Structure-activity relationships of 3-methyl and 3,3-dimethyl analogs of 2-(2,4-difluorophenyl)-3-(ω-substituted alkyl)sulfonyl-1-(1H-1,2,4-triazol-1-yl)-2-propanols

Chemical and Pharmaceutical Bulletin

Volumn 44, Issue 4, 1996, Pages 785-792

  Miyauchi, Hiroshi ^a   Kozuki, Koichi ^a   Tanio, Tomoharu ^a   Ohashi, Naohito ^a  

^a DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

Author keywords

Antifungal activity; Murine systemic aspergillosis; Structure activity relationship; Synthesis; Triazole antifungal

Indexed keywords

2 (2,4 DIFLUOROPHENYL) 3 (2 HYDROXYETHYLSULFONYL) 1 (1H 1,2,4 TRIAZOL 1 YL) 2 BUTANOL; 2 (2,4 DIFLUOROPHENYL) 3 (2 HYDROXYETHYLSULFONYL) 3 METHYL 1 (1H 1,2,4 TRIAZOL 1 YL) 2 BUTANOL; 2 (2,4 DIFLUOROPHENYL) 3 (2 HYDROXYETHYLTHIO) 1 (1H 1,2,4 TRIAZOL 1 YL) 2 BUTANOL; 2 (2,4 DIFLUOROPHENYL) 3 (2 HYDROXYETHYLTHIO) 3 METHYL 1 (1H 1,2,4 TRIAZOL 1 YL) 2 BUTANOL; ANTIFUNGAL AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIFUNGAL ACTIVITY; ARTICLE; ASPERGILLOSIS; ASPERGILLUS FUMIGATUS; CANDIDA ALBICANS; CANDIDIASIS; DRUG CONFORMATION; DRUG EFFICACY; DRUG POTENCY; DRUG SYNTHESIS; INFECTION PREVENTION; MALE; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTIFUNGAL AGENTS; ASPERGILLOSIS; ASPERGILLUS FUMIGATUS; CANDIDA ALBICANS; CANDIDIASIS; MALE; MICE; MICE, INBRED STRAINS; MICROBIAL SENSITIVITY TESTS; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES;

EID: 0029919049     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.44.785     Document Type: Article

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