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Volumn 72, Issue 4, 1996, Pages 177-183

Clinical applications of new antithrombotic agents

Author keywords

Antithrombotic agents; Hirudin; Low molecular weigth heparin; Thrombosis

Indexed keywords

ANTICOAGULANT AGENT; ANTITHROMBIN III; BLOOD CLOTTING FACTOR 10A; DANAPAROID; HEPARIN; HEPARIN BINDING PROTEIN; HEPARINOID; HIRUDIN; HIRULOG; LOW MOLECULAR WEIGHT HEPARIN; NADROPARIN; PROTHROMBIN; STREPTOKINASE; THROMBIN; THROMBIN INHIBITOR;

EID: 0029918642     PISSN: 09395555     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002770050158     Document Type: Review
Times cited : (35)

References (52)
  • 1
    • 0026605356 scopus 로고
    • A randomized, double blind, placebo controlled trial of dermatan sulphate for prevention of deep-vein thrombosis in hip fracture
    • Agnelli G. Cosmi B. Di Filippo P et al. (1992) A randomized, double blind, placebo controlled trial of dermatan sulphate for prevention of deep-vein thrombosis in hip fracture. Thromb Haemost 67:203-208
    • (1992) Thromb Haemost , vol.67 , pp. 203-208
    • Agnelli, G.1    Cosmi, B.2    Di Filippo, P.3
  • 2
    • 0017044123 scopus 로고
    • Anticoagulant properties of heparin fractioned by affinity chromatography on matrix-bound antithrombin III and by gel filtration
    • Andcrsson L-O, Barrowcliffe TW, Johnson EA et al (1976) Anticoagulant properties of heparin fractioned by affinity chromatography on matrix-bound antithrombin III and by gel filtration. Thromb Res 9:575-583
    • (1976) Thromb Res , vol.9 , pp. 575-583
    • Andcrsson, L.-O.1    Barrowcliffe, T.W.2    Johnson, E.A.3
  • 3
    • 0018647312 scopus 로고
    • Molecular weight dependency of the heparin potentiated inhibition of thrombin and activated factor X. Effect of heparin neutralization in plasma
    • Andersson LO. Barrowcliffe TW, Holmer E et al. (1979) Molecular weight dependency of the heparin potentiated inhibition of thrombin and activated factor X. Effect of heparin neutralization in plasma. Thromb Res 15:531-541
    • (1979) Thromb Res , vol.15 , pp. 531-541
    • Andersson, L.O.1    Barrowcliffe, T.W.2    Holmer, E.3
  • 4
    • 0028092111 scopus 로고
    • Hirudin in acute myocardial infarction
    • for the TIMI 9A Investigators
    • Antman EM, for the TIMI 9A Investigators (1994) Hirudin in acute myocardial infarction. Circulation 90:1624-1630
    • (1994) Circulation , vol.90 , pp. 1624-1630
    • Antman, E.M.1
  • 5
    • 0024256963 scopus 로고
    • Initiation of coagulation by tissue factor
    • Bach RR (1988) Initiation of coagulation by tissue factor. Crit Rev Biochem 23:339-367
    • (1988) Crit Rev Biochem , vol.23 , pp. 339-367
    • Bach, R.R.1
  • 6
    • 0021268420 scopus 로고
    • Low-affinity heparin potentiates the action of high-affinity heparin oligosaccharide
    • Barrowcliffe TW. Merton RE. Havercroft SJ et al. (1984) Low-affinity heparin potentiates the action of high-affinity heparin oligosaccharide. Thromb Res 34:125-133
    • (1984) Thromb Res , vol.34 , pp. 125-133
    • Barrowcliffe, T.W.1    Merton, R.E.2    Havercroft, S.J.3
  • 7
    • 0028296628 scopus 로고
    • Dermatan sulfate is a more potent inhibitor of clot-bound throm-bin than unfractionated and low-molecular-weight heparins
    • Bendayan P, Boccalon H, Dupouy D, Boneu B (1994) Dermatan sulfate is a more potent inhibitor of clot-bound throm-bin than unfractionated and low-molecular-weight heparins. Thromb Haemost 71:576-580
    • (1994) Thromb Haemost , vol.71 , pp. 576-580
    • Bendayan, P.1    Boccalon, H.2    Dupouy, D.3    Boneu, B.4
