Functional characterization of a non-AUUUA AU-rich element from the c-jun proto-oncogene mRNA: Evidence for a novel class of AU-rich elements

Molecular and Cellular Biology

Volumn 16, Issue 4, 1996, Pages 1490-1499

  Peng, Sheila S Y ^a   Chen, Chyi Ying A ^a   Shyu, Ann Bin ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID ANALYSIS; ARTICLE; GENETIC ANALYSIS; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTO ONCOGENE; RNA BINDING; RNA DEGRADATION; RNA SEQUENCE;

EID: 0029918710     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.16.4.1490     Document Type: Article

References (21)

1. Aharon, T., and R. J. Schneider. 1993. Selective destabilization of short-lived mRNAs with the granulocyte-macrophage colony-stimulating factor AU-rich noncoding region is mediated by a cotranslational mechanism. Mol. Cell. Biol. 13:1971-1980.
2. Akashi, M., G. Shaw, M. Hachiya, E. Elstner, G. Suzuki, and P. Koeffler. 1994. Number and location of AUUUA motifs: Role in regulating transiently expressed RNAs Blood 83:3182-3187.
3. Caput, D., B. Beutler, K. Hartog, R. Thayer, S. Brown-Shimer, and A. Cerami. 1986. Identification of a common nucleotide sequence in the 3′-untranslated regions of mRNA molecules specifying inflammatory mediators. Proc. Natl. Acad Sci USA 83:1670-1674.
4. Chen, C.-Y. A., T.-M. Chen, and A.-B. Shyu. 1994. Interplay of two functionally and structurally distinct domains of the c-fos AU-rich element specifics its mRNA-destabilizing function. Mol. Cell. Biol 14:416-426.
5. Chen, C.-Y. A., N. Xu, and A.-B. Shyu. 1995 mRNA decay mediated by two distinct AU-rich elements from c-fos and granulocyre-macrophage colony-stimulating factor transcripts. different deadenylation kinetics and uncoupling from translation. Mol. Cell. Biol. 15:5777-5788
6. Chen, C.-Y. A., and A.-B. Shyu. 1995. AU-rich elements: characterization and importance in mRNA degradation. Trends Biochem. Sci. 20:465-470.
7. Chen, C.-Y. A., and A.-B. Shyu. 1994. Selective degradation of early-response-gene mRNAs: functional analyses of sequence features of the AU-rich elements. Mol. Cell. Biol 14:8471-8482.
8. Curatola, A. M., M. S. Nadal, and R. J. Schneider. 1995 Rapid degradation of AU-rich element (ARE) mRNAs is activated by ribosome transit and blocked by secondary structure at any position 5′ to the ARE. Mol. Cell. Biol. 15:6331-6340.
9. Higuchi, R. 1990. Recombinant PCR, p. 177-183. In M. A. Innis, D. H. Gelfand, J J Sninsky, and T. J White (ed.), PCR protocols: a guide to methods and applications. Academic Press, Inc., San Diego, Calif.
10. Hirsch, H. H., P. K. Asha, V. Backenstoss, and C. Moroni. 1995. Interleukin-3 mRNA stabilization by a trans-acting mechanism in autocrine tumors lacking interleukin-3 gene rearrangements. J. Biol. Chem. 270:20629-20635.
11. Koeller, D. M., J. A. Horowitz, J. L. Casey, R. D. Klausner, and J. B. Harford. 1991. Translation and the stability of mRNAs encoding the transferrin receptor and c-fos. Proc. Natl. Acad. Sci. USA 88:7778-7782.
12. Kozak, M. 1989. Circumstances and mechanisms of inhibition of translation by secondary structure in eucaryotic mRNAs. Mol. Cell. Biol. 9:5134-5142.
13. Lagnado, C. A., C. Y. Brown, and G. J. Goodall. 1994 AUUUA is not sufficient to promote poly(A) shortening and degradation of an mRNA: the functional sequence within AU-rich elements may be UUAUUUA(U/A)(U/ A). Mol. Cell Biol. 14:7984-7995.
14. Ross, J. 1995. mRNA stability in mammalian cells. Microbiol Rev. 59:16-95.
15. Savant-Bhonsale, S., and D. W. Cleveland. 1992. Evidence for instability of mRNAs containing AUUUA motifs mediated through translation-dependent assembly of a >20S degradation complex Genes Dev. 6:1927-1939
16. Shaw, G., and R. Kamen. 1986. A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation Cell 46:659-667.
17. Shyu, A.-B., J. G. Belasco, and M. E. Greenberg. 1991. Two distinct destabilizing elements in the c-fos message trigger deadenylation as a first step in rapid mRNA decay. Genes Dev. 5:221-231.
18. Shyu, A.-B., M. E. Greenberg, and J. G. Belasco. 1989. The c-fos transcript is targeted for rapid decay by two distinct mRNA degradation pathways. Genes Dev. 3:60-72.
19. Stoecklin, G., S. Hahn, and C. Moroni. 1994. Functional hierarchy of AUUUA motifs in mediating rapid interleukin-3 mRNA decay. J. Biol. Chem. 269:28591-28597.
20. Winstall, E., M. Gamache, and V. Raymond. 1995 Rapid mRNA degradation mediated by the c-fos 3′ AU-rich element and that mediated by the granulocyte-macrophage colony-stimulating factor 3′ AU-rich element occur through similar polysome-associated mechanisms. Mol. Cell. Biol. 15:3796-3804
21. Zubiaga, A. M., J. G. Belasco, and M. E. Greenberg. 1995. The nonamer UUAUUUAUU is the key AU-rich sequence motif that mediates mRNA degradation. Mol. Cell. Biol. 15:2219-2230.