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Volumn 104, Issue 2, 1996, Pages 93-101

New therapeutic agents for the treatment of NIDDM

Author keywords

Carbonic acid derivatives; Insulin resistance; NIDDM; Pathophysiology; Thiazolidindiones; Treatment

Indexed keywords

7 (4 CHLOROPHENYL) 2 (4 METHYLPHENOXY)HEPTANOIC ACID; ANTIDIABETIC AGENT; BM 170249; CIGLITAZONE; ENGLITAZONE; INSULIN; METFORMIN; PIOGLITAZONE; TROGLITAZONE; UNCLASSIFIED DRUG;

EID: 0029920573     PISSN: 09477349     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0029-1211429     Document Type: Review
Times cited : (28)

References (54)
  • 1
    • 0002633987 scopus 로고
    • Clinical evaluation of a new oral hypoglycemic agent CS-045 in patients with non-insulin dependent diabetes mellitus poorly controlled by diet alone - A dose finding study by dose increasing method
    • Akanuma Y, Kosaka K, Kuzuya T, Shimizu N, Shigeta Y, Kaneko T: Clinical evaluation of a new oral hypoglycemic agent CS-045 in patients with non-insulin dependent diabetes mellitus poorly controlled by diet alone - A dose finding study by dose increasing method. J Clin Ther Med 9 (2-3): 19-37, 1993.
    • (1993) J Clin Ther Med , vol.9 , Issue.2-3 , pp. 19-37
    • Akanuma, Y.1    Kosaka, K.2    Kuzuya, T.3    Shimizu, N.4    Shigeta, Y.5    Kaneko, T.6
  • 2
    • 0002094315 scopus 로고
    • Clinical evaluation of a new oral hypoglycemic agent CS-045 in patients with non-insulin dependent diabetes mellitus poorly controlled by sulfonylureas - A dose finding study by dose increasing method
    • Akanuma Y, Kosaka K, Kuzuya T, Shimizu N, Shigeta Y, Kaneko T: Clinical evaluation of a new oral hypoglycemic agent CS-045 in patients with non-insulin dependent diabetes mellitus poorly controlled by sulfonylureas - A dose finding study by dose increasing method. J Clin Ther Med 9 (S-3): 39-60, 1993.
    • (1993) J Clin Ther Med , vol.9 , Issue.S-3 , pp. 39-60
    • Akanuma, Y.1    Kosaka, K.2    Kuzuya, T.3    Shimizu, N.4    Shigeta, Y.5    Kaneko, T.6
  • 3
    • 0029036467 scopus 로고
    • Effect of the new oral antidiabetic agent (-)-BM 13.0913. Na on insulin resistance in lean and obese zucker rats
    • Apweiler R, Kühnle HF, Ritter G, Schell R, Freund P: Effect of the new oral antidiabetic agent (-)-BM 13.0913. Na on insulin resistance in lean and obese zucker rats. Metabolism 44, No. 5: 577-583, 1995.
    • (1995) Metabolism , vol.44 , Issue.5 , pp. 577-583
    • Apweiler, R.1    Kühnle, H.F.2    Ritter, G.3    Schell, R.4    Freund, P.5
  • 4
    • 2042467035 scopus 로고
    • Effekt von CS045 auf die Kinaseaktivität des Insulinrezeptors im Skelettmuskel insulin-resistenter Zucker-Ratten
    • Bader S, Kiehn R, Häring HU: Effekt von CS045 auf die Kinaseaktivität des Insulinrezeptors im Skelettmuskel insulin-resistenter Zucker-Ratten. Diabetes und Stoffwechsel 2: 56-61, 1993.
    • (1993) Diabetes und Stoffwechsel , vol.2 , pp. 56-61
    • Bader, S.1    Kiehn, R.2    Häring, H.U.3
  • 5
    • 0024433742 scopus 로고
    • Synthesis and Hypolipidemic and antidiabetogenic activities of β,β,β,β,-Tetrasubstituted, Long-Chain Dioic acids
    • Bar-Tana J, Ben-Shoshan S, Blum J, Migron Y, Hertz R, Pill J, G. Rose-Khan G, Witte EC: Synthesis and Hypolipidemic and antidiabetogenic activities of β,β,β,β,-Tetrasubstituted, Long-Chain Dioic acids. J Med Chem 32: 2072-2084, 1989.