  • 8
    • 0029103184 scopus 로고
    • Treatment with bivalirudin (hirulog) as compared with heparin during coronary angioplasty for unstable or postinfarction angina
    • Bittl FA, Strony J. Brinker JA et al. (1995) Treatment with bivalirudin (hirulog) as compared with heparin during coronary angioplasty for unstable or postinfarction angina. N Enal J Med 333:764-769
    • (1995) N Enal J Med , vol.333 , pp. 764-769
    • Bittl, F.A.1    Strony, J.2    Brinker, J.A.3
  • 9
    • 0028001666 scopus 로고
    • Fibrin-targeted recombinant hirudin inhibits fibrin deposition on experimental clots more efficiently than recombinant hirudin
    • Bode C. Hudelmayer M. Mehwald P et al. (1994) Fibrin-targeted recombinant hirudin inhibits fibrin deposition on experimental clots more efficiently than recombinant hirudin. Circulation 90:1956-1963
    • (1994) Circulation , vol.90 , pp. 1956-1963
    • Bode, C.1    Hudelmayer, M.2    Mehwald, P.3
  • 10
    • 0026685143 scopus 로고
    • Lowmolecular-weight heparin reduces neointimal proliferation after coronary stent implantation in hypercholesterolemic minipigs
    • Buchwald AB, Unterberg C, Nebendahl K et al. 1992 Lowmolecular-weight heparin reduces neointimal proliferation after coronary stent implantation in hypercholesterolemic minipigs. Circulation 86:531-537
    • (1992) Circulation , vol.86 , pp. 531-537
    • Buchwald, A.B.1    Unterberg, C.2    Nebendahl, K.3
  • 11
    • 0028296374 scopus 로고    scopus 로고
    • A pilot trial of recombinant desulfatohirudin compared with heparin in conjunction with tissue-type plasminogen activator and aspirin for acute myocardial infarction: Results of the thrombolysis in myocardial infarction (TIMI) 5 trial
    • Cannon CP, McCabe CH, Henry TD et al. (1994) A pilot trial of recombinant desulfatohirudin compared with heparin in conjunction with tissue-type plasminogen activator and aspirin for acute myocardial infarction: results of the thrombolysis in myocardial infarction (TIMI) 5 trial. J Am Coll Cardiol 23:993-1003
    • J Am Coll Cardiol , vol.23 , pp. 993-1003
    • Cannon, C.P.1    McCabe, C.H.2    Henry, T.D.3
  • 12
    • 0027392867 scopus 로고
    • Anticoagulant activity of Hirulog, a direct thrombin inhibitor, in humans
    • Fox I, Dawson A, Loynds P et al. (1993) Anticoagulant activity of Hirulog, a direct thrombin inhibitor, in humans. Thromb Haemost 69:157-163
    • (1993) Thromb Haemost , vol.69 , pp. 157-163
    • Fox, I.1    Dawson, A.2    Loynds, P.3
  • 13
    • 0027985641 scopus 로고
    • Use of hirulog in the prevention of venous thrombosis after major hip or knee surgery
    • Ginsberg JS, Nurmohamed MT, Gent M et al. (1994) Use of hirulog in the prevention of venous thrombosis after major hip or knee surgery. Circulation 90:2385-2389
    • (1994) Circulation , vol.90 , pp. 2385-2389
    • Ginsberg, J.S.1    Nurmohamed, M.T.2    Gent, M.3
  • 14
    • 0028037517 scopus 로고
    • Randomized trial of intravenous heparin versus recombinant hirudin for acute coronary syndromes
    • The global use of strategies to open occluded coronary arteries (GUSTO) IIa investigators
    • The global use of strategies to open occluded coronary arteries (GUSTO) IIa investigators (1994) Randomized trial of intravenous heparin versus recombinant hirudin for acute coronary syndromes. Circulation 90:1631-1637
    • (1994) Circulation , vol.90 , pp. 1631-1637
  • 16
    • 0029082921 scopus 로고
    • Antithrombotic benefits and hemorrhagic risks of direct thrombin antagonist
