The tachykinin NK1 receptor mediates the migration-promoting effect of substance P on human skin fibroblasts in culture

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 353, Issue 5, 1996, Pages 475-481

  Parenti, A ^a   Amerini, S ^a   Ledda, F ^a   Maggi, C A ^b   Ziche, M ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

^b Menarini Ricerche SpA   (Italy)

Author keywords

Cell migration; Human skin fibroblasts; NK1 receptor; Substance P

Indexed keywords

2 BENZHYDRYL 3 (2 METHOXYBENZYLAMINO) 1 AZABICYCLO[2.2.2]OCTANE; MEN 10627; N BENZYL N2 [4 HYDROXY 1 [(1 METHYL 1H INDOL 3 YL)CARBONYL]PROLYL] N METHYL 3 (2 NAPHTHYL)ALANINAMIDE; NEUROKININ 1 RECEPTOR; NEUROKININ 1 RECEPTOR AGONIST; NEUROKININ 1 RECEPTOR ANTAGONIST; NEUROKININ 2 RECEPTOR AGONIST; NEUROKININ 2 RECEPTOR ANTAGONIST; NEUROKININ 3 RECEPTOR AGONIST; NEUROKININ A [4-10][8 BETA ALANINE]; NEUROKININ B [7 METHYLPHENYLALANINE]; PLATELET DERIVED GROWTH FACTOR; SUBSTANCE P; SUBSTANCE P SULFONE [9 SARCOSINE]; TACHYKININ RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; CELL ADHESION; CELL CULTURE; CELL MIGRATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ANTAGONISM; HUMAN; HUMAN CELL; MICROSCOPY; NORMAL HUMAN; SKIN FIBROBLAST;

ANALYSIS OF VARIANCE; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BIPHENYL COMPOUNDS; CELL ADHESION; CELL MOVEMENT; CELLS, CULTURED; DIPEPTIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; FIBROBLASTS; HUMANS; INDOLES; MALE; PEPTIDES, CYCLIC; PLATELET-DERIVED GROWTH FACTOR; RECEPTORS, NEUROKININ-1; RECEPTORS, NEUROKININ-2; SKIN; SUBSTANCE P;

EID: 0029919003     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF00169165     Document Type: Article

References (33)

