Combinations of ganciclovir and antibody for experimental CMV infections

Antiviral Research

Volumn 29, Issue 1, 1996, Pages 61-64

  Stals, Frans S ^a   Wagenaar, Sjoerd Sc ^b   Kloover, Jeroen S ^a   Vanagt, Ward Y R ^a   Bruggeman, Cathrien A ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b ONZE LIEVE VROUWE GASTHUIS   (Netherlands)

Author keywords

Animal; Combination therapy; Cytomegalovirus; Ganciclovir; Hyper immune serum

Indexed keywords

GANCICLOVIR; HYPERIMMUNE GLOBULIN;

ANIMAL MODEL; CONFERENCE PAPER; CONTROLLED STUDY; CYTOMEGALOVIRUS INFECTION; DRUG EFFICACY; DRUG POTENTIATION; EXPERIMENTAL INFECTION; HISTOPATHOLOGY; IMMUNE DEFICIENCY; INTERSTITIAL LUNG DISEASE; INTRAVENOUS DRUG ADMINISTRATION; MENINGOENCEPHALITIS; NONHUMAN; PRIORITY JOURNAL; RAT; SURVIVAL; VIRUS TITRATION;

EID: 0029918475     PISSN: 01663542     EISSN: None     Source Type: Journal    
DOI: 10.1016/0166-3542(95)00918-3     Document Type: Conference Paper

References (6)

1. Bruggeman, C.A., Debie, W.M., Grauls, G., Majoor, G. and van-Boven, C.P. (1983) Infection of laboratory rats with a new cytomegalo-like virus. Arch. Virol. 76, 189-199.
2. Emanuel, D., Cunningham, I., Jules-Elysee, K., Brochstein, J.A., Kernan, N.A., Laver, J., Stover, D., White, D.A., Fels, A., Polsky, B., Castro-Malaspina, H., Peppard, J.R., Bartus, P., Hammerling, U. and O'Reilly, R.J. (1988 Cytomegalovirus pneumonia after bone marrow transplantation successfully treated with the combination of ganciclovir and high-dose intravenous immune globulin. Ann. Intern. Med. 109, 777-782.
3. Reed, E.C., Bowden, R.A., Dandliker, P.S., Lilleby, K.E. and Meyers, J.D. (1988) Treatment of cytomegalovirus pneumonia with ganciclovir and intravenous cytomegalovirus immunoglobulin in patients with bone marrow transplants. Ann. Intern. Med. 109, 783-788.
4. Stals, F.S., Bosman, F., van-Boven, C.P. and Bruggeman, C.A. (1990) An animal model for therapeutic intervention studies of CMV infection in the immunocompromised host. Arch. Virol. 114, 91-107.
5. Stals, F.S., de-Clercq, E. and Bruggeman, C.A. (1991) Comparative activity of (S)-1-(3-hydroxy-2-phosphonyl-methoxypropyl)cytosine and 9-(1,3-dihydroxy-2-propoxymethyl)guanine against rat cytomegalovirus infection in vitro and in vivo. Antimicrob. Agents. Chemother. 35, 2262-2266.
6. Stals, F.S., Wagenaar, S.S. and Bruggeman, C.A. (1994) Generalized cytomegalovirus (CMV) infection and CMV-induced pneumonitis in the rat: combined effect of 9-(1,3-dihydroxy-2-propoxymethyl)guanine and specific antibody treatment. Antiviral. Res. 25, 147-160.