Destabilizing effect of proline substitutions in two helical regions of T4 lysozyme: Leucine 66 to proline and leucine 91 to proline

Protein Science

Volumn 5, Issue 4, 1996, Pages 742-751

  Gray, Terry M ^a,i   Arnoys, Eric J ^a,b   Blankespoor, Stephen ^a,c   Born, Tim ^a,d   Jagar, Rebekah ^a,e   Everman, Rebecca ^a,f   Plowman, Darla ^a,g   Stair, Angela ^a   Zhang, Daisy ^a,h  

^a CALVIN COLLEGE   (United States)

^b Michigan State University   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d MAYO GRADUATE SCHOOL   (United States)

^e UNIVERSITY OF NOTRE DAME   (United States)

^f UNIVERSITY OF WISCONSIN MADISON   (United States)

^g UNIVERSITY OF COLORADO   (United States)

^h NORTHERN ARIZONA UNIVERSITY   (United States)

ⁱ Matthews Laboratory   (United States)

Author keywords

cavity; CD; molecular dynamics; proline substitution; protein stability; T4 lysozyme; temperature sensitive mutants; UV difference spectroscopy

Indexed keywords

AMINO ACID SUBSTITUTION; ARTICLE; DENATURATION; HYDROGEN BOND; HYDROPHOBICITY; PRIORITY JOURNAL; PROTEIN STABILITY; SITE DIRECTED MUTAGENESIS; TEMPERATURE SENSITIVITY; ULTRAVIOLET SPECTROSCOPY;

EID: 0029921211     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: 10.1002/pro.5560050419     Document Type: Article

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