Effects of topoisomerase II inhibition in lymphoblasts from patients with progeroid and "chromosome instability" syndromes

Cancer Genetics and Cytogenetics

Volumn 87, Issue 2, 1996, Pages 112-116

  Elli, R ^a,b   Chessa, L ^a   Antonelli, A ^a   Petrinelli, P ^a   Ambra, R ^a   Marcucci, L ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b POLICLINICO UMBERTO I   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ATAXIA; ATAXIA TELANGIECTASIA;

ETOPOSIDE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; ATAXIA TELANGIECTASIA; BLOOM SYNDROME; CANCER RISK; CHROMOSOME BREAKAGE; COCKAYNE SYNDROME; DRUG DNA BINDING; DRUG EFFECT; HUMAN; HUMAN CELL; METAPHASE; PRIORITY JOURNAL; WERNER SYNDROME; XERODERMA PIGMENTOSUM;

ATAXIA TELANGIECTASIA; BLEOMYCIN; BLOOM SYNDROME; CELL LINE; COCKAYNE SYNDROME; DNA DAMAGE; DNA TOPOISOMERASES, TYPE II; ETOPOSIDE; GENETIC DISEASES, INBORN; HUMANS; LYMPHOCYTES; WERNER SYNDROME; XERODERMA PIGMENTOSUM;

EID: 0029917980     PISSN: 01654608     EISSN: None     Source Type: Journal    
DOI: 10.1016/0165-4608(95)00294-4     Document Type: Article

References (25)

1. Hoeijmakers JHJ (1993): Nucleotide excision repair II: from yeast to mammals. TIG 9:211-217.
2. Nicotera M (1991): Molecular and biochemical aspects of Bloom's syndrome. Cancer Genet Cytogenet 53:1-13.
3. Monnat RJ (1992): Werner syndrome: molecular genetics and mechanistic hypotheses. Exp Gerontol 27:447-453.
4. Liu LF (1989): DNA topoisomerase poisons as antitumor drugs. Annu Rev Biochem 58:351-375.
5. Chatterjee S, Trivedi D, Petzold S, Berger NA (1990): Mechanism of epipodophyllotoxin-induced cell death in poly(adenosinediphosphate-ribose) synthesis-deficient V79 Chinese Hamster cell lines. Cancer Res 50:2713-2718.
6. Tominaga K, Shinkai T, Saijo N, Nakajima T, Ochi H, Suemasu K (1986): Cytogenetic effects of etoposide (VP-16) on human lymphocytes, with special reference to the relation between sister chromatid exchange and chromatid breakage. Jpn J Cancer Res77:385-391.
7. Elli R, Antonelli A, Petrinelli P, Chessa L, Proietti M, Marcucci L (1991): VP16-induced chromosomal instability in classical and low-radiosensitivity Ataxia telangiectasia lymphoblasts. Am J Hum Genet (suppl) 49:133.
8. Caporossi D, Porfirio B, Nicoletti B, Palitti F, Degrassi F, De Salvia R, Tanzarella C (1993): Hypersensitivity of lymphoblastoid lines derived from ataxia telangiectasia patients to the induction of chromosomal aberrations by etoposide (VP-16). Mutat Res 290:265-272.
9. Berger NA, Chatterjee S, Schmotzer JA, Helms SR (1991): Etoposide (VP-16-213)-induced gene alterations: potential contribution to cell death. Proc Natl Acad Sci USA 88:8740-8743.
10. Povirk LF, Austin MJ (1991): Genotoxicity of bleomycin. Mutat Res 257:127-143.
11. Chessa L, Petrinelli P, Antonelli A, Fiorilli M, Elli R, Marcucci L, Federico A, Gandini E (1992): Heterogeneity in ataxia-telangiectasia: classical phenotype associated with intermediate cellular radiosensitivity. Am J Med Genet 42:741-746.
12. Antonelli A, Petrinelli P, Marcucci L, Billi D, Cardona F, Leuzzi V, Elli R (1992): Effects of DNA-breaking agents on Cockayne syndrome cells. In: Aging and cellular defense mechanisms, vol. 663. Franceschi C, Crepaldi G, Cristofalo VJ, Vijg J, eds. Ann NY Acad Sci (New York) pp. 418-420.
13. Gebhart E, Schinzel M, Ruprecth KW (1985): Cytogenetic studies using various clastogens in two patients with Werner syndrome and control individuals. Hum Genet 70:324-327.
14. Hurt MM, Beaudet AL, Moses RE (1983): Repair response of human fibroblasts to bleomycin damage. Mutat Res 112:181-189.
15. Kojis TL, Gatti RA, Sparkes RS (1991): The cytogenetics of ataxia telangiectasia. Cancer Genet Cytogenet 56:143-156.
16. Debenham PG, Webb MBT, Jones J, Cox R (1987): Molecular studies on the nature of the repair defect in ataxia telangiectasia and their implications for cellular radiobiology. J Cell Sci (suppl) 6:177-189.
17. Antonelli A, Elli R, Marcucci L, Bosi R, Kobal D, Petrinelli P (1991): Human cells (normal and ataxia telangiectasia) transfected with pR plasmid are hypersensitive to DNA strand-breaking agents. Mutat Res 255:11-18.
18. Petrinelli P, Elli R, Marcucci L, Barbieri C, Ambra R, Antonelli A (1996): VP16 hypersensitivity and increased faulty recombination in ataxia-telangiectasia lymphocytes characterized by the tandem translocation t(14;14) (q11;q32). Carcinogenesis (in press).
19. Salk D, Au K, Hoehn H, Martin GM (1985): Cytogenetic aspects of Werner syndrome. Adv Exp Med Biol 190:541-546.
20. Runger TM, Bauer C, Dekant B, Moller K, Sobotta P, Czerny C, Poot M, Martin GM (1994): Hypermutable ligation of plasmid DNA ends in cells from patients with Werner syndrome. J Invest Dermatol 102:45-48.
21. Stefanini M, Scappaticci S, Lagomarsini P, Borroni G, Berardesca E, Nuzzo F (1989): Chromosome instability in lymphocytes from a patient with Werner's syndrome is not associated with DNA repair defects. Mutat Res 219:179-185.
22. Saito H, Moses RE (1991): Immortalization of Werner syndrome and progeria fibroblasts. Exp Cell Res 192:373-379.
23. Kusunoki Y, Hayashi T, Hirai Y, Kushiro J, Tatsumi K, Kurihara T, Zghal M, Kamoun MR, Takebe H (1994): Increased rate of spontaneous mitotic recombination in T lymphocytes from a Bloom's syndrome patient using a flow-cytometry assay at HLA-A locus. Jpn J Cancer Res 85:610-618.
24. Pommier Y, Runger TM, Kerrigan D, Kraemer KH (1991): Relationship of DNA strand breakage produced by bromode-oxyuridine to topoisomerase II activity in Bloom syndrome. Mutat Res 254:185-190.
25. Tanaka K, Wood R (1994): Xeroderma pigmentosum and nucleotide excision repair of DNA. TIBS 19:83-86.