Intestinal absorption and first-pass elimination of 2′,3′-dideoxynucleosides following oral administration in rats

Biological and Pharmaceutical Bulletin

Volumn 19, Issue 4, 1996, Pages 599-603

  Hasegawa, Tetsuya ^a   Juni, Kazuhiko ^a   Saneyoshi, Mineo ^b   Kawaguchi, Takeo ^a  

^a JOSAI UNIVERSITY   (Japan)

^b Nishi Tokyo University   (Japan)

Author keywords

2 ,3 dideoxynudeoside; AIDS; Intestinal absorption

Indexed keywords

2',3' DIDEOXYNUCLEOSIDE; ANTIVIRUS AGENT; DIDANOSINE; STAVUDINE; ZIDOVUDINE;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ANTIVIRAL ACTIVITY; AREA UNDER THE CURVE; ARTICLE; DRUG BIOAVAILABILITY; DRUG ELIMINATION; ENZYME DEGRADATION; INTESTINE ABSORPTION; INTRADUODENAL DRUG ADMINISTRATION; INTRAGASTRIC DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PORTAL VEIN; RAT; VIRUS INHIBITION;

ADMINISTRATION, ORAL; ANIMALS; ANTI-HIV AGENTS; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; DIDANOSINE; DIDEOXYNUCLEOSIDES; INTESTINAL ABSORPTION; INTESTINES; MALE; RATS; RATS, WISTAR; STAVUDINE; ZIDOVUDINE;

EID: 0029913892     PISSN: 09186158     EISSN: None     Source Type: Journal    
DOI: 10.1248/bpb.19.599     Document Type: Article

References (30)

1. Dournon E., Rozenbaum W., Michon C., Perronne C., DeTruchis P., Bouvet E., Levacher M., Matheron S., Gharakhanian S., Girard P. M., Salmon D., Leport C., Dazza M. C., Regnier B., Lancet, ii. 1297 (1988).
2. Mir N., Costello C.. Lancet, ii, 1195 (1988).
3. Butler K. M., Venzon D., Henry N., Husson R. N., Mueller B. U., Balis F. M., Jacobsen F., Lewis L. L., Pizzo P. A., Pediatrics, 91, 747 (1993).
4. Seidlin M., Lambert J. S., Dolin R., Valentine F. T., AIDS, 6, 831 (1992).
5. Dunkle L., Cross A., Gugliotti R., Martin R., Brown M., Murray H., Antiviral Res. Suppl., 1, 116 (1990).
6. Brown M., Mayer K. M., Chaffee S. B. D., Dudley M. N., Posner M. R., Steinberg S. M., Graham K. K., Geletko S. N., Zinner S. H., Denman S. L., Dunkle L. M., Kaul S., McLaren C., Skowron G., Kouttab N., Kennedy T. A., Weitgerg A. B., Curt G. A., J. Infect. Dix., 167, 21 (1993).
7. Furman P. A., Fyfe J. A., St. Clair M. H., Weinhold K., Rideoat J. L., Freeman G. A., Lehrman S. N., Bolognesi D. P., Broder S., Mitsuya H., Barry D. W., Proc. Natl. Acad. Sci. U.S.A., 83, 8333 (1986).
8. Merigan T. C., Am. J. Med., 90, 8S (1991).
9. Yorchoan R., Pluda J. M., Perno C. F., Mitsuya H., Thomas R. V., Wyvill K. M., Broder S., Ann. N. Y. Acad. Sci., 616, 328 (1990).
10. Resetar A., Spector T., Biochem. Pharmacol., 38, 1389 (1989).
11. Klecker R. W., Jr., Collins J. M., Yorchoan R., Thomas R., Jenkins J. F., Broder S., Myers C. E., Clin. Pharmacol. Ther., 41, 407 (1987).
12. Russell J. W., Klunk L. J., Biochem. Pharmacol., 38, 1358 (1989).
13. Kawaguchi T., Hasegawa T., Saneyoshi M., Juni K., Seki T., Morimoto Y., Abstracts of Papers, Advances in the Delivery of Therapeutic and Diagnostic Agents '92, Sydney, 9-11 December 1992, p.62.
14. Hasegawa T., Seki T., Juni K., Saneyoshi M., Kawaguchi T., Abstracts of Papers, 2nd U.S.-Japan Symposium on Drug Delivery Systems, Maui, 12-17 December 1993, p. 28.
15. Horwitz P. J., Chua J., DaRooge M. A., Noel M., Klundt I. L., J. Org. Chem., 31, 205 (1966).
16. Kiyasu J. Y., Chaikoff I. L., J. Biol. Chem., 224, 935 (1957).
17. Weiss M., Forster W., Eur. J. Clin. Pharmacol., 16, 287 (1979).
18. Kawaguchi T., Ishikawa K., Seki T., Juni K., J. Pharm. Sci., 79, 531 (1990).
19. Kawaguchi T., Hasegawa T., Seki T., Juni K., Morimoto Y., Miyakawa A., Saneyoshi M., Chem. Pharm. Bull., 40, 1338 (1992).
20. Hasegawa T., Seki T., Juni K., Saneyoshi M., Kawaguchi T.. J. Pharm. Sci, 82, 1232 (1993).
21. Williams W. M., Warren B. S., Lin F., Anal. Biochem., 147, 478 (1985).
22. Anderson B. D., Wygant M. B., Xiang T. X., Waugh W. A., Stella V. J., Jnt. J. Pharm., 45, 27 (1988).
23. Kawaguchi T., Fukushima S., Ohmura M., Nakano M., Chem. Pharm. Bull., 37, 1944 (1989).
24. Kawaguchi T., Fukushima S., Hayashi Y., Nakano M., Pharm. Res., 5, 741 (1988).
25. Mirchandani H. L., Chien Y. W., J. Pharm. Sci., 84, 44 (1995).
26. Sugiura K., Ann. N. Y. Acad. Sci., 76, 575 (1958).
27. Burchenal J. H., Holmberg E. A. D., Fox J. J., Hemphill S. C., Cancer Res., 19, 494 (1959).
28. Kanazawa F., Hoshi A., Kuretani K., Eur. J. Cancer. 16, 1087 (1980).
29. Bramer S. L., Au J. L. S., Weintjes M. G., J Pharmacol Exp. Ther., 265, 731 (1993).
30. Sinko P. J., Patel N. R., Hu P., Int. J. Pharm., 109, 125 (1994).