Ligand interactions with E-selectin. Identification of a new binding site for recognition of N-acyl aromatic glucosamine substituents of sialyl Lewis X

Journal of Medicinal Chemistry

Volumn 39, Issue 7, 1996, Pages 1357-1360

  Ramphal, John Y ^a,d   Hiroshige, Mariann ^a   Lou, Boliang ^a   Gaudino, John J ^a,d   Hayashi, Masaji ^b   Chen, Shiow Meei ^c   Chiang, Lin C ^c   Gaeta, Federico C A ^a,e   DeFrees, Shawn A ^a  

^a CYTEL CORPORATION   (United States)

^b DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

^c NuMega Resonance Labs Inc   (United States)

^d AMGEN INC   (United States)

^e Geron   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; ETHYL (SODIUM 5 ACETAMIDO 3,5 DIDEOXY ALPHA D GLYCERO D GALACTO 2 NONULOPYRONOSYLONATE) (2,3) O (BETA D GALACTOPYRANOSYL) (1,4) O (ALPHA L FUCOPYRANOSYL) (1,3) O [2 (2 NAPHTHAMIDO) 2 DEOXY BETA D GLUCOPYRANOSYL] (1,3) O BETA D GALACTOPYRANOSIDE; GLUCOSAMINE DERIVATIVE; SIALYL LEWIS X DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; BLOOD GROUP LEWIS SYSTEM; CELL ADHESION; DRUG POTENCY; DRUG SYNTHESIS; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; INFLAMMATION; LEUKOCYTE ADHERENCE; LIGAND BINDING; NUCLEAR MAGNETIC RESONANCE;

BINDING SITES; CARBOHYDRATE CONFORMATION; CARBOHYDRATE SEQUENCE; CELL ADHESION; E-SELECTIN; GLUCOSAMINE; HL-60 CELLS; HUMANS; LEWIS BLOOD-GROUP SYSTEM; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR SEQUENCE DATA; OLIGOSACCHARIDES;

EID: 0029916376     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9600611     Document Type: Article

References (23)

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18. 5b
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23. 4 produced varying amounts of an overreduced naphthamide product. The catalytic phase transfer hydrogenation conditions were found to produce no detectable amounts of the overreduced product.