Nitric oxide donor alleviates ovariectomy-induced bone loss

Bone

Volumn 18, Issue 4, 1996, Pages 301-304

  Wimalawansa, Sunil J ^a   De Marco, G ^a   Gangula, P ^a   Yallampalli, C ^a  

^a UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

Author keywords

Bone mineral density; HRT; Nitric oxide synthese; Prevention of postmenopausal bone loss

Indexed keywords

ESTRADIOL; ESTROGEN; GLYCERYL TRINITRATE; NITRIC OXIDE; NITRIC OXIDE DONOR; NITRIC OXIDE SYNTHASE INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; BONE ATROPHY; BONE DENSITY; BONE MASS; BONE MINERAL; CONTROLLED STUDY; DUAL ENERGY X RAY ABSORPTIOMETRY; ESTROGEN DEFICIENCY; FEMALE; FEMUR; HORMONE DEFICIENCY; NONHUMAN; OSTEOCLAST; OSTEOLYSIS; OVARIECTOMY; RAT; SUBCUTANEOUS DRUG ADMINISTRATION; TRANSDERMAL DRUG ADMINISTRATION;

EID: 0029921126     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/8756-3282(96)00005-1     Document Type: Article

References (28)

1. Conference report. Consensus Development Conference: Diagnosis, prophylaxis and treatment of osteoporosis. Am J Med 94:646-650; 1993.
2. Fukishima, O. and Gay, C. V. Ultrastructural localisation of guanylate cyclase in bone cells. J Histochem Cytochem 39:529-535; 1991.
3. Gowen, M., Nedwin, G. E., and Mundy, G. R. Preferential inhibition of cytokine stimulated bone resorption by recombinant interferon gamma. J Bone Miner Res 1:469-473; 1986.
4. Horowitz, M. Cytokines and estrogen in bone: Anti-osteoporotic effects. Science 260:626; 1993.
5. Kalu, D. N. The ovariectomized rat model of postmenopausal bone loss. Bone Miner 15:175-192: 1991.
6. Kasten, T. P., Collin-Osdoby, P., Patel. N., Osdoby, P., Krukowski, M., Misko, T., Settle, S. L., Currie, M. G., and Nickols, G. A. Potentiation of osteoclastic bone resorbing activity by inhibition of nitric oxide synthase. Proc Natl Acad Sci USA 91:3569-3573; 1994.
7. Kawase, T., Howard, G. A., Roos, B. A., and Burns, D. M. Nitric oxide stimulates mineralization in osteoblastic cell cultures. J Bone Miner Res 8:S372; 1993.
8. Lincoln, T. M. Cyclic GMP and mechanisms of vasodilation. Pharmacol Ther 41:497-502; 1989.
9. Lindsay, R. and Cossman, F. Estrogen in prevention and treatment of osteoporosis. Ann NY Acad Sci 592:326-345: 1990.
10. Lowik, C. W. G. M., Nibbering, P. H., Van der Ruit, M., and Papapoulos, S. E. Inducible production of nitric oxide in osteoblast-like cells and in fetal mouse bone explants is associated with suppression of osteoclastic bone resorption. J Clin Invest 93:1465-1472: 1994.
11. MacIntyre, I., Zaidi, M., Towhidul, A. A. S. M., Datta, H. K., Moonga, B. S., Lidbury, P. S., Hecker, M., and Vane, J. M. Osteoclast inhibition: an action of nitric oxide not mediated by cyclic GMP. Proc Natl Acad Sci USA 88:2936-2940; 1991.
12. Moncada, S. and Higgs, A. The L-argimne: nitric oxide pathway. N Engl J Med 329:2002-2012: 1993
13. Moncada, S., Palmer, R. M. G., and Higgs, E. A. Nitric oxide: physiology, pathophysiology and pharmacology. Pharmacol Rev 43:109-142; 1991.
14. 2 release: A new experimental method. Calcif Tissue Int 47:35-39; 1990.
15. Nussler, A. K., DiSilvio, M., Billiar, T. R., Hoffman, R. A., Geller, D. A., Selby, R., Madrigas, J., and Simmons, R. L. Stimulation of the nitric oxide synthase pathways in human hepatocytes by cytokines and endotoxin. J Exp Med 176:261-264; 1992.
16. Peunova, N. and Enikolopov, G. Amplification of calcium-induced gene transcription by nitric oxide in neuronal cells. Nature 364:450-453; 1993.
17. Pastoureau, P., Chomel, A., and Bonnet, J. Specific evaluation of localized bone mass and bone loss in the rat using dual-energy X-ray absorptiometry subregional analysis. Osteopor Int 5:143-149; 1995.
18. Punjabi, C. J., Laskin, D. L., Heck, D. E., and Laskin, J. D. Production of nitric oxide by murine bone marrow cells. J Immunol 149:2179-2184; 1992.
19. Ralston, S. H., Todd, D., Helfrich, M. H., Benjamin, N., and Grabowski, P. Human osteoblast-like cells produce nitric oxide and express inducible nitric oxide synthase. Endocrinology 135:330-336; 1994.
20. Ralston, S. H., Ho, L. P., Helfrich, M. H., Grabowski, P. S., Johnston, P. W., and Benjamin, N. Nitric oxide: a cytokine-induced regulator of bone resorption. J Bone Miner Res 10:1040-1049; 1995.
21. 2 produces similar responses in both G6PD activity and RNA production as mechanical loading, and increases IGF-II release, in adult cancellous bone in culture. Calcif Tissue Int 53:324-329; 1993.
22. Rodan, G. A., Bourret, L. A., Harvey, A., and Mensi, T. Cyclic AMP and cyclic GMP: mediators of the mechanical effects on bone remodelling. Science 189:467-469; 1975.
23. Wimalawansa, S. J. Calcitonin gene-related peptide: Isolation, distribution and receptor binding. University of London: Ph.D. Thesis; 1989.
24. Wimalawansa, S. J. Therapeutic options in prevention and treatment of osteoporosis, Exp Clin Endocrinol (Life Sci Adv) 12:1-27; 1993.
25. Wronski, T. J., Dann, L. M., Qi, H., and Yen, C-F. Skeletal effects of withdrawal of estrogen and diphosphonate treatment in ovariectomized rats. Calcif Tissue Int 53:210-216; 1993.
26. Wronski, T. J. and Yen, C. F. The ovariectomized rat model as an animal model for postmenopausal bone loss. Cells Mater Suppl 1:69-74; 1991.
27. Yallampalli, C. and Garfield, R. E. Inhibition of nitric oxide synthesis in rats during pregnancy produces signs similar to those of preeclampsia. Am J Obstet Gynecol 169:1316-1320; 1993.
28. Yamauchi, H., Kushida, K., Yamazaki, K., and Inoue, T. Assessment of spine bone mineral density in ovariectomized rats using DXA. J Bone Miner Res 10:1033-1039; 1995.