    • (1989) J Med Chem , vol.32 , pp. 2072-2084
    • Bar-Tana, J.1    Ben-Shoshan, S.2    Blum, J.3    Migron, Y.4    Hertz, R.5    Pill, J.6    G. Rose-Khan, G.7    Witte, E.C.8
  • 6
    • 0028091753 scopus 로고
    • Metabolic and genetic characterization of prediabetic states, sequence of events leading to non-insulin dependent diabetes mellitus
    • Beck-Nielsen H, Groop LC: Metabolic and genetic characterization of prediabetic states, sequence of events leading to non-insulin dependent diabetes mellitus. J Clin Invest 94: 1714-1721, 1994.
    • (1994) J Clin Invest , vol.94 , pp. 1714-1721
    • Beck-Nielsen, H.1    Groop, L.C.2
  • 7
    • 0020572164 scopus 로고
    • Ciglitazone, a new hypoglycemic agent II. Effect of glucose and lipid metabolisms and insulin binding in the adipose tissue of C57BL/6J-ob/ob and -+/? mice
    • Chang AY, Wyse BM, Gilchrist BJ: Ciglitazone, a new hypoglycemic agent II. effect of glucose and lipid metabolisms and insulin binding in the adipose tissue of C57BL/6J-ob/ob and -+/? mice. Diabetes 32: 839-845, 1983.
    • (1983) Diabetes , vol.32 , pp. 839-845
    • Chang, A.Y.1    Wyse, B.M.2    Gilchrist, B.J.3
  • 8
    • 0020561695 scopus 로고
    • Ciglitazone, a new hypoglycemic agent I. Studies in ob/ob and db/db mice, diabetic chinese hamsters, and normal and streptozotocin-diabetic rats
    • Chang AY, Wyse BM, Gilchrist BJ, Peterson T, Diani AR: Ciglitazone, a new hypoglycemic agent I. studies in ob/ob and db/db mice, diabetic chinese hamsters, and normal and streptozotocin-diabetic rats. Diabetes 32, 830-838, 1983.
    • (1983) Diabetes , vol.32 , pp. 830-838
    • Chang, A.Y.1    Wyse, B.M.2    Gilchrist, B.J.3    Peterson, T.4    Diani, A.R.5
  • 10
    • 0021244284 scopus 로고
    • Ciglitazone, a new hypoglycaemic agent. 4. Effect on pancreas islets of C57BL/ 6J-ob/ob and C57BL/KsJ-db/db mice
    • Diani AR, Peterson T, Sawada GA, Wyse BM. Gilchrist BJ, Hearron AE, Chang AY: Ciglitazone, a new hypoglycaemic agent. 4. effect on pancreas islets of C57BL/ 6J-ob/ob and C57BL/KsJ-db/db mice. Diabetologia 27: 225-234, 1984.
    • (1984) Diabetologia , vol.27 , pp. 225-234
    • Diani, A.R.1    Peterson, T.2    Sawada, G.A.3    Wyse, B.M.4    Gilchrist, B.J.5    Hearron, A.E.6    Chang, A.Y.7
  • 11
    • 15844430514 scopus 로고
    • Pioglitazone increases insulin sensitivity in insulin-resistant rats and control rats as measured by the glucose clamp
    • Doebber T, Wu M, Ventre J: Pioglitazone increases insulin sensitivity in insulin-resistant rats and control rats as measured by the glucose clamp. Diabetes 41, No. 1: 76A, 1992.
    • (1992) Diabetes , vol.41 , Issue.1
    • Doebber, T.1    Wu, M.2    Ventre, J.3
  • 12
    • 4243516062 scopus 로고
    • Determination of the tissues responsible for insulin resistance in zucker diabetic fatty rats as measured by the glucose clamp technique: Effect of pioglitazone
    • Doebber T, Wu M, Ventre J: Determination of the tissues responsible for insulin resistance in zucker diabetic fatty rats as measured by the glucose clamp technique: effect of pioglitazone. Diabetes 42, No. 1: 66A, 93-31353, 1993.
    • (1993) Diabetes , vol.42 , Issue.1
    • Doebber, T.1    Wu, M.2    Ventre, J.3
  • 14
    • 15844400194 scopus 로고
    • Ein neues orales Antidiabetikum mit Wirkung auf die periphere Insulinresistenz
    • Freund P, Kühnle HF, Wolff HP, Apweiler R: Ein neues orales Antidiabetikum mit Wirkung auf die periphere Insulinresistenz. Diabetes Stoffw 1: 102-106, 1992.
