Identification and characterization of a 230-kDa Golgi-associated protein recognized by autoantibodies from a patient with HBV hepatitis

Cell Structure and Function

Volumn 21, Issue 1, 1996, Pages 63-72

  Funaki, Toshiharu ^a,b   Fujiwara, Toshiyuki ^a   Hong, Hong Shang ^c   Misumi, Yoshio ^a   Nishioka, Mikio ^b   Ikehara, Yukio ^a  

^a FUKUOKA UNIVERSITY   (Japan)

^b KAGAWA UNIVERSITY   (Japan)

^c CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

Author keywords

Autoantibodies; GCP230; Golgi complex; Peripheral membrane protein

Indexed keywords

ALPHA MANNOSIDASE; AUTOANTIBODY; AUTOANTIGEN; BREFELDIN A; CELL PROTEIN; NOCODAZOLE;

ANIMAL CELL; ARTICLE; CASE REPORT; CELL CULTURE; CELL LYSATE; CELL MEMBRANE; CYTOSOL; GOLGI COMPLEX; HEPATITIS B; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; NONHUMAN; PRIORITY JOURNAL;

ANIMALIA; HEPATITIS B VIRUS; MAMMALIA;

EID: 0029920847     PISSN: 03867196     EISSN: None     Source Type: Journal    
DOI: 10.1247/csf.21.63     Document Type: Article

References (43)

