Prevention of Platelet-activating Factor-induced Gastrointestinal Lesions in Rats by the New Specific Antagonist N-(2-Dimethylaminoethyl)-N-(3-pyridinylmethyl)[4-(2,4,6-triisopropylphenyl) thiazol-2yl]amine

Arzneimittel-Forschung/Drug Research

Volumn 46, Issue 4, 1996, Pages 407-412

  Giudice, Antonia ^a   Herbert, Jean Marc ^b   Maffrand, Jean Pierre ^b   Manara, Luciano ^a,c   Manzoni, Laurenzia ^a   Le Fur, Gérard ^b  

^a Research Center Sanofi Midy   (Italy)

^b SANOFI   (France)

^c Research Centre Sanofi Midy   (Italy)

Author keywords

Apafant; CAS 136468 36 5; N (2 Dimethylaminoethyl) N (3 pyridinylmethyl) 4 (2,4,6 triisopropylphenyl) thiazol 2 yl amine; Platelet activating factor, antagonists; SR 27417, pharmacology

Indexed keywords

APAFANT; FOROPAFANT; N (2 DIMETHYLAMINOETHYL) N (3 PYRIDINYLMETHYL) [4 (2,4,6 TRIISOPROPYLPHENYL)THIAZOL 2 YL]AMINE; THROMBOCYTE ACTIVATING FACTOR; THROMBOCYTE ACTIVATING FACTOR ANTAGONIST; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG SPECIFICITY; DUODENUM; GASTROINTESTINAL TOXICITY; ILEUM; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PROTECTION; RAT; STOMACH;

ANIMALS; AZEPINES; DOSE-RESPONSE RELATIONSHIP, DRUG; GASTRIC MUCOSA; GASTROINTESTINAL DISEASES; INTESTINAL MUCOSA; MALE; PLATELET ACTIVATING FACTOR; PLATELET AGGREGATION INHIBITORS; RATS; THIAZOLES; TRIAZOLES;

EID: 0029921463     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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