Impact of angiotensin-converting enzyme substrate conformation on fractional hydrolysis in lung

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 270, Issue 2 14-2, 1996, Pages

  Merker, Marilyn P ^b   Armitage, Ian M ^a   Audi, Said H ^c   Kakalis, Lazaros T ^c   Linehan, John H ^c   Maehl, Jeffrey R ^c   Roerig, David L ^c   Dawson, Christopher A ^c  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b CLEMENT J ZABLOCKI VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c NONE

Author keywords

cyclophilin; cyclosporin A

Indexed keywords

DIPEPTIDYL CARBOXYPEPTIDASE;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME CONFORMATION; ENZYME SUBSTRATE; ENZYME SUBSTRATE COMPLEX; LUNG CAPILLARY; LUNG PERFUSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; RABBIT; STEREOISOMERISM;

EID: 0029918454     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.1996.270.2.l251     Document Type: Article

References (33)

1. Chung, A. Y. K., J. W. Ryan, and F. Valido. Effects of prolyl cis,trans isomerase on peptide hormone metabolism (Abstract). FASEB J. 5: A1579, 1991.
2. Cziraki, A., J. W. Ryan, I. Horvath, L. E. Fisher, J. Parkerson, and J. D. Catravas. Comparison of the hydrolyses of two synthetic ACE substrates by rabbit lung in vivo (Abstract). FASEB J. 9: A719, 1995.
3. Dawson, C. A., R. D. Bongard, D. A. Rickaby, J. H. Linehan, and D. L. Roerig. Effect of transit time on metabolism of a pulmonary endothelial enzyme substrate. Am. J. Physiol. 257 (Heart Cire. Physiol. 26): H853-H965, 1989.
4. Dupuis, J., C. A. Goresky, J. W. Ryan, J. L. Rouleau, and G. G. Bach. Pulmonary angiotensin-converting enzyme substrate hydrolysis during exercise. J. Appl. Physiol. 72: 1868-1886, 1992.
5. Fischer, G. Peptidyl-prolyl cis/trans isomerases and their effectors. Angew. Chem. Int. Ed. Engl. 33: 1415-1436, 1994.
6. Fischer, G., H. Bang, E. Berger, and A. Schellenberger. Conformational specificity of chymotrypsin proline-containing substrates. Chim. Biophys. Acta 791: 87-97, 1984.
7. Gillis, C. N. Pharmacological aspects of metabolic processes in the pulmonary microcirculation. Am. Rev. Pharmacol. Toxicol. 26: 183-200, 1986.
8. Horvath, I., A. Cziraki, J. Parkerson, and J. D. Catravas. The effect of left anterior descending (LAD) coronary occlusion on dynamically perfused coronary capillary surface area in dog (Abstract). FASEB J. 9: A847, 1995.
9. Hsu, V. L., R. E. Handschumacher, and I. M. Armitage. Peptidyl-prolyl cis-trans isomerase activity of cyclophilin studied by one dimensional 1H nuclear magnetic spectroscopy. J. Am. Chem. Soc. 112: 6745-6747, 1990.
10. King, G. K., C. R. Middlehurst, and P. W. Kuchel. Direct NMR evidence that prolidase is specific for the trans isomer of imidopeptide substrates. Biochemistry 25: 1054-1062, 1986.
11. Lin, L.-N., and J. F. Brandts. Evidence showing that a proline-specific endopeptidase has an absolute requirement for a trans peptide bond immediately preceding the active bond. Biochemistry 22: 4480-4485, 1983.
12. Lin, L. N., and J. F. Brandts. Evidence suggesting that some proteolytic enzymes may cleave only the trans form of the peptide bond. Biochemistry 18: 43-47, 1979.
13. Lin, L.-N., and J. F. Brandts. Role of cis-trans isomerism of the peptide bond in protease specificity. Kinetic studies on small proline-containing peptides and on polyproline. Biochemistry 18: 5037-5042, 1979.