    • Harker LA, Hanson SR, Kelly AB (1995) Antithrombotic benefits and hemorrhagic risks of direct thrombin antagonist. Thromb Haemost 74:464-472
    • (1995) Thromb Haemost , vol.74 , pp. 464-472
    • Harker, L.A.1    Hanson, S.R.2    Kelly, A.B.3
  • 17
    • 0343902282 scopus 로고
    • Biochemical and pharmacological properties of sanorg 32701. a potent analogue of the natural pentasaccharide
    • 1321. mr. 1617
    • Herbert JM, Herault JP. Barzu T, Bernat A. Lormeau JC, Petitou M (1995) Biochemical and pharmacological properties of sanorg 32701. a potent analogue of the natural pentasaccharide. Thromb Haemost 73:1321. mr. 1617
    • (1995) Thromb Haemost , vol.73
    • Herbert, J.M.1    Herault, J.P.2    Barzu, T.3    Bernat, A.4    Lormeau, J.C.5    Petitou, M.6
  • 18
    • 0026593425 scopus 로고
    • Low-molecular-weight heparin
    • Hirsh J, Levine MN (1992) Low-molecular-weight heparin. Blood 79:1-17
    • (1992) Blood , vol.79 , pp. 1-17
    • Hirsh, J.1    Levine, M.N.2
  • 19
    • 0017074450 scopus 로고
    • Anticoagulant activity of heparin: Separation of high-activity and low-activity heparin species by affinity chromatography on immobilized antithrombin
    • Hook M, Bjork I. Hopwood J et al. (1976) Anticoagulant activity of heparin: separation of high-activity and low-activity heparin species by affinity chromatography on immobilized antithrombin. FEBS Letters 66:90-93
    • (1976) FEBS Letters , vol.66 , pp. 90-93
    • Hook, M.1    Bjork, I.2    Hopwood, J.3
  • 20
    • 0027286646 scopus 로고
    • Prophylaxis of postoperative thromboembolism with low-molecular-weiaht heparins
    • Jorgensen LN, Wille-Jorgensen P, Hauch O (1993) Prophylaxis of postoperative thromboembolism with low-molecular-weiaht heparins. Br J Surg 80:689-704
    • (1993) Br J Surg , vol.80 , pp. 689-704
    • Jorgensen, L.N.1    Wille-Jorgensen, P.2    Hauch, O.3
  • 21
    • 0028871958 scopus 로고
    • Low-molecular-weight heparin for the treatment of acute ischmic stroke
    • Kay R. Sing Wong K, Yuk Ling Yu, Yuk Wah Chan et al. (1995), Low-molecular-weight heparin for the treatment of acute ischmic stroke, N Engl J Med 333. (No. 24) 1588-1593
    • (1995) N Engl J Med , vol.333 , Issue.24 , pp. 1588-1593
    • Kay, R.1    Sing Wong, K.2    Yu, Y.L.3    Chan, Y.W.4
  • 22
    • 0029969612 scopus 로고    scopus 로고
    • Treatment of venous thrombosis with intravenous unfractionated heparin administrated in the hospital as compared with subcutaneous low-molecular weight heparin administered at home.
    • Koopman MMW, et al. Treatment of venous thrombosis with intravenous unfractionated heparin administrated in the hospital as compared with subcutaneous low-molecular weight heparin administered at home. (1996) New England. J Mediane 334:682-687
    • (1996) New England. J Mediane , vol.334 , pp. 682-687
    • Koopman, M.M.W.1
  • 24
    • 0021344246 scopus 로고
    • Anticoagulant activities of heparin oligosaccharides and their neutralization by platelet factor 4
    • Lane DA. Denton J. Flynn AM et al. (1984) Anticoagulant activities of heparin oligosaccharides and their neutralization by platelet factor 4. Biochem J 218:725-732
    • (1984) Biochem J , vol.218 , pp. 725-732
    • Lane, D.A.1    Denton, J.2    Flynn, A.M.3
  • 26
    • 0026761832 scopus 로고    scopus 로고
    • Low-molecular-weight heparin in prevention of perioperative thrombosis
    • Leizorovicz A, Haugh MC, Chapuis F-R et al. (1992) Low-molecular-weight heparin in prevention of perioperative thrombosis. Br Med J 305:913-920
    • Br Med J , vol.305 , pp. 913-920
    • Leizorovicz, A.1    Haugh, M.C.2    Chapuis, F.-R.3
  • 27
