The human 5-hydroxytryptamine 1A receptor differentially modulates phospholipase C and adenylyl cyclase activities

General Pharmacology

Volumn 27, Issue 2, 1996, Pages 263-268

  Fenrick, Randy ^a   Pou, Chantevy ^a   Beliveau, Manon ^a   Fargin, Annick ^a  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

5 HT1A serotonergic receptor; adenylyl cyclase; agonist potency; G protein; phospholipase C; signal transduction

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; ADENYLATE CYCLASE; ALKYLATING AGENT; CYCLIC AMP; FORSKOLIN; PHOSPHATIDYLINOSITOL; PHOSPHOLIPASE C; PINDOBIND; RADIOLIGAND; SEROTONIN; SEROTONIN 1A ANTAGONIST; SEROTONIN 1A RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; CELL CLONE; CELL LINE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVITY; GENE EXPRESSION; HUMAN; HYDROLYSIS; PRIORITY JOURNAL; RECEPTOR DENSITY; SIGNAL TRANSDUCTION;

EID: 0029921297     PISSN: 03063623     EISSN: None     Source Type: Journal    
DOI: 10.1016/0306-3623(95)02028-4     Document Type: Article

References (37)

1. Albert P. R., Zhou Q. Y., Van Tol H. H. M., Bunzow J. R. and Civelli O. J. (1990) Cloning, functional expression, and mRNA tissue distribution of the rat 5-hydroxytrypamine 1A receptor gene. J. Biol. Chem. 265, 5825-5832.
2. Arad H., Rosenbusch J. P. and Levitzki A. (1984) Stimulatory GTP regulatory unit Ns and catalytic unit of adenylate cyclase are tightly associated: mechanistic consequences. Proc. Nat. Acad. Sci. 81, 6579-6583.
3. Ashkenazi A., Winslow J. W., Peralta E. G., Peterson G. L., Schimerlik M. I., Capon D. J. and Ramachandran J. (1987) An M2 muscarinic receptor subtype coupled to both adenylyl cyclase and phosphoinositide turnover. Science 438, 672-675.
4. Bard J. A., Zgombick J., Adham N., Vaysse P., Branchek T. and Weinshank R. L. (1993) Cloning of a novel human serotonin receptor (5-HT7) positively coupled to adenylyl cyclase. J. Biol. Chem. 268: 23422-23426.
5. Birnbaumer L., Abramovitz J. A. and Brown A. M. (1990) Receptor-effector coupling by G proteins. Biochem. Biophys. Acta 1031, 163-223.
6. Black J. W. and Leff P. (1983) Operational models of pharmacological agonism. Proc. R. Soc. Lond. 220, 141-162.
7. Black J. W., Leff P. and Shankley N. P. (1985) An operational model of pharmacological agonism: the effect of E/[A] curve shape on agonist dissociation constant estimation. Br. J. Pharm. 84, 561-571.
8. Boddeke H. W. G. M., Fargin A., Raymond J. R., Schoeffter P. and Hoyer D. (1992) Agonist/antagonist interactions with cloned human 5-HT1A receptors: variations in intrinsic activity studied in transfected HeLa cells. Naunyn-Schmiedeberg's Arch. Pharmacol. 345: 257-263.
9. Braun S. and Levitzki A. (1979) Adenosine receptor permanently coupled to turkey erythrocyte adenylate cyclase. Biochem. 18: 2134-2138.
10. De Lean A., Munson P. and Rodbard D. (1978) Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay, and physiological dose-response curves. Amer. J. Physiol. 235, E97-E102.
11. De Léan A., Hancock A. A. and Lefkowitz R. J. (1982) Validation and statistical analysis of a computer modeling method for quantitative analysis of radioligand binding data for mixtures of pharmacological receptor subtypes. Mol. Pharm. 21, 5-16.
12. Fang Y. F. and Albert P. (1991) Cell-specific signaling of the 5-HT1A receptor. J. Biol. Chem. 266, 23689-23687.
13. Fargin A., Raymond J. R., Lohse M., Kobilka B. K., Caron M. G. and Lefkowitz R. J. (1988) The genomic clone G-21 which resembles a β-adrenergic receptor sequence encodes the 5-HT1A receptor. Nature 335, 358-360.
14. Fargin A., Raymond J. R., Regan J. W., Cotecchia S., Lefkowitz R. J. and Caron M. G. (1989) Effector coupling mechanisms of the cloned 5-HT1A receptor. J. Biol. Chem. 264, 14848-14859.
15. Fargin A., Yamamoto K., Cotecchia S., Goldsmith P. K., Spiegel A.M., Lapetina E. G., Caron M. G. and Lefkowitz R. J. (1991) Dual coupling of the cloned 5-HT1A receptor to both adenylyl cyclase and phospholipase C is mediated via the same Gi protein. Cellular Signaling 3, 547-557.
