Properties and anti-HIV activity of hairpin antisense oligonucleotides containing 2′-methoxynucleosides with base-pairing in the stem region at the 3′-end

Antiviral Chemistry and Chemotherapy

Volumn 7, Issue 2, 1996, Pages 86-93

  Hosono, K ^a   Kuwasaki, T ^a   Inagawa, T ^a,b   Takai, K ^a   Nakashima, H ^b   Saito, T ^c   Yamamoto, N ^d   Takaku, H ^a  

^a CHIBA INSTITUTE OF TECHNOLOGY   (Japan)

^b UNIVERSITY OF YAMANASHI   (Japan)

^c ASTELLAS PHARMA INC   (Japan)

^d TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

2 Methoxynucleoside; Anti HIV activity; Exonuclease resistance, hairpin oligonucleotide phosphorothioate; Hairpin structure, RNase H activity; Synthetic oligonucleotide

Indexed keywords

2' METHOXYNUCLEOSIDE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; ANTISENSE OLIGODEOXYNUCLEOTIDE; ANTISENSE OLIGONUCLEOTIDE; ANTIVIRUS AGENT; COMPLEMENTARY RNA; DNA POLYMERASE; EXONUCLEASE; OLIGONUCLEOTIDE PHOSPHOROTHIOATE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CELL LINE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DEGRADATION; DRUG STABILITY; FETAL CALF SERUM; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; PRIORITY JOURNAL; T LYMPHOCYTE;

EID: 0029916257     PISSN: 09563202     EISSN: None     Source Type: Journal    
DOI: 10.1177/095632029600700205     Document Type: Article

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