Significance of human cytomegalovirus DNA detection in immunocompromised heart transplant patients

Transplantation

Volumn 61, Issue 5, 1996, Pages 750-757

  Wolff, Carsten ^a,b   Skourtopoulos, Menelaos ^a   Hörnschemeyer, Dirk ^a   Wolff, Dietmar ^a   Körner, Michael ^c   Hufert, Frank ^d   Körfer, Reiner ^c   Kleesiek, Knut ^a  

^a Inst F Laboratoriums T   (Germany)

^b RUHR UNIVERSITY BOCHUM   (Germany)

^c RUHR UNIVERSITY BOCHUM   (Germany)

^d UNIVERSITY OF FREIBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOSUPPRESSIVE AGENT; VIRUS DNA;

ARTICLE; CYTOMEGALOVIRUS INFECTION; DISEASE PREDISPOSITION; FEMALE; GRAFT REJECTION; HEART TRANSPLANTATION; HUMAN; HUMAN CYTOMEGALOVIRUS; IMMUNOSUPPRESSIVE TREATMENT; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; POSTOPERATIVE COMPLICATION; POSTOPERATIVE INFECTION; PRIORITY JOURNAL; VIRUS DETECTION;

ANTIBODIES, VIRAL; BASE SEQUENCE; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTIONS; DNA, VIRAL; FEMALE; HEART TRANSPLANTATION; HUMANS; IMMUNOCOMPROMISED HOST; IMMUNOGLOBULIN M; MALE; MOLECULAR SEQUENCE DATA; PHOSPHOPROTEINS; POLYMERASE CHAIN REACTION; VIRAL MATRIX PROTEINS;

EID: 0029919224     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-199603150-00014     Document Type: Article

References (65)

