Effect of high FFA on glycogenolysis in oxidative rat hindlimb muscles during twitch stimulation

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 270, Issue 4 39-4, 1996, Pages

  Dyck, David J ^a   Peters, Sandra J ^a   Wendling, Paula S ^a   Spriet, Lawrence L ^a  

^a UNIVERSITY OF GUELPH   (Canada)

Author keywords

acetyl coenzyme A; citrate; glucose fatty acid cycle

Indexed keywords

ACETYL COENZYME A; CITRIC ACID; FATTY ACID; GLYCOGEN; LACTIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ELECTROSTIMULATION; ERYTHROCYTE; GASTROCNEMIUS MUSCLE; GLUCOSE TRANSPORT; GLYCOGENOLYSIS; HINDLIMB; MALE; MUSCLE EXCITATION; MUSCLE METABOLISM; MUSCLE PERFUSION; MUSCLE TWITCH; NONHUMAN; OXYGEN CONSUMPTION; PLANTARIS MUSCLE; PRIORITY JOURNAL; RAT; SOLEUS MUSCLE;

EID: 0029915338     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.1996.270.4.r766     Document Type: Article

References (31)

1. Armstrong, R. B., and R. O. Phelps. Muscle fiber type composition of the rat hindlimb. Am. J. Anat. 171: 259-272, 1984.
2. Berger, M., S. A. Hagg, M. N. Goodman, and N. B. Ruderman. Glucose metabolism in perfused skeletal muscle; effects of starvation, diabetes, fatty acids, acetoacetate, insulin and exercise on glucose uptake and disposition. Biochem. J. 158: 191-202, 1976.
3. Bergmeyer, H. U. Methods of Enzymatic Analysis. New York: Academic, 1974.
4. Bosca, L., J. J. Aragon, and A. Sols. Modulation of muscle phosphofructokinase at physiological concentration of enzyme. J. Biol. Chem. 260: 2100-2107, 1985.
5. Cederblad, G., J. I. Carlin, D. Constantin-Teodosiu, P. Harper, and E. Hultman. Radioisotopic assays of CoASH and carnitine and their acetylated forms in human skeletal muscle. Anal. Biochem. 185: 274-278, 1990.
6. Dobson, G. P., E. Yamamoto, and P. W. Hochochka. Phosphofructokinase control in muscle: nature and reversal of pH-dependent ATP inhibition. Am. J. Physiol. 250 (Regulatory Integrate Comp Physiol. 19): R71-R76, 1986.
7. Dyck, D. J., C. T. Putman, G. J. F. Heigenhauser, E. Hultman, and L. L. Spriet. Regulation of fat-carbohydrate interaction in skeletal muscle during intense aerobic cycling. Am. J. Physiol. 265 (Endocrinol. Metab. 28): E852-E859, 1993.
8. Dyck, D. J., and L. L. Spriet. Elevated muscle citrate does not reduce carbohydrate utilization during tetanic stimulation. Can. J. Physiol. Pharmacol 72: 117-125, 1994.
9. Garland, P. B., E. A. Newsholme, and P. J. Randle. Regulation of glucose uptake by muscle 9 Effects of fatty acids and ketone bodies, and of alloxan-diabetes and starvation on pyruvate metabolism and on lactate/pyruvate and L-glycerol 3-phosphate-dihydroxyacetone phosphate concentration ratios in rat heart and rat diaphragm muscle. Biochem. J. 93: 665-678, 1964.
10. Garland, P. B., and P. J. Randle. Control of pyruvate dehydrogenase in the perfused rat heart by the intracellular concentration of acetyl-coenzyme A. Biochem. J. 91: 6c-7c, 1964.
11. Garland, P. B., and P. J. Randle. Regulation of glucose uptake by muscle. 10. Effects of alloxan-diabetes, starvation, hypophysectomy and adrenalectomy, and of fatty acids, ketone bodies and pyruvate, on the glycerol output and concentrations of free fatty acids, long-chain fatty acyl coenzyme A, glycerol phosphate and citrate-cycle intermediates in rat heart and diaphragm muscles. Biochem. J. 93: 678-687, 1964.
12. Garland, P. B., P. J. Randle, and E. A. Newsholme. Citrate as an intermediary in the inhibition of phosphofructokinase in rat heart muscle by fatty acids, ketone bodies, pyruvate, diabetes and starvation. Nature Lond. 200: 169-170, 1963.
13. Hagg, S. A., S. I. Taylor, and N. B. Ruderman. Glucose metabolism in perfused skeletal muscle: pyruvate dehydrogenase activity in starvation, diabetes and exercise. Biochem. J. 158: 203-210, 1976.
