Kinetics of radioiodinated species in subcellular fractions from rat hearts following administration of iodine-123-labelled 15-(p-iodophenyl)-3-(R,S)-methylpentadecanoic acid (123I-BMIPP)

European Journal of Nuclear Medicine

Volumn 23, Issue 4, 1996, Pages 383-389

  Morishita, Shigenori ^a   Kusuoka, Hideo ^b   Yamamichi, Yoshihiro ^a   Suzuki, Noriaki ^a   Kurami, Miki ^a   Nishimura, Tsunehiko ^b  

^a Nihon Medi Physics   (Japan)

^b OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

Author keywords

Fatty acids; Iodine 123 labelled 15 (p iodophenyl) 3 (R,S) methylpentadecanoic acid; Mitochondria; Myocardium; Oxidation

Indexed keywords

DIACYLGLYCEROL; FATTY ACID; IODINE 123; LIPID; LONG CHAIN FATTY ACID; PHOSPHOLIPID; SUBTILISIN; TRIACYLGLYCEROL;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL FRACTIONATION; CELLULAR DISTRIBUTION; CENTRIFUGATION; CYTOSOL; FATTY ACID METABOLISM; HEART MUSCLE; HOMOGENATE; INTRAVENOUS DRUG ADMINISTRATION; MICROSOME; MITOCHONDRION; NONHUMAN; RAT; THIN LAYER CHROMATOGRAPHY; TIME;

ANIMALS; CHROMATOGRAPHY, THIN LAYER; CYTOSOL; FATTY ACIDS; FEMALE; IODINE RADIOISOTOPES; IODOBENZENES; MITOCHONDRIA, HEART; MYOCARDIUM; RATS; RATS, SPRAGUE-DAWLEY; SUBCELLULAR FRACTIONS;

EID: 0029921015     PISSN: 03406997     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF01247365     Document Type: Article

References (35)

