Aken WG Thrombocytopenia (and consumption coagulopathy) induced by heparin. A case report Scand J Haermatol 25 Suppl. 36 1980 85 90
78. Fratantoni JC Pollet R Gralnick HR Heparin-induced thrombocytopenia. Confirmation of diagnosis with in vitro methods Blood 45 1975 395 401
79. Green D Harris K Reynold N Roberts M Patterson R Heparin immune thrombocytopenia: evidence for a heparin-platelet complex as the antigenic determinant J Lab Clin Med 91 1978 167 175
80. Lynch DM Howe SE Heparin-associated thrombocytopenia. Antibody binding specificity to platelet antigens Blood 66 1985 1176 1181
81. Salzman EW Rosenberg RD Smith MH Lindon JN Favreau L Effect of heparin and heparin fractions on platelet aggregation J Clin Invest 65 1980 64 73
82. Brace LD Fareed J An objective assessment of the interaction of heparin and its fractions with human platelets Sem Thromb Hemost 11 1985 190 198
83. Messmore HL Jr. Griffin B Fareed J Coyne E Seghatchian J In vitro studies of the interaction of heparin, low molecular weight heparin and heparinoids with platelets Ann NY Acad Sci 556 1989 217 232
84. Horne MK III Heparin binding to normal and abnormal platelets Thromb Res 51 1988 135 144
85. Sobel M Adelman B Characterization of platelet binding of heparins and other glycosaminoglycans Thromb Res 50 1988 815 826
86. Chong BH Castaldi PA Platelet proaggregating effect of heparin: possible mechanism of non-immune heparin-associated thrombocytopenia Aust NZJ Med 16 1986 715 716
87. Lecrubier C Conrad J Horellou MH Khar H Samama M Spontaneous platelet aggregation in heparin-treated patients Acta Haematol 7 1984 63 65
88. Mikhailidis DP Barradas MA Jeremy JY Gracey L Wakeling A Dandona P Heparin-induced platelet aggregation in anorexia nervosa and in severe peripheral vascular disease Eur J Clin Invest 15 1985 313 319
89. Chong BH Castaldi PA Heparin-induced thrombocytopenia: further studies of the effects of heparin-dependent antibodies on platelets Br J Haematol 64 1986 347 354
90. Stead RB Schafer AI Rosenberg RD Handin RI Josa M Khuri SF Heterogeneity of heparin lots associated with thrombocytopenia and thromboembolism Am J Med 77 1984 185 188
91. Visentin GP Ford SE Scot JP Aster RH Antibodies from patients with heparin-induced thrombocytopenia/thrombosis are specific for platelet factor 4 complexed with heparin or bound to endothelial cells J Clin Invest 93 1994 81 88
92. Pfueller SL David R Firkin BG Bilston RA Cortizo WF Raines G Platelet aggregating IgG antibody to platelet surface glycoproteins associated with thrombosis and thrombocytopenia Br J Haematol 74 1990 336 341
93. Kelton JG Sheridan D Santos A Heparin induced thrombocytopenia: Laboratory studies Blood 72 1988 925 930
94. Anderson GP Insight into heparin-induced thrombocytopenia Br J Haematol 80 1992 504 508
95. Amiraal J Bridey F Dreyfus M Platelet factor 4 complexed to heparin is the target for antibodies generated in heparin-induced thrombocytopenia Thromb Haemost 68 1992 95 96
96. Olinger GN Hussey CV Olive JA Malik MI Cardiopulmonary bypass for patients with previously documented heparin-induced platelet aggregation J Thorac Cardiovasc Surg 87 1984 673 677
97. Kappa JR Fisher CA Todd B Intraoperative management of patients with heparin-induced thrombocytopenia Ann Thorac Surg 49 1990 714 723
98. Cines DB Tomaski A Tannenbaum S Immune endothelial-cell injury in heparin-associated thrombocytopenia N Eng J Med 316 1987 581 589
99. Sheridan D Carter C Kelton JG A diagnostic test for heparin-induced thrombocytopenia Blood 67 1986 27 30
100. Silberman S Kovarik P Heparin-induced thrombocytopenia: Use of indirect immunofluorescence Ann Clin Lab Sci 17 1987 106 110
