γδ-T cell-receptor-positive lymphocytes inhibit human hematopoietic progenitor cell growth in HIV type 1-infected patients

AIDS Research and Human Retroviruses

Volumn 12, Issue 7, 1996, Pages 577-584

  Geissler, R G ^a   Rossol, R ^b   Mentzel, U ^b   Ottmann, O G ^b   Klein, A S ^b   Gute, P ^b   Helm, E B ^b   Hoelzer, D ^b   Ganser, A ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b GOETHE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; T LYMPHOCYTE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; BURST FORMING UNIT E; CELL PROLIFERATION; CLINICAL ARTICLE; COLONY FORMING UNIT GEMM; COLONY FORMING UNIT GM; CONTROLLED STUDY; GROWTH INHIBITION; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INTERFERON PRODUCTION; LYMPHOCYTE SUBPOPULATION; MALE; PRIORITY JOURNAL; T LYMPHOCYTE;

EID: 0029921374     PISSN: 08892229     EISSN: None     Source Type: Journal    
DOI: 10.1089/aid.1996.12.577     Document Type: Article

References (55)

1. Zon LI, Arkin C, and Groopman JE: Haematologic manifestations of the human immune deficiency virus (HIV). Br J Haematol 1987;66:251-256.
2. Ganser A, Ottmann OG, von Briesen H, Völkers B, Rübsamen-Waigmann H, and Hoelzer D: Changes in the haematopoietic progenitor cell compartment in the acquired immunodeficiency syndrome. Res Virol 1990;141:185-193.
3. Fauci AS: The human immunodeficiency virus: Infectivity and mechanisms of pathogenesis. Science 1988;239:617-622.
4. Kojouharoff G, Ottmann OG, von Briesen H, Rübsamen-Waigmann H, Hoelzer D, and Ganser A: Infection of granulocyte/monocyte progenitor cells with HIV 1. Res Virol 1991;142:151-157.
5. Stanley SK, Kessler SW, Justement JS, Schnittman SM, Greenhouse JJ, Brown CC, Musongela L, Musey K, Kapita B, and Fauci AS: CD34+ bone marrow cells are infected with HIV in a subset of seropositive individuals. J Immunol 1992;149:689-697.
6. Scadden DT, Zeira M, Woon A, Wang Z, Schieve L, Ikeuchi K, Lim B, and Groopman JE: Human immunodeficiency virus infection of human bone marrow stromal fibroblasts. Blood 1990;76:317-322.
7. Fuchs D, Hausen A, Reibnegger G, Werner ER, Werner-Felmayer G, Dierich M, and Wacher H: Interferon-gamma concentration are increased in sera from individuals infected with human immunodeficiency virus type 1. J AIDS 1989;2:158-162.
8. Rossol S, Voth R, Laubenstein HP, Müller WEG, Schröder HC, Meyer zum Büschenfelde KH, and Hess G: Interferon production in patients infected with HIV-1. J Infect Dis 1989;159:815-821.
9. Lähdevirta J, Maury CPJ, Teppo AM, and Repo H: Elevated levels of circulating cachetin/tumor necrosis factor in patients with acquired immunodeficiency syndrome. Am J Med 1988;85: 289-291.
10. Eyster ME, Goedert J, Poon MC, and Peble OT: Acid-labile alpha interferon. A possible preclinical marker of acquired immune deficiency syndrome in hemophilia. N Engl J Med 1983;309:58-586.
11. Kekow J, Wachsman W, McCutchan JA, Carson DA, and Lot M: Transforming growth factor β and noncytopathic mechanisms of immunodeficiency in HIV infection. Blood 1989;74(Suppl. 1):769. (Abstr.).
12. Leiderman IZ, Greenberg ML, Adelsberg BR, and Siegal FP: A glycoprotein inhibitor of in vitro granulopoiesis associated with AIDS. Blood 1987;70:1267-1272.
13. Donahue RE, Johnson MM, Zon LI, Clark SC, and Groopman JE: Suppression of in vitro haematopoiesis following human immunodeficiency virus infection. Nature (London) 1987;326:200-203.
14. Carlo Stella C, Ganser A, and Hoelzer D: Defective in vitro growth of the hemopoietic progenitor cells in acquired immunodeficiency syndrome. J Clin Invest 1987;80:286-293.
15. Dalgleish AG, Beverly PCL, Clapham PR, Crawford DH, Greaves MF, and Weiss RA: The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus. Nature (London) 1984;312:763-767.
16. Klatzmann D, Champagne E, Chamaret S, Gruest J, Guetard D, Hercend T, Gluckman JC, and Montagnier L: T-lymphocytes T4 molecule behaves as the receptor for human retrovirus LAV. Nature (London) 1984;312:767-768.