1. Alford CA, Britt WJ. Cytomegalovirus. In: Fields BN, Knipe DM, eds. Virology. 2nd ed. New York: Raven Press, 1990: 1981.
2. Rubin RH. Impact of cytomegalovirus infection on organ transplant recipients. Rev Infect Dis 1990; 12: S754.
3. van der Bij W, Torensma R, van Son WJ, et al. Rapid immunodiagnosis of active cytomegalovirus infection by monoclonal antibody staining of blood leukocytes. J Med Virol 1988: 25: 179.
4. Revello MG, Percivalle E, Zavattoni M, Parea M, Battaglia M. Detection of human cytomegalovirus immediate early antigen in leukocytes as a marker of viremia in immunocompromised patients. J Med Virol 1989; 29: 88.
5. Boland GJ, de Weger RA, Tilanus MGJ, Ververs C, Bosboom-Kalsbeek K, de Gast GC. Detection of cytomegalovirus (CMV) in granulocytes by polymerase chain reaction compared with the CMV antigen test. J Clin Microbiol 1992; 30: 1763.
6. Grefte JMM, van der Gun BTF, Schmolke S, et al. The lower matrix protein pp 65 is the principal viral antigen present in peripheral blood leukocytes during an active cytomegalovirus infection. J Gen Virol 1992; 73: 2923.
7. The TH, van der Ploeg M, van den Berg AP, Vlieger AM, van der Giessen M, van Son WJ. Direct detection of cytomegalovirus in peripheral blood leucocytes - a review of the antigenemia assay and polymerase chain reaction. Transplantation 1992; 54: 193.
8. Vlieger AM, Boland GJ, Jiwa NM, et al. Cytomegalovirus antigenemia assay or PCR can be used to monitor ganciclovir treatment in bone marrow transplant recipients. Bone Marrow Transplant 1992; 9: 247.
9. Koskinen PK, Nieminen M, Mattila S, Lautenschlager I. Quantitative immunodetection of cytomegalovirus antigenemia in the clinical diagnosis of CMV infection after heart transplantation. Transplant Proc 1993; 25: 1426.
10. Koskinen PK, Nieminen MS, Mattila SP, Hayry PJ. The correlation between symptomatic CMV infection and CMV antigenemia in heart allograft recipients. Transplantation 1993; 55: 547.
11. Boeckh M, Bowden RA, Goodrich JM, Pettinger M, Meyers JD. Cytomegalovirus antigen detection in peripheral blood leukocytes after allogeneic marrow transplantation. Blood 1992; 80: 1358.
12. Halwachs G, Zach R, Pogglitsch H, et al. A Rapid Immunocytochemical assay for CMV detection in peripheral blood of organtransplanted patients in clinical practice. Transplantation 1993; 56: 338.
13. Bein G, Bitsch A, Hoyer J, et al. A longitudinal prospective study of cytomegalovirus pp 65 antigenemia in renal tranplant recipients. Transpl Int 1993; 6: 185.
14. Buffone GJ, Frost A, Samo T, Demmler GJ, Cagle PT, Lawrence EC. The diagnosis of CMV pneumonitis in lung and heart/lung transplant patients by PCR compared with traditional laboratory criteria. Transplantation 1993; 56: 342.
15. Saiki RK, Bugawan TL, Horn GT, Mullis K, Erlich HA. Analysis of enzymatically amplified beta-globin and HLA-DQ alpha DNA with allele-specific oligonucleotide probes. Nature 1986; 324: 163.
16. Bevan IS, Daw RA, Day PJR, Ala FA, Walker MR. Polymerase chain reaction for detection of human cytomegalovirus infection in a blood donor population. Br J Haematol 1991; 78: 94.
17. van den Berg AP, van Son WJ, Haagsma EB, et al. Prediction of recurrent cytomegalovirus disease after treatment with ganciclovir in solid-organ transplant recipients. Transplantation 1993; 55: 847.
18. Cassol SA, Poon MC, Pal R, et al. Primer-mediated enzymatic amplification of cytomegalovirus (CMV) DNA. Application to the early diagnosis of CMV infection in marrow transplant recipients. J Clin Invest 1989; 83: 1109.
19. Cathomas G, Morris P, Pekle K, Cunningham I, Emanuel D. Rapid diagnosis of cytomegalovirus pneumonia in marrow transplant recipients by bronchoalveolar lavage using the polymerase chain reaction, virus culture, and the direct immunostaining of alveolar cells. Blood 1993; 81: 1909.
20. Drouet E, Boibieux A, Michelson S, et al. Polymerase chain reaction detection of cytomegalovirus DNA in peripheral blood leucocytes as a predictor of cytomegalovirus disease in HIV-infected patients. AIDS 1993; 7: 665.
21. Einsele H, Ehninger G, Steidle M, et al. Polymerase chain reaction to evaluate antiviral therapy for cytomegalovirus disease. Lancet 1991; 338: 1170.
