Early indicators of immunotoxicity: Development of molecular biological test batteries

Human and Experimental Toxicology

Volumn 15, Issue SUPPL. 1, 1996, Pages

  Vandebriel, Rob J ^a   Meredith, Clive ^b   Scott, Mary P ^b   Gleichmann, Ernst ^c   Bloksma, Nanne ^d   Van't Erve, Ellen H M ^d   Descotes, Jacques ^e   Van Loveren, Henk ^a  

^a NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^b Immunotoxicology Department   (United Kingdom)

^c HEINRICH HEINE UNIVERSITY   (Germany)

^d UTRECHT UNIVERSITY   (Netherlands)

^e CNRS   (France)

Author keywords

Autoimmunity; Cytokines; Hypersensitivity; Immunosuppression; Immunotoxicology; T helper cell subsets

Indexed keywords

CYTOKINE;

ALLERGY; ARTICLE; AUTOIMMUNITY; ETIOLOGY; GENE EXPRESSION; IMMEDIATE TYPE HYPERSENSITIVITY; IMMUNE SYSTEM; IMMUNOTOXICITY; MOLECULAR BIOLOGY; PRIORITY JOURNAL; TOXICOLOGY; ANIMAL; AUTOIMMUNE DISEASE; BIOSYNTHESIS; CHEMICALLY INDUCED DISORDER; HYPERSENSITIVITY; IMMUNOSUPPRESSIVE TREATMENT; METHODOLOGY; REVIEW;

ANIMALS; AUTOIMMUNE DISEASES; CYTOKINES; HYPERSENSITIVITY; IMMUNOSUPPRESSION; TOXICOLOGY;

EID: 0029917010     PISSN: 01445952     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. + T helper cell subsets. Current Opinion in Immunology 1993; 5: 391-397.
2. Van Loveren H, Vos JG. Immunotoxicological considerations: a practical approach to immunotoxicity testing in the rat. In: Advances in applied toxicology, Dayan AD & Paine AJ eds, pp. 143-163. Taylor & Francis, Philadelphia: 1989.
3. Bloksma N, Kubicka-Muranyi M, Schuppe H-C, Gleichmann H, Gleichmann E. Predictive immunotoxicological test systems: suitability of the popliteal lymph node assay in mice and rats. Critical Reviews in Toxicology 1995; 25: 369-396.
4. Noble A, Staynov DZ, Kemeny DM. Generation of rat Th2-like cells in vitro is interleukin-4-dependent and inhibited by interferon-γ. Immunology 1993; 79: 562-567.
5. O'Garra A, Vieira P. Polymerase chain reaction for detection of cytokine gene expression. Current Opinion in Immunology 1992; 4: 211-215.
6. Dallman MJ, Larsen CP, Morris PJ. Cytokine gene transcription in vascularised organ grafts: analysis using semiquantitative polymerase chain reaction. Journal of Experimental Medicine 1991; 174: 493-496.
7. Siebert PD, Larrick JW. PCR MIMICS: competitive DNA fragments for use as internal standards in quantitative PCR. Biotechniques 1993; 14: 244-249.
8. 32P-based hybridizations. Analytical Biochemistry 1993; 210: 235-244.
9. Van Vliet E, Uhrberg M, Stein C, Gleichmann E. MHC control of IL-4-dependent enhancement of B cell Ta expression and Ig class switching in mice treated with mercuric chloride. International Archives of Allergy and Immunology 1993; 101: 392-401.
10. Kimber I, Dearman RJ, Scholes EW, Basketter DA. The local lymph node assay: developments and applications. Toxicology 1994; 93: 13-31.