17. Maddon PJ, Dalgleish AG, McDougal JS, Clapham PR, Weiss RA, and Axel R: The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain. Cell 1986;47:333-348.
18. McDougal JS, Kennedy MS, Sligh JM, Cort SP, Mawle A, and Nicholson JKA: Binding of HTLVIII/LAV to T4+ cells by a complex of the 110k viral protein and the T4 molecule. Science 1986;231:382-385.
19. Mittler RS and Hoffmann MK: Synergism between HIV gp 120 and gp 120-specific antibody in blocking human T cell activation. Science 1989;245:1380-1382.
20. Weinhold KJ, Lyerly HK, Stanley SD, Austin AA, Matthews TJ, and Bolognesi DP: HIV-1 gp120-mediated immune suppression and lymphocyte destruction in the absence of viral infection. J Immunol 1989;142:3091-3097.
21. Chirmule N, Kalyanaraman VS, Oyaizu N, Slade HB, and Pahwa S: Inhibition of functional properties of tetanus antigen-specific-T-cell clones by envelope glycoprotein gp 120 of human immunodeficiency virus. Blood 1990;75:152-159.
22. Robey E and Axel R: CD4: Collaborator in immune recognition and HIV infection. Cell 1990;60:697-700.
23. Di Rienzo AM, Furlini G, Oliver R, Ferris S, Heeney J, and Montagnier L: Different proliferative response of human and chimpanzee lymphocytes after contact with human deficiency virus type 1 gp 120. Eur J Immunol 1994;24:34-40.
24. Brenner MB, McLean J, Dialynas DP, Strominger JL, Smith JA, Owen FL, Seidman JG, Ip SH, Rosen F, and Krangel MS: Identification of a putative second T-cell receptor. Nature (London) 1986;322:145-149.
25. Rossol-Voth R, Rossol S, Trippler M, Geissler G, Ottmann OG, Hoelzer D, and Ganser A: Enhanced delta-TCS-positive gamma-delta-TCR expression in bone marrow and peripheral blood cells associated with HIV-1 infection. Exp Hematol 1991;19:153. (Abstr.).
26. De Paoli P, Gennari D, Martelli P, Basaglia G, Crovatto M, Battistin S, and Santini G: A subset of gamma-delta-lymphocytes is increased during HIV-1 infection. Clin Exp Immunol 1991;83:187-191.
27. - T lymphocytes. A CD 3-associated disulfide-linked gamma chain heterodimer. J Exp Med 1987;165:1076-1094.
28. + human T cell clones. J Immunol 1989; 143:1108-1117.
29. Morio T, Nagasawa M, Nonoyama S, Okawa H, and Yata JI: Phenotypic profile and functions of T cell receptor-gamma-delta-bearing cells from patients with primary immunodeficiency syndrome. J Immunol 1990;144:1270-1275.
30. Geissler RG, Ottmann OG, Eder M, Kojouharoff G, Hoelzer D, and Ganser A: Effect of recombinant human transforming growth factor beta and tumor necrosis factor alpha on bone marrow progenitor cells of HIV-infected persons. Ann Hematol 1991;62:151-155.
31. Geissler RG, Ottmann OG, Kojouharoff G, Reutzel P, Eder M, Hoelzer D, and Ganser A: Influence of human recombinant interferon-alpha and interferon-gamma on bone marrow progenitor cells of HIV-positive individuals. AIDS Res Hum Retroviruses 1992;8:521-525.
32. Borst J, van de Griend RJ, van Oostveen JW, Ang SL, Melief CJ, Seidman JG, and Bolhuis RHL: A T cell receptor gamma/delta CD3 complex found on cloned functional lymphocytes. Nature (London) 1987;325:683-688.
33. O'Brien RL, Happ MP, Dallas A, Palmer E, Kubo R, and Born WK: Stimulation of a major subset of lymphocytes expressing T cell receptor gamma delta by an antigen derived from Mycobacterium tuberculosis. Cell 1989;57:667-674.
34. Kabelitz D: Function and specificity of human gamma/delta-positive T cells. Crit Rev Immunol 1992;11:281-303.
35. Huber SA, Moraska A, and Choate M: T cells expressing the gamma delta T-cell receptor potentiate Coxsackie virus B3-induced myocarditis. J Virol 1992;66:6541-6546.
36. Doberty PC, Allan W, Eichelberger M, and Carding SR: Role of alpha beta and gamma delta T cell subsets in viral immunity. Annu Rev Immunol 1992;10:123-151.
37. Brenner MB, McLean J, Scheft H, Riberdy J, Ang SL, Seidman JG, Devlin P, and Krangel MS: Two forms of the T-cell receptor gamma protein found on peripheral blood cytotoxic T lymphocytes. Nature (London) 1987;325:689-694.
