Anticonvulsant drug effects on spontaneous thalamocortical rhythms in vitro: Valproic acid, clonazepam, and α-methyl-α-phenylsuccinimide

Epilepsy Research

Volumn 23, Issue 1, 1996, Pages 37-53

  Zhang, Yun Fu ^a   Gibbs III, John W ^a   Coulter, Douglas A ^a,b  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

Benzodiazepine; Cortex; GABA; Generalized absence epilepsy; Generalized tonic clonic seizure; Nucleus reticularis thalami; Patch clamp; Seizure; Spike wave discharge; Thalamus

Indexed keywords

CLONAZEPAM; NORMESUXIMIDE; VALPROIC ACID;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EPILEPSY; GABAERGIC SYSTEM; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; THALAMOCORTICAL TRACT;

ACTION POTENTIALS; ANIMALS; CEREBRAL CORTEX; CLONAZEPAM; DOSE-RESPONSE RELATIONSHIP, DRUG; MICE; MICE, INBRED ICR; RATS; RATS, SPRAGUE-DAWLEY; SUCCINIMIDES; THALAMUS; VALPROIC ACID;

EID: 0029919799     PISSN: 09201211     EISSN: None     Source Type: Journal    
DOI: 10.1016/0920-1211(95)00080-1     Document Type: Article

References (49)