101. Makhoul RG Devine DV Brenckman WD Jr McCann RL Greenberg CS Evidence for involvement of platelet glycoproteins other than GpIb in heparin-associated thrombocytopenia and thrombosis Thromb Res 45 1987 421 425
102. Chooi CC Gallus AS Platelet aggregation test for heparin-induced thrombocytopenia Life Science 3 1991 66 69
103. Gruel Y Rupin A Darnige L Specific quantification of heparin-dependent antibodies for the diagnosis of heparinassociated thrombocytopenia using an enzyme-linked immunosorbent assay Thromb Res 62 1991 377 387
104. Chong BH Burgess J Ismail F The clinical usefulness of the platelet aggregation test for the diagnosis of heparin-induced thrombocytopenia Thromb Haemost 69 1993 344 350
105. Greinacher A Michels I Kiefel V Mueller-Eckhardt C A rapid and sensitive test for diagnosing heparin-associated thrombocytopenia Thromb Haemost 66 1991 734 736
106. Garrelts JC LaRocca J Ast D Smith DF Jr Sweet DE Comparison of heparin and 0.9% sodium chloride injection in the maintenance of indwelling intermittent i.v. devices Clin Pharm 8 1989 34 39
107. Gouault-Heilmann M Huet Y Adnot S Low molecular weight heparin fractions as an alternative therapy in heparin-induced thrombocytopenia Haemostasis 17 1987 134 140
108. Vitoux JF Mathieu JF Roncato M Fiessinger JN Aiach M Heparin-associated thrombocytopenia. Treatment with low molecular weight heparin Thromb Haemost 55 1986 37 39
109. Horellou MH Conard J Lecrubier C Persistent heparin induced thrombocytopenia despite therapy with low molecular weight heparin Thromb Haemost 51 1984 134 135
110. Huisse MG Guillin MC Bezeaud A Toulemonde F Kitzis M Andreassian B Heparin-associated thrombocytopenia. In vitro effects of low molecular weight heparin fractions Thromb Res 27 1982 485 490
111. Mikhailidis DP Barradas A Mikhailidis AM Magnani H Dandona P Comparison of the effect of a conventional heparin and a low molecular weight heparinoid on platelet function Br J Clin Pharm 17 1984 43 48
112. Chong BH Ismail F Cade J Gallus A Gordan S Chesterman CN Heparin-induced thrombocytopenia: studies with a new low molecular weight heparinoid Org 10172 Blood 73 1989 1592 1596
113. Blockmans D Bounmeaux H Vermylen J Versraete M Heparin-induced thrombocytopenia. Platelet aggregation studies in the presence of heparin fractions or semi-synthetic analogues of various molecular weights and anticoagulant activities Thromb Haemost 55 1986 90 93
114. Vender JS Matthew EB Silverman IM Korovitz H Dau PC Heparin-associated thrombocytopenia: Alternative managements Anesth Analg 65 1986 520 522
115. Long RW Management of patients with heparin-induced thrombocytopenia requiring cardiopulmonary by pass (letter) J Thorac Cardiovasc Surg 89 1985 950 951
116. Smith JP Walls JT Muscato MS Extracorporeal circulation in a patient with heparin-induced thrombocytopenia Anaesthesiology 62 1985 363 365
117. Makhoul RG McCann RL Austin EH Greenberg CS Lowe JE Management of patients with heparin-associated thrombocytopenia and thrombosis requiring cardiac surgery Ann Thorac Surg 43 1987 617 621
118. Addonizio VP Jr Fisher CA Kappa JR Ellison N Prevention of heparin-induced thrombocytopenia during open heart surgery with iloprost (ZK 36374) Surgery 102 1987 796 807
119. Teasdale SJ Zulys VJ Mycyk T Baird J Glynn MFX Ancrod anticoagulation for cardiopulmonary by pass in heparin-induced thrombocytopenia and thrombosis Ann Thorac Surg 48 1989 712 713
120. Demers C Ginsberg JS Brill-Edwards P Rapid anticoagulation using Ancrod for heparin-induced thrombocytopenia Blood 78 1991 2194 2197