38. Vissinga CS, Fatur-Saunders DJ, and Takei F: Dual role of IL-7 in the growth and differentiation of immature thymocytes. Exp Hematol 1992;20:998-1003.
39. Perussia B, Chan SH, D'Andrea A, Tsuji K, Santoli D, Pospisil M, Young D, Wolf SF, and Trinchieri G: Natural killer (NK) cell stimulatory factor or IL-12 has differential effects on the proliferation of TCR-alpha beta+, TCR gamma delta+ T lymphocytes, and NK cells. J Immunol 1992;149:3495-3502.
40. Ottmann OG and Pelus LM: Differential proliferative effects of transforming growth factor-B on human hematopoietic progenitor cells. J immunol 1988;140:2661-2665.
41. Stewart S, Zhu B, and Axelrad A: A "serum-free" medium for the production of erythropoietic bursts by murine bone marrow cells. Exp Hematol 1984;12:309-313.
42. Margolick JB, Scott ER, Odaka N, and Saah AJ: Flow cytometric analysis of gamma delta T cells and natural killer cells in HIV-1 infection. Clin Immunol Immunopathol 1991;58:126-138.
43. Kozbor D, Hyjek E, Wiaderkiewicz R, Kurzawski G, and Lischner HW: Analysis of gamma delta+ T cells in peripheral blood of children with perinatal human immunodeficiency virus (HIV) infection. J Clin Immunol 1993;13:193-203.
44. Bensussan A, Rabian C, Schiavon V, Bengoufa D, Leca G, and Boumsell L: Significant enlargement of a specific subset of CD3+CD8+ peripheral blood leukocytes mediating cytotoxic T-lymphocyte activity during human immunodeficiency virus infection. Proc Natl Acad Sci USA 1993;90:9427-9430.
45. Boullier S, Cochet M, Poccia F, and Gougeon ML: CDR3-independent gamma-delta V delta 1 + T cell expansion in the peripheral blood of HIV-infected persons. J Immunol 1995;154:1418-1431.
46. Ganser A: Abnormalities of hematopoiesis in the acquired immunodeficiency syndrome. Blut 1988;56:49-53.
47. Bagnara GP, Zauli G, Re MC, Furlini G, Giovannini M, Ranieri S, Brizzi MF, and La Placa M: Impaired GM-CSF production by cultured light density mononuclear cells in HIV-1 seropositive subjects. Int J Cell Cloning 1991;9:239-250.
48. Balleari E, Timitilli S, Puppo F, Gaffuri L, Musselli C, Rizzi F, Indiveri F, and Ghio R: Impaired in vitro growth of peripheral blood hematopoietic progenitor cells in HIV-infected patients: Evidence of an inhibitory effect of autologous T lymphocytes. Ann Hematol 1991;63:320-325.
49. Geissler RG, Ganser A, Rossol R, Ottmann OG, Klein AS, Mentzel U, and Hoelzer D: Inhibition of bone marrow derived hematopoietic colony formation by a delta-TCS-1-positive gamma-delta-T-cell-population in patients with AIDS. Exp Hematol 1992;20:733.
50. Van Oostveen JW, Breit TM, de Wolf JT, Brandt RW, Smit JW, van Dongen JJ, Borst J, and Melief CJ: Polyclonal expansion of T-cell receptor-gamma delta+ T lymphocytes associated with neutropenia and thrombocytopenia. Leukemia 1992;6:410-418.
51. Wilhelm M, Meyer P, Batram C, Tony HP, Dummer R, Nestle F, Burg G, and Wilms K: Gamma/delta receptor-expressing T-cell clones from a cutaneous T-cell lymphoma suppress hematopoiesis. Ann Hematol 1992;65:111-115.
52. Emerson SG and Antin JH: Bone marrow progenitor cells induce a regulatory autologous proliferative T lymphocyte response. J Immunol 1992;142:766-772.
53. Nilsson DE, Aukrust P, Froland SS, Müller F, Fausa O, Halstensen TS, and Brandtzaeg P: Duodenal intraepithelial gamma/delta T cells and soluble CD8, neopterin, and beta 2-microglobulin in serum of IgA-deficient subjects with or without IgG subclass deficiency. Clin Exp Immunol 1993;94:91-98.
54. Chia WK, Freedman J, Li X, Salit I, Kardish M, and Read SE: Programmed cell death induced by HIV type 1 antigen stimulation is associated with a decrease in cytotoxic T lymphocyte activity in advanced HIV type 1 infection. AIDS Res Hum Retroviruses 1995;11:249-256.
55. Miura A, Endo K, Sugawara T, Kameoka JI, Watanabe N, Meguro K, Fukuhara O, Sato I, Suzuki C, and Yoshinaga K: T cell-mediated inhibition of erythropoiesis in aplastic anaemia: The possible role of IFN- and TNF-α. Br J Haematol 1991;78:442-449.