Solvation of lithium hexamethyldisilazide by N,N-dimethylethylenediamine: Effects of chelation on competitive solvation and mixed aggregation

Journal of the American Chemical Society

Volumn 118, Issue 14, 1996, Pages 3529-3530

  Lucht, Brett L ^a   Collum, David B ^a  

^a Department of Population Medicine and Diagnostic Sciences   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LITHIUM DERIVATIVE;

ARTICLE; DRUG STRUCTURE; NUCLEAR MAGNETIC RESONANCE; SOLUBILIZATION;

EID: 0029916758     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja953517x     Document Type: Article

References (40)

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26. 13N double-labeling studies, see ref 9c.
27. Gilchrist, J H.; Harrison, A. T.; Fuller, D. J.; Collum, D. B. J Am. Chem. Soc. 1990, 112, 4069.
28. 1H coupling is not significant.
29. There exist several species throughout the range of LiHMDS: DMEDA proportions whose low concentrations precluded their characterization.
30. For a general discussion of the laddering principle in lithium amides, see ref 9a.b. For additional leading references and examples of laddering in lithium amide mixed aggregates, see: Mair, R S : Clegg, W., O'Neil, P. A. J. Am. Chem. Soc. 1993, 115, 3388. See also: Engelhardt, L. M.; Jacobsen, G. E.; White, A. H.; Raston, C. L. Inorg Chem. 1991, 30, 3978, Williard, P G.; Hintze, M. J. J. Am. Chem. Soc. 1987, 109, 5539. Romesberg, F. E., Collum, D. B. J. Am. Chem. Soc 1994, 116, 9187. Henderson, K W , Dorigo, A. E., Liu, Q.-Y , Williard, P. G , Schleyer, P. v. R.; Bernstein, P. R J. Am. Chem. Soc. 1996, 118, 1339.
31. For a general discussion of the laddering principle in lithium amides, see ref 9a.b. For additional leading references and examples of laddering in lithium amide mixed aggregates, see: Mair, R S : Clegg, W., O'Neil, P. A. J. Am. Chem. Soc. 1993, 115, 3388. See also: Engelhardt, L. M.; Jacobsen, G. E.; White, A. H.; Raston, C. L. Inorg Chem. 1991, 30, 3978, Williard, P G.; Hintze, M. J. J. Am. Chem. Soc. 1987, 109, 5539. Romesberg, F. E., Collum, D. B. J. Am. Chem. Soc 1994, 116, 9187. Henderson, K W , Dorigo, A. E., Liu, Q.-Y , Williard, P. G , Schleyer, P. v. R.; Bernstein, P. R J. Am. Chem. Soc. 1996, 118, 1339.
32. For a general discussion of the laddering principle in lithium amides, see ref 9a.b. For additional leading references and examples of laddering in lithium amide mixed aggregates, see: Mair, R S : Clegg, W., O'Neil, P. A. J. Am. Chem. Soc. 1993, 115, 3388. See also: Engelhardt, L. M.; Jacobsen, G. E.; White, A. H.; Raston, C. L. Inorg Chem. 1991, 30, 3978, Williard, P G.; Hintze, M. J. J. Am. Chem. Soc. 1987, 109, 5539. Romesberg, F. E., Collum, D. B. J. Am. Chem. Soc 1994, 116, 9187. Henderson, K W , Dorigo, A. E., Liu, Q.-Y , Williard, P. G , Schleyer, P. v. R.; Bernstein, P. R J. Am. Chem. Soc. 1996, 118, 1339.
33. For a general discussion of the laddering principle in lithium amides, see ref 9a.b. For additional leading references and examples of laddering in lithium amide mixed aggregates, see: Mair, R S : Clegg, W., O'Neil, P. A. J. Am. Chem. Soc. 1993, 115, 3388. See also: Engelhardt, L. M.; Jacobsen, G. E.; White, A. H.; Raston, C. L. Inorg Chem. 1991, 30, 3978, Williard, P G.; Hintze, M. J. J. Am. Chem. Soc. 1987, 109, 5539. Romesberg, F. E., Collum, D. B. J. Am. Chem. Soc 1994, 116, 9187. Henderson, K W , Dorigo, A. E., Liu, Q.-Y , Williard, P. G , Schleyer, P. v. R.; Bernstein, P. R J. Am. Chem. Soc. 1996, 118, 1339.
34. For a general discussion of the laddering principle in lithium amides, see ref 9a.b. For additional leading references and examples of laddering in lithium amide mixed aggregates, see: Mair, R S : Clegg, W., O'Neil, P. A. J. Am. Chem. Soc. 1993, 115, 3388. See also: Engelhardt, L. M.; Jacobsen, G. E.; White, A. H.; Raston, C. L. Inorg Chem. 1991, 30, 3978, Williard, P G.; Hintze, M. J. J. Am. Chem. Soc. 1987, 109, 5539. Romesberg, F. E., Collum, D. B. J. Am. Chem. Soc 1994, 116, 9187. Henderson, K W , Dorigo, A. E., Liu, Q.-Y , Williard, P. G , Schleyer, P. v. R.; Bernstein, P. R J. Am. Chem. Soc. 1996, 118, 1339.
35. Gilchrist, J. H.; Harrison, A. T., Fuller, D J.; Collum, D. B. Magsn. Reson. Chem. 1992, 30, 855.
36. Lucht, B. L.; Collum, D. B. Unpublished.
37. 15N]-LiDMEDA display unusual features that cannot be adequately discussed in this communication.
38. For leading references to the solvent dependence of mixed aggregation, see: Romesberg, F. E ; Collum, D. B. J. Am. Chem. Soc. 1994, 116, 9198. Kremer, T.; Harder, S.; Junge, M.; Schleyer, P. v. R. Organometallics 1996, 15, 585.
39. For leading references to the solvent dependence of mixed aggregation, see: Romesberg, F. E ; Collum, D. B. J. Am. Chem. Soc. 1994, 116, 9198. Kremer, T.; Harder, S.; Junge, M.; Schleyer, P. v. R. Organometallics 1996, 15, 585.
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