1. Augustin-Voss HA, Pauli BU (1992) Quantitative analysis of autocrine-regulated, matrix-induced and tumor cell-stimulated endothelial cell migration using a silicon template compartmentalisation technique. Exp Cell Res 198:221-227
2. 1 receptors by use of the non-peptide antagonist, (±) CP 96,345. Br J Pharmacol 104:292-293
3. Diemel LT, Brewster WJ, Fernyhough P, Tomlinson DR (1994) Expression of neuropeptides in experimental diabetes; effects of treatment with nerve growth factor or brain-derived neurotrophic factor. Mol Brain Res 21:171-175
4. D'Orlean-Juste P, Dion S, Mizrahi J, Regoli D (1985) Effects of peptides and nonpeptides on isolated arterial smooth muscle: role of endothelium. Eur J Pharmacol 114:9-21
5. Foreman JC, Jordan CC (1984) Neurogenic inflammation. Trends Pharmacol Sci 5:116-119
6. 1 receptor antagonist, FK 888. Br J Pharmacol 107:785-789
7. Fujita S, Shimizu T, Izumi K, Fukuda K, Sameshima M, Ohba N (1984) Capsaicin-induced neuroparalytic keratitis-like corneal changes in the mouse. Exp Eye Res 38:165-171
8. Hunt TK, La Van FB (1989) Enhancement of wound healing by growth factors. N Engl J Med 321:111-112
9. Jacques L, Couture R, Drapeau G, Regoli D (1989) Capillary permeability induced by intravenous neurokinins. Naunyn-Schmiedeberg's Arch Pharmacol 340:170-179
10. Kähler CM, Sitte BA, Reinisch N, Wiedermann CJ (1993) Stimulation of the chemotactic migration on human fibroblasts by substance P. Eur J Pharmacol 249:281-286
11. Kingsnorth AN, Slavin J (1991) Peptide growth factors and wound healing. Br J Surg 78:1286-1290
12. Kjartansson J, Dalsgaard C-J, Jonsson C-E (1987) Decreased survival of experimental critical flaps in rats after sensory denervation with capsaicin. Plast Reconstr Surg 79:218-221
13. Lembeck F, Holzer P (1979) Substance P as a neurogenic mediator of antidromic vasodilation and neurogenic plasma extravasation. Naunyn-Schmiedeberg's Arch Pharmacol 310:175-183
14. Lindsay RM, Lockett C, Sternberg J, Winter J (1989) Neuropeptide expression in cultures of adult sensory neurones: modulation of substance P and calcitonin gene-related peptide levels by nerve growth factor. Neuroscience 33:53-65
15. Maggi CA, Borsini F, Santicioli P, Geppetti P, Abelli L, Evangelista S, Manzini S, Theodorsson Norheim E, Somma V, Amenta F, Bacciarelli C, Meli A (1987) Cutaneous lesions in capsaicin pretreated rats. Naunyn-Schmiedeberg's Arch Pharmacol 336:538-545
16. Maggi CA, Patacchini R, Rovero P, Giachetti A (1993) Tachykinin receptors and tachykinin receptor antagonists. J Auton Pharmacol 13:23-93
17. 2 receptors. J Pharmacol Exp Ther 27:1489-1500
18. Mitsuhashi M, Payan DG (1987) The mitogenic effects of vasoactive neuropeptides on cultured smooth muscle cell line. Life Sci 40:853-861
19. Morbidelli L, Maggi CA, Ziche M (1993) Effect of selective tachykinin receptor antagonists on the growth of human skin fibroblasts. Neuropeptides 24:335-341
20. Nilsson J, Von Euler AM, Dalsgaard CJ (1985) Stimulation of connective tissue cell growth by substance P and substance K. Nature 315:61-63
21. Payan BG, Brewester R, Goetzl EJ (1983) Specific stimulation of human T lymphocytes by substance P. J Immunol 131:1613-1615
22. Regoli D, Drapeau G, Dion S, Couture R (1988) New selective agonists for neurokinin receptors: pharmacological tools for receptor characterisation. Trends Pharmacol Sci 9:290-295
23. Rhudy RW, McPherson JM (1988) Influence of the extracellular matrix on the proliferative response of human skin fibroblasts to serum and purified Platelet-Derived Growth Factor. J Cell Physiol 137:185-191
24. Robinson JP, Willars GB, Tomlinson DR, Keen P (1987) Axonal transport and tissue contents of substance P in rats with long-term streptozotocin-diabetes. Effects of the aldose reductase inhibitor "statil". Brain Res 426:339-348
25. Scicchitano R, Bienenstock J, Stanisz AM (1988) In vivo immunomodulation by the neuropeptide substance P. Immunology 63:733-735
26. 1) receptor. Science 251:435-435
27. Van Rossum JM (1963) Cumulative dose-response curves. Techniques for making dose-response curves in isolated organs and the evaluation of drug parameters. Arch Int Pharmacodyn Ther 143:299-330
28. Vedder H, Affolter H-U, Otten U (1993) Nerve growth factor (NGF) regulates tachykinin gene expression and biosynthesis in rat sensory neurons during early postnatan development. Neuropeptides 24:351-357
29. Walsh DA, Terenghi G, Polak JM (1994) Neural and vascular regulatory factors of the skin. J Eur Acad Dermatol Venereol 3:116-139
30. 1 receptor antagonist. Br J Pharmacol 111:1342-1346
31. Ziche M, Morbidelli L, Pacini M, Geppetti P, Alessandri G, Maggi CA (1990a) Substance P stimulates neovascularization in vivo and proliferation of cultured endothelial cells. Microvasc Res 40:264-278
32. 1 receptors mediate the proliferative response of human fibroblasts to tachykinins. Br J Pharmacol 100:11-14
33. 1 selective receptor mediated activity. Life Sci 48:PL7-PL11