Synthesis and structural characterization of enantiopure levodropropizine

Chirality

Volumn 8, Issue 1, 1996, Pages 6-10

  Shum, Wilfred P ^a   Chen, Jian ^a  

^a BP EXPLORATION   (United Kingdom)

Author keywords

(R) glycidol; binary melting point phase diagram; chiral HPLC; crystal structure determination; enantiomeric enrichment; enantiomeric separation; enantiopure levodropropizine; intermolecular hydrogen bonding interactions; synthesis

Indexed keywords

1 PHENYLPIPERAZINE DERIVATIVE; DROPROPIZINE; GLYCIDOL; LEVDROPROPIZINE;

CONFERENCE PAPER; CRYSTAL STRUCTURE; CRYSTALLIZATION; DRUG SYNTHESIS; ENANTIOMER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROGEN BOND; PRIORITY JOURNAL;

EID: 0029915434     PISSN: 08990042     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1520-636X(1996)8:1<6::AID-CHIR3>3.0.CO;2-J     Document Type: Conference Paper

References (14)

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9. Dougherty, W., Liotta, F., Mondimore, D., Shum, W. A convenient gas Chromatographic method for the optical purity determination of chiral epoxy alcohols. Tetrahedron Lett. 31:4389-4390, 1990.
10. Chen, J., Shum, W. A practical synthetic route to enantiopure 3-aryloxy-1,2-propanediols from chiral giycidol. Tetrahedron Lett 36:2379-2380, 1995.
11. Calatozzolo, M., Celentano, G., Clenci, F., Giammarusti, G., Stradi, R. FT-IR spectroscopy for the evaluation of the enantiomeric punty of levodropropizine. A comparison with HPLC analysis. Boll. Chim. Farm. 132: 467-471, 1993.
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14. For a discussion on the subject, see reference 12, page 423-424.