Is zinc protoporphyrin an indicator of iron-deficient erythropoiesis in maintenance haemodialysis patients?

Nephrology Dialysis Transplantation

Volumn 11, Issue 3, 1996, Pages 492-497

  Braun, J ^a,c   Hammerschmidt, M ^a   Schreiber, M ^a   Heidler, R ^a   Horl W H ^b  

^a Haemodialysis Unit Nürnberg   (Germany)

^b UNIVERSITY OF VIENNA   (Austria)

^c KfH Dialysezentrum Nürnberg   (Germany)

Author keywords

Anaemia; Haemodialysis; Iron deficiency; Lead; Zinc protoporphyrin

Indexed keywords

ALUMINUM; DEFEROXAMINE; FERRITIN; FERROUS GLUCONATE; HEMOGLOBIN; IRON; LEAD; PROTOPORPHYRIN ZINC;

ADULT; AGED; ARTICLE; ERYTHROPOIESIS; FEMALE; FERRITIN BLOOD LEVEL; HEMODIALYSIS; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; IRON DEFICIENCY; IRON THERAPY; LEAD BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RETICULOENDOTHELIAL SYSTEM;

EID: 0029916412     PISSN: 09310509     EISSN: None     Source Type: Journal    
DOI: 10.1093/oxfordjournals.ndt.a027317     Document Type: Article

References (18)

1. Macdougall I, Cavill I. Detection of functional iron deficiency during erythropoietin treatment: a new approach. Br Med J 1992; 304: 225-228
2. Hastka J, Lassere JJ, Schwarzbeck A, Hehlmann R, Strauch M. Zinkprotoporphyrin als Alternative zu Ferritin bei Steuerung der Eisensubstitution erythropoietinbedürftiger Dialysepatienten. Nieren-Hochdruckkrankheiten 1991; 12: 697-700
3. Fishbane S, Lynn RI. The utility of zinc protoporphyrin (ZPP) as an assay for iron deficiency in hemodialysis patients J Am Soc Nephrol 1993; 4: 425
4. Ahmed U, Fadia A, Baskin S, Lasker N. What is the best laboratory indicator of iron availability in hemodialysis patients. J Am Soc Nephrol 1993; 4: 423
5. Hastka J, Lassere JJ, Schwarzbeck A, Strauch M, Hehlmann R. Washing erythrocytes to remove interferents in measurement of zinc protoporphyrin by front hematofluorometry. Clin Chem 1992; 38: 2184-2189
6. Schifman RB, Rivers SL, Finley PR, Thiers C. RBC zinc protoporphyrin to screen blood donors for iron deficiency anemia. JAMA 1982; 248: 2012-2015
7. Hastka J, Lassere JJ, Schwarzbeck A, Strauch M, Hehlmann R Zinc protoporphyrin in anemia of chronic disorders. Blood 1993; 81: 1200-1204
8. Eschbach JW. The anemia of chronic renal failure: pathophysiology and the effects of recombinant erythropoietin. Kidney Int 1989; 35: 134-148
9. Descamps-Latscha B, Herbelin A. Long term dialysis and cellular immunity: A critical survey. Kidney Int 1993; 43 [suppl 41]: S135-S142
10. Fontanellas A, Coronel F, Santos JL et al. Heme biosynthesis in uremic patients on CAPD or hemodialysis. Kidney Int 1994; 45: 220-223
11. Staessen JA, Lauwerys RR, Buchet JP et al Impairment of renal function with increased blood lead concentrations in the general population. N Engl J Med 1992; 327: 1515-1516
12. Colleoni N, Arrigo G, Gandini E, Corigliano C, D'Amico G. Blood lead in hemodialysis patients. Am J Nephrol 1993; 13: 198-202
13. Batuman V, Wedeen RP. Impairment of renal function with increasing blood lead concentrations. N Engl J Med 1992; 327: 1394
14. Emmerson BT. Lead stores in patients with renal insufficiency. Nephron 1991; 58: 233-234
15. Turk S, Schonfeld DJ, Cullen M, Rainey P. Sensitivity of erythrocyte protoporphyrin as screening test for lead poisoning. N Engl J Med 1992; 326: 137-138
16. Fishbane S, Lynn RI. The utility of zinc protoporphyrin for predicting the need for intravenous iron therapy in hemodialysis patients. Am J Kidney Dis 1995; 25: 426-432
17. Moreb J, Popovetzer MM, Friedlander MM, Konijin AM, Hershko C. Evaluation of iron status in patients on chronic hemodialysis: relative usefulness of bone marrow hemosiderin, serum ferritin, transferrin saturation, mean corpuscular volume, and red cell protoporphyrin. Nephron 1983; 35: 196-200
18. Krantz SB. Pathogenesis and treatment of the anemia of chronic disease. Am J Med Sci 1994; 307: 353-359