Membrane action of chloramphenicol measured by protozoan motility inhibition

Archives of Toxicology

Volumn 70, Issue 12, 1996, Pages 850-853

  Wu, Changhao ^a   Clift, Paul ^a   Fry, Christopher H ^b   Henry, John A ^a  

^a GUY S HOSPITAL   (United Kingdom)

^b INSTITUTE OF UROLOGY AND NEPHROLOGY   (United Kingdom)

Author keywords

Anaesthetic like effect; Chloramphenicol; Grey baby syndrome; Partition coefficient; Tetrahymena pyriformis

Indexed keywords

AMITRIPTYLINE; AMOXICILLIN; AMPICILLIN; CEFUROXIME; CHLORAMPHENICOL; CHLORAMPHENICOL HEMISUCCINATE; LIDOCAINE; METOPROLOL TARTRATE; METRONIDAZOLE; OXPRENOLOL; PROCAINE; PROPRANOLOL; QUINIDINE; TETRACYCLINE; THIAMPHENICOL;

ANIMAL EXPERIMENT; ARTICLE; CELL MOTILITY; CONTROLLED STUDY; DOSE RESPONSE; IMAGE ANALYSIS; NONHUMAN; PARTITION COEFFICIENT; PRIORITY JOURNAL; TETRAHYMENA PYRIFORMIS;

1-OCTANOL; ANIMALS; ANTI-BACTERIAL AGENTS; CHLORAMPHENICOL; DOSE-RESPONSE RELATIONSHIP, DRUG; LETHAL DOSE 50; MOVEMENT; OCTANOLS; OVERDOSE; PROTEIN SYNTHESIS INHIBITORS; REFERENCE STANDARDS; TETRAHYMENA PYRIFORMIS; WATER;

ANIMALIA; PROTOZOA; TETRAHYMENA PYRIFORMIS;

EID: 0029917375     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002040050349     Document Type: Article

References (33)

1. Al-Saadi D, Sneader WE (1991) Pharmacological and microbiological evaluations of potential new long-acting local anaesthetics. Arzneimittelforschung 41: 1098-1100
2. Al-Saadi D, Baillie AJ, Farrell W, Sneader WE, Waton NG (1981) Inhibition of protozoan motility by local anaesthetics. J Pharm Pharmacol 33 (Suppl): 93
3. Albert A (1985) Selective toxicity: the physico-chemical basis of therapy, 7th edn. Chapman & Hall, London
4. Bartlett JG. Tally FP (1980) Chloramphenicol. In: Kagan BM (ed) Antimicrobial therapy. Saunders, London, pp 127-136
5. Burns LE, Hodgman JE, Cass AB (1959) Fatal circulatory collapse in premature infants receiving chloramphenicol. N Engl J Med 261: 1318-1321
6. Cassidy SL, Lympany PA, Henry JA (1988) Lipid solubility of a series of drugs and its relevance to fatal poisoning. J Pharm Pharmacol 40: 130-132
7. Cassidy SL, Henry JA, Roberts AM (1989) Determination of membrane-stabilizing potency of drugs by video analysis of protozoan motility. Toxicol In Vitro 3: 181-187
8. Connoly JG, Kerkut GA (1983) Ion regulation and membrane potential in Tetrahymena and Paramecium. Comp Biochem Physiol 76A: 1-16
9. Contreras A, Barbacid M, Vazquez D (1974) Comparative aspects of the action of chloramphenicol and thiamphenicol on bacterial ribosomes. Postgrad Med J 50 (Suppl 5): 50-53
10. Craft AW, Brocklebank JT, Hey EN, Jackson RH (1974) The "grey toddler": chloramphenicol toxicity. Arch Dis Child 49: 235-237
11. Freeman KB (1970) Effects of chloramphenicol and its isomers and analogues on the mitochondrial respiratory chain. Can J Biochem 48: 469-478
12. Gregus Z, Klaassen CD (1995) Mechanisms of toxicity. In: Klaassen CD, Amdur MO, Doull J (eds) Casarett and Doul's toxicology: the basic science of poisons, 5th edn. McGraw-Hill, New York, pp 35-74
13. Hansch C, Dunn W (1972) Linear relationships between lipophilic character and biological activity of drugs. J Pharm Sci 61: 1-19
14. Hellenbrecht D, Lemmer B, Wiethold G, Grobecker H (1973) Measurement of hydrophobicity, surface activity, local anaesthesia, myocardial velocity as quantitative parameters of the non-specific membrane affinity of nine β-adrenergic blocking agents. Naunyn Schmiedebergs' Arch Pharmacol 227: 221-226
15. Henry JA, Cassidy SL (1986) Membrane stabilising activity: a major cause of fatal poisoning. Lancet 1: 1414-1417
16. Lambdin MA, Waddell-Jr WW, Birdsong M (1960) Chloramphenicol toxicity in the premature infant. Pediatrics 25: 935-940
17. Leitman PS (1979) Chloramphenicol and the neonate - 1979 view. Clin Perinatol 6: 151-152
18. Leo A, Hansch C, Elkins D (1971) Partition coefficients and their uses. Chem Rev 71: 525-616
19. Mulhall A, De-Louvois J, Hurley R (1983) The pharmacokinetics of chloramphenicol in the neonate and young infant. J Antimicrob Chemother 12: 629-639
20. Nijhof W, Kroon AM (1974) The interactions of chloramphenicol and thiamphenicol with biogenesis of mitochondria in animal tissues. A possible clue to the toxic action. Postgrad Med J 50 (Suppl 5): 53-59
21. Nunn JF, Sturrock JE, Wills EJ, Richmond JE., McPherson CK (1974) The effects of inhalational anesthetics on the swimming velocity of Tetrahymena pyriformis. J Cell Sci 15: 537-554
22. Prasad AB (1994) British national formulary. British Medical Association and Royal Pharmaceutical Society of Great Britain. London
23. Schultz TW, Wyatt NL, Lin DT (1990) Structure-toxicity relationships for nonpolar narcotics: a comparison of data from the Tetrahymena, photobacterium and pimephales systems. Bull Environ Contam Toxicol 44: 67-72
24. Seeman P (1972) The membrane actions of anesthetics and tranquillizers, Pharmacol Rev 24: 583-655
25. Shaible DH, Audet PR, Lierde SV, Ferguson RK (1985) Chloramphenicol induced "grey adolescent syndrome". Vet Hum Toxicol 28: 316
26. Shalit I, Marks MI (1984) Chloramphenicol in the 1980s. Drugs 28: 281-291
27. Smith AL, Weber A (1983) Pharmacology of chloramphenicol. Pediatr Clin North Am 30: 209-236
28. Smyth EG, Pallett AP (1988) Clinician's guide to antibiotics. Chloramphenicol. Br J Hosp Med 39: 424-428
29. Sutherland JM (1959) Fatal cardiovascular collapse of infants receiving large amounts of chloramphenicol. Am J Dis Child 97: 671-676
30. Szorady I (1973) Twenty years of chloramphenicol therapy in paediatrics. Ther Hung 21: 3-9
31. Thompson WL, Anderson SE, Lipsky JJ, Lietman PS (1975) Overdoses of chloramphenicol. J Am Med Assoc 234: 149-150
32. Weiss CF, Glazko AJ, Weston JK (1960) Chloramphenicol in the newborn infant: a physiological explanation of its toxicity when given in excessive doses. N Engl J Med 262: 787-794
33. Woods PB, Robinson M L (1981) An investigation of the comparative liposolubilities of β-adrenoceptor blocking agents. J Pharm Pharmacol 33: 172-173