Desensitization of the antigen receptor primes B cells for activation by superstimulatory influenza virus

Journal of Inflammation

Volumn 46, Issue 1, 1996, Pages 51-60

  Rott, Ortwin ^a   Charreire, Jeannine ^a   Cash, Evelyne ^b  

^a INSERM   (France)

^b Hôpital Cochin ^*  (France)

Author keywords

antigen presenting cells; B cell receptor; desensitization; hemagglutinin; superstimulatory influenza virus; surface immunoglobulin

Indexed keywords

LYMPHOCYTE ANTIGEN RECEPTOR;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; DESENSITIZATION; IMMUNOSTIMULATION; INFLUENZA VIRUS; LYMPHOCYTE ACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE;

ANIMALS; ANTIBODIES, ANTI-IDIOTYPIC; ANTIGENS, CD80; B-LYMPHOCYTES; CELL DIVISION; CELLS, CULTURED; HEMAGGLUTININ GLYCOPROTEINS, INFLUENZA VIRUS; HISTOCOMPATIBILITY ANTIGENS CLASS II; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; PHENOTYPE; RECEPTORS, ANTIGEN, B-CELL; RECEPTORS, INTERLEUKIN-2;

EID: 0029914576     PISSN: 10787852     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Sibley DR, Lefkowitz RJ: Molecular mechanisms of receptor desensitization using the -adrenergic receptor-coupled adenylate cyclase system as a model. Nature 317:124-129, 1985.
2. Benovic JL, Bouvier M, Caron MG, Lefkowitz RJ: Regulation of adenyl cyclase-coupled beta-adrenergic receptors. Annu Rev Cell Biol 4:405-428, 1988.
3. Gambier J, Chen Z-Z, Pasternak J, Ransom J, Sandoval V, Pickles H: Ligand-induced desensitization of B-cell membrane immunoglobulin-mediated Ca2 mobilization and protein kinase C translocation. Proc IMatl Acad Sci USA 85:6493-6497, 1988.
4. Gambier JC, Fisher CL, Pickles H, Morrison DC: Dual molecular mechanisms mediate ligand-induced membrane Ig desensitization. J Immunol 145:13-19, 1990.
5. Warner GL, Scott DW: A polyclonal model for B cell tolerance. I. Fc-dependent and Fc-independent induction of nonresponsiveness by pretreatment of normal splenic B cells with anti-lg. J Immunol 146:2185-2191, 1991.
6. Rijkers GT, Griffioen AW, Zegers BUM, Cambier JC: Ligation of membrane immunoglobulin leads to inactivation of the signal-transducing ability of membrane immuno-globulin, CD19, CD21, and B-cell gp95. Proc Natl Acad Sci USA 87:8766-8770, 1990.
7. Lazarus AH, Mills GB, Delovitch TL: Antigen-induced Ca2 ' signaling and desensitization in B cells. J Immunol 144:4147-4155, 1990.
8. Lazarus AH, Mills GB, Crow AR, Delovitch TL: Antigeninduced Fc receptor-dependent and -independent B cell desensitization. An elevation in [Ca2t], is not sufficient and protein kinase C activation is not required for these pathways of surface IgM-mediated desensitization. J Immunol 147:1739-1745, 1991.
9. Gaur A, Yao X, Scott DW: B cell tolerance induction by cross-linking of membrane IgM, but not IgD, and synergy by cross-linking of both isotypes. J Immunol 150:1663-1669, 1993.
10. Brunswick M, June CH, Mond JJ: B lymphocyte immunoglobulin receptor desensitization is downstream of tyrosine kinase activation. Cell Immunol 156:240-244, 1994.
11. Rott 0, Cash E: Influenza virus hemagglutinin induces differentiation of mature resting B cells and growth arrest of immature WEHI-231 lymphoma cells. J Immunol 152:5381-5391, 1994.
12. Rott 0, Charreire J, Semichon M, Bismuth G, Cash E: B cell superstimulatory influenza virus (H2-subtype) induces B cell proliferation by a PKC-activating, Ca2tindependent mechanism. J Immunol 154:2092-2103, 1995.
13. Rott 0, Charreire J, Mignon-Godefroy K, Cash E: B cell superstimulatory influenza virus activates peritoneal B cells. J Immunol 155:134-142, 1995.