1. BARON, MD. and GAROFF, H. 1990. Mannosidase II and the 135-kD Golgi-specific antigen recognized by monoclonal antibody 53FC3 are the same dimeric protein. J. Biol. Chem., 265: 19928-19931.
2. BECK, K.A., BUCHANAN, J.A., MALHOTRA, V., and NELSON, W.J. 1994. Golgi spectrin: Identification of an erythroid β-spectrin homolog associated with the Golgi complex. J. Cell Biol., 127: 707-723.
3. BENNETT, V. 1983. Protein involved in membrane-cytoskeleton association in human erythrocytes: spectrin, ankyrin and band 3. Methods Enzymol., 96: 313-324.
4. BENNETT, V. 1990. Spectrin-based membrane skeleton: a multipotential adaptor between plasma membrane and cytoplasm. Physiol. Rev., 70: 1029-1065.
5. BLANSCHEK, M.A., PENNEC, Y.L., SMITZIS, A.M., LE GOFF, P., LAMOUR, A., KERDRAON, G., JOURQUAN, J., and YOUINOUM, P. 1988. Anti-Golgi complex autoantibodies in patients with primary Sjögren syndrome. Scand. J. Rheumatol., 17: 291-296.
6. BORDIER, C. 1981. Phase separation of integral membrane proteins in Triton X-114 solution. J. Biol. Chem., 256: 1604-1607.
7. CLARY, D.O., GRIFF, I.C., and ROTHMAN, J.E. 1990. SNAPs, a family of NSF attachment proteins involved in membrane fusion in animals and yeast. Cell, 61: 709-721.
8. COHEN, C. and PARRY, D.A.D. 1986. α-Helical coiled coils - a widespread motif in proteins. Trends Biochem. Sci., 11: 245-248.
9. DOMS, R.W., RUSS, G., and YEWDEL, J.W. 1989. Brefeldin A redistributes resident and itinerant Golgi proteins to the endoplasmic reticulum. J. Cell Biol., 109: 61-72.
10. DONALDSON, J.G., LIPPINCOTT-SCHWARTZ, J., BLOOM, G.S., KREIS, T.E., and KLAUSNER, R.D. 1990. Dissociation of a 110 kD peripheral membrane protein from the Golgi apparatus is an early event in brefeldin A action. J. Cell. Biol., 111: 2295-2306.
11. DONALDSON, J., KAHN, R.A., LIPPINCOTT-SCHWARTZ, J., and KLAUSNER, R.D. 1991. Binding of ARF and β-COP to Golgi membranes: possible regulation by a trimeric G protein. Science, 254: 1197-1199.
12. DONALDSON, J.G., FINAZZI, D., and KLAUSNER, R.D. 1992. Brefeldin A inhibits Golgi membrane-catalysed exchange of guanine nucleotide bound to ARF. Nature, 360: 350-352.
13. DUDEN, R., GRIFFITHS, G., FRANK, R., ARGOS, P., and KREIS, T.E. 1991. β-COP, a 110 kD protein associated with non-clathrin-coated vesicles and the Golgi complex, shows homology to β-adaptin. Cell, 64: 649-664.
14. FARQUHAR, M.G. and PALADE, G.E. 1981. The Golgi apparatus (complex) - (1954-1981) - from artifact to center stage. J. Cell Biol., 91: 77s-103s.
15. FARQUHAR, M.G. 1985. Progress in unraveling pathways of Golgi traffic. Annu. Rev. Cell Biol., 1: 447-488.
16. FRITZLER, M.J., HAMEL, J.C., OCHS, R.L., and CHAN, E.K.L. 1993. Molecular characterization of two human autoantigens: unique cDNAs encoding 95- and 160-KD proteins of a putative family in the Golgi complex. J. Exp. Med., 178: 49-62.
17. FUJIKI, Y., HUBBARD, A.L., FOWLER, S., and LAZAROW, P.W. 1982. Isolation of intracellular membranes by means of sodium carbonate treatment: application to endoplasmic reticulum. J. Cell Biol., 93: 97-102.
18. FUJIWARA, T., ODA, K., YOKOTA, S., TAKATSUKI, A., and IKEHARA, Y. 1988. Brefeldin A causes disassembly of the Golgi complex and accumulation of secretory proteins in the endoplasmic reticulum. J. Biol. Chem., 263: 18545-18552.
19. FUJIWARA, T., ODA, K., and IKEHARA, Y. 1989. Dynamic distribution of the Golgi marker thiamine pyrophosphatase is modulated by brefeldin A in rat hepatoma cells. Cell Struct. Funct., 14: 605-616.
20. HELMS, J.B. and ROTHMAN, J.E. 1992. Inhibition by brefeldin A of Golgi membrane enzyme that catalyses exchange of guanine nucleotide bound to ARF. Nature, 360: 352-354.
21. HO, W.C., ALLAN, V.J., VAN MEER, G., BERGER, E.G., and KREIS, T.E. 1989. Reclustering of scattered Golgi elements occurs along microtubules. Eur. J. Cell. Biol., 48: 250-263.
22. HONG, H.S., MORSHED, S.A., TANAKA, S., FUJIWARA, T., IKEHARA, Y., and NISHIOKA, M. 1992. Anti-Golgi antibody in rheumatoid arthritis patients recognizes a novel antigen of 79 kDa (doublet) by Western blot. Scand. J. Immunol., 36: 785-792.
