Binding of the Ets factor GA-binding protein to an upstream site in the factor IX promoter is a critical event in transactivation

Molecular and Cellular Biology

Volumn 16, Issue 5, 1996, Pages 1929-1935

  Boccia, Lara M ^a   Lillicrap, David ^a   Newcombe, Kari ^a   Mueller, Christopher R ^a  

^a QUEEN S UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR 9; DNA BINDING PROTEIN; SERINE PROTEINASE;

ARTICLE; BLOOD CLOTTING; ENZYME INDUCTION; GENE EXPRESSION REGULATION; HEMOPHILIA B; NONHUMAN; PATHOGENESIS; POINT MUTATION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; RAT;

RICKETTSIA SP. PAR;

EID: 0029913598     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.16.5.1929     Document Type: Article

References (33)

1. Birkenmeier, E. H., B. Gwynn, S. Howard, J. Jerry, J. I. Gordon, W. H. Landschulz, and S. L. McKnight. 1989. Tissue-specific expression, developmental regulation, and genetic mapping of the gene encoding CCAAT/ enhancer binding protein. Genes Dev. 3:1146-1156.
2. Bolton-Maggs, P. H. B., P. Jones, C. R. Rizza, K. M. Stowell, M. S. Figueiredo, and G. G. Brownlee. 1995. Haemophilia B Liverpool a new British family with mild haemophilia B associated with a G→A mutation at -6 in the factor IX promoter. Thromb. Haemostasis 69:848. (Abstract.)
3. Bolwig, G., J. Bruder, and P. Hearing. 1992. Different binding site requirements for binding and activation for the bipartite factor EF-1A. Nucleic Acids Res. 20:6555-6564.
4. Briet, E., R. M. Bertina, N. H. Van Tilburg, and J. J. Veltkamp. 1982. Hemophilia B Leyden: a sex linked hereditary disorder that improves after puberty. N. Engl. J. Med. 306:782-788.
5. Brown, T. A., and S. L. McKnight. 1992. Specificities of protein-protein and protein-DNA interaction of GABPα and two newly defined ets-related proteins. Genes Dev. 6:2502-2512.
6. Carter, R. S., and N. G. Avandhani. 1994. Cooperative binding of GA-binding protein transcription factors to duplicated transcription initiation region repeats of the cytochrome c oxidase subunit IV gene. J. Biol. Chem. 269:4381-4387.
7. Crossley, M., and G. G. Brownlee. 1990. Disruption of a C/EBP binding site in the factor IX promoter is associated with haemophilia B. Nature (London) 345:444-446.
8. Crossley, M., M. Ludwig, K. M. Stowell, P. De Vos, K. Olek, and G. G. Brownlee. 1992. Recovery from hemophilia B Leyden: an androgen-responsive element in the factor IX promoter. Science 257:377-379.
9. de la Brousse, F. C., E. H. Birkenmeier, D. S. King, L. B. Rowe, and S. L. McKnight. 1994. Molecular and genetic characterization of GABP-beta Genes Dev. 8:1853-1865.
10. Drolet, D. W., K. M. Scully, D. M. Simmons, M. Wegner, K. T. Chu, L. W. Swanson, and M. G. Rosenfeld. 1991. TEF, a transcription factor expressed specifically in the anterior pituitary during embryogenesis, defines a new class of leucine zipper proteins. Genes Dev. 5:1739-1753.
11. Dupriez, V., M. Darville, I. Antoine, A. Gegonne, J. Ghysdael, and G. Rousseau. 1993. Characterization of a hepatoma mRNA transcribed from a third promoter of a 6-phosphofructo-2-kinase/fructose-2,5-bisphosphatase-encoding gene and controlled by ets oncogene-related products. Proc. Natl. Acad. Sci. USA 90:8224-8228.
12. Genuarino, R. R., D. E. Kelly, and R. P. Perry. 1993. Comparative utilization of transcription factor GABP by the promoters of ribosomal protein genes rpL30 and rpL32. Gene Expr. 3:279-288.
13. Gorski, K., M. Carneiro, and U. Schibler. 1986. Tissue-specific in vitro transcription from the mouse albumin promoter. Cell 47:767-776.
14. Hunger, S. P., R. Brown, and M. L. Cleary. 1994. DNA-binding and transcriptional regulatory properties of hepatic leukemia factor (HLF) and the t(17;19) acute lymphoblastic leukemia chimera E2A-HLF. Mol. Cell. Biol. 14:5986-5996.
