The differential contribution of spinopetal projections to increases in vocalization and motor reflex thresholds generated by the microinjection of morphine into the periaqueductal gray

Behavioral Neuroscience

Volumn 110, Issue 2, 1996, Pages 368-388

  Borszcz, George S ^a   Johnson, Christine P ^a   Thorp, Matthew V ^a  

^a Lamont Doherty Earth Observatory   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; METHYSERGIDE; MORPHINE; MU OPIATE RECEPTOR; NALOXONE; OPIATE ANTAGONIST; PHENTOLAMINE; SEROTONIN ANTAGONIST; SODIUM CHLORIDE;

AFTERDISCHARGE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; ELECTRIC SHOCK; INTRATHECAL DRUG ADMINISTRATION; MALE; NERVE PROJECTION; NONHUMAN; PERIAQUEDUCTAL GRAY MATTER; RAT; SPINAL REFLEX; VOCALIZATION;

ANIMALS; BRAIN MAPPING; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROSHOCK; GANGLIA, SPINAL; MALE; METHYSERGIDE; MICROINJECTIONS; MORPHINE; MOTOR NEURONS; NALOXONE; NEURAL PATHWAYS; PAIN THRESHOLD; PERIAQUEDUCTAL GRAY; PHENTOLAMINE; RATS; RECEPTORS, ADRENERGIC; RECEPTORS, OPIOID, MU; RECEPTORS, SEROTONIN; REFLEX; SPINAL CORD; VOCALIZATION, ANIMAL;

EID: 0029915062     PISSN: 07357044     EISSN: None     Source Type: Journal    
DOI: 10.1037/0735-7044.110.2.368     Document Type: Article

References (96)

1. Albe-Fessard, D., Berkley, K. J., Kruger, L., Ralston, H. J., & Willis, W. D. (1985). Diencephalic mechanisms in pain sensation. Brain Research Review, 9, 217-296.
2. Alhaider, A. A., Lei, S. Z., & Wilcox, G. L. (1991). Spinal 5HT3 receptor-mediated antinociception: Possible release of GABA. Journal of Neuroscience, 11, 1881-1888.
3. Anden, N. E., Dahlström, A., Fuxe, K., Larson, K., Olson, L., & Ungerstedt, U. U. (1966). Ascending monoamine neurons to the telencephalon and diencephalon. Acta Physiologica Scandinavica, 67, 313-326.
4. Andersen, E., & Dafny, N. (1983). An ascending serotonergic pain modulation pathway from the dorsal raphé nucleus to the parafascicularis nucleus of the thalamus. Brain Research, 269, 57-67.
5. Andersen, E., & Dafny, N. (1982). Microiontophoretically applied 5-HT reduces responses to noxious stimuli in the thalamus. Brain Research, 241, 176-178.
6. Astrachan, D. I., & Davis, M. (1981). Spinal modulation of the acoustic startle response: The role of norepinephrine, serotonin and dopamine. Brain Research, 206, 223-228.
7. Barasi, S., Ben-Sreti, M. M., Clatworthy, A. L., Duggal, K. N., Gonzalez, J. P., Robertson, J., Rooney, K. F., & Sewell, R. D. E. (1987). Dopamine receptor-mediated spinal antinociception in the normal and haloperidol pretreated rat: Effects of sulpiride and SCH 23390. British Journal of Pharmacology, 90, 15-22.
8. Barasi, S., & Clatworthy, A. (1987). The effects of intrathecally applied noradrenaline and 5-hydroxytryptamine on spinal nocifensive reflexes and the rostral transmission of noxious information to the thalamus in the rat. Neuroscience Letters, 78, 328-332.
9. Basbaum, A. I., & Fields, H. L. (1984). Endogenous pain control system: Brainstem spinal pathways and endorphin circuitry. Annual Review of Neuroscience, 7, 309-338.
10. Basbaum, A. I., Marley, N. J. E., O'Keefe, J., & Clanton, C. H. (1977). Reversal of morphine and stimulus-produced analgesia by subtotal spinal cord lesions. Pain, 3, 43-56.
