Maternal reproductive effects of oral salicylic acid in Sprague-Dawley rats

Toxicology Letters

Volumn 84, Issue 3, 1996, Pages 135-141

  Davis, D P ^a,c   Daston, G P ^a   Odio, M R ^a   York, R G ^b   Kraus, A L ^a  

^a PROCTER AND GAMBLE COMPANY   (United States)

^b Intl R and D Corporation   (United States)

^c Sharon Woods Technical Center   (United States)

Author keywords

Acetylsalicylic acid; Fetotoxicity; Gestation; Labor; Maternal reproductive toxicity; Salicylic acid

Indexed keywords

ACETYLSALICYLIC ACID; SALICYLATE SODIUM; SALICYLIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; EMBRYO; FEMALE; FETOTOXICITY; FETUS; LABOR; NONHUMAN; ORAL DRUG ADMINISTRATION; PREGNANCY; PRIORITY JOURNAL; RAT; REPRODUCTIVE TOXICITY; STRUCTURE ACTIVITY RELATION;

ANIMALIA;

EID: 0029917880     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/0378-4274(95)03538-9     Document Type: Article

References (13)

1. Insel, P. (1990) Analgesic-antipyretics and antiinflammatory agents: Drugs employed in the treatment of rheumatoid arthritis and gout. In: A.G. Gilman, T.W. Rall, A.S. Nies and P. Taylor (Eds.), Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th Ed, Pergamon Press, New York, pp. 638-681.
2. Tuchmann-Duplessis, H., Hiss, D., Mottot, G. and Rosner, I. (1975) Effects of prenatal administration of acetylsalicylic acid in rats. Toxicology 3, 207-211.
3. Chester, R., Dukes, M., Slater, S.R. and Walpole, A.L. (1972) Delay of parturition in the rat by antiinflammatory agents which inhibit the biosynthesis of prostaglandins. Nature 240, 37-38.
4. Aiken, J.W. (1972) Aspirin and indomethacin prolong parturition in rats: Evidence that prostaglandins contribute to expulsion of foetus. Nature 240, 21-25.
5. Lewis, R.B. and Schulman, J.D. (1973) Influence of acetylsalicylic acid, an inhibitor of prostaglandin synthesis, on the duration of human gestation and labor. Lancet 1, 1159-1161.
6. Collins, E. and Turner, G. (1975) Fetal effects of regular salicylate ingestion in pregnancy. Lancet 2, 338-339.
7. Gyory, G., Kiss, C., Benyo, R., Bagdany, S., Szalay, J., Kurcz, M. and Virag, S. (1974) Inhibition of labor by prostaglandin antagonists in impending abortion and preterm and term labor. Lancet 2, 293.
8. Dekker, G.A. and Sibai, B.M. (1993) Low-dose aspirin in the prevention of pre-eclampsia and fetal growth retardation: Rationale, mechanisms and clinical trials. Am. J. Obstet. Gynecol. 168, 214-227.
9. Steel, R.G.D. and Tome, J.H. (1980) Principles and Procedures of Statistics, A Biometrical Approach, 2nd Ed. McGraw-Hill Book Company, New York, pp. 106-107, 137-170, and 471-472.
10. Eriksson, M. (1969) Salicylate-induced fetal hemorrhage in two mouse strains. Acta Pathol. Microbiol. Scand. 76, 164-170.
11. Eriksson, M. (1970) Salicylate-induced fetal damage during later pregnancy in mice. The modifying effect of repeated administration and dosage. Acta Paediatr. Scand. 59, 517-522.
12. Trudinger, B.J., Cook, C.M., Thompson, R.S., Giles, W. B. and Connelly, A. (1988) Low-dose aspirin therapy improves fetal weight in umbilical placental insufficiency. Am J. Obstet. Gynecol. 159, 681-685.
13. Shapiro, S., Siskind, V., Monson R.R., Heinonen, O.P., Kaufman, D.W. and Slone, D. (1976) Perinatal mortality and birth-weight in relation to aspirin taken during pregnancy. Lancet 1, 1375-1376.