14. Harris, R. C., E. Hultman, and L. O. Nordesjo. Glycogen, glycolytic intermediates and high-energy phosphates determined in muscle biopsy samples of musculus quadriceps femoris of man at rest. Stand. J. Clin. Invest. 33: 109-119, 1974.
15. Hickson, R. C., M. J. Rennie, R. K. Conlee, W. W. Winder, and J. O. Holloszy. Effects of increased plasma fatty acids on glycogen utilization and endurance. J. Appl. Physiol. 43: 829-833, 1977.
16. Hood, D. A., J. Gorski, and R. Terjung. Oxygen cost of twitch and tetanic isometric contractions of rat skeletal muscle. Am. J. Physiol. 250 (Endocrinol. Metab. 13): E449-E456, 1986.
17. Houghton, C. R. S., and N. B. Ruderman. Acetoacetate as a fuel for perfused rat skeletal muscle. Biochem. J. 121: 15-16, 1971.
18. Jefferson, L. S., J. O. Koehler, and H. E. Morgan. Effect of insulin on protein synthesis in skeletal muscle of an isolated perfused preparation of rat hemicorpus. Proc. Natl. Acad. Sci. USA 69: 816-820, 1972.
19. Jones, N. L., G. J. F. Heigenhauser, A. Kukis, C. G. Matsos, J. R. Sutton, and C. J. Toews. Fat metabolism in heavy exercise. Clin. Sci. Lond. 5: 469-478, 1980.
20. Newsholme, E. A., and P. J. Randle. Regulation of glucose uptake by muscle. 7. Effects of fatty acids, ketone bodies and pyruvate and of alloxan-diabetes, starvation, hypophysectomy and adrenalectomy, on the concentrations of hexose phosphates, nucleotides and inorganic phosphate in perfused rat heart. Biochem. J. 93: 641-651, 1964.
21. Peters, S. J., and L. L. Spriet. Skeletal muscle phosphofructokinase activity examined under physiological conditions in vitro. J. Appl. Physiol. 78: 1853-1858, 1995.
22. Putman, C. T., L. L. Spriet, E. Hultman, M. I. Lindinger, L. C. Lands, R. S. McKelvie, G. Cederblad, N. L. Jones, and G. J. F. Heigenhauser. Pyruvate dehydrogenase activity and acetyl group accumulation during exercise after different diets. Am. J. Physiol. 265 (Endocrinol. Metab. 28): E752-E760, 1993.
23. Randle, P. J., C. N. Hales, P. B. Garland, and E. A. Newsholme. The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet 1: 785-789, 1963.
24. Randle, P. J., E. A. Newsholme, and P. B. Garland. Regulation of glucose uptake by muscle. 8. Effects of fatty acids, ketone bodies and pyruvate, and of alloxan-diabetes and starvation, on the uptake and metabolic fate of glucose in rat heart and diaphragm muscles. Biochem. J. 93: 652-665, 1964.
25. Rennie, M. J., and J. O. Holloszy. Inhibition of glucose uptake and glycogenolysis by availability of oleate in well-oxygenated perfused skeletal muscle. Biochem. J. 168: 161-170, 1977.
26. Rennie, M. J., W. W. Winder, and J. O. Holloszy. A sparing effect of increased plasma fatty acids on muscle and liver glycogen content in the exercising rat. Biochem. J. 156, 647-655, 1976.
27. Richter, E. A., N. B. Ruderman, H. Gavras, E. R. Belur, and H. Galbo. Muscle glycogenolysis during exercise; dual control by epinephrine and contractions. Am. J. Physiol. 242 (Endocrinol Metab. 5): E25-E32, 1982.
28. Romijn, J. A., E. F. Coyle, L. S. Sidossis, A. Gastaldelli, J. F. Horowitz, E. Endert, and R. R. Wolfe. Regulation of endogenous fat and carbohydrate metabolism in relation to exercise intensity and duration. Am. J. Physiol. 265 (Endocrinol. Metab 28):E380-E391, 1993.
29. Spriet, L. L., D. J. Dyck, G. Cederblad, and E. Hultman. Effects of fat availability on acetyl-CoA and acetylcarnitine metabolism in rat skeletal muscle. Am. J. Physiol. 263 (Cell Physiol. 32): C653-C659, 1992.
30. Spriet, L. L., M. I. Lindinger, G. J. F. Heigenhauser, and N. L. Jones. Effects of alkalosis on skeletal muscle metabolism and performance during exercise. Am. J. Physiol 251 (Regulatory Integrative Comp. Physiol. 201: R833-R839, 1986.
31. Turcotte, L. P., P. Hespel, and E. A. Richter. Circulating palmitate uptake and oxidation are not altered by glycogen depletion in contracting skeletal muscle. J. Appl. Physiol. 78: 1266-1272, 1994.