15. Hunger, S. P., K. Ohyashiki, K. Toyama, and M. L. Cleary. 1992. Hlf, a novel hepatic bZIP protein shows altered DNA-binding properties following fusion to E2A in t(17;19) acute lymphoblastic leukemia. Genes Dev. 6:1608-1620.
16. Inaba, T., W. M. Roberts, L. H. Shapiro, K. W. Jolly, S. C. Raimondi, S. D. Smith, and A. T. Look. 1992. Fusion of the leucine zipper gene HLF to the E2A gene in human acute B-lineage leukemia. Science 257:531-534.
17. Inaba, T., L. H. Shapiro, T. Funabiki, A. Sinclair, B. Jones, R. Ashmun, and T. Look. 1994. DNA-binding specificity and trans-activating potential of the leukemia-associated E2A-hepatic leukemia factor fusion protein. Mol. Cell. Biol. 14:3403-3413.
18. LaMarco, K., and S. L. McKnight. 1989. Purification of a set of cellular polypeptides that bind to the purine-rich cis-regulatory element of herpes simplex virus immediate early genes. Genes Dev. 3:1372-1383.
19. Leggett, R. W., and C. R. Mueller. 1994. Retinoblastoma control element binding proteins are induced during in vivo terminal differentiation of the liver and bind to the DBP promoter. DNA Cell Biol. 13:693-703.
20. Lichsteiner, S., J. Wuarin, and U. Schibler. 1987. The interplay of DNA-binding proteins on the promoter of the mouse albumin gene. Cell 51:963-973.
21. Maire, P., J. Wuarin, and U. Schibler. 1989. The role of cis-acting elements in tissue-specific albumin gene transcription. Science 244:343-346.
22. Mueller, C. R., P. Maire, and U. Schibler. 1990. DBP, a liver-enriched transcriptional activator is expressed late in ontogeny and its tissue specificity is determined posttranscriptionally. Cell 61:279-291.
23. Picketts, D. J., C. D'Souza, P. J. Bridge, and D. P. Lillicrap. 1992 An A to T transversion at position -5 of the factor IX promoter results in hemophilia B. Genomics 12:161-163.
24. Picketts, D. J., D. P. Lillicrap, and C. R. Mueller. 1993. Synergy between transcription factors DBP and C/EBP compensates for a haemophilia B Leyden factor IX mutation. Nat. Genet. 3:175-179.
25. Picketts, D. J., C. R. Mueller, and D. P. Lillicrap. 1994. Transcriptional control of the factor IX gene: analysis of five cis-acting elements and the deleterious effects of naturally occurring hemophilia B Leyden mutations. Blood 84:2992-3000.
26. Reijnen, M. J., D. Maasdam, R. M. Bertina, and P. H. Reitsma. 1994. Haemophilia B Leyden: the effect of mutations at position +13 on the liver-specific transcription of the factor IX gene. Blood Coagul. Fibrinolysis 5:341-348.
27. Reijnen, M. J., K. Peerlinck, D. Maasdam, R. M. Bertina, and P. H. Reitsma. 1993. Hemophilia B Leyden: substitution of thymine for guanine at position -21 results in a disruption of a hepatocyte nuclear factor 4 binding site in the factor IX promoter. Blood 82:151-158.
28. Reijnen, M. J., F. M. Sladek, R. M. Bertina, and P. H. Reitsma. 1992. Disruption of a binding site for hepatocyte nuclear factor 4 results in hemophilia B Leyden. Proc. Natl. Acad. Sci. USA 89:6300-6303
29. Sweeney, J. D., and L. A. Hoernig. 1993. Age-dependent effect on the level of factor IX. Am. J. Clin. Pathol. 99:687-688.
30. Thompson, A. R. 1986. Structure, function and molecular defects of factor IX. Blood 67:565-572.
31. Virbasius, J., C.-M. Virbasius, and R. Scarpulla. 1993. Identity of GABP with NRF-2, a multisubunit activator of cytochrome oxidase expression, reveals a cellular role for an ETS domain activator of viral promoters. Genes Dev. 7:380-392.
32. Wasylyk, B., S. L. Hahn, and A. Giovane. 1993. The Ets family of transcription factors. Eur. J. Biochem. 211:7-18.
33. Wuarin, J., and U. Schibler. 1990. Expression of the liver enriched transcriptional activator protein DBF follows a stringent circadian rhythm. Cell 63: 1257-1266.