22. Einsele H, Steidle M, Vallbracht A, Saal J, Ehninger G, Müller CA. Early occurrence of human cytomegalovirus infection after bone marrow transplantation as demonstrated by the polymerase chain reaction technique. Blood 1991; 77: 1104.
23. Gerdes JC, Spees EK, Fitting K, et al. Prospective study utilizing a quantitative polymerase chain reaction for detection of cytomegalovirus DNA in the blood of renal transplant patients. Transplantation 1993; 25: 1411.
24. Gerna G, Zipeto D, Parea M, et al. Early virus isolation, early structural antigen detection and DNA amplification by the polymerase chain reaction in polymorphonuclear leukocytes from AIDS patients with human cytomegalovirus viremia. Mol Cell Probes 1991; 5: 365.
25. Gerna G, Zipeto D, Parea M, et al. Monitoring of human cytomegalovirus infections and ganciclovir treatment in heart transplant recipients by determination of viremia antigenemia and DNAemia. J Infect Dis 1991; 164: 488.
26. Jiwa NM, van Gemert GW, Raap AK, et al. Rapid detection of human cytomegalovirus DNA in peripheral blood leucocytes of viremic transplant recipients by the polymerase chain reaction. Transplantation 1989; 48: 72.
27. Lee WT, Antoszewska H, Powell KF, et al. Polymerase chain reaction in detection of CMV DNA in renal allograft recipients. Aust N Z J Med 1992; 22: 249.
28. Prosch S, Kimel V, Dawydowa I, Krüger DH. Monitoring of patients for cytomegalovirus after organ transplantation by centrifugation culture and PCR. J Med Virol 1992; 38: 246.
29. Ratnamohan VM, Mathys JM, McKenzie A, Cunningham AL. HCMV DNA is detected more frequently than infectious virus in blood leucocytes of immunocompromised patients: a direct comparison of culture-immunofluorescence and PCR for detection of HCMV in clinical specimens. J Med Virol 1992; 38: 252.
30. Rowley AH, Wolinsky SM, Sambol SP, Barkholt L, Ehrnst A, Andersson JP. Rapid detection of cytomegalovirus DNA and RNA in blood of renal transplant patients by in vitro enzymatic amplification. Transplantation 1991; 51: 1028.
31. Sandin RL, Rodriguez ER, Rosenberg E, et al. Comparison of sensitivity for human cytomegalovirus of the polymerase chain reaction, traditional tube culture and shell vial assay by sequential dilutions of infected cell lines. J Virol Methods 1990; 32: 181.
32. Shibata D, Martin WJ, Appleman MD, Causey DM, Leedom JM, Arnheim N. Detection of cytomegalovirus DNA in peripheral blood of patients infected with human immunodeficiency virus. J Infect Dis 1988; 158: 1185.
33. Schmidt CA, Oettle H, Neuhaus P, et al. Demonstration of cytomegalovirus by polymerase chain reaction after liver transplantation. Transplantation 1993; 56: 872.
34. Smith KL, Dunstan RA. PCR detection of cytomegalovirus: a review. Br J Haematol 1993; 84: 187.
35. Wiens M, Schmidt CA, Lohmann R, Oettle H, Blumhardt G, Neuhaus P. Cytomegalovirus disease after liver transplantation: diagnostics and therapy. Transplantation 1993; 25: 2673.
36. Wolf DG, Spector SA. Early diagnosis of human cytomegalovirus disease in transplant recipients by DNA amplification in plasma. Transplantation 1993; 56: 330.
37. Smith KL, Kulski JK, Cobain T, Dunstan RA. Detection of cytomegalovirus in blood donors by the polymerase chain reaction. Transfusion 1992; 33: 497.
38. Stanier P, Taylor DL, Kitchen AD, Wales N, Tryhorn Y, Tyms AS. Persistence of cytomegalovirus in mononuclear cells in peripheral blood from blood donors. BMJ 1989; 299: 897.
39. Brytting M, Xu W, Wahren B, Sundqvist VA. Cytomegalovirus DNA detection in sera from patients with active cytomegalovirus infections. J Clin Microbiol 1992; 30: 1937.
40. Stanier P, Kitchen AD, Taylor DL, Tyms AS. Detection of human cytomegalovirus in peripheral mononuclear cells and urine samples using PCR. Mol Cell Probes 1992; 6: 51.
41. Bitsch A, Kirchner H, Dupke R, Bein G. Failure to detect human cytomegalovirus DNA in peripheral blood leucocytes of healthy blood donors by the polymerase chain reaction. Transfusion 1992; 32: 612.
42. Taylor-Wiedeman J, Sissons JGP, Borysiewicz LK, Sinclair JH. Monocytes are a major site of persistence of human cytomegalovirus in peripheral blood mononuclear cells. J Gen Virol 1991; 72: 2059.
43. Urushibara N, Kwon KW, Takahashi TA, Sekiguchi S. Human cytomegalovirus DNA is not detectable with nested double polymerase chain reaction in healthy blood donors. Vox Sang 1995; 68: 9.