11. Beitz, A. J. (1985). The midbrain periaqueductal gray in the rat. I. Nuclear volume, cell number, density, orientation, and regional subdivisions. Journal of Comparative Neurology, 237, 445-459.
12. Belcher, G., Ryall, R. W., & Schaffner, R. (1978). The differential effects of 5-hydroxytryptamine, noradrenaline and raphé stimulation on nociceptive and non-nociceptive dorsal horn interneurons in cat. Brain Research, 151, 307-321.
13. Bell, J. A., & Matsumiya, T. (1981). Inhibitory effects of dorsal horn and excitant effects of ventral horn intraspinal microinjections of norepinephrine and serotonin in the cat. Life Sciences, 29, 1507-1514.
14. Bennett, G. J., & Mayer, D. J. (1979). Inhibition of spinal cord interneurons by narcotic microinjection and focal electrical stimulation in the periaqueductal gray matter. Brain Research, 172, 243-257.
15. Bernard, J. F., & Besson, J. M. (1990). The spino(trigemino)-ponto-amygdaloid pathway: Electrophysiological evidence for an involvement in pain processes. Journal of Neurophysiology, 63, 473-490.
16. Borszcz, G. S. (1993). The capacity of motor reflex and vocalization thresholds to support avoidance conditioning in the rat. Behavioral Neuroscience, 107, 678-693.
17. Borszcz, G. S. (1995a). Increases in vocalization and motor reflex thresholds are influenced by the site of morphine microinjection: Comparisons following administration into the periaqueductal gray, ventral medulla and spinal subarachnoid space. Behavioral Neuroscience, 109, 502-523.
18. Borszcz, G. S. (1995b). Pavlovian conditional vocalizations of the rat: A model system for analyzing the fear of pain. Behavioral Neuroscience, 109, 648-662.
19. Borszcz, G. S., Johnson, C. P., Anderson, M. E., & Young, B. J. (1992). Characterization of tailshock elicited withdrawal reflexes in intact and spinal rats. Physiology & Behavior, 52, 1055-1062.
20. Borszcz, G. S., Johnson, C. P., & Fahey, K. A. (1994). Comparison of motor reflex and vocalization thresholds following systemically administered morphine, fentanyl and diazepam in the rat: Assessment of sensory and performance variables. Pharmacology, Biochemistry & Behavior, 49, 827-834.
21. Borszcz, G. S., & Leaton, R. N. (1994). Vocalization afterdischarges predict Pavlovian conditioned vocalizations in the rat: The effect of amygdala lesions. Society for Neuroscience Abstract, 20, 799.
22. Bowery, N. G., Hudson, A. L., & Price, G. W. (1987). GABAA and GABAB receptor site distribution in the rat central nervous system. Neuroscience, 20, 365-383.
23. Bromm, B., & Meier, W. (1984). The intracutaneous stimulus: A new pain model for algesimetric studies. Methods and Findings in Experimental Clinical Pharmacology, 6, 405-410.
24. Camarata, P. J., & Yaksh, T. L. (1985). Characterization of the spinal adrenergic receptors mediating the spinal effects produced by the microinjection of morphine into the periaqueductal gray. Brain Research, 336, 133-142.
25. Carroll, M. N. Jr., & Lim, R. K. S. (1960). Observations on the neuropharmacology of morphine and morphinelike analgesia. Archives Internationales de Pharmacodynamie en Therapie, 125, 383-403.
26. Carstens, E. (1988). Inhibition of rat spinothalamic tract neuronal responses to noxious skin heating by stimulation in midbrain periaqueductal gray or lateral reticular formation. Pain, 33, 215-224.
27. Casey, K. D. (1978). Neural mechanisms of pain. In E. C. Cartereete & M. P. Friedman (Eds.), Handbook of perception, Vol. VIB. Feeling and hurting (pp. 183-230). New York: Academic Press.