    • (1992) Diabetes Stoffw , vol.1 , pp. 102-106
    • Freund, P.1    Kühnle, H.F.2    Wolff, H.P.3    Apweiler, R.4
  • 15
    • 0020552510 scopus 로고
    • Reduction of insulin resistance in obese and/or diabetic animals by 5-[4-(1-methylcyclohexylmethoxy)benzyl]-thiazolidine-2,4-dione (ADD-3878, U-63,287, Ciglitazone), a new antidiabetic agent
    • Fujita T, Sugiyama Y, Taketomi S, Sohda T, Kawamatsu Y, Iwatsuka H, Suzucki Z: Reduction of insulin resistance in obese and/or diabetic animals by 5-[4-(1-methylcyclohexylmethoxy)benzyl]-thiazolidine-2,4-dione (ADD-3878, U-63,287, Ciglitazone), a new antidiabetic agent. Diabetes 32: 804-810, 1983.
    • (1983) Diabetes , vol.32 , pp. 804-810
    • Fujita, T.1    Sugiyama, Y.2    Taketomi, S.3    Sohda, T.4    Kawamatsu, Y.5    Iwatsuka, H.6    Suzucki, Z.7
  • 16
    • 0024160854 scopus 로고
    • Charakterization of a new oral antidiabetic agent CS-045. Studies in KK and ob/ob mice and zucker fatty rats
    • Fujiwara T, Yoshioka S, Yoshioka T, Ushiyama I, Horikoshi H: Charakterization of a new oral antidiabetic agent CS-045. Studies in KK and ob/ob mice and zucker fatty rats. Diabetes 37 (11): 1549-58, 1988.
    • (1988) Diabetes , vol.37 , Issue.11 , pp. 1549-1558
    • Fujiwara, T.1    Yoshioka, S.2    Yoshioka, T.3    Ushiyama, I.4    Horikoshi, H.5
  • 17
    • 0025938575 scopus 로고
    • Characterization of CS-045, a new oral antidiabetic agent, II. Effects on glycemic control and pancreatic islet structure at a late stage of the diabetic syndrome in C57BL/KsJ-db/db mice
    • Fujiwara T, et al: Characterization of CS-045, a new oral antidiabetic agent, II. Effects on glycemic control and pancreatic islet structure at a late stage of the diabetic syndrome in C57BL/KsJ-db/db mice. Metabolism 40, No. 11: 1213-1218, 1991.
    • (1991) Metabolism , vol.40 , Issue.11 , pp. 1213-1218
    • Fujiwara, T.1
  • 18
    • 0028937422 scopus 로고
    • Suppression of Hepatic Gluconeogenesis in Long-Term Troglitazone Treated Diabetic KK and C57BL/KsJ-db/db Mice
    • Fujiwara T, Okuno A, Yoshioka S, Horikoshi H: Suppression of Hepatic Gluconeogenesis in Long-Term Troglitazone Treated Diabetic KK and C57BL/KsJ-db/db Mice. Metabolism 44 (No 4): 486-490, 1995.
    • (1995) Metabolism , vol.44 , Issue.4 , pp. 486-490
    • Fujiwara, T.1    Okuno, A.2    Yoshioka, S.3    Horikoshi, H.4
  • 19
    • 0344221430 scopus 로고
    • A novel antidiabetic agent CP 68.722 increases levels of glucose transport and glucose transporter protein in 3T3L-1 adipocytes
    • abstr 491A
    • Gibbs EM, Genereux PE, Keutter DK, et al: A novel antidiabetic agent CP 68.722 increases levels of glucose transport and glucose transporter protein in 3T3L-1 adipocytes. Diabetologia 32: (abstr 491A), 1989.
    • (1989) Diabetologia , vol.32
    • Gibbs, E.M.1    Genereux, P.E.2    Keutter, D.K.3
  • 21
    • 0026554640 scopus 로고
    • Molecular physiology and genetics of NIDDM
    • Granner DK, O'Brien RM: Molecular physiology and genetics of NIDDM. Diabetes Care 15: 369-388, 1992.