1. Agmon, A. and Connors, B.W., Thalamocortical responses of mouse somatosensory (barrel) cortex in vitro, Neuroscience, 41 (1991) 365-379.
2. 2-subunit mRNA-containing neurons in the rat central nervous system, Neuroscience, 47 (1992) 45-61.
3. Ayala, G.F., Matsumoto, H. and Gumnit, R.J., Excitability changes and inhibitory mechanisms in neocortical neurons during seizures, J. Neurophysiol., 33 (1970) 73-85.
4. Baldino, F. and Geller, H.M., Sodium valproate enhancement of GABA inhibition: Electrophysiological evidence for anticonvulsant activity, J. Pharmacol. Exp. Ther., 217 (1981) 445-450.
5. Browne, T.R., Other succinimides. Methsuximide. In: R. Levy, R. Mattson, B. Meldrum, J.K. Penry and F.E. Dreifuss (Eds.), Antiepileptic Drugs, third edition, Raven Press, New York, 1989.
6. Browne, T.R. and Penry, J.K., Benzodiazepines in the treatment of epilepsy, Epilepsia, 14 (1973) 277-310.
7. Chapman, A.G., Riley, K., Evans, M.C. and Meldrum, B.S., Acute effects of sodium valproate and γ-vinyl GABA on regional amino acid metabolism in the rat brain, Neurochem. Res., 7 (1982) 1089-1105.
8. Choi, D.W., Farb, D.H. and Fischbach, G.D., Chlordiazepoxide selectively augments GABA action in spinal cord cell cultures, Nature, 269 (1977) 342-344.
9. 2+ medium, Brain Res., 631 (1993) 137-142.
10. Coulter, D.A. and Zhang, Y.-F., Differential dependence of two distinct types of generalized epileptiform discharges on intact thalamocortical connections in mouse thalamocortical slices, Epilepsia, 34 (S6) (1993) 22.
11. Coulter, D.A., Huguenard, J.R. and Prince, D.A., Characterization of ethosuximide reduction of low-threshold calcium current in thalamic neurons, Ann. Neurol., 25 (1989) 582-593.
12. Coulter, D.A., Huguenard, J.R. and Prince, D.A., Differential effects of petit mal anticonvulsants and convulsants on thalamic neurones. I. Calcium current reduction, Br. J. Pharmacol., 100 (1990) 800-806.
13. Coulter, D.A., Huguenard, J.R. and Prince, D.A., Differential effects of petit mal anticonvulsants and convulsants on thalamic neurones. II. GABA current blockade, Br. J. Pharmacol., 100 (1990) 807-813.
14. 2+ channels by petit mal anticonvulsants, Exp. Brain Res., 20 (1991) 201S-204S.
15. Curtis, D.R., Lodge, D., Johnson, G.A.R. and Brand, S.I., Central actions of benzodiazepines, Brain Res., 118 (1976) 344-347.
16. Fariello, R. and Smith, M.C., Valproate. Mechanisms of action. In: R. Levy, R. Mattson, B. Meldrum, J.K. Penry and F.E. Dreifuss (Eds.), Antiepileptic Drugs, third edition, Raven Press, New York, 1989.
17. Gale, K., Subcortical structures and pathways involved in convulsive seizure generation, J. Clin. Neurophysiol., 9 (1992) 264-277.
18. Gloor, P. and Fariello, R.G., Generalized epilepsy: Some of its cellular mechanisms differ from those of focal epilepsy, Trends Neurosci., 11 (1988) 63-68.
19. Gram, L., Larsonn, O.M., Johnson, A.H. and Schousboe, A., Effects of valproate, vigabatrin and aminooxyacetic acid on release of endogenous and exogenous GABA from cultured neurons, Epilepsy Res., 2 (1988) 87-95.
20. B receptor activation in absence seizures of lethargic (1h/1h) mice, Science, 257 (1992) 398-400.
21. 2+-dependent burst firing in GABAergic neurons of rat thalamic reticular neurons, J. Neurosci., 12 (1992) 3804-3817.
22. Kelly, K., Gross, R.A. and Macdonald, R.L., Valproic acid selectively reduces the low threshold (T) calcium current in rat nodose neurons, Neurosci. Lett., 116 (1990) 233-238.
23. Kerwin, R.W., Olpe, H.R. and Schmutz, M., The effect of sodium-n-dipropyl acetate on GABA dependent inhibition in rat cortex in vitro, Br. J. Pharmacol., 71 (1980) 545-551.
24. Larsson, O.M., Gram, L., Schousboe, I. and Schousboe, E., Differential effects of gamma-vinyl GABA and valproate on GABA-transaminase from cultured neurons and astrocytes, Neuropharmacology, 25 (1986) 617-625.
25. Laurie, D.J., Wisden, W. and Seeburg, P.H., The distribution of thirteen GABAA receptor subunit mRNAs in the rat brain. III. Embryonic and postnatal development, J. Neurosci., 12 (1992) 4151-4172.
26. Liu, Z., Vergnes, M., Depaulis, A. and Marescaux, C., Evidence for a critical role of GABAergic transmission within the thalamus in the genesis and control of absence seizures in the rat, Brain Res., 545 (1991) 1-7.
27. Löscher, W., Valproate induced changes in GABA metabolism at the subcellular level, Biochem. Pharmacol., 30 (1981) 1364-1366.
28. Löscher, W., In vivo administration of valproate reduces the nerve terminal (synaptosomal) activity of GABA aminotransferase in discrete brain areas of rats, Neurosci. Lett., 160 (1993) 177-180.
29. Löscher, W., Effects of the antiepileptic drug valproate on metabolism and function of inhibitory and excitatory amino acids in the brain, Neurochem. Res., 18 (1993) 485-502.
30. Macdonald, R.L. and Bergey, G.K., Valproic acid augments GABA-mediated post-synaptic inhibition in cultured mammalian neurons, Brain Res., 170 (1979) 558-562.
31. Macdonald, R.L. and Kelly, K.M., Mechanisms of action of currently prescribed and newly developed antiepileptic drugs, Epilepsia, 35 (S4) (1994), S41-S50.
32. Miller, J.W. and Ferrendelli, J.A., The central medial nucleus: Thalamic site of seizure regulation, Brain Res., 508 (1990) 297-300.
33. Miller, J.W. and Ferrendelli, J.A., Characterization of GABAergic seizure regulation in the midline thalamus, Neuropharmacology, 29 (1990) 649-655.
34. A receptor function rat somatosensory thalamus and cortex: Whole cell voltage-clamp recordings in acutely isolated neurons, J. Neurosci., 15 (1995) 1341-1351.
35. A receptor subtypes: Autoradiographic studies of GABA, benzodiazepine, and convulsant binding sites in the rat central nervous system, J. Chem. Neuroanat., 3 (1990) 59-76.
36. Pellock, J.M., Standard approach to antiepileptic drug treatment in the United States, Epilepsia, 35 (S4) (1994) S11-S18.
37. Porter, R.J. and Kupferberg, H.J., Other succinimides. Methsuximide and phensuximide. In: D.M. Woodbury, J.K. Penry and C.E. Pippenger (Eds.), Antiepileptic Drugs, second edition, Raven Press, New York, 1982, chapter 57.
38. Prichett, D.B., Sontheimer, H., Shivers, B.D., Ymer, S., Kettenmann, H., Schofield, P.R. and Seeburg, P., Importance of a novel GABAA receptor subunit for benzodiazepine pharmacology, Nature, 338 (1989) 582-585.
39. Sato, S., Benzodiazepines. Clonazepam. In: R. Levy, R. Mattson, B. Meldrum, J.K. Penry and F.E. Dreifuss (Eds.), Antiepileptic Drugs, third edition, Raven Press, New York, 1989.
40. Steriade, M. and Llinas, R.R., The functional states of the thalamus and associated neuronal interplay, Physiol. Rev., 68 (1988) 649-742.
41. Ticku, M.K. and Davis, W.C., Effect of valproic acid on H-diazepam and H-dihydropicrotoxin binding sites at the benzodiazepine-GABA receptor-ionophore complex, Brain Res., 223 (1981) 218-222.
42. A receptor channels by diazepam and phenobarbital, Ann. Neurol., 25 (1989) 213-220.
43. Vergnes, M. and Marescaux, C., Cortical and thalamic lesions in rats with genetic absence epilepsy, J. Neural Transm., 35 (Suppl) (1992) 71-83.
44. Vergnes, M., Marescaux, C. and Depaulis, A., Mapping of spontaneous spike and wave discharges in Wistar rats with genetic generalized non-convulsive epilepsy, Brain Res., 523 (1990) 87-91.
45. Vergnes, M., Marescaux, C., Depaulis, A., Micheletti, G. and Warter, J.M., Spontaneous spike and wave discharges in thalamus and cortex of a rat model of generalized petit mal-like seizure, Exp. Neurol., 96 (1987) 127-136.
46. Williams, D.A., A study of thalamic and cortical rhythms in petit mal, Brain, 76 (1953) 50-69.
47. A receptor subunit mRNAs in the rat brain. I. Telencephalon, diencephalon, mesencephalon, J. Neurosci., 12 (1992) 1040-1062.
48. Zhang, Y.-F. and Coulter, D.A., Anticonvulsant drug effects on spontaneous thalamocortical rhythms in vitro: Phenytoin, carbamazepine, and phenobarbital, Epilepsy Res., 23 (1996) 55-70 (this issue).
49. Zhang, Y.-F., Gibbs III, J.W. and Coulter, D.A., Anticonvulsant drug effects on spontaneous thalamocortical rhythms in vitro: Ethosuximide, trimethadione, and dimethadione, Epilepsy Res., 23 (1996) 15-36 (this issue).