    • 0027932867 scopus 로고
    • Comparison of efficacy and safety of low-molecular-weight heparins and unfractionated heparin in initial treatment of deep-vein thrombosis: A meta-analysis
    • Leizorovicz A, Simonneau G, Decousus H. Boissel JP (1994) Comparison of efficacy and safety of low-molecular-weight heparins and unfractionated heparin in initial treatment of deep-vein thrombosis: a meta-analysis. Br Med J 309:299-304
    • (1994) Br Med J , vol.309 , pp. 299-304
    • Leizorovicz, A.1    Simonneau, G.2    Decousus, H.3    Boissel, J.P.4
  • 28
    • 0028939906 scopus 로고
    • Treatment of deep venous thrombosis with low-molccular-weight heparins
    • Lensing AWA, Prins MH, Davidson BL, Hirsh J (1995) Treatment of deep venous thrombosis with low-molccular-weight heparins. Arch Intern Med. 155:601-607
    • (1995) Arch Intern Med. , vol.155 , pp. 601-607
    • Lensing, A.W.A.1    Prins, M.H.2    Davidson, B.L.3    Hirsh, J.4
  • 29
    • 0028326748 scopus 로고
    • A pilot, early angiographic patency study using a direct thrombin inhibitor as adjunctive therapy to streptokinase in acute myocardial infarction
    • Lidon R-M, Theroux P, Lesperance J et al. (1994) A pilot, early angiographic patency study using a direct thrombin inhibitor as adjunctive therapy to streptokinase in acute myocardial infarction. Circulation 89:1567-1572
    • (1994) Circulation , vol.89 , pp. 1567-1572
    • Lidon, R.-M.1    Theroux, P.2    Lesperance, J.3
  • 30
    • 0027442550 scopus 로고
    • Heparin-induced thrombocytopenia (HIT): An overview of 230 patients treated with Orgaran (Org 10172)
    • Magnani HN (1993). Heparin-induced thrombocytopenia (HIT): an overview of 230 patients treated with Orgaran (Org 10172). Thromb Haemost 70:554-561
    • (1993) Thromb Haemost , vol.70 , pp. 554-561
    • Magnani, H.N.1
  • 31
    • 0025346345 scopus 로고
    • Design and characterization of hirulogs: A novel class of bivalent peptide inhibitors of thrombin
    • Maraganore JM, Bourdon P, Jablonski J et al. (1990) Design and characterization of hirulogs: A novel class of bivalent peptide inhibitors of thrombin. Biochemistry 29:7095-7101
    • (1990) Biochemistry , vol.29 , pp. 7095-7101
    • Maraganore, J.M.1    Bourdon, P.2    Jablonski, J.3
  • 32
    • 0027257780 scopus 로고
    • Clinical pharmacology of intravenously administered recombinant desulfalohirudin (CGP 39393) in healthy volunteers
    • Marbet GA, Verstraete M, Kienast J et al. (1993) Clinical pharmacology of intravenously administered recombinant desulfalohirudin (CGP 39393) in healthy volunteers. J Cardiovasc Pharmacol 22:364-372
    • (1993) J Cardiovasc Pharmacol , vol.22 , pp. 364-372
    • Marbet, G.A.1    Verstraete, M.2    Kienast, J.3
  • 33
    • 0027968823 scopus 로고
    • The development of hirudin as an antithrombotic drug
    • Markwardt F (1994) The development of hirudin as an antithrombotic drug. Thromb Res 74.1-23
    • (1994) Thromb Res , vol.74 , pp. 1-23
    • Markwardt, F.1
  • 34
    • 0028077556 scopus 로고
    • Local delivery of r-hirudin by a double balloon perfusion catheter prevents mural thrombosis and minimizes platelet deposition after angioplasty
    • Meyer BL, Fernandez-Ortiz A, Mailhac A et al. (1994) Local delivery of r-hirudin by a double balloon perfusion catheter prevents mural thrombosis and minimizes platelet deposition after angioplasty. Circulation 90:2474-2480
    • (1994) Circulation , vol.90 , pp. 2474-2480
    • Meyer, B.L.1    Fernandez-Ortiz, A.2    Mailhac, A.3
  • 35
    • 0028117846 scopus 로고
