Incorporation of amide linked thymidine dimers into oligodeoxynucleotides

Bioorganic and Medicinal Chemistry Letters

Volumn 6, Issue 8, 1996, Pages 987-990

  Viswanadham, Garimella ^a   Petersen, Gorm V ^a   Wengel, Jesper ^a  

^a UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; DNA SYNTHESIS; DRUG STABILITY; REACTION ANALYSIS; THERMAL ANALYSIS;

EID: 0029912921     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0960-894X(96)00159-X     Document Type: Article

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21. + .
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24. 4,140 mM NaCl.
25. m= -6.8.
26. MM+ calculations on 6-mer DNA:DNA or DNA:RNA duplexes containing 5a and 5c, using Hyperchem™, suggest that the 5 atom linkages are longer than the phosphodiester linkage. This causes a distortion of the base pairing in the duplexes. However no clear pattern were seen between the thermal behaviour of the duplexes and the molecular modeling results.