The clinical use of didanosine

Advances in Experimental Medicine and Biology

Volumn 394, Issue , 1996, Pages 245-256

  Kahn, James ^b  

^a SAN FRANCISCO GENERAL HOSPITAL   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

DIDANOSINE; VIRUS DNA; ZIDOVUDINE;

CHRONICITY; CLINICAL TRIAL; CONFERENCE PAPER; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE CONTROL; DNA SYNTHESIS; DRUG EFFICACY; DRUG INHIBITION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MAJOR CLINICAL STUDY; PANCREATITIS; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL; REVERSE TRANSCRIPTION; VIRUS REPLICATION;

DNA VIRUSES; HUMAN IMMUNODEFICIENCY VIRUS;

EID: 0029913920     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4757-9209-6_22     Document Type: Conference Paper

References (47)

1. Hirsch MS, D'Aquilla RT. Therapy for human immunodeficiency virus infection. N Engl J Med 1993;328:1686-95.
2. Mitsuya H, Broder S. Inhibition of the in vitro infectivity and cytopathic effect of human T-lymphotrophic virus type III/lymphadenoapthy-associaled virus (HTLV-III/LAV) by 2,3′-dideoxynucleosides. Proc Natl Acad Sci USA 1986; 83:1911-15.
3. Mitsuya H, Jarrett RF, Matsukura M et al. Long-term inhibition of human T-lymphotropic virus type III/lymphoadenopathy-associated virus (human immunodeficiency virus) DNA synthesis and RNA expression in T cells protected by 2′,3′-dideoxynucleosides in vitro. Proc Natl Acad Sci USA 1987; 84:2033-7.
4. Sommadossi JP. Nucleoside Analogs: Similarities and Differences. Clinical Infectious disease 1993;S1:S7-15.
5. Reichman RC, Tejani N, Lambert JL et al. Didanosine (ddI) and zidovudine (ZDV) susceptibilities of human immunodeficiency virus (HIV) isolates from long-term recipients of ddI. Antiviral Research 1993;20:267-7.
6. McLeod GX, McGrath JM, Ladd EA, Hammer SM. Didanosine and zidovudine resistance patterns in clinical isolates of human immunodeficiency virus type 1 as determined by replication endpoint concentration assay. Antimicrob Agents Chemother 1992;36:920-5.
7. Martin JL, Wilson JE, Haynes RL Furman PA. Mechanism of resistance of human immunodeficiency virus type 1 to 2′,3′-dideoxyinosine. Proc. Natl. Acad. Sci. USA 1993;9061:35-9.
8. Gao Q, Gu Z, Parniak MA, Li X Wainberg MA. In vitro selection of variants of human immunodeficiency virus type 1 resistant to 3′-azido-3′deoxythymidine and 2′-,3′-dideoxyinosine. J Virology. 1992;66:12-9.
9. Gu Z, Gao Q, Li X, Parniak MA Wainberg MA. Novel mutation in the human immunodeficiency virus type 1 reverse transcriptase gene that encodes cross-resistance to 2′-3′-dideoxyinosine and 2′-3′didoxycytidine. J Virology. 1992;66:7128-35.
10. St. Clair MH, Martin JL, Tudor-Williams et al. Resistance to ddI and sensitivity to AZT induced by a mutation in HIV-1 reverse transcriptase. Science 1991;253:1557-9.
11. Eron JJ, Chow YK, Caliendo AM. pol mutations conferring zidovudine and didanosine resistance with different effects in vitro yield multiply resistance human immunodeficiency virus type 1 isolates in vivo. Antimicrob Agents Chemotherap 1993;37:1480-7.
12. Erice A, Balfour HH. Resistance of Human Immunodeficiency Virus Type 1 to antiretroviral gents: A review. J Infect Dis 1994; 18: 149-56.
13. Mayers DL, Japour AJ, Arduino JM et al. Dideoxynucleoside resistance emerges with prolonged zidovudine monotherapy. Antimicrob Agent Chemotherap. 1994; 38:307-14.
14. Knupp CA, Shyu WC, Dolin R et al. Pharmacokinetics of didanosine in patietns with acquired immunodeficiency syndrome or acquired immunodeficiency syndrome-related complex. Clin Pharmacol Ther 1991;49:523-35.
15. Balis FM, Pizzo PA, Butler KM et al. Clinical pharmacology of 2′,3′-dideoxyinosine in human immunodeficiency virus-infected children. J Infect Dis 1992;165:99-104.
16. Knupp CA, Bilbrath R and Barbhaiya RH. Effect of time of food administration on the bioavailability of didanosine from a chewable tablet formulation. J Clin Pharmacol 1993;33:568-73.
17. Knupp CA, Graziano FM, Dixon RN, Barbhaiya RH. Pharmacokinetic-Interaction study of didanosine and ranitidine in patients seropositive for human immunodeficiency virus. Antimicrob Agents and Chemo 1993; 36:2075-9.
18. Neuzil KM. Pharmacologic therapy for human immunodeficiency virus infection: a review. Amer J Med Sci 1994;307:368-73.
19. Mueller BU, Pizzo PA, Farley M et al. Pharmacokinetic evaluation of the combination of zidovudine and didanosine in children with human immunodeficiency virus infection. J Pediatrics. 1994;125:142-6.
20. Yarchoan R, Mitsuya H, Thomas RV et al. In vivo activity against HIV and favorable toxicity profile of 2′,3′-dideoxyinosine. Science 1989;245:412-5.
21. Cooley TP, Kunches LM, Saunders CA et al. Once-daily administration of 2′,3′-dideoyinosine (ddI) in patients with the acquired immunodeficiency syndrome or AIDS-related complex. N Engl J Med 1990; 322:1340-5.