    • (1992) Diabetes Care , vol.15 , pp. 369-388
    • Granner, D.K.1    O'Brien, R.M.2
  • 22
    • 0026539663 scopus 로고
    • The metabolic profile of NIDDM is fully established in glucose-tolerant offspring of two Mexican-American NIDDM parents
    • Gulli G, Ferrannini ETL, Stern M, Haffner S, DeFronzo R: The metabolic profile of NIDDM is fully established in glucose-tolerant offspring of two Mexican-American NIDDM parents. Diabetes 41, 1575-1587, 1992.
    • (1992) Diabetes , vol.41 , pp. 1575-1587
    • Gulli, G.1    Ferrannini, E.T.L.2    Stern, M.3    Haffner, S.4    DeFronzo, R.5
  • 23
    • 0027500670 scopus 로고
    • Pathogenesis of Type 2 (non-insulin-dependent) diabetes mellitus: Candidates for a signal transmitter defect causing insulin resistance of the skeletal muscle
    • Häring HU, Mehnert H: Pathogenesis of Type 2 (non-insulin-dependent) diabetes mellitus: Candidates for a signal transmitter defect causing insulin resistance of the skeletal muscle Diabetologia 36: 176-182, 1993.
    • (1993) Diabetologia , vol.36 , pp. 176-182
    • Häring, H.U.1    Mehnert, H.2
  • 24
    • 0023573935 scopus 로고
    • Prevalence of diabetes and impaired glucose tolerance and plasma glucose levels in U.S. populations aged 20-74 yr
    • Harris MI, Hadden WC, Knowler WC, Bennett PH: Prevalence of diabetes and impaired glucose tolerance and plasma glucose levels in U.S. populations aged 20-74 yr. Diabetes 36: 523-534, 1987.
    • (1987) Diabetes , vol.36 , pp. 523-534
    • Harris, M.I.1    Hadden, W.C.2    Knowler, W.C.3    Bennett, P.H.4
  • 25
    • 0025996821 scopus 로고
    • Glucose transport deficiency in diabetic animals is corrected by treatment with the oral antihyperglycemic agent pioglitazone
    • Hofmann C, Lorenz K, Colca JR: Glucose transport deficiency in diabetic animals is corrected by treatment with the oral antihyperglycemic agent pioglitazone. Endocrinology 129, No. 4: 1915-1925, 1991.
    • (1991) Endocrinology , vol.129 , Issue.4 , pp. 1915-1925
    • Hofmann, C.1    Lorenz, K.2    Colca, J.R.3
  • 26
    • 85035164513 scopus 로고
    • Pioglitazone-treatment sensitized diabetic rats to insulin inhibition of PEPCK expression in liver
    • Hofmann C, Lorenz K, Palazuk BJ, Colca JR: Pioglitazone-treatment sensitized diabetic rats to insulin inhibition of PEPCK expression in liver. Diabetes 42, No. 1: 169 A, 1993.
    • (1993) Diabetes , vol.42 , Issue.1
    • Hofmann, C.1    Lorenz, K.2    Palazuk, B.J.3    Colca, J.R.4
  • 28
    • 0025941863 scopus 로고
    • Effect of new oral antidiabetic agent CS-045 on glucose tolerance and insulin secretion in patients with NIDDM
    • Iwamoto Y, et al: Effect of new oral antidiabetic agent CS-045 on glucose tolerance and insulin secretion in patients with NIDDM. Diabetes Care 14, No. 11: 1083-1086, 1991.
    • (1991) Diabetes Care , vol.14 , Issue.11 , pp. 1083-1086
    • Iwamoto, Y.1
  • 29
    • 0026766036 scopus 로고
    • Pioglitazone increases insulin sensitivity by activating insulin receptor kinase
    • Kobayashi M, Iwanishi M, Kogawa K, Shigeta Y: Pioglitazone increases insulin sensitivity by activating insulin receptor kinase. Diabetes 412: 476-483, 1992.
    • (1992) Diabetes , vol.412 , pp. 476-483
    • Kobayashi, M.1    Iwanishi, M.2    Kogawa, K.3    Shigeta, Y.4
  • 30
    • 0011609413 scopus 로고
    • Clinical evaluation of a new oral hypoglycemic drug CS-045 in patients with non-insulin dependent diabetes mellitus poorly controlled by diet alone - A double-blind, placebo-controlled study
    • Kosaka K, Kuzuya T, Akanuma Y, Shigeta Y, Kaneko T: Clinical evaluation of a new oral hypoglycemic drug CS-045 in patients with non-insulin dependent diabetes mellitus poorly controlled by diet alone - A double-blind, placebo-controlled study. J Clin Ther Med 9 (S-3): 61-93, 1993.