44. Bitsch A, Kirchner H, Dennin R, et al. The long persistence of CMV DNA in the blood of renal transplant patients after recovery from CMV infection. Transplantation 1993; 56: 108.
45. Taylor-Wiedemann J, Hayhurst GP, Sissons JGP, Sinclair JH. Polymorphonuclear cells are not sites of persistence of human cytomegalovirus in healthy individuals. J Gen Virol 1993; 74: 265.
46. Minton EJ, Tysoe C, Sinclair JH, Sissons JGP. Human cytomegalovirus infection of the monocyte/macrophage lineage in bone marrow. J Virol 1994; 68: 4017.
47. Gerna G, Zipeto D, Percivalle E, et al. Human cytomegalovirus infection of the major leukocyte subpopulations and evidence for initial replication in polymorphnuclear leukocytes from viremic patients. J Infect Dis 1992; 166: 1236.
48. Grefte A, van der Giessen M, van Son WJ, The TH. Circulating cytomegalovirus (CMV)-infected endothelial cells in patients with an active CMV infection. J Infect Dis 1993; 167: 270.
49. Grefte A, Blom N, van der Giessen M, van Son WJ, The TH. Ultrastructural analysis of circulating cytomegalic cells in patients with cytomegalovirus infection: evidence for virus production and endothelial origin. J Infect Dis 1993; 168: 1110.
50. Ibanez CE, Schrier R, Ghazal P, Wiley C, Nelson JA. Human cytomegalovirus productively infects primary differentiated macrophages. J Virol 1991; 65: 6581.
51. Söderberg C, Larsson S, Bergstedt-Lindqvist S, Möller E. Definition of a subset of human peripheral blood mononuclear cells that are permissive to human cytomegalovirus infection. J Virol 1993; 67: 3166.
52. Lathey JL, Wiley CA, Verity MA, Nelson JA. Cultured human brain capillary endothelial cells are permissive for infection by human cytomegalovirus. Virology 1990; 176: 266.
53. Zipeto D, Revello MG, Silini E, et al. Development and clinical significance of a diagnostic assay based on the polymerase chain reaction for detection of human cytomegalovirus DNA in blood samples from immunocompromised patients. J Clin Microbiol 1992; 30: 527.
54. Meyer-König U, Serr A, von Laer D, Kirste G, Wolff C, Haller O, Neumann-Haefelin D, Hufert FT. Human cytomegalovirus immediate early and late transcripts in peripheral blood leukocytes - diagnostic value in renal transplant recipients. J Infect Dis 1995; 171: 607.
55. Ishigaki S, Takeda M, Kura T, Ban N, Saitoh T, Sakamaki S, Watanabe N, Kohgo Y, Niitsu Y. Cytomegalovirus DNA in the sera of patients with cytomegalovirus pneumonia. Br J Haematol 1991; 79: 198.
56. Kidd IM, Fox JC, Pillay D, Charman H, Griffiths PD, Emery VC. Provision of prognostic information in immunocompromised patients by routine application of the polymerase chain reaction for cytomegalovirus. Transplantation 1993; 56: 867.
57. Xu W, Sundqvist VA, Brytting M, Linde A. Diagnosis of cytomegalovirus infections using polymerase chain reaction, virus isolation and serology. Scand J Infect Dis 1993; 25: 311.
58. Buffone GJ, Demmler GJ, Schimbor CM, Greer J. Improved amplification of cytomegalovirus from urine after purification of DNA with glass beads. Clin Chem 1991; 37: 1945.
59. Stamminger T, Puchtler E, Fleckenstein B. Discordant expression of the immediate-early 1 and 2 gene regions of human cytomegalovirus at early times after infection involves post-transcriptional processing events. J Virol 1991; 65: 2273.
60. Gold E, Nankervis GA. Cytomegalovirus. In: Evans AS, ed. Viral infections of humans: epidemiology and control. 2nd ed. New York: Plenum Press, 1982: 167.
61. Hayes K, Alford CA, Britt WJ. Antibody response to virus-encoded proteins after cytomegalovirus mononucleosis. J Infect Dis 1987; 156: 615.
62. Ensoli F, Fiorelli V, Mezzaroma I, et al. Plasma viremia in seronegative HIV-1 infected individuals. AIDS 1991; 5: 1195.
63. Imagawa DT, Lee MH, Wolinsky SM, et al. Human immunodeficiency virus type 1 infection in homosexual men who remain seronegative for prolonged periods. N Engl J Med 1989; 320: 1458.
64. Wolinsky SM, Rinaldo CR, Kwok S, et al. Human immunodeficiency virus Type 1 (HIV-1) infection a median of 18 months before a diagnostic western blot. Ann Intern Med 1989; 111: 961.
65. Zaaijer HL, Cuypers HTM, Reesink HW, Winkel IN, Gerken G, LeKe PN. Reliability of polymerase chain reaction for detection of hepatitis C virus. Lancet 193; 341: 722.