28. Clark, S. L., Edeson, R. O., & Ryall, R. W. (1983). The relative significance of spinal and supraspinal actions in the antinociceptive effect of morphine in the dorsal horn: An evaluation of the microinjection technique. British Journal of Pharmacology, 79, 807-818.
29. Dafny, N., Reyes-Vázquez, C., & Qiao, J. T. (1990). Modification of nociceptively identified neurons in thalamic parafascicularis by chemical stimulation of dorsal raphé with glutamate, morphine, serotonin and focal dorsal raphé electrical stimulation. Brain Research Bulletin, 24, 717-723.
30. Dahlström, A., & Fuxe, K. (1965). Evidence for the existence of monoamine neurons in the central nervous system. II. Experimentally induced changes in the intraneuronal amine levels of the bulbospinal neuron systems. Acta Physiologica Scandinavica, 64 (Suppl. 247), 1-36.
31. Danneman, P. J., Kiritsy-Roy, J. A., Morrow, T. J., & Casey, K. L. (1994). Central delay of the laser-activated rat tail-flick reflex. Pain, 58, 39-44.
32. Duggan, A. W., Hall, J. G., & Headley, P. M. (1977). Suppression of transmission of nociceptive impulses by morphine: Selective effects of morphine administered in the region of the substantia gelatinosa. British Journal of Pharmacology, 61, 65-76.
33. Ellenberger, H. H., & Feldman, J. L. (1990). Brainstem connections of the rostral ventral respiratory group of the rat. Brain Research, 513, 35-42.
34. Fleetwood-Walker, S. M., Mitchell, R., Hope, P. J., Molony, P. J., & Iggo, A. (1985). An alpha2 receptor mediates the selective inhibition by noradrenaline of nociceptive responses of identified dorsal horn neurons. Brain Research, 334, 243-254.
35. Gebhart, G. F. (1982). Opiate and Opioid peptide effects on brain stem neurons: Relevance to nociception and antinociceptive mechanisms. Pain, 12, 93-140.
36. Gebhart, G. F., Sandkühler, J., Thalhammer, J. G., & Zimmerman, M. (1984). Inhibition in spinal cord of nociceptive information by electrical stimulation and morphine microinjection at identical sites in midbrain of the cat. Journal of Neurophysiology, 51, 75-89.
37. Gerhart, K. D., Yezierski, R. P., Wilcox, T. K., & Willis, W. D. (1984). Inhibition of primate spinothalamic tract neurons by stimulation in periaqueductal gray or adjacent midbrain reticular formation. Journal of Neurophysiology, 51, 450-466.
38. Glaum, S. R., Proudfit, H. K., & Anderson, E. G. (1988). Reversal of the antinociceptive effects of intrathecally administered serotonin in the rat by a selective 5-HT3 receptor antagonist. Neuroscience Letters, 95, 313-317.
39. Goodchild, C. S., & Serrao, J. M. (1987). Intrathecal midazolam in the rat: Evidence for spinally-mediated analgesia. British Journal of Anaesthesia, 59, 1563-1570.
40. Hammond, D. L., & Washington, J. D. (1993). Antagonism of L-baclofen-induced antinociception by CGP 35348 in the spinal cord of the rat. European Journal of Pharmacology, 234, 255-262.
41. Hayes, R. L., Price, D. D., Ruda, M. A., & Dubner, R. (1979). Suppression of nociceptive responses in the primate by electrical stimulation of the brain or morphine administration: Behavioral and electrophysiological comparisons. Brain Research, 167, 417-421.
42. Headley, P. M., Duggan, A. W., & Griersmith, B. T. (1978). Selective reduction by noradrenaline and 5-hydroxytryptamine of nociceptive responses of cat dorsal horn neurons. Brain Research, 145, 185-189.
43. Hoffmeister, F. (1968). Effects of psychotropic drugs on pain. In A. Soulariarc, J. Cahn, & J. Charpentier (Eds.), Pain (pp. 309-319). New York: Academic Press.
