Anabolic-androgenic steroids and brain reward

Pharmacology Biochemistry and Behavior

Volumn 53, Issue 3, 1996, Pages 741-745

  Clark, Ann S ^a   Lindenfeld, Ralph C ^a   Gibbons, Christopher H ^a  

^a Dartmouth College   (United States)

Author keywords

Amphetamine; Androgen; Intracranial self stimulation

Indexed keywords

ANABOLIC AGENT; ANDROGEN; BOLDENONE UNDECENOATE; DEXAMPHETAMINE; METANDIENONE; NANDROLONE DECANOATE; STEROID; TESTOSTERONE CIPIONATE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; INSTRUMENTAL CONDITIONING; LATERAL HYPOTHALAMUS; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REWARD; SELF STIMULATION; SUBCUTANEOUS DRUG ADMINISTRATION;

EID: 0029916007     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/0091-3057(95)02082-9     Document Type: Article

References (25)

1. Alexander, G. M.; Packard, M. G.; Hines, M. Testosterone has rewarding affective properties in male rats: Implications for the biological basis of sexual motivation. Behav. Neurosci. 108:424-428; 1994.
2. Bonson, K. R.; Garrick, N. A.; Murphy, D. L. Evidence for a withdrawal syndrome following chronic administration of an anabolic steroid to rats. Soc. Neurosci. Abstr. 20:1527; 1994.
3. Borowski, T. B.; Kokkinidis, L. Long-term influence of d-amphetamine on mesolimbic brain-stimulation reward: Comparison to chronic haloperidol and naloxone effects. Pharmacol. Biochem. Behav. 43:1-15; 1992.
4. Brower, K. J.; Blow, F. C.; Young, J. P.; Hill, E. M. Symptoms and correlates of anabolic-androgenic steroid dependence. Br. J. Addict. 86:759-768; 1991.
5. Caggiula, A. R. Analysis of the copulation-reward properties of posterior hypothalamic stimulation in male rats. J. Comp. Physiol. Psychol. 70:399-412; 1970.
6. Clark, A. S.; Mitre, M. C.; Brinck-Johnsen, T. Anabolic-androgenic steroid and adrenal steroid effects on hippocampal plasticity. Brain Res. 679:64-71; 1995.
7. Clark, A. S.; Fast, A. S. Anabolic-androgenic steroids and sexual behavior in intact male rats. Soc. Neurosci. (Abstr.) 21:1463; 1995.
8. De Beun, R. D.; Jansen, E.; Slangen, J.; Van de Poll, N. E. Testosterone as appetitive and discriminative stimulus in rats: Sex- and dose-dependent effects. Physiol. Behav. 52:629-634; 1992.
9. Forgie, M. L.; Stewart, J. Sex differences in the locomotor-activating effects of amphetamine: Role of circulating testosterone in adulthood. Physiol. Behav. 55:639-644; 1994.
10. Grimm, J. W.; See, R. E. Effects of 170-estradiol on intravenous cocaine self-administration by castrated female rats. Soc. Neurosci. Abstr. 20:1633; 1994.
11. Holtzman, S. G. Comparison of the effects of morphine, pentacocine, cyclazocine and amphetamine on intracranial self-stimulation in the rat. Psychopharmacologia 46:223-227; 1976.
12. Kashkin, K. B.; Kleber, H. D. Hooked on hormones? An anabolic steroid addiction hypothesis. JAMA 262:3166-3170; 1989.
13. Kibble, M.; Ross, M. B. Adverse effects of anabolic steroids in athletes. Clin. Pharm. 6:686-692; 1987.
14. Lucas, S. E. Current perspectives on anabolic-androgenic steroid abuse. Trends Pharmacol. Sci. 14:61-68; 1993.
15. Miliaressis, E.; Rompre, P.; Laviolette, P.; Phillipe, L.; Coulombe, D. The curve-shift paradigm of self-stimulation. Physiol. Behav. 37:85-91; 1986.
16. Mitchell, J. B.; Stewart, J. Effects of castration, steroid replacement, and sexual experience on mesolimbic dopamine and sexual behaviors in the male rat. Brain Res. 491:116-127; 1989.
17. Nakajima, S.; O'Regan, N. B. The effects of dopaminergic agonists and antagonists on the frequency-response function for hypothalamic self-stimulation in the rat. Pharmacol. Biochem. Behav. 39:465-468; 1991.
18. Olds, J. Effects of hunger and male sex hormone on self-stimulation of the brain. J. Comp. Physiol. Psychol. 51:320-324; 1958.
19. Pudiak, C. M.; Bozarth, M. A. Failure of chronic estrogen to alter lateral hypothalamic brain stimulation reward. Soc. Neurosci. Abstr. 17:1238; 1991.
20. Schaefer, G. J.; Michael, R. P. Interactions of naloxone with morphine, amphetamine and phencyclidine on fixed interval responding for intracranial self-stimulation in rats. Psychopharmacology (Berlin) 102:263-268; 1990.
21. Stellar, J. R. Investigating the neural circuitry of brain stimulation reward. Prog. Psychobiol. Physiol. Psychol. 14:235-294; 1990.
22. Stewart, J.; Woodside, B.; Shaham, Y. Ovarian hormones do not alter self-administration of heroin in ovariectomized female rats. Soc. Neurosci. Abstr. 20:1230; 1994.
23. Tennant, F.; Black, D. L.; Voy, R. O. Anabolic steroid dependence with opioid-type features. N. Engl. J. Med. 319:578; 1988.
24. Wilson, J. D. Androgen abuse by athletes. Endocr. Rev. 9:181-199; 1988.
25. Wise, R. The brain and reward. In: Liebman, J.; Cooper, S. J., eds. Neuropharmacological basis of reward. New York: Oxford University Press; 1989:377-424.