14. . Linehan, J. H., T. A. Bronikowski, D. A. Rickaby, and C. A. Dawson. Hydrolysis of a synthetic angiotensin converting enzyme substrate in dog lungs. Am. J. Physiol. 257 (Heart Circ. Physiol. 26): H2006-H2016, 1989.
15. 6 analog are substrates of cyclopbilin: a fluorine-19 magnetization transfer study. Biochemistry 29: 10298-10302, 1990.
16. 6]-bradykinin. Role of serine in reducing structural heterogeneity. J. Am. Chem. Soc. 101: 2455-2462, 1979.
17. Markham, J., T. J. McCarthy, M. J. Welch, and D. P. Schuster. In vivo measurements of pulmonary angiotensin-converting enzyme kinetics. I. Theory and error analysis. J. Appl. Physiol. 78: 1158-1168, 1995.
18. Merker, M. P., and C. A. Dawson. Cyclophilin facilitated bradykinin inactivation in the perfused rat lung. Biochem. Pharm. 50: 2085-2091, 1995.
19. Merker, M., and R. E. Handschumacher. Uptake and nature of the intracellular binding of cyclosporin A in a murine thymoma cell line, BW5147. J. Immunology 132: 1-6, 1984.
20. Merker, M. P., C. A. Dawson, R. Bongard, D. Roerig, S. Haworth, and J. Linehan. Angiotensin converting enzyme preferentially hydrolyzes the trans isomer of a proline containing substrate. J. Appl. Physiol. 75: 1519-1524, 1993.
21. Moalli, R., B. R. Pitt, and C. N. Gillis. Effect of flow and surface area on angiotensin converting enzyme activity in rabbit lungs. J. Appl. Physiol. 62: 2042-2050, 1987.
22. Myers, C. L., and B. R. Pitt. Selective effect of phorbol ester on serotonin removal and ACE activity in rabbit lungs. J. Appl. Physiol. 65: 377-384, 1988.
23. Orfanos, S. E., D. Langleben, J. Khoury, R. D. Schlesinger, L. Dragatakis, C. Roussos, and J. D. Catravas. Single versus uble lung capillary endothelial angiotensin converting enzyme activity in man (Abstract). FASEB J. 9: A626, 1995.
24. Pitt, B. R., G. Lister, P. Davies, and L. Reid. Correlation of pulmonary ACE activity and capillary surface area during postnatal development. J. Appl. Physiol. 62: 2031-2041, 1987.
25. Rabenstein, D. L., and A. A. Isab. Conformational and acidbase equilibria of captopril in aqueous solution. Anal. Chem. 54: 526-529, 1982.
26. Rickaby, D. A., R. D. Bongard, M. J. Tristani, J. H. Linehan, and C. A. Dawson. Effects of gas composition and pH on kinetics of lung angiotensin converting enzyme. J. Appl. Physiol. 62: 1216-1221, 1987.
27. Ryffel, B. Cyclosporin binding proteins. Identification, distribution, function and relation to FK binding proteins. Biochem. Pharm. 46: 1-12, 1993.
28. Ryffel, B., G. Woerly, B. Greiner, B. Haendler, M. J. Mihatsch, and B. M. J. Foxwell. Distribution of the cyclosporine binding protein cyclophilin in human tissues. Immunology 72: 399-404, 1991.
29. Schuster, D. P., T. J. McCarthy, M. J. Welch, S. Holmberg, P. Sandiford, and J. Markham. In vivo measurements of pulmonary angiotensin converting enzyme kinetics. II. Implementation and application. J. Appl. Physiol. 78: 1169-1178, 1995.
30. Simmons, W. H., and A. T. Orawski. Membrane-bound aminopeptidase P from bovine lung. J. Biol. Chem. 267: 4897-4903, 1992.
31. Skoglof, A., I. Nilsson, S. Gustafsson, J. Deinum, and P. Gothe. cis-trans isomerization of an angiotensin converting enzyme inhibitor. An enzyme kinetic and nuclear magnetic resonance study. Biochim Biophys. Acta 1041: 22-30, 1990.
32. Toivonen, H. J., and J. D. Catravas. Effects of blood flow on lung ACE kinetics: evidence for microvascular recruitment. J. Appl. Physiol. 71: 2244-2254, 1991.
33. Wuethrich, K. NMR of Proteins and Nucleic Acids. New York: Wiley, 1986.