Intratracheal administration of fentanyl: Pharmacokinetics and local tissue effects

Intensive Care Medicine

Volumn 22, Issue 2, 1996, Pages 129-133

  Irazuzta, J E ^a   Ahmed, U ^b   Gancayco, A ^b   Ahmed, S T ^b   Zhang, J ^b   Anand, K J S ^c  

^a Pediatric Intensive Care Unit   (United States)

^b WEST VIRGINIA UNIVERSITY   (United States)

^c EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Absorption; Animals; Fentanyl; Intensive care unit; Intratracheal administration; Safety

Indexed keywords

FENTANYL; FENTANYL CITRATE; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOAVAILABILITY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; DRUG ADMINISTRATION; HUMAN; INFLAMMATION; INTENSIVE CARE; INTERMETHOD COMPARISON; INTRATRACHEAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; LUNG; LUNG INJURY; LUNG PARENCHYMA; MALE; NEWBORN INTENSIVE CARE; PHARMACOKINETICS; RABBIT; RADIOIMMUNOASSAY; RANDOMIZED CONTROLLED TRIAL; RESPIRATORY SYSTEM; RESPIRATORY TRACT INTUBATION; SINGLE BLIND PROCEDURE; TRACHEA;

ANALGESICS, OPIOID; ANALYSIS OF VARIANCE; ANIMALS; DRUG EVALUATION, PRECLINICAL; FENTANYL; INJECTIONS, INTRAVENOUS; LUNG; MALE; PROSPECTIVE STUDIES; RABBITS; RANDOM ALLOCATION; TIME FACTORS; TRACHEA;

EID: 0029918523     PISSN: 03424642     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF01720719     Document Type: Article

References (24)

1. Clotz MA, Nahata MC (1991) Clinical uses of fentanyl, sufentanyl and alfenlanyl. Clin Pharm 10: 581-593
2. Mickey PR, Hansen DD, Wesel et al (1985) Blunting of stress response in the pulmonary circulation of infants by fentanyl. Anesth Analg 64: 1137-1142
3. Irazuzta J, Pascucci R, Perlman N, Wessel D (1993) Effects of fentanyl administration on respiratory system compliance in infants. Crit Care Med 21: 1001-1004
4. Anand KJ, Sippell WG, Aynsley-Green A (1987) Randomized trial of fentanyl anaesthesia in preterm babies undergoing surgery: effects on the stress response. Lancet 1: 62-66
5. Humphrey GB, Boon CM, et al (1992) The occurrence of high levels of acute behavioral distress in children and adolescents undergoing routine venipunctures. Pediatrics 90: 87-91
6. Anand KJS (1993) Relationships between stress responses and clinical outcome in newborns, infants, and children. Crit Care Med 21: S357-S362
7. Billmire DA, Neale HW, Gregory RO (1985) Use of intravenous fentanyl in the outpatient treatment of pediatric facial trauma. J Trauma 25: 1079-1080
8. Katz R, Kelly HW (1993) Pharmacokinetics of continuous infusions of fentanyl in critically ill children. Crit Care Med 21: 995-1000
9. Gourlay KG, Murphy TM, Plummer JL, et al (1989) Pharmacokinetics of fentanyl in lumbar and cervical CSF following lumbar epidural and intravenous administration. Pain 38: 253-259
10. Kayser V, Gobeux D, Lombard MC, Guilbaud G, Besson JM (1990) Potent and long lasting antinocioceptive effects after injection of low doses of a muopioid receptor agonist, fentanyl into the brachial plexus sheath of the rat. Pain 42: 215-225
11. Higgins MJ, Asbury AJ, Brodie MJ (1991) Inhaled nebulized fentanyl for postoperative analgesia. Anaesthesia 46: 973-976
12. Streisand JB, Varvel JR, Stanski DR (1991)) Absorption and bioavailability of oral and transmucosal fentanyl citrate. Anesthesiology 75; 223-229
13. Varvel JR, Shafer SL, Hwang SS, et al (1989) Absorption characteristics of transdermally administered fentanyl. Anesthesiology 70: 928-934
14. Tobias JD (1992) Transdermal fentanyl: applications and indications in the pediatric patient. Am J Pain Management 2: 30-33
15. Mather LE (1983) Clinical pharmacokinetics of fentanyl and its newer derivatives. Clin Pharmacokinet 8: 422-446
16. Roberts J, Greenberg M, Knaub M, Kendrick Z, Baskins (1979) Blood levels following intravenous and endotracheal epinephrine administration. JACEP 8: 53-56
17. Chernow B, Holbrook P, D'Angona D, Zaritsky A, Casey L, Fletcher et al (1984) Epinephrine absorption after intratracheal administration. Anesth Analg 63: 829-832
18. Hasegawa EA (1986) The endotracheal use of emergency drugs. Pharmacol Crit Care 15: 60-63
19. Mace SE (1986) Effect of technique of administration on plasma lidocaine levels. Ann Emerg Med 15: 552-556
20. Jaimovich DG, Osborne JS, Shabino CL (1992) Comparison of intravenous and endotracheal administration of midazolam and the effect on pulmonary functions and histology in the lamb model. Ann Emerg Med 21: 480-489
21. Barsan WG, Ward JT, Otten EJ (1982) Blood levels of diazepam after endotracheal administration in dogs. Ann Emerg Med 11: 242-247
22. Hug CC (1984) Pharmacokinetics and dynamics of narcotic analgesics. In: Prys-Roberts C, Hug CC (eds) Pharmacokinetics of anaesthesia. Blackwell Scientific, Oxford, UK, 187-237
23. Worsley MH, Macleod AD, Brodie MJ, Asbury AJ, Clark C (1990) Inhaled fentanyl as a method of analgesia. Anaesthesia 45: 449-451
24. Schuyt H, Leene W (1977) An improved method of tracheal intubation in the rabbit. Lab Anim Sci 27: 690-693