    • (1993) J Clin Ther Med , vol.9 , Issue.S-3 , pp. 61-93
    • Kosaka, K.1    Kuzuya, T.2    Akanuma, Y.3    Shigeta, Y.4    Kaneko, T.5
  • 31
    • 0011881842 scopus 로고
    • Clinical evaluation of a new oral hypoglycemic drug CS-045 in patients with non-insulin dependent diabetes mellitus poorly controlled by sulfonylureas - A double-blind, placebo-controlled study
    • Kosaka K, Kuzuya T, Akanuma Y, Shigeta Y, Kaneko T: Clinical evaluation of a new oral hypoglycemic drug CS-045 in patients with non-insulin dependent diabetes mellitus poorly controlled by sulfonylureas - A double-blind, placebo-controlled study. J Clin Ther Med 9 (S-3): 95-126, 1993.
    • (1993) J Clin Ther Med , vol.9 , Issue.S-3 , pp. 95-126
    • Kosaka, K.1    Kuzuya, T.2    Akanuma, Y.3    Shigeta, Y.4    Kaneko, T.5
  • 32
    • 0025166078 scopus 로고
    • Insulin-like activity of new antidiabetic agent CP 68.722 in 3T3-L1 adipocytes
    • Kreutter DK, Adrews KM, Gibbs EM, et al: Insulin-like activity of new antidiabetic agent CP 68.722 in 3T3-L1 adipocytes. Diabetes 39: 1414-1419, 1990.
    • (1990) Diabetes , vol.39 , pp. 1414-1419
    • Kreutter, D.K.1    Adrews, K.M.2    Gibbs, E.M.3
  • 33
    • 0026081202 scopus 로고
    • A pilot clinical trial of a new oral hypoglycemic agent, S-045, in patients with non-insulin dependent diabetes mellitus
    • Kuzuya T, et al: A pilot clinical trial of a new oral hypoglycemic agent, S-045, in patients with non-insulin dependent diabetes mellitus. Diabetes Research and Clinical Practice 11: 147-154, 1991.
    • (1991) Diabetes Research and Clinical Practice , vol.11 , pp. 147-154
    • Kuzuya, T.1
  • 35
    • 0027762766 scopus 로고
    • Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus: Prospective studies of Pima Indians
    • Lillioja S, Mott DM, Spraul M: Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus: prospective studies of Pima Indians. N Engl J Med 329: 1988-1992, 1993.
    • (1993) N Engl J Med , vol.329 , pp. 1988-1992
    • Lillioja, S.1    Mott, D.M.2    Spraul, M.3
  • 36
    • 0026793446 scopus 로고
    • Role of glucose and insulin resistance in development of type 2 diabetes mellitus: Results of a 25-year follow-up study
    • Martin BC, Warram JH, Krolewski RN, Soeldner JS, Kahn CR: Role of glucose and insulin resistance in development of type 2 diabetes mellitus: results of a 25-year follow-up study. Lancet 340: 925-929, 1992.
    • (1992) Lancet , vol.340 , pp. 925-929
    • Martin, B.C.1    Warram, J.H.2    Krolewski, R.N.3    Soeldner, J.S.4    Kahn, C.R.5
  • 37
    • 0028939417 scopus 로고
    • Effects of Troglitazone (CS-045) on insulin secretion in isolated rat pancreatic islets and HIT cells: An insulinotropic mechanism distinct from glibenclamide
    • Masuda H., Okamoto Y, Tsuura Y, Kato S, Miura T, Tsuda K, Horikoshi H, Ishida H, Seino Y: Effects of Troglitazone (CS-045) on insulin secretion in isolated rat pancreatic islets and HIT cells: an insulinotropic mechanism distinct from glibenclamide. Diabetologia 38: 24-30, 1995.