44. Holstege, G. (1989). Anatomical study of the final common pathway for vocalization in the cat. The Journal of Comparative Neurology, 284, 242-252.
45. Huang, G. F., Besson, J. M., & Bernard, J. F. (1993). Intravenous morphine depresses the transmission of noxious messages to the nucleus centralis of the amygdala. European Journal of Pharmacology, 236, 449-456.
46. Hylden, J. L. K., & Wilcox, G. L. (1986). Antinociceptive effect of morphine on rat spinothalamic tract neurons and other dorsal horn neurons. Neuroscience, 19, 393-401.
47. Jensen, T. S. (1986). Endogenous antinociceptive systems: Studies on spinal and supraspinal modulating mechanisms with particular reference to monoaminergic and opioid systems. Acta Neurologica Scandinavica, 74, Supplement 108, 1-35.
48. Jensen, T. S., & Yaksh, T. L. (1984). Effects of an intrathecal dopamine agonist, apomorphine, on thermal and chemical evoked noxious responses in rats. Brain Research, 296, 285-293.
49. Jensen, T. S., & Yaksh, T. L. (1986a). I. Comparison of antinociceptive action of morphine in the periaqueductal gray, medial and paramedial medulla in rat. Brain Research, 363, 99-113.
50. Jensen, T. S., & Yaksh, T. L. (1986b). II. Examination of spinal monoamine receptors through which brainstem opiate-sensitive systems act in the rat. Brain Research, 363, 114-127.
51. Jordan, L. M., Kenshalo, D. R., Martin, R. F., Haber, L. H., & Willis, W. D. (1978). Depression of primate spinothalamic tract neurons by iontophoretic application of 5-hydroxytryptamine. Pain, 5, 135-142.
52. Jourdan, D., Ardid, D., Chapuy, E., Eschalier, A., & Le Bars, D. (1995). Audible and ultrasonic vocalization elicited by single electrical nociceptive stimuli to the tail in the rat. Pain, 63, 237-249.
53. Jurna, I. (1980). Effect of stimulation in the periaqueductal grey matter on activity in ascending axons of the rat spinal cord: Selective inhibition of activity evoked by afferent Aδ and C fibre stimulation and failure of naloxone to reduce inhibition. Brain Research, 196, 33-42.
54. Jurna, I. & Heinz, G. (1979). Differential effects of morphine and opioid analgesics on A and C fibre-evoked activity in ascending axons of the rat spinal cord. Brain Research, 171, 573-576.
55. Levine, J. D., Lane, S. R., Gordon, N. C., & Fields, H. L. (1982). A spinal opioid synapse mediates the interaction of spinal and brain stem sites in morphine analgesia. Brain Research, 236, 85-91.
56. Lewis, V. A., & Gebhart, G. F. (1977). Evaluation of the periaqueductal central gray (PAG) as a morphine-specific locus of action and examination of morphine-induced and stimulation-produced analgesia at coincident PAG loci. Brain Research, 124, 283-303.
57. Li, Y. Q., Jia, H. G., Rao, Z. R., & Shi, J. W. (1990). Serotonin-, substance P- or leucine-enkephalin-containing neurons in the midbrain periaqueductal gray and nucleus raphe dorsalis send projection fibers to the central amygdaloid nucleus in the rat. Neuroscience Letters, 120, 124-127.
58. LoPachin, R. M., Rudy, R. A., & Yaksh, T. L. (1981). An improved method for chronic catheterization of the rat spinal subarachnoid space. Physiology & Behavior, 27, 559-561.
59. Ma, Q. P., Yin, G. F., Ai, M. K., & Han, J. S. (1991). Serotonergic projections from the nucleus raphé dorsalis to the amygdala in the rat. Neuroscience Letters, 134, 21-24.
60. Masters, D. B., & Komisaruk, B. R. (1991). Neonatal capsaicin treatment attenuates sensory-induced analgesia and nociception. Physiology and Behavior, 50, 901-906.
61. Morgan, M. M., Sohn, J. H., & Liebeskind, J. C. (1989). Stimulation of the periaqueductal gray matter inhibits nociception at the supraspinal as well as spinal level. Brain Research, 502, 61-66.