    • Safety observations from the pilot phase of the randomized r-hirudin for improvement of thrombolysis (HIT-III) study
    • Neuhaus KL, von Essen R, Tebbe U et al. (1994) Safety observations from the pilot phase of the randomized r-hirudin for improvement of thrombolysis (HIT-III) study. Circulation 90:1638-1642
    • (1994) Circulation , vol.90 , pp. 1638-1642
    • Neuhaus, K.L.1    Von Essen, R.2    Tebbe, U.3
  • 36
    • 0026194172 scopus 로고
    • Long-term efficacy and safety of a low-molecular-weight heparin in chronic hemodialysis patients. A comparison with standard heparin
    • Nurmohamed MT, ten Cate J, Stevens P et al. (1991) Long-term efficacy and safety of a low-molecular-weight heparin in chronic hemodialysis patients. A comparison with standard heparin. ASAIO Trans 37: M 459-461
    • (1991) ASAIO Trans , vol.37
    • Nurmohamed, M.T.1    Ten Cate, J.2    Stevens, P.3
  • 37
    • 0026718529 scopus 로고
    • Low -molecular-weight heparin in general and orthopedic surgery: A meta analysis
    • Nurmohamed MT, Rosendaal FR, Buller HR et al. (1992) Low -molecular-weight heparin in general and orthopedic surgery: a meta analysis. Lancet 340:152-156
    • (1992) Lancet , vol.340 , pp. 152-156
    • Nurmohamed, M.T.1    Rosendaal, F.R.2    Buller, H.R.3
  • 39
    • 0027293280 scopus 로고
    • Treatment of severe venous thrombo-embolism with intravenous hirudin (HBW 023): An open pilot study
    • Parent F, Bridey F, Dreyfus M et al. (1993) Treatment of severe venous thrombo-embolism with intravenous hirudin (HBW 023): an open pilot study. Thromb Haemost 70:386-388
    • (1993) Thromb Haemost , vol.70 , pp. 386-388
    • Parent, F.1    Bridey, F.2    Dreyfus, M.3
  • 40
    • 0025809685 scopus 로고
    • Molecular cloning, characterization and expression of cDNA for rabbit brain tissue factor
    • Pawashe A, Ezekowitz M, Lin TC et al. (1991), Molecular cloning, characterization and expression of cDNA for rabbit brain tissue factor. Thromb Haemost 66:315-320
    • (1991) Thromb Haemost , vol.66 , pp. 315-320
    • Pawashe, A.1    Ezekowitz, M.2    Lin, T.C.3
  • 41
    • 0041051072 scopus 로고
    • Thesis. Swedish University of Agricultural Science, Uppsala
    • Pejler G (1988) Why does heparin bind antithrombm? Thesis. Swedish University of Agricultural Science, Uppsala
    • (1988) Why Does Heparin Bind Antithrombm?
    • Pejler, G.1
  • 42
    • 0027973884 scopus 로고
    • Thromboembolic prophylaxis with low-molecular-weight heparin during pregnancy
    • Rasmussen C. Wadt J. Jacobsen B (1994) Thromboembolic prophylaxis with low-molecular-weight heparin during pregnancy, Int J Gynaecol Obstet 47:121-125
    • (1994) Int J Gynaecol Obstet , vol.47 , pp. 121-125
    • Rasmussen, C.1    Wadt, J.2    Jacobsen, B.3
  • 43
    • 0029101260 scopus 로고
    • A comparison of hirudin with heparin in the prevention of restenosis after coronary angioplasty
    • Serruys PW, Herrman JR, Simon R et al. (1995) A comparison of hirudin with heparin in the prevention of restenosis after coronary angioplasty. N Engl J Med 333:757-763
    • (1995) N Engl J Med , vol.333 , pp. 757-763
    • Serruys, P.W.1    Herrman, J.R.2    Simon, R.3
  • 44
    • 0023618805 scopus 로고
    • Randomized double-blind, placebo controlled safety study of a low-molecular-weight heparinoid in patients undergoing transurethral resection of the prostate
    • ten Cate H, Henny CP, ten Cate JW et al. (1987) Randomized double-blind, placebo controlled safety study of a low-molecular-weight heparinoid in patients undergoing transurethral resection of the prostate. Thromb Haemost 57:92-96