    • (1995) Diabetologia , vol.38 , pp. 24-30
    • Masuda, H.1    Okamoto, Y.2    Tsuura, Y.3    Kato, S.4    Miura, T.5    Tsuda, K.6    Horikoshi, H.7    Ishida, H.8    Seino, Y.9
  • 38
    • 0027983920 scopus 로고
    • Improvement in glucose tolerance and insulin resistance in obese subjects treated with troglitazone
    • Nolan JJ, Ludvik B, Beerdsen P, Joyce M, Olefsky J: Improvement in glucose tolerance and insulin resistance in obese subjects treated with troglitazone. The New Engl J of Med 3: 1188-1193, 1994.
    • (1994) The New Engl J of Med , vol.3 , pp. 1188-1193
    • Nolan, J.J.1    Ludvik, B.2    Beerdsen, P.3    Joyce, M.4    Olefsky, J.5
  • 40
  • 41
    • 0027363596 scopus 로고
    • Role of insulin resistance in the pathophysiology of non-insulin dependent diabetes mellitus
    • Reaven GM: Role of insulin resistance in the pathophysiology of non-insulin dependent diabetes mellitus. Diabetes Metabolism, Reviews 9, (Supplement 1): 5-12, 1993.
    • (1993) Diabetes Metabolism, Reviews , vol.9 , Issue.1 SUPPL. , pp. 5-12
    • Reaven, G.M.1
  • 42
    • 0025861715 scopus 로고
    • Risk factors for developing non-insulin dependent diabetes mellitus: A 10-year follow-up of men in Uppsala
    • Skarfors ET, Selenus KI, Lithell HO: Risk factors for developing non-insulin dependent diabetes mellitus: a 10-year follow-up of men in Uppsala. Br Med J 303: 755-760, 1991.
    • (1991) Br Med J , vol.303 , pp. 755-760
    • Skarfors, E.T.1    Selenus, K.I.2    Lithell, H.O.3
  • 43
    • 0020397038 scopus 로고
    • Studies on antidiabetic agents. I. Synthesis of 5-[4-(2-Methyl-2-phenylpropoxy)-benzyl]thiazolidine-2,4-dione (AL-321) and related compounds
    • Sohda T, Mizuno K, Tawada H, Sugiyama Y, Fujita T, Kawamatsu Y: Studies on antidiabetic agents. I. synthesis of 5-[4-(2-Methyl-2-phenylpropoxy)-benzyl]thiazolidine-2,4-dione (AL-321) and related compounds. Chem Pharm Bull 30 (10): 3563-3573, 1982.
    • (1982) Chem Pharm Bull , vol.30 , Issue.10 , pp. 3563-3573
    • Sohda, T.1    Mizuno, K.2    Tawada, H.3    Sugiyama, Y.4    Fujita, T.5    Kawamatsu, Y.6
  • 44
    • 15844384905 scopus 로고
    • A new antidiabetic agent, AD-4833, and structure-activity relationships of 5-[4-(pyridyl-alkoxy)benzyl]-2,4-thiazolidinediones
    • Sohda T, Meguro K, Kawamatsu Y, Ikeda H, Fujita T: A new antidiabetic agent, AD-4833, and structure-activity relationships of 5-[4-(pyridyl-alkoxy)benzyl]-2,4-thiazolidinediones. J Pharm Sci 76: 173, 1987.
    • (1987) J Pharm Sci , vol.76 , pp. 173
    • Sohda, T.1    Meguro, K.2    Kawamatsu, Y.3    Ikeda, H.4    Fujita, T.5
  • 45
    • 0025055470 scopus 로고
    • Studies on antidiabetica agents. Synthesis and hypoglycemic activity of 5-[4-(pyridylalkoxy)bezyi]-2,4-thiazolidmediones
    • I
    • Sohda T, Momose Y, Meguro K, Kawamatsu Y, Sugiyama Y, Ikeda H: Studies on antidiabetica agents. Synthesis and hypoglycemic activity of 5-[4-(pyridylalkoxy)bezyi]-2,4-thiazolidmediones. Arzneim.-Forsch./ Drag Res. 40 (I), Nr. 1: 37-42, 1990.
    • (1990) Arzneim.-Forsch./ Drag Res. , vol.40 , Issue.1 , pp. 37-42
    • Sohda, T.1    Momose, Y.2    Meguro, K.3    Kawamatsu, Y.4    Sugiyama, Y.5    Ikeda, H.6
  • 46
    • 0025053123 scopus 로고
    • Actions of novel antidiabetic agent englitazone in hyperglycemic hyperinsulinemic ob/ob mice
    • Stevenson RW, et al: Actions of novel antidiabetic agent englitazone in hyperglycemic hyperinsulinemic ob/ob mice. Diabetes 39: 1218-1227, 1990.