23. KARECLA, P.I. and KREIS, T.E. 1992. Interaction of membranes of Golgi complex with microtubules in vitro. Eur. J. Cell Biol., 57: 139-146.
24. KREIS, T.E. 1990. Role of microtubules in the organization of the Golgi apparatus. Cell. Motil. Cytoskeleton, 15: 67-70.
25. LINSTEDT, A.D. and HAURI, H.-P. 1993. Giantin, a novel conserved Golgi membrane protein containing a cytoplasmic domain of at least 350 kDa. Mol. Biol. Cell, 4: 679-693.
26. LIPPINCOTT-SCHWARTZ, J., YUAN, L.C., BONIFACINO, J.S., and KLAUSNER, R.D. 1989. Rapid redistribution of Golgi proteins into the ER in cells treated with brefeldin A; evidence for membrane cycling from Golgi to ER. Cell, 56: 801-813.
27. MALHOTRA, V., ORCI, L., GLICK, B.S., BLOCK, M.R., and ROTHMAN, J.E. 1988. Role of an N-ethylmaleimide-sensitive transport component in promoting fusion of transport vesicles with cisternae of the Golgi stack. Cell, 54: 221-227.
28. MISUMI, Y., MISUMI, Y., MIKI, K., TAKATSUKI, A., TAMURA, G., and IKEHARA, Y. 1986. Novel blockade by brefeldin A of intracellular transport of secretory proteins in cultured rat hepatocytes. J. Biol. Chem., 261: 11398-11403.
29. NARULA, N., MCMORROW, I., PLOPPER, G., DOHERTY, J., MATLIN, K.S., BURKE, B., and STOW, J.L. 1992. Identification of a 200-KD, brefeldin-sensitive protein on Golgi membranes. J. Cell Biol., 117: 27-38.
30. ORCI, L., PALMER, D.J., AMHERDT, M., and ROTHMAN, J.E. 1993. Coated vesicle assembly in the Golgi requires only coatomer and ARF proteins from the cytosol. Nature, 364: 732-734.
31. ROGALSKI, A.A. and SINGER, S.J. 1984. Association of elements of the Golgi apparatus with microtubules. J. Cell Biol., 99: 1092-1100.
32. ROTHMAN, J.E. 1994. Mechanisms of intracellular protein transport. Nature, 372: 55-63.
33. ROTHMAN, J.E. and ORCI, L. 1992. Molecular dissection of the secretory pathway. Nature, 335: 409-415.
34. SEELING, H.P., SCHRANZ, P., SCHRÖTER, H., WIEMANN, C., and RENZ, M. 1994. Macrogolgin - A new 376 kD Golgi complex outer membrane protein as target of antibodies in patient with rheumatic diseases and HIV infections. J. Autoimmun., 7: 67-91.
35. SEGUCHI, T., GOTO, Y., ONO, M., FUJIWARA, T., SHIMADA, T., KUNG, H., NISHIOKA, M., IKEHARA, Y., and KUWANO, M. 1992. Brefeldin A-resistant mutants of human epidermoid carcinoma cell line with structural changes of the Golgi apparatus. J. Biol. Chem., 267: 11626-11630.
36. SERAFINI, T., ORCI, L., AMMHERDT, M., BRUNNER, M., KAHN, R.A., and ROTHAMN, J.E. 1991. ADP-ribosylation factor is a subunit of the coat of Golgi-derived COP-coated vesicles: a novel role for a GTP-binding protein. Cell, 67: 239-253.
37. SERAFINI, T., STENBECK, G., BRECHT, A., LOTTSPEICH, F., ORCI, L., ROTHMAN, J.E., and WIELAND, F.T. 1991. A coat subunit of Golgi-derived non-clathrin-coated vesicle with homology to the clathrin-coated vesicle coat protein β-adaptin. Nature, 349: 215-220.
38. SÖLLNER, T., WHITEHEART, S.W., BRUNNER, M., ERDJUMENT-BROMAGE, H., GEROMANOS, S., TEMPST, P., and ROTHMAN, J.E. 1993. SNAP receptors implicated in vesicle targeting and fusion. Nature, 362: 318-324.
39. SOHDA, M., MISUMI, Y., FUJIWARA, T., NISHIOKA, M., and IKEHARA, Y. 1994. Molecular cloning and sequence analysis of a human 372-kDa protein localized in the Golgi complex. Biochem. Biophys. Res. Ceommun., 205: 1399-1408.
40. TAKAMI, N., OGATA, S., ODA, K., MISUMI, Y., and IKEHARA, Y. 1988. Biosynthesis of placental alkaline phosphatase and its post-translational modification by glycophospholipid for membrane-anchoring. J. Biol. Chem., 263: 3016-3021.
41. TAKAMI, N., MISUMI, Y., KUROKI, M., MATSUOKA, Y., and IKEHARA, Y. 1988. Evidence for carbosyl-terminal processing and glycolipid-anchoring of human carcinoembryonic antigen. J. Biol. Chem., 263: 12716-12720.
42. TAN, E.M. 1989. Antinuclear antibodies: diagnostic markers for autoimmune diseases and probes for cell biology. Adv. Immunol., 44: 93-151.
43. WATERS, M.G., SERAFINI, T., and ROTHMAN, J.E. 1991. 'Coatomer': a cytosolic protein complex containing subunits of non-clathrin-coated Golgi transport vesicles. Nature, 349: 248-251.