    • (1987) Thromb Haemost , vol.57 , pp. 92-96
    • Ten Cate, H.1    Henny, C.P.2    Ten Cate, J.W.3
  • 45
    • 0023933747 scopus 로고
    • Clinical studies with low-molecular-weight heparin (oid)s: An interim analysis
    • ten Cate H, Henny CP, ten Cate JW, Buller HR (1988) Clinical studies with low-molecular-weight heparin (oid)s: an interim analysis. Am J Hematol 27:146-153
    • (1988) Am J Hematol , vol.27 , pp. 146-153
    • Ten Cate, H.1    Henny, C.P.2    Ten Cate, J.W.3    Buller, H.R.4
  • 46
    • 0019953801 scopus 로고
    • Effects of heparin oligosaccharides with high affinity for antithrombin III in experimental venous thrombosis
    • Thomas DP, Merton RE, Barrowcliffe TW et al. (1982) Effects of heparin oligosaccharides with high affinity for antithrombin III in experimental venous thrombosis. Thromb Haemost 47:244-248
    • (1982) Thromb Haemost , vol.47 , pp. 244-248
    • Thomas, D.P.1    Merton, R.E.2    Barrowcliffe, T.W.3
  • 47
    • 0028922945 scopus 로고
    • Novel antithrombotic approaches to coronary artery disease
    • Topol EJ (1995), Novel antithrombotic approaches to coronary artery disease. Am J Cardiol 75:27B-33B
    • (1995) Am J Cardiol , vol.75
    • Topol, E.J.1
  • 48
    • 0028346249 scopus 로고
    • Recombinant hirudin for unstable angina pectoris
    • Topol EJ, Fuster V. Harrington RA et al. (1994) Recombinant hirudin for unstable angina pectoris. Circulation 89:1557-1566
    • (1994) Circulation , vol.89 , pp. 1557-1566
    • Topol, E.J.1    Fuster, V.2    Harrington, R.A.3
  • 49
    • 0027496925 scopus 로고
    • Safety and efficacy of recombinant hirudin (CGP 39393) versus heparin in patients with stable angina undergoing coronary angioplasty
    • van den Bos AA, Deckers JW, Heyndrickx GR et al. (1993) Safety and efficacy of recombinant hirudin (CGP 39393) versus heparin in patients with stable angina undergoing coronary angioplasty. Circulation 88:2058-2066
    • (1993) Circulation , vol.88 , pp. 2058-2066
    • Van Den Bos, A.A.1    Deckers, J.W.2    Heyndrickx, G.R.3
  • 50
    • 0027340349 scopus 로고
    • Pentasaccharide and Orgaran arrest, whereas heparin delays thrombus formation in a rat arteriovenous shunt
    • Vogel GMT, van Amsterdam RGM, Kop WJ Meuleman DG (1993) Pentasaccharide and Orgaran arrest, whereas heparin delays thrombus formation in a rat arteriovenous shunt. Thromb Haemost 69:29-34
    • (1993) Thromb Haemost , vol.69 , pp. 29-34
    • Vogel, G.M.T.1    Van Amsterdam, R.G.M.2    Kop, W.J.3    Meuleman, D.G.4
  • 51
    • 0023214250 scopus 로고
    • Antithrombotic activity of a synthetic heparin pentasaccharide in a rabbit stasis thrombosis model using different thrombogenic challenges
    • Walenga JM. Petitou M, Lormeau JC et al. (1987) Antithrombotic activity of a synthetic heparin pentasaccharide in a rabbit stasis thrombosis model using different thrombogenic challenges. Thromb Res 46:187-198
    • (1987) Thromb Res , vol.46 , pp. 187-198
    • Walenga, J.M.1    Petitou, M.2    Lormeau, J.C.3
  • 52
    • 0025146426 scopus 로고
    • Clot-bound thrombin is protected from inhibition by heparin-antithrombin III, but is susceptible to mactivation by antithrombin III independent inhibitor
    • Weitz JI. Hudoba M. Massel D et al. (1992), Clot-bound thrombin is protected from inhibition by heparin-antithrombin III, but is susceptible to mactivation by antithrombin III independent inhibitor. J Clin Invest 86:385-391
    • (1992) J Clin Invest , vol.86 , pp. 385-391
    • Weitz, J.I.1    Hudoba, M.2    Massel, D.3


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