The efficacy and tolerability of aceclofenac compared to indomethacin in patients with rheumatoid arthritis

Rheumatology International

Volumn 15, Issue 6, 1996, Pages 225-230

  Kornasoff, D ^a   Maisenbacher, J ^b   Bowdler, J ^c   Raber, A ^d  

^a AFA ^*  (Germany)

^b AFA   (Germany)

^c Pharmakopius (Services) Ltd   (United Kingdom)

^d Prodesfarma Research Centre   (Spain)

Author keywords

Aceclofenac; Indomethacin; Morning stiffness; Pain; Rheumatoid arthritis

Indexed keywords

ACECLOFENAC; INDOMETACIN; NONSTEROID ANTIINFLAMMATORY AGENT;

ADULT; ANALGESIA; ANKLE EDEMA; ARTHRALGIA; ARTICLE; CLINICAL FEATURE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; EPIGASTRIC PAIN; FACE EDEMA; FATIGUE; FEMALE; GASTROINTESTINAL SYMPTOM; GRIP STRENGTH; HEADACHE; HEARTBURN; HEMATOMA; HUMAN; LIVER TOXICITY; MAJOR CLINICAL STUDY; MALE; MORNING STIFFNESS; MULTICENTER STUDY; MUSCULOSKELETAL DISEASE; NEUROTOXICITY; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RHEUMATOID ARTHRITIS; SKIN MANIFESTATION; THORAX PAIN; VASCULAR DISEASE; VERTIGO; WEIGHT REDUCTION;

ALANINE TRANSAMINASE; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ARTHRITIS, RHEUMATOID; DICLOFENAC; ELASTICITY; FEMALE; HAND STRENGTH; HEARTBURN; HUMANS; INDOMETHACIN; JOINTS; MALE; MIDDLE AGED; PAIN MEASUREMENT; STATISTICS, NONPARAMETRIC; TREATMENT OUTCOME; VERTIGO;

EID: 0029918776     PISSN: 01728172     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF00290375     Document Type: Article

References (19)

1. Zvaifler NL (1973) The immunopathology of joint inflammation in rheumatoid arthritis. Adv Immunol 16:256-356
2. Grau M, Guasch J, Montero JL, Felipe A, Carrasco E, Juliá S (1991) Pharmacology of the potent new non-steroidal anti-inflammatory agent aceclofenac. Arzneimittelforschung/Drug Res 41:1265-1276
3. 2-prostaglandin levels in the synovial fluid and in the serum. Clin Trials J 25:144-151
4. Díaz C, Rodríguez A, Geli C, Llobet JM, Tapounet R (1988) Comparison of aceclofenac and diclofenac in osteoarthritic pain. Curr Ther Res 44:252-256
5. Torrejón VA (1988) Treatment of severe rheumatic pain with aceclofenac: results of a comparative study vs placebo. Acta Ther 14:275-280
6. Sainz Olalla F (1989) Analgesic efficacy of aceclofenac. Double-blind study vs placebo in the treatment of odontalgia. Curr Ther Res 43:900-902
7. Bubani G (1988) The analgesic activity and tolerability of aceclofenac in the treatment of odontalgia. Clin Trials J 23: 244-253
8. Movilia PG (1988) Evaluation of analgesic activity and tolerability of aceclofenac in the treatment of postepisiotomy pain. Drugs Exp Clin Res 15:47-51
9. Ballesteros R, Ansoleaga JJ, Tapounet R (1990) The efficacy and tolerance of aceclofenac in rheumatoid arthritis. A double-blind study vs placebo. Clin Trials J 27:12-19
10. Giorgianni G, Ottaviani C, Soliano A, Campi N (1992) Efficacy and tolerability of aceclofenac versus ketoprofen in the treatment of rheumatoid arthritis. Curr Ther Res 51:175-183
11. Wassif W, Bjarnason I (1992) A comparison of the effects of aceclofenac and diclofenac on gastrointestinal blood loss. Br J Clin Res 3:109-114
12. Grupo de Estudio de Artritis Reumatoide (1992) Estudio de eficacia y tolerancia de aceclofenaco frente a ketoprofeno en el tratamiento de la artritis reumatoide. Rev Esp Reumatol 19: 263-268
13. Fehr K, Miehle W, Schattenkirchner M, Tillmann K (1989) Rheumatologie in Praxis und Klinik. Thieme, Stuttgart
14. Martín-Mola E, Gijón-Baños J (1995) Aceclofenac in comparison to ketoprofen in the treatment of rheumatoid arthritis. Rheumatol Int 15:111-116
15. Furst DE, Dromgoole SH (1987) Indomethacin and sulindac. In: Paulus HE, Furst DE, Dromgoole SH (eds) Drugs for rheumatic disease. Churchill Livingstone, New York, pp 285-314
16. Anonymous (1994) Current problems in pharmacovigilance, vol 20. U. K. Committee on Safety of Medicines
17. Gøtzsche PC (1989) Patients' preference in indomethacin trials: an overview. Lancet 1:88-91
18. Accardo S, Seriolo B, Tirri G, Colombo B, Fumagali M, Lotti G, Pagliara L, Parnham MJ, Alepuz M (1995) Long term safety profile of aceclofenac in the treatment of articular pain. Eur J Rheumatol Inflam 15:35-41
19. Lichtenstein DR, Syngal S, Wolfe MM (1995) Nonsteroidal anti-inflammatory drugs and the gastrointestinal tract. The double-edged sword. Arthritis Rheum 38:5-18