    • (1990) Diabetes , vol.39 , pp. 1218-1227
    • Stevenson, R.W.1
  • 47
    • 0026338157 scopus 로고
    • Antidiabetic agent englitazone enhances insulin action in nondiabetic rats without producing hypoglycemia
    • Stevenson RW, et al: Antidiabetic agent englitazone enhances insulin action in nondiabetic rats without producing hypoglycemia. Metabolism 40, No. 12: 1268-1274, 1991.
    • (1991) Metabolism , vol.40 , Issue.12 , pp. 1268-1274
    • Stevenson, R.W.1
  • 49
    • 0025267698 scopus 로고
    • Effects of pioglitazone on glucose and lipid metabolism in Wistar fatty rats
    • Sugiyama Y, Taketomi S, Shimura Y, Ikeda H, Fujita T: Effects of pioglitazone on glucose and lipid metabolism in Wistar fatty rats. Arzneim.-Forsch./Drug Res. 40 (I), Nr. 3: 263-267, 1990.
    • (1990) Arzneim.-Forsch./Drug Res. , vol.40 , Issue.1-3 , pp. 263-267
    • Sugiyama, Y.1    Taketomi, S.2    Shimura, Y.3    Ikeda, H.4    Fujita, T.5
  • 50
    • 0026517631 scopus 로고
    • Metabolic effects of new oral hypoglycemic agent CS-045 in NIDDM subjects
    • Suter SL, Nolan JJ, Wallace P, Gumbiner B, Olefsky JM: Metabolic effects of new oral hypoglycemic agent CS-045 in NIDDM subjects. Diabetes Care 15, 2: 193-203, 1992.
    • (1992) Diabetes Care , vol.15 , Issue.2 , pp. 193-203
    • Suter, S.L.1    Nolan, J.J.2    Wallace, P.3    Gumbiner, B.4    Olefsky, J.M.5
  • 51
    • 0028963260 scopus 로고
    • United Kingdom prospective diabetes study group. Br Med J 310: 83-88, 1995.
    • (1995) Br Med J , vol.310 , pp. 83-88
  • 52
    • 0026575758 scopus 로고
    • Decreased insulin activation of glycogen synthase in skeletal muscles in young monobese caucasian first-degree relatives of patients with non-insulin dependent diabetes mellitus
    • Vaag A, Henriksen JE, Beck-Nielsen H: Decreased insulin activation of glycogen synthase in skeletal muscles in young monobese caucasian first-degree relatives of patients with non-insulin dependent diabetes mellitus. J Clin Invest 89: 782-788, 1992.
    • (1992) J Clin Invest , vol.89 , pp. 782-788
    • Vaag, A.1    Henriksen, J.E.2    Beck-Nielsen, H.3
  • 53
    • 85035161566 scopus 로고
    • A comparison of the effects of pioglitazone with CS-045 in C57BL/6J-ob/ob mice
    • Wyse BM, Burr JE, Dinh DM, Dailley CF: A comparison of the effects of pioglitazone with CS-045 in C57BL/6J-ob/ob mice. Diabetes 39, No. 1: 212 A, 1990.
    • (1990) Diabetes , vol.39 , Issue.1
    • Wyse, B.M.1    Burr, J.E.2    Dinh, D.M.3    Dailley, C.F.4
  • 54
    • 0024516539 scopus 로고
    • Studies on hindered phenols and analogues. 1. Hypolipidemic and hypoglycemic agents with ability to inhibit lipid peroxidation
    • Yoshioka T, Fujita T, Kanai T, Aizawa Y, Kutumada, T, Hasegawa K, Horikoshi H: Studies on hindered phenols and analogues. 1. Hypolipidemic and hypoglycemic agents with ability to inhibit lipid peroxidation. J Med Chem 32 (2): 421-428, 1989.
    • (1989) J Med Chem , vol.32 , Issue.2 , pp. 421-428
    • Yoshioka, T.1    Fujita, T.2    Kanai, T.3    Aizawa, Y.4    Kutumada, T.5    Hasegawa, K.6    Horikoshi, H.7


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