22. Lambert JS, Seidlin M, Reichman RC et al. 2′,3′-dideoxyinosine (ddI) in patients with the acquired immunodeficiency syndrome or AIDS-related complex. N Eng J Med 1990; 322:1333-9.
23. Yarchoan R, Pluda JM, Thomas RV et al. Long-term toxicity/activity profile of 2′,3′-dideoxyinosine in AIDS or AIDS-related complex Lancet 1990;336:526-9.
24. Lambert JS, Seidlin M, Valentine FT, Reichman RC, Dolin R. Didanosine: Long-term follow-up of patients in a phase 1 study. Clin Infect Dis 1993; 16S1:S40-5.
25. McLaren C, Rozencweig M, Beltangady M et al. Longitudinal analysis of responses to oral didanosine therapy following zidovudine therapy in advanced infection with human immunodeficiency virus. Clini Infect Dis 1993:16S1:S32-9.
26. Allan JD, Connolly KJ, Fitch h et al. Long-term follow-up of didanosine administered orally twice daily to patients with advanced human immunodeficiency virus infection and hematologic intolerance of zidovudine. Clin Infect Dis 1993; 16S1:S46-51.
27. Pike IM, Nicaise C. The didanosine Expanded Access Program: Safety analysis. Clin Infect Dis 1993;16(S1): S63-8.
28. Montaner JSG, Rachlis A, Beaulieu R et al. Safety profile of didanosine among patients with advanced HIV disease who are intolerant to or deteriorate despite zidovudine therapy: Results of the Canadian open ddI treatment program. J AIDS 1994;7:924-30.
29. Kahn J, Lagakos SW, Richman DD et al. A controlled trial comparing continued zidovudine with didansosine in human immunodeficiency virus infection. N Engl J Med. 1992;327:581-7.
30. Dolin R, Amato D, Fischl MA et al. Zidovudine compared to didanosine in patients with advanced HIV-1 infection and little or no previous experience with zidovudine. Arch Intern Med (in press, 1995).
31. Spruance SL, Pavia AT, Peterson D et al. Didanosine compared with continuation of zidovudine in HIV-infected patients with signs of clinical deterioration while receiving zidovudine. Ann Intern Med 1994; 120:360-8.
32. Darbyshire JH, Aboulker JP. Didanosine for zidovudine-intolerant patients with HIV disease. Lancet 1992;340:1346-7.
33. Nelson MR, Moyle GJ, Gazzard BG. Use of didanosine in zidovudine-intolerant patients infected with Human Immunodeficiency Virus. Clini Infect Dis 1993; 16S1:S59-62.
34. Abrams DI, Goldman AI, Launer C et al. A comparative trial of didanosine or zalcitabine after treatment with zidovudine in patients with human immunodeficiency virus infection. N Engl J Med 1994;330:657-62.
35. D'Aquila RT, Johnson VA, Wells SL et al. Zidovudine resistance and human immunodeficiency virus type 1 disease progression during antiretroviral therapy. Ann Intern Med (in press, 1995).
36. Japour AJ, Wells S, D'Aquilla RT et al. Prevalence and clinical significance of zidovudine resistance mutations in human immunodeficiency virus isolated from patients following long-term zidovudine treatment. J Infect Dis (in press, 1995).
37. Yarchoan R, Lietzau JA, Nguyen BY et al. Didanosine therapy in patients with symptomatic human immunodeficiency virus infection. J Infect Dis 1994; 169:9-17.
38. Collier AC, Coombs RW, Fischl MA et al. Combination therapy with zidovudine and didanosine compared with zidovudine alone in HIV-1 infection. Ann Intern Med 1993; 119:786-93.
39. Holodniy M, Katzenstein D, Winters M eta l. Measurement of HIV virus load and gneotypic resistance by gne amplification in asymptomatic subjects treated with combination therapy. J AIDS 1993:6;366-9.
40. Butler KM, Husson RN Balis FM et al. Dideoxyinosine in children with symptomatic human immunodeficiency virus infection. N Engl J Med 324:135-44.
41. Clerici M, Riolides E, Butler KM. Changes in T-helper cell function in human immunodeficiency virus-infected children during didansoine therapy as a measure of antiretroviral activity. Blood 1992 80:2196-2202.
42. Blanche S, Calves T, Rouzloux C et al. Randomized study of two doses of didanosine in children infected with human immunodeficiency virus. J Pediatrics 1993:966-73.
43. Mueller BU, Butler KM, Tocker VL et al. Clinical and pharmacokinetic evaluation of long-term therapy with didanosine in children with HIV infection. Pediatrics. 1994;94:724-31.
44. Husson RN, Mueller BU, Farley M et al. Zidovudine and didanosine combination therapy in children with human immunodeficiency virus infection. Pediatrics 1994:93: 316-22.
45. Working group on antiretroviral therapy: national Pediatrice HIV Resource Center. Antiretroviral therapy and medical management of the human immunodeficiency virus-infected hild. Pediat Infect Dis J 1993:12:513-22.
46. Schacter LP, Rozencweig M, Beltangady M et al. Effects of therapy with didansine on hematologic parameters in patients with advanced human immunodeficiency virus disease. Blood 1992; 80:2969-76.
47. Bozzette SA, Parker R, Hay J. A cost analysis of approved antiretrovirlastreageties in person with advanced human immunodeficiency virus disease and zidovudine intolerance. J AIDS 1994;7:355-62.