Segregation analysis of alzheimer pedigrees: Rare mendelian dominant mutation(s) explain a minority of early-onset cases

American Journal of Medical Genetics - Seminars in Medical Genetics

Volumn 67, Issue 1, 1996, Pages 9-12

  Martinez, M ^a   Campion, D ^a   Babron, M C ^a   Hannequin, D ^b   Agid, Y ^a   Bellis, M ^d   Brice, A ^a   Mallet, J ^d   Michon, A ^a   Thomas Anterion, C ^c   Clerget Darpoux, F ^a   Dubios, B ^d   Goas, Y ^d   Jaillard Serradt, A ^d   Ledoze, F ^d   Pasquier, F ^d   Puel, M ^d   Zimmerman, M A ^d  

^a INSERM   (France)

^b ROUEN UNIVERSITY HOSPITAL   (France)

^c UNIVERSITY HOSPITAL OF SAINT ETIENNE   (France)

^d INSERM U 289 ^*

Author keywords

Alzheimer disease; Genetic heterogeneity; Segregation analysis

Indexed keywords

ADULT; ALZHEIMER DISEASE; ARTICLE; GENE SEGREGATION; GENETIC ANALYSIS; GENETIC HETEROGENEITY; HUMAN; MAJOR CLINICAL STUDY; MUTATION; ONSET AGE; PEDIGREE ANALYSIS; PRIORITY JOURNAL;

AGE FACTORS; AGE OF ONSET; ALZHEIMER DISEASE; FEMALE; GENES, DOMINANT; HUMANS; MALE; MATHEMATICAL COMPUTING; MUTATION; PEDIGREE; RISK FACTORS; SEX FACTORS;

EID: 0029921428     PISSN: 01487299     EISSN: None     Source Type: Journal    
DOI: 10.1002/ajmg.1320670102     Document Type: Article

References (10)

1. Abel L, Bonney GE (1990): A time-dependent logistic hazard function for modeling variable age of onset in analysis of familial diseases. Genet Epidemiol 7:391-407.
2. Bonney GE (1986): Regressive logistic model for familial disease and other binary traits. Biometrics 42:611-625.
3. Campion D, Brice A, Hannequin D, Tardieu S, Dubois B, Calenda A, Brun E, Pertet C, Tayot J, Martinez M, Mallet J, Agid Y, Clerget-Darpoux F (1995a): A large pedigree with early-onset Alzheimer's disease: clinical, neuropathologic and genetic characterization. Neurology 45:80-85.
4. Campion D, Martinez M, Hannequin D, Thomas-Anterion C, Michon A, Babron MC, Clerget-Darpoux F (1995b): Characteristics of familial aggregation in early-onset Alzheimer disease: evidence of subgroups. Am J Med Genet 60:221-227.
5. Goate AM, Chartier-Harlin MC, Mullan M, Brown J, Crawford F, Fidani L, Giuffra L, Haynes A, Irving N, James L, Mant R, Newton P, Rooke K, Roques P, Talbot C, Pericak-Vance M, Roses A, Williamson R, Rossor M, Owen M, Hardy J (1991): Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature 349:704-706.
6. Lalouel JM (1979): "GEMINI: A Computer Program for Optimization of General Nonlinear Functions." Department of Medical Biophysics and Computing, Technical Report 14. Salt Lake City: University of Utah.
7. Martinez M, Campion D, Babon MC, Clerget-Darpoux F (1994): Towards a resolution of early-onset Alzheimer etiologies. Genet Epidemiol 11:301.
8. Perez-Tur J, Campion D, Martinez M, Brice A, Tardieu S, Hannequin D, Agid Y, Delacourte A, Clerget-Darpoux F, Chartier-Harlin MC, French Alzheimer Group (1995): Evidence for association in early-onset Alzheimer patients with late-onset relatives. Am J Med Genet (in press).
9. Rao VS, van Duijn C, Connor-Lacke L, Cupples A, Growdon JH, Farrer L (1994): Multiple etiologies for Alzheimer disease are revealed by segregation analysis. Am J Hum Genet 55:991-1000.
10. Schellenberg GD, Bird T, Wijsman EM, Orr HT, Anderson L, Nemens E, White JA, Pericak-Vance MA, Moore DK, Gaskell PC Jr, Yamaoka LA, Bebout JL, Welsh KA, Clark CM, Martin GM, Roses AD (1992): Genetic linkage evidence for a familial Alzheimer's disease locus on chromosome 14. Science 258:688-671.