Adenovirus vector-transduced hepatocytes implanted via a preformed collagen/PTFE support persist for at least 4 weeks in vivo

Gene Therapy

Volumn 3, Issue 10, 1996, Pages 932-936

  Kremer, E J ^a   Di Falco, N ^a   Opolon, P ^a   Perricaudet, M ^a  

^a CNRS   (France)

Author keywords

Adenovirus vectors; Ex vivo gene transfer; Hepatocytes; Solid support

Indexed keywords

COLLAGEN; POLITEF;

ADENOVIRUS; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL TRANSPLANTATION; CELL VIABILITY; CONTROLLED STUDY; EXPRESSION VECTOR; GENE EXPRESSION; GENE TARGETING; GENE TRANSFER; GENETIC TRANSDUCTION; LIVER; LIVER CELL; NONHUMAN; PRIORITY JOURNAL; RAT; REPORTER GENE; TRANSGENE;

ADENOVIRIDAE; ANIMALS; CELLS, CULTURED; COLLAGEN; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HUMANS; LIVER; MICE; POLYTETRAFLUOROETHYLENE; RABBITS; RATS; TIME FACTORS;

ADENOVIRIDAE; ANIMALIA;

EID: 0029912631     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Kilpe VE, Krakauer H, Wren RE. An analysis of liver transplant experience from 37 transplant centers as reported to Medicare. Transplantation 1993; 56: 554-561.
2. Howard RB, Christensen AK, Gibbs FA, Pesch LA The enzymatic preparation of isolated intact parenchymal cells from the liver. J Cell Biol 1967; 35: 675-684.
3. Selgen PO Preparation of isolated rat liver cells. Meth Cell Biol 1967; 16: 28-93.
4. Rozga J et al. Development of a bioartificial liver: properties and function of a hollow-fiber module inoculated with liver cells. Hepatology 1993; 17: 258-265.
5. Shatford RA et al. Hepatocytes function m a hollow fibre bioreactor: a potential bioartificial liver. J Surg Res 1992; 53: 549-557.
6. Ponder KP et al Mouse hepatocytes migrate to liver parenchyma and function indefinitely after intrasplenic transplantation. Proc Natl Acad Sci USA 1991; 88. 1217-1221.
7. Gupta S, Lee CD, Vemuru RP, Bhargava KK. Indium labeling of hepatocytes for analysis of short-term biodistribution of transplanted cells. Hepatology 1994; 19: 750-757.
8. Gupta S, Rajvanshi P, Lee CD. Integration of transplanted hepatocytes into host liver plates demonstrated with dipeptidyl peptidase IV-deficient rats. Proc Natl Acad Sci USA 1995; 13: 5860-5864.
9. Gupta S et al. Studies on the safety of intrasplenic hepatocyte transplantation: relevance to ex vivo gene therapy and liver repopulation in acute hepatic failure. Hum Gene Ther 1993; 3: 249-257.
10. Uyama S, Kaufmann PM, Takeda T, Vacanti JP. Delivery of whole liver-equivalent hepatocyte mass using polymer devices and hepatotrophic stimulation. Transplantation 1993; 55: 932-935.
11. Dixit V et al. Restoration of liver function in Gunn rats without immunosuppression using transplanted microencapsulated hepatocytes. Hepatology 1990; 12: 1342-1349.
12. Moscioni AD et al In vivo regional delivery of retrovirally mediated foreign genes to rat liver cells: need for partial hepatectomy for successful foreign gene expression. Surgery 1993; 113: 304-311.
13. Jaffe HA et al. Adenovirus-mediated in vivo gene transfer and expression in normal rat liver. Nat Genet 1992; 1: 372-378.
14. Kolodka TM, Finegold M, Kay MA, Woo SL. Hepatic gene therapy: efficient retroviral-mediated gene transfer into rat hepatocytes in vivo (published erratum appears in Somat Cell Mol Genet 1994; 20: 251). Somat Cell Mol Genet 1993; 19: 491-497.
15. Kay MA et al. Hepatic gene therapy: persistent expression of human alpha 1-antitrypsin in mice after direct gene delivery in vivo. Hum Gene Ther 1992; 3: 641-647.
16. Hickman MA et al. Gene expression following direct injection of DNA into the liver. Hum Gene Ther 1994; 5: 1477-1483.