1. Goodman MM, Kirsch G, Knapp FF. Synthesis and evaluation of radioiodinated terminal p-iodophenyl-substituted α- and β-methyl-branched fatty acids. J Med Chem 1984; 27: 390-397.
2. Livni E, Elmaleh DR, Barlai-Kovach MM, Goodman MM, Knapp FF, Strauss HW. Radioiodinated beta-methyl phenyl fatty acids as potential tracers for myocardial imaging and metabolism. Eur Heart J 1985; 6 Suppl B: 85-89.
3. 123I-BMIPP myocardial imaging for myocardial infarction and hypertrophic cardiomyopathy. Ann Nucl Med 1993; 7: SII-35-SII-39.
4. Kawamoto M, Tamaki N, Yonekura Y, Tadamura E, Fujibayashi Y, Magata Y, Nohara R, Sasayama S, Ikekubo K, Kato H, Konishi J. Combined study with I-123 fatty acid and thallium-201 to assess ischemic myocardium: comparison with thallium redistribution and glucose metabolism. Ann Nucl Med 1994; 8: 47-54.
5. 123I-β-methyl-iodo-phenyl pentadecanoic aicd. Eur J Nucl Med 1994; 21: 283-291.
6. Kurata C, Tawarahara K, Okayama K, Wakabayashi Y, Kobayashi A, Yamazaki N, Kaneko M. Myocardial imaging with radioiodinated beta-methyl-branched fatty acid in cardiomyopathy. Ann Nucl Med 1993; 7: SII-2-SII-33.
7. Matsunari I, Saga T, Taki J, Akashi Y, Hirai J, Wakasugi T, Aoyama T, Matoba M, Ichiyanagi K, Hisada K. Kinetics of iodine-123-BMIPP in patients with prior myocardial infarction: assessment with dynamic rest and stress images compared with stress thallium-201 SPECT. J Nucl Med 1994; 35: 1279-1285.
8. 123I-BMIPP in patients with hypertrophic cardiomyopathy: assessment by radial long-axis SPET. Nucl Med Commun 1995; 16: 336-343.
9. Knapp FF, Ambrose KR, Goodman MM. New radioiodinated methyl-branched fatty acids for cardiac studies. Eur J Nucl Med 1986; 12: S39-S44.
10. Ambrose KR, Owen BA, Goodman MM, Knapp FF. Evaluation of the metabolism in rat hearts of two new radioiodinated 3-methyl-branched fatty acid myocardial imaging agents. Eur J Nucl Med 1987; 12: 486-491.
11. Ambrose KR, Owen BA, Callahan AP, Goodman MM, Knapp FF. Effects of fasting on the myocardial subcellular distribution and lipid distribution of terminal p-iodophenyl-substituted fatty acids in rats. Nucl Med Biol 1988; 15: 695-700.
12. 125I] iodoaryl β-methyl fatty acids. Int J Nucl Med Biol 1985; 12: 223-226.
13. DeGrado TR, Holden JE, Ng CK, Raffel DM, Gatley SJ. β-Methyl-l5-p-iodophenylpentadecanoic acid metabolism and kinetics in the isolated rat heart. Eur J Nucl Med 1989; 15: 78-80.
14. Knapp FF, Reske SN, Ambrose KR, Kropp J, Kohlen S, Kolkmeier J, Goodman MM, Cunningham EB. Formation of polar products from radioiodinated 15-(p-iodophenyl)-3-(R,S)-methylpentadecanoic acid (BMIPP) by isolated Langendorff rat hearts. NucCompact 1990; 21: 133-138.
15. Knapp FF, Reske SN, Kirsch G, Ambrose KR, Blystone SL, Goodman MM. Radioiodinated methyl-branched fatty acids - evaluation of catabolites formed in-vivo. NucCompact 1990; 21: 229-231.
16. Knapp FF, Kropp J, Goodman MM, Franken P, Reske SN, Ambrose KR, Som P, Biersack HJ, Sloof GW, Visser FC. The development of iodine-123-methyl-branched fatty acids and their applications in nuclear cardiology. Ann Nucl Med 1993; 7:SII-1-SII-14.
17. Yamamichi Y, Kusuoka H, Morishita K, Shirakami Y, Kurami M, Okano K, Itoh O, Nishimura T. Metabolism of I-123-labeled-15-(p-iodophenyl)-3-(R,S)-methyl-pentadecanoic acid (BMIPP) in perfused rat hearts. J Nucl Med 1995; 36: 1043-1050.
18. Knapp FF, Goodman MM, Callahan AP, Kirsch G. Radioiodinated 15-(p-iodophenyl)-3,3-diemthylpentadecanoic acid: a useful new agent to evaluate myocardial fatty acid uptake. J Nucl Med 1986; 27: 521-531.
19. Reske SN, Knapp FF, Winkler C. Experimental basis of metabolic imaging of the myocardium with radioiodinated aromatic free fatty acids. Am J Physiol Imag 1986; 1: 214-229.
20. Kropp J, Jorgens M, Glanzer KP, Luderitz B, Biersack HJ, Knapp FF. Evaluation of ischemia and myocardial viability in patients with coronary artery disease (CAD) with iodone-123 labeled 15-(p-iodophenyl)-3-R,S-methylpentadecanoic acid (BMIPP). Ann Nucl Med 1993; 7: SII-93-SII-100.
21. Plati JT, Strain WH, Warren SL. Iodinated organic compounds as contrast media for radiographic diagnoses. II. Ethyl esters of iodinated straight and branched chain phenyl fatty acids. J Am Chem Soc 1943; 65: 1273-1276.
22. De Duve C, Pressman BC, Gianetto R, Wattiaux R, Appelmans F. Tissue fractionation studies. 6. Intracellular distribution patterns of enzymes in rat-liver tissue. Biochem J 1955; 60: 604-617.
23. Pande SV, Blanchaer MC. Reversible inhibition of mitochondrial adenosine diphosphate phosphorylation by long chain acyl coenzyme A esters. J Biol Chem 1971; 246: 401-411.
24. Hogeboom GH, Schneider WC, Pallade GE. Cytochemical studies of mammalian tissues. I. Isolation of intact mitochondria from rat liver; some biochemical properties of mitochondria and submicroscopic particulate material. J Biol Chem 1948; 172: 619-639.
25. Green JD, Narahara HT. Assay of succinate dehydrogenase activity by the tetrazolium method: evaluation of an improved technique in skeletal muscle fractions. J Histochem Cytochem 1980; 28: 408-412.
26. Aebi H. Catalase. In: Bergmeyer HU, ed. Methods of enzymatic analysis, vol 2, 2nd edn. New York: Academic Press; 1980: 673-684.
27. Folch J, Lees M, Stanley GHS. A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 1957; 226: 497-509.
28. Cernansky G, Liau DF, Hashim SA, Ryan SF. Estimation of phosphatidylglycerol in fluids containing pulmonary surfactant. J Lipid Res 1980; 21: 1128-1131.
29. Kropp J, Ambrose KR, Knapp FF, Nissen HP, Biersack HJ. Incorporation of radioiodinated IPPA and BMIPP fatty acid analogues into complex lipids from isolated rat hearts. Nucl Med Biol 1992; 19: 283-288.
30. Christie WW. Rapid separation and quantification of lipid classes by high performance liquid chromatography and mass (light-scattering) detection. J Lipid Res 1985; 26: 507-512.
31. Knapp FF, Kropp J. Iodine-123-labelled fatty acids for myocardial single-photon emission tomography: current status and future perspectives. Eur J Nucl Med 1995; 22: 361-381.
32. Singh I, Pahan K, Dhaunsi GS, Lazo O, Ozand P. Phytanic acid α-oxidation; differential subcellular localization in rat and human tissues and its inhibition by Nycodenz. J Biol Chem 1993; 268: 9972-9979.
33. Singh I, Pahan K, Singh AK, Barbosa E. Refsum disease: a defect in the α-oxidation of phytanic acid in peroxisomes. J Lipid Res 1993; 34: 1755-1764.
34. Magnani M, Serafini G, Antonelli A, Malatesta M, Gazzanelli G. Evidence for a particulate location of ubiquitin conjugates and ubiquitin-conjugating enzymes in rabbit brain. J Biol Chem 1991; 266: 21018-21024.
35. Lai JCK, Clark JB. Preparation of synaptic and nonsynaptic mitochondria from mammalian brain. Methods Enzymol 1979; LV: 51-60.