16. Gilman A. G (1987) G proteins: transducers of receptor-generated signals. Ann. Rev. Biochem. 56: 615-649.
17. 3H-PAT. Nature 305, 140-142.
18. Hoyer D. (1989) 5-Hydroxytryptamine receptors and effector coupling mechanisms in peripheral tissues. In: Peripheral actions of 5-Hydroxytryptamine. (Edited by Fozard J. R.), pp. 72-99, Oxford University Press, Oxford.
19. Hoyer D., Boddeke H. and Schoeffter P. (1991) Second messengers in the definition of 5-HT receptors. In: Serotonin: Molecular Biology, Receptors and Functional Effects. (Edited by Saxena P. R. and Fozard J. R.), pp. 117-132, Birkauser Verlag, Basel.
20. Humphrey P. P. A., Hartig P. and Hoyer D. (1993) A proposed new nomenclature for 5-HT receptors. Trends Pharmocoi. Sci. 14, 233-236.
21. Kobilka B. K., Frielle T., Collins S., Yang-Feng T., Kobilka T. S., Francke U., Lefkowitz R. J. and Caron M. G. (1987) An intronless gene encoding a potential member of the family of receptors coupled to guanine nucleotide regulatory proteins. Nature 329, 75-79.
22. Kusiak J. W. and Pitha J. (1987) A bromoacetylated analogue of cyanopindolol: an irreversible antagonist of rat β-adrenoreceptors. Life Sciences 41, 15-23.
23. Lefkowitz R. J. (1992) The subunit story thickens. Nature 358, 372.
24. Liau L. M., Sleight A. J., Pitha J. and Peroutka S. J. (1991) Characterization of a novel and potent 5-Hydroxytryptamine 1A receptor antagonist. Pharmocol. Biochem. Behav. 38, 555-559.
25. Lopez-Ibor J. J., Jr. (1988) The involvement of serotonin in psychiatric disorders and behavior. Br. J. Psychiatry 153: 26-39.
26. Marick A. V., Peterson A. S., Brake A. J., Myers R. M. and Julius D. (1991). Primary structure and functional expression of the 5HT3 Receptor, a serotonin-gated ion channel. Science 254, 432-437.
27. Martin T. F. J. (1983) Thyrothropin-releasing hormone rapidly activates the phosphodiester hydrolysis of polyphosphoinitides in GH3 pituitary cells. J. Biol. Chem. 258, 14816-14822.
28. Matthes H., Boschert U., Amlaiky N., Graihle R., Plassat J.-L., Muscatelli F., Mattei M.-G. and Hen R. (1993) Mouse 5-hydroxytryptamine 5A and 5-hydroxytryptamine 5B receptors define a new family of serotonin receptors: cloning, functional expression and chromosomal location. Mol. Pharm. 43, 313-319.
29. Monsma F. J., Shen Y., Ward R. P., Hamblin M. W. and Sibley D. R. (1993) Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotic drugs. Mol. Pharm. 43: 320-327.
30. Pazos A., Hoyer D., Dietel M. M. and Palacios J. M. (1988) Autoradiography of serotonin receptors. In: Neuronal Serotonin. Edited by Osborne N. N. and Hamon M., pp. 507-543, John Wiley, New York.
31. Ree S. G. and Choi L. (1992) Regulation of inositol phospholipids-specific phospholipase C isozymes. J. Biol. Chem. 267, 12393-12396.
32. Tang W.-J. and Gilman A. G. (1992). Adenylyl cyclase. Cell 70, 869-872.
33. Tolkovsky A. M. and Levitzki A. (1978) Mode of coupling between the β-adrenergic receptor and adenylate cyclase in turkey erythrocytes. Biochem. 17: 3795-3810.
34. Varrault A., Journot L., Audigier Y. and Bockaert J. (1992) Transfection of human 5-hydroxytryptamine 1A receptors in NIH-3T3 fibroblasts: effects of increasing receptor density on the coupling of 5-hydroxytryptamine 1A receptors to adenylyl cyclase. Mol. Pharm. 41, 999-1007.
35. Wilkinson L. O. and Dourish C. T. (1991) Serotonin and animal behaviour. In: Serotonin receptor subtypes: basic and clinical aspects. (Edited by Peroutka S. J.), pp. 147-210, Wiley-Liss, New York.
36. Wu D., Katz A. and Simon M. I. (1993) Activation of phospholipase Cβ2 by α and βγ subunits of trimeric GTP-binding protein. Proc. Nat. Acad. Sci. 90, 5297-5301.
37. Yocca F. D., Iben L. and Meller L. (1992) Lack of apparent receptor reserve at postsynaptic 5-hydroxytryptamine 1A receptors negatively coupled to adenylyl cyclase activity in rat hippocampal membranes. Mol. Pharm. 41, 1066-1072.