121. Fiessinger JN Aiach M Roncato M Debure C Gaux JC Critical ischemia during heparin-induced thrombocytopenia. Treatment by intraarterial streptokinase Thromb Res 33 1984 235 238
122. Cohen JI Cooper MR Greenberg CS Streptokinase therapy of pulmonary emboli with heparin associated thrombocytopenia Arch Intern Med 145 1985 1725 1726
123. Cummings JM Mason TJ Chomka EV Pouget JM Fibrinolytic therapy of acute myocardial infarction in the heparin thrombosis syndrome Am Heart J 112 1986 407 409
124. Brady J Riccio JA Yumen OH Makary AZ Greenwood SM Plasmapheresis a therapeutic option in the management of heparin-associated thrombocytopenia with thrombosis Am J Clin Pathol 96 1991 394 397
125. Frame JN Mulvey KP Phares JC Anderson MJ Correction of severe heparin-associated thrombocytopenia with intravenous immunoglobulin Ann Intern Med 111 1989 946 947
126. Matsuo T Yamada T Yamanashi T Ryo R Anticoagulant therapy with MD 805 of a hemodialysis patient with heparin-induced thrombocytopenia Thromb Res 58 1990 663 666
127. Matsuo T Kario K Chikahira Y Nakao K Yamada T Treatment of heparin-induced thrombocytopenia by use of Argatroban, a synthetic thrombin inhibitor Br J Haematol 82 1992 627 629
128. Stevenson MM Thrombocytopenia during heparin therapy (letter) N Eng J Med 295 1976 1200 1201
129. Kappa JR Cottrell ED Berkowitz HD Carotid endarterectomy in patients with heparin induced platelet activation: comparative efficacy of aspirin and iloprost (ZK 36374) J Vasc Surg 5 1987 693 701
130. Cole CW Bormanis J Ancrod: a practical alternative to heparin J Vasc Surg 8 1988 59 63
131. Gouault-Heilmann M Huet Y Contant G Payen D Bloch G Rapin M Cardiopulmonary bypass with low-molecular-weight heparin fraction (letter) Lancet 2 1983 1374
132. Matsuo T Yamada T Chikahira Y Kadowaki T Effect of aspirin on heparin-induced thrombocytopenia (HIT) in a patient requiring hemodialysis Blut 59 1989 393 395
133. Leehey DJ Kanak RJ Messmore HL Nawab ZM Popli S Ing TS Heparin-associated thrombocytopenia in maintenance hemodialysis patients Int J Artif Organs 10 1987 390 392
134. Hall AV Clark WF Parbtani A Heparin-induced thrombocytopenia in renal failure Clin Nephrology 38 1992 86 89
135. 2) as sole anticoagulant Dial Transplant 14 1985 579 580
136. Greinacher A Philippen KH Kemkes-Matthes B Möckl M Mueller-Eckhardt C Schaefer K Heparin-associated thrombocytopenia type II in a patient with end-stage renal disease: successful anticoagulation with low-molecular-weight heparinoid Org 10172 during haemodialysis Nephrol Dial Transplant 8 1993 1176 1177
137. Laster J Elfrink R Silver D Reexposure to heparin of patients with heparin-associated antibodies J Vasc Surg 9 1989 677 682
138. Meytes D Ayalon H Virag I Weisbort Y Zakut H Heparin induced thrombocytopenia and recurrent thrombosis in pregnancy. A case report J Reprod Med 31 1986 993 996
139. Copplestone A Oscier DG Heparin-induced thrombocytopenia in pregnancy (letter) Br J Haematol 65 1987 248
140. Greinacher A Eckhardt T Muzmann J Mueller-Eckhardt C Pregnancy complicated by heparin associated thrombocytopenia: Management by a prospectively in vitro selected heparinoid (Org 10172) Thromb Res 71 1993 123 126
141. Calhoun BC Hesser JW Heparin-induced thrombocytopenia associated with pregnancy: discussion of two cases Am J Obstet Gynecol 156 1987 964 966
142. van Besien K Hoffman R Golichowski A Pregnancy associated with lupus anticoagulant and heparin induced thrombocytopenia: Management with a low molecular heparinoid Thromb Res 62 1991 23 29
143. Grinsberg JS Hirsh J Turner DC Levine MN Burrows R Risks to the fetus of anticoagulant therapy during pregnancy Thromb Haemost 61 1989 197 203