Adaptation of the gastric epithelium to injury is maintained in vitro and is associated with increased TGF-α expression

Journal of Gastroenterology and Hepatology (Australia)

Volumn 11, Issue 3, 1996, Pages 259-263

  Doljanin, Katrina ^a   Skeljo, Maryanne V ^a   Yeomans, Neville D ^a   Giraud, Andrew S ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Adaptation; Diclofenac; Gastric epithelium; Organ culture; TGF

Indexed keywords

ALCOHOL; CHROMIUM 51; DICLOFENAC; TRANSFORMING GROWTH FACTOR ALPHA;

ADAPTATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIOIMMUNOASSAY; STOMACH MUCOSA INJURY; TISSUE REGENERATION;

EID: 0029920690     PISSN: 08159319     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1440-1746.1996.tb00072.x     Document Type: Article

References (23)

1. Freston JW. Overview of medical therapy of peptic ulcer disease. Gastroenterol. Clin. North Am. 1990; 19: 121-40.
2. Du Plessis DJ. Pathogenesis of gastric ulceration. Lancet 1965; 1: 974-8.
3. Palmer ED. Gastritis: A re-evaluation. Medicine 1954; 33: 199-290.
4. Vane JR. Inhibition of prostaglandin-synthesis as a mechanism of action of aspirin-like drugs. Nature 1971; 231: 232-5.
5. Bollman JL, Stalker LK, Mann FC. Experimental peptic ulcer produced by cincophen. Arch. Int. Med. 1938; 61: 119-28.
6. St John DBJ, Yeomans ND, McDermott MB, de Boer WGRM. Adaptation of the gastric mucosa to repeated administration of aspirin in the rat. Am. J. Dig. Dis. 1973; 18: 881-6.
7. Graham DY, Smith JL, Dobbs SM. Gastric adaptation occurs with aspirin administration in man. Dig. Dis. Sci. 1983; 28: 1-6.
8. Robert A, Lancaster C, Gilbertson-Beadling S, Olfsson AS. Gastric adaptation to ethanol-induced mucosal necrosis by daily administration of either aspirin or 100% ethanol. Gastroenterology 1990; 98: A112 (Abstract).
9. Skeljo MV, Giraud AS, Yeomans ND. Adaptation of rat gastric mucosa to repeated doses of non-salicylate non-steroidal anti-inflammatory drugs. J. Gastroenterol. Hepatol. 1992; 7: 586-90.
10. Konturek JW, Dembinski A, Stoll R, Domschke W, Konturek SJ. Mucosal adaptation to aspirin induced gastric damage in humans. Studies on blood flow, gastric mucosal growth and neutrophil activation. Gut 1994; 35: 1197-204.
11. Konturek SJ, Brzowski T, Stachura J, Dembinski A, Majka J. Role of gastric blood flow, neutrophil infiltration and mucosal cell proliferation in gastric adaptation to aspirin in the rat. Gut 1994; 35: 1189-96.
12. Derynck R. Transforming growth factor-alpha: Structure and biological activities. J. Cell Biochem. 1986; 32: 293-304.
13. Dembinski A, Gregory H, Konturek SJ, Polanski M. Trophic action of epidermal growth factor on pancreas and gastrointestinal mucosa in rats. J. Physiol. (Lond.) 1982; 325: 35-42.
14. Konturek SJ, Brzowski T, Malka J, Dembinski A, Slomiany A, Slomiany BL. Transforming growth factor alpha and epidermal growth factor in protection and healing of gastric mucosal injury. Scand. J. Gastroenterol. 1992; 27: 649-55.
15. Tarnawski A, Lu SY, Stachura J, Sarfeh IJ. Adaptation of gastric mucosa to chronic alcohol administration is associated with increased mucosal expression of growth factors and their receptors. Scand. J. Gastroenterol. 1992; 27 (Suppl. 193): 59-63.
16. Dembinski A, Konturek ST, Stoll R, Domschke W. Gastric mucosal blood flow, epithelial cell proliferation and neutrophil activation in gastric adaptation to aspirin induced gastric damage in man. Gastroenterology 1993; 104: A70 (Abstract).
17. Yeomans ND, Millar SJ. Synthesis and secretion of glycoproteins by mucosa of rat gastric antrum in organ culture. Dig. Dis. Sci. 1980; 25: 295-301.
18. Browning TH, Trier JS. Organ culture of mucosal biopsies of human small intestine. J. Clin. Invest. 1969; 48: 1423-32.
19. Sewell RB, Ling TS, Yeomans ND. Ethanol-induced cell damage in cultured rat antral mucosa assessed by chromium-51 release. Dig. Dis. Sci. 1986; 31: 853-8.
20. Skeljo MV, Cook GA, Elliott SL, Giraud AS, Yeomans ND. Characteristics of gastric adaptation to NSAID-induced damage in the rat. J. Gastroenterol. Hepatol. 1993; 8: A36 (Abstract).
21. 2 differ in patterns of protection of rat gastric mucosa against ethanol injury. Gastroenterology 1986; 90: 1699 (Abstract).
22. Romano M, Guglietta A, Lesch CA et al. Role of transforming growth factor-alpha (TGFα) and epidermal growth factor (EGF) in the gastric adaptation to aspirin in monkeys and rats. Gastroenterology 1994; 106: A836 (Abstract).
23. Fowler KJ, Walker F, Alexander W et al. A mutation in the epidermal growth factor receptor in waved-2 mice has a profound effect on receptor biochemistry resulting in impaired lactation. Proc. Natl Acad. Sci. 1996; 92: 1465-9.