17. Stratford-Perricaudet LD et al. Evaluation of the transfer and expression in mice of an enzyme encoding gene using a human adenovirus vector. Hum Gene Ther 1990; 1: 241-256.
18. Li J et al. In vivo gene therapy for hyperlipidemia: phenotypic correction in Watanabe rabbits by hepatic delivery of the rabbit LDL receptor gene. J Clin Invest 1995; 95: 768-773.
19. Kozarsky KF et al. In vivo correction of low density lipoprotein receptor deficiency in the Watanabe heritable hyperlipidemic rabbit with recombinant adenoviruses. J Biol Chem 1994; 269: 13695-13702.
20. Ishibashi S et al. Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery. J Clin Invest 1993; 92: 883-893.
21. Yang Y et al. Inactivation of E2a in recombinant adenoviruses improves the prospect for gene therapy in cystic fibrosis. Nat Genet 1994; 7: 362-369.
22. Yang Y et al. Cellular immunity to viral antigens limits E-1 deleted Ad for gene therapy. Proc Natl Acad Sci USA 1994; 91: 4407-4411.
23. Lu B, Gupta S, Federoff H. Ex vivo hepatic gene transfer in mouse using a defective herpes simplex virus-1 vector. Hepatology 1995; 21: 752-759.
24. Descamps V et al. Organoids direct systemic expression of erythropoietin in mice. Gene Therapy 1995; 2: 411-417.
25. Thompson JA et al. Heparin-binding growth factor 1 induces the formation of organoid neovascular structures in vivo. Proc Natl Acad Sci USA 1989; 86: 7928-7932 (published erratum appears in Proc Natl Acad Sci USA 1992; 89: 7849.
26. Thompson JA et al. Site-directed neovessel formation in vivo. Science 1988; 241: 1349-1352.
27. Wachstein M, Meisel E. On the histochemical demonstration of glucose-6-phosphatase. J Histochem Cytochem 1956; 4: 592-598.
28. Kremer EJ et al. Characterisation of a method of an ex vivo gene transfer using adenovector-transduced fibroblasts embedded in collagen: potential for short-term cytokine therapy (submitted for publication).
29. Borel Rinkes IHM et al. Proliferative response of hepatocytes transplanted into spleen or solid support. J Surg Res 1994; 56: 417-423.
30. Chowdhury JR et al. Long-term improvement of hypercholesterolemia after ex vivo gene therapy in LDLR-deficient rabbits. Science 1991; 254: 1802-1805.
31. Grossman M, Wilson JM, Raper SE. A novel approach for introducing genetically modified hepatocytes into the portal circulation. J Lab Clin Med 1993; 121: 472-478.
32. Grossman M, Raper SE, Wilson JM. Transplantation of genetically modified autologous hepatocytes into nonhuman primates: feasibility and short-term toxicity. Hum Gene Ther 1992; 5: 501-510.
33. Grossman M et al. Successful ex vivo gene therapy directed to liver in a patient with familial hypercholesterolaemia. Nat Genet 1994; 4: 335-341.
34. Seldon RF et al. Regulation of insulin gene expression: implications for gene therapy. New Engl J Med 1987; 317: 1067-1076.
35. Simpson AM et al. Functional expression of the human insulin gene in a human hepatoma cell line (HEP G2). Gene Therapy 1995; 2: 223-231.
36. Kolodka TM, Finegold M, Moss L, Woo SL. Gene therapy for diabetes mellitus in rats by hepatic expression of insulin. Proc Natl Acad Sci USA 1995; 92: 3293-3297.
37. Smeeken SP et al. Proinsulin processing by the subtilisin-related proprotein convertase furin, PC2, and PC3. Proc Natl Acad Sci USA 1992; 89: 8822-8826.
38. Spady DK, Cuthbert JA, Willard MM, Meidell RS. Adenovirus-mediated transfer of a gene encoding cholesterol 7α-hydroxylase into hamsters increases hepatic enzyme activity and reduces plasma total and low density lipoprotein cholesterol. J Clin Invest 1995; 96: 700-709.