62. Murfin, R., Bennett, G. J., & Mayer, D. J. (1976). The effect of dorsolateral spinal cord lesions on analgesia from morphine microinjection into the periaqueductal gray matter of the rat. Society for Neuroscience Abstract, 2, 946.
63. Núñez-Abades, P. A., Pásaro, R., & Bianchi, A. L. (1991). Localization of respiratory bulbospinal and propriobulbar neurons in the region of the nucleus ambiguus of the rat. Brain Research, 568, 165-172.
64. Núñez-Abades, P. A., Portillo, F., & Pásaro, R. (1990). Characterization of afferent projections to the nucleus ambiguus of the rat by means of fluorescent double labeling. Journal of Anatomy, 172, 1-15.
65. Olds, R. J., & Olds, J. R. (1979). A colour atlas of the rat-a dissection guide. London: Wolfe Medial Publications Ltd.
66. Paxinos, G., & Watson, C. (1986). The rat brain in stereotaxic coordinates. New York: Academic Press.
67. Pert, A., & Yaksh, T. L. (1975). Localization of the antinociceptive action of morphine in primate brain. Pharmacology, Biochemistry and Behavior, 3, 133-138.
68. Peschanski, M., & Besson, J. M. (1984). A spino-reticulo-thalamic pathway in the rat: An anatomical study with reference to pain transmission. Neuroscience, 12, 165-178.
69. Peschanski, M., Guilbaud, G., & Gautron, M. (1981). Posterior intralaminar nuclei in the rat-neuronal responses to noxious and non-noxious cutaneous stimuli. Experimental Neurology, 72, 226-238.
70. Prieto-Gómez, B., Dafny, N., & Reyes-Vázquez, C. (1989). Dorsal raphé stimulation, 5-HT and morphine microiontophoresis effects on noxious and nonnoxious identified neurons in the medial thalamus of the rat. Brain Research Bulletin, 22, 937-943.
71. Reddy, S. V. R., Maderdrut, J. L., & Yaksh, T. L. (1980). Spinal cord pharmacology of adrenergic agonist-mediated antinociception. Journal of Pharmacology and Experimental Therapeutics, 213, 525-533.
72. Reichling, D. B., & Basbaum, A. I. (1990). Contribution of brainstem GABAergic circuitry to descending antinociceptive controls. I. GABA-immunoreactive projection neurons in the periaqueductal gray and nucleus raphé magnus. Journal of Comparative Neurology, 302, 370-377.
73. Reyes-Vázquez, C., Qiao, J. T., & Dafny, N. (1989). Nociceptive responses in nucleus parafascicularis thalami are modulated by dorsal raphé stimulation and microiontophoretic application of morphine and serotonin. Brain Research Bulletin, 23, 405-411.
74. Shiomi, H., & Takagi, H. (1974). Morphine analgesia and bulbospinal noradrenergic systems: Increase in the concentration of normetanephrine in the spinal cord of the rat by analgesia. British Journal of Pharmacology, 52, 519-526.
75. Sim, L. J., & Joseph, S. A. (1992). Serotonin and substance P afferents to parafascicular and central medial nuclei. Peptides, 13, 171-176.
76. Skagerberg, G., & Lindvall, O. (1983). Organisation of diencephalic dopamine neurones projecting to the spinal cord in the rat. Brain Research, 342, 340-357.
77. Takano, Y., & Yaksh, T. L. (1992). Characterization of the pharmacology of intrathecally administered alpha-2 agonists and antagonists in rats. Journal of Pharmacology and Experimental Therapeutics, 261, 764-772.
78. Tseng, L. F., Higgins, M. J., Hong, J. S., Hudson, P. M., & Fujimoto, J. M. (1985). Release of immunoreactive Met-enkephalin from the spinal cord by intraventricular β-endorphin but not morphine in anesthetized rats. Brain Research, 343, 60-69.
