Novel 4,4-bis(trifluoromethyl) imidazolines as stereospecific and orally active acyl CoA: Cholesterol acyltransferase (ACAT) inhibitors and antihypercholesterolemic agents

Bioorganic and Medicinal Chemistry Letters

Volumn 6, Issue 7, 1996, Pages 885-888

  Boswell, George A ^a,b   Li, Hui Yin ^a   Delucca, Indawari ^a   Billheimer, Jeffrey T ^a   Drummond, Spencer ^a   Gillies, Peter J ^a   Robinson, Candy ^a  

^a DUPONT COMPANY   (United States)

^b 226 Sequoia Circle ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 [N (4 CYANOBENZOY) N METHYLAMINO] 2 (4 CYANOPHENYL) 4,4 BIS(TRIFLUOROMETHYL 4,5 DIHYDROIMIDAZOLE; ANTILIPEMIC AGENT; CHOLESTEROL ACYLTRANSFERASE; CHOLESTEROL ACYLTRANSFERASE INHIBITOR; IMIDAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BIOAVAILABILITY; CELL LINE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOMER; ENZYME INHIBITION; MACROPHAGE; MOLECULAR MODEL; NONHUMAN; ORAL DRUG ADMINISTRATION; RABBIT;

ANIMALIA; ORYCTOLAGUS CUNICULUS;

EID: 0029921270     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0960-894X(96)00137-0     Document Type: Article

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