14. Fazekas G, Rajnavolgyi E, Kurucz I, Sintar E, Kiss K, Laszlo G, Gergely J: Isolation and characterization of lgG2a-reactive autoantibodies from influenza virus-infected BALB/c mice. Eur J Immunol 20:2719-2729, 1990.
15. Roman LM, Simon LF, Hammer RE, Sambrook JF, Gething M-JH: The expression of influenza virus hemagglutinin in the pancreatic cells of transgenic mice results in autoimmune diabetes. Cell 61:383-396, 1990.
16. Mond JJ, Lees A, Snapper CM: T cell-independent antigens type 2. Annu Rev Immunol 13:655-692, 1995.
17. Julius MH, Heusser CH, Hartmann K-U: Induction of resting B cells to DMA synthesis by soluble monoclonal anti-immunoglobulin. Eur J Immunol 14:753-757, 1984.
18. Rigley KP, Harnett MM, Klaus GGB: Co-cross-linking of surface immunoglobulin Fc gamma receptors on B lymphocytes uncouples the antigen receptors from their associated G protein. Eur J Immunol 19:481-485, 1989.
19. Goodnow CC, Crosbie J, Adelstein S, Lavoie TB, SmithGill SJ, Brink RA, Prichard-Briscoe H, Wotherspoon JS, Loblay RH, Raphael K, Trent RJ, Basten A: Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice. Nature 334:676-682, 1988.
20. Liou LB, Warner GL, Scott DW: Can peritoneal B cells be rendered unresponsive? Int Immunol 4:15-21, 1992.
21. Andersson J, Coutinho A, Melchers F: Stimulation of murine B lymphocytes to IgG synthesis and secretion by the mitogens lipopolysaccharide and lipoprotein and its inhibition by anti-immunoglobulin antibodies. Eur J Immunol 8:336-343, 1978.
22. Chen-Bettecken U, Wecker E, Schimpl A: IgM RNA switch from membrane to secretory form is prevented by adding antireceptor antibody to bacterial lipopolysaccharide-stimulated murine primary B-cell cultures. Proc Natl Acad Sci 82:7384-7388, 1985.
23. Berberich I, Schimpl A: Regulation of immunoglobulin gene expression in normal lymphocytes. II. Mechanisms of down-regulation of immunoglobulin secretion after engagement of the B cell antigen receptor. Eur J Immunol 22:525-529, 1992.
24. Uhr JW, Möller G: Regulatory effect of antibody on the immune response. Adv Immunol 8:81-121, 1968.
25. Fridman WH: Regulation of B cell activation and antigen presentation by Fc receptors. Curr Opin Immunol 5:355-360, 1993.
26. Choquet D, Partiseti M, Amigorena S, Bonnerot C, Fridman WH, Korn H: Cross-linking of IgG receptors inhibits membrane immunoglobulin-stimulated calcium influx in B lymphocytes. J Cell Biol 121:355-363, 1993.
27. Scott DW: Analysis of B cell tolerance in vitro. Adv Immunol 54:393-425, 1993.
28. Goodnow CC, Adelstein S, Basten A: The need for central and peripheral tolerance in the B cell repertoire. Science 248:1373-1379, 1990.
29. Goodnow CC: Transgenic mice and analysis of B-cell tolerance. Annu Rev Immunol 10:489-518, 1992.
30. Ferber l, Schönrich G, Schenkel J, Mellor AL, Hämmerling GJ, Arnold B: Levels of peripheral T cell tolerance induced by different doses of tolerogen. Science 263:674-676, 1994.
31. Hämmerling GJ, Schönrich G, Ferber I, Arnold B: Peripheral tolerance as a multi-step mechanism. Immunol Rev 133:93-104, 1993.
32. Cooke MP, Heath AW, Shokat KM, Zeng Y, Finkelman FD, Linsley PS, Howard M, Goodnow CC: Immunoglobulin signal transduction guides the specificity of B cellT cell interactions and is blocked in tolerant self-reactive B cells. J Exp Med 179:425-438, 1994.
33. Lo D, Freedman J, Hesse S, Brinster RL, Sherman L: Peripheral tolerance in transgenic mice: Tolerance to class II MHC and non-MHC transgene antigens. Immunol Rev 122:87-102, 1991.
34. Lo D, Freedman J, Hesse S, Palmiter RD, Brinster RL, Sherman LA: Peripheral tolerance to an islet cell-specific hemagglutinin transgene affects both CD4+ and CD8+ T cells. Eur J Immunol 22: 1013-1022, 1992.