79. Tseng, L. F., & Tang, R. (1989). Differential actions of the blockade of spinal opioid, adrenergic and serotonergic receptors on the tail-flick inhibition induced by morphine microinjected into dorsal raphé, and central gray in rats Neuroscience, 33, 93-100.
80. Vertes, R. P., Martin, G. F., & Waltzer, R. (1986). An autoradiographic analysis of ascending projections from the medullary reticular formation in the rat. Neuroscience, 19, 873-898.
81. Wang, J. K. (1977). Antinociceptive effect of intrathecally administered serotonin. Anesthesiology, 47, 269-271.
82. White, S. R., & Neuman, R. S. (1980). Facilitation of spinal motoneuron excitability by 5-hydroxytryptamine and noradrenaline. Brain Research, 188, 119-127.
83. Willcockson, W. S., Chung, Y., Hori, Y., Lee, K. H., & Willis, W. D. (1984). Effects of iontophoretically released peptides on primate spinothalamic tract cells. Journal of Neuroscience, 4, 741-750.
84. Xu, W., Qiu, X. C., & Han, J. S. (1994). Serotonin receptor subtypes in spinal antinociception in the rat. Journal of Pharmacology and Experimental Therapeutics, 269, 1182-1189.
85. Xu, D. Y., Zhou, Z. F., & Han, J. S. (1985). Amygdaloid serotonin and endogenous opioid substances (OLS) are important for mediating electroacupuncture analgesia and morphine analgesia in the rabbit. Acta Physiologica Sinica, 37, 162-171.
86. Yaksh, T. L. (1985). Pharmacology of spinal adrenergic systems which modulate spinal nociceptive processing. Pharmacology, Biochemistry & Behavior, 22, 845-858.
87. Yaksh, T. L. (1979). Direct evidence that spinal serotonin and noradrenaline terminals mediate the spinal antinociceptive effects of morphine in the periaqueductal gray. Brain Research, 160, 180-185.
88. Yaksh, T. L., & Rudy, T. A. (1977). Studies on the direct spinal action of narcotics in the production of analgesia in the rat. Journal of Pharmacology and Experimental Therapeutics, 202, 411-428.
89. Yaksh, T. L., & Rudy, T. A. (1978). Narcotic analgetics: CNS sites and mechanisms of action as revealed by intracerebral injection techniques. Pain, 4, 299-359.
90. Yaksh, T. L., & Tyce, G. M. (1979). Microinjection of morphine into the periaqueductal gray evokes the release of serotonin from the spinal cord. Brain Research, 171, 176-181.
91. Yaksh, T. L., & Wilson, P. R. (1979). Spinal serotonin terminal system mediates antinociception. Journal of Pharmacology and Experimental Therapeutics, 208, 446-453.
92. Yaksh, T. L., Yeung, J. C., & Rudy, T. A. (1976). Systematic examination in the rat of brain sites sensitive to the direct application of morphine: Observation of differential effects within the periaqueductal gray. Brain Research, 114, 83-103.
93. Yanez, A., Sabbe, M. B., Stevens, C. W., Yaksh, T. L. (1990). Interaction of midazolam and morphine in the spinal cord of the rat. Neuropharmacology, 29, 359-364.
94. Yen, C. T., Fu, T. C., & Chen, R. C. (1989). Distribution of thalamic nociceptive neurons activated from the tail of the rat. Brain Research, 498, 118-122.
95. Yezierski, R. P., Wilcox, T. K., & Willis, W. D. (1982). The effects of serotonin antagonists on the inhibition of primate spinothalamic tract cells produced by stimulation of nucleus raphé magnus or periaqueductal gray. Journal of Pharmacology and Experimental Therapeutics, 220, 266-277.
96. Zeng, S. L., Li, Y. Q., Rao, Z. R., & Shi, J. W. (1991). Projections from serotonin- and substance P-like immunoreactive neurons in the midbrain periaqueductal gray onto the nucleus reticularis gigantocellularis pars alpha in the rat. Neuroscience Letters, 131, 205-209.