Genetic engineering of endothelial cells to ameliorate xenograft rejection

Clinical Transplantation

Volumn 10, Issue 1 II, 1996, Pages 124-127

  Bach, Fritz H ^a   Robson, Simon C ^a   Wrighton, Christopher J ^a   Stuhlmeier, Karl ^a   Ferran, Christiane ^a   Winkler, Hans ^a  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

Discordant xenotransplantation; Endothelial cell activation; Genetic engineering; Rejection; Xenotransplantation

Indexed keywords

CONFERENCE PAPER; ENDOTHELIUM CELL; GENETIC ENGINEERING; GRAFT REJECTION; HUMAN; NONHUMAN; PRIORITY JOURNAL; SWINE; XENOTRANSPLANTATION;

ANIMALS; COMPLEMENT SYSTEM PROTEINS; DIRECTED MOLECULAR EVOLUTION; ENDOTHELIUM, VASCULAR; GENETIC ENGINEERING; GRAFT REJECTION; HUMANS; SWINE; TRANSPLANTATION, HETEROLOGOUS;

EID: 0029912529     PISSN: 09020063     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (19)

1. BACH FH, et al. Endothelial cell activation and thromboregulation during xenograft rejection. Immunol Rev 1994: 141:5.
2. POBER JS, et al. The role of endothelial cells in inflammation. Transplantation 1990: 50: 537.
3. BACH FH, et al. Accommodation: a working paradigm for progressing toward clinical discordant xenografting. Transplant Proc 1991: 23: 205.
4. DALMASSO AP, et al. Inhibition of complement-mediated endothelial cell cytotoxicity by decay-accelerating factor. Potential for prevention of xenograft hyperacute rejection. Transplantation 1991: 52: 530.
5. FODOR WL, et al. Engineering of transgenic pigs for xenogeneic organ transplantation. Xeno 1995: 3: 23.
6. SANDRIN MS. et al. Enzymatic remodeling of the carbohydrate surface of xenogeneic cells substantially reduces human antibody binding and complement-mediated cytolysis. Nature Med 1995 (submitted).
7. COOPER DKC, et al. Identification of alpha-galactosyl and other carbohydrate epitopes that are bound by human antipig antibodies: relevance to discordant xenografting in man. Transplant Immunol 1993: 1: 198.
8. GALILI U. Interaction of the natural anti-gal antibody with α-galactosyl epitopes - a major obstacle for xenotransplantation in humans. Immunol Today 1993; 14: 480.
9. BAEUERLE PA, et al. Function and activation of NF-κB in the immune system. Annu Rev Immunol 1994: 12: 141.
10. FERRAN C, et al. Inhibition of NF-κB by pyrrolidine dithiocarbamate blocks endothelial cell activation. Biochem Biophys Res Commun 1995: 214: 212.
11. BAEUERLE PA, et al. IκB: a specific inhibitor of the NF-κB transcription factor. Science 1988: 242: 541.
12. DE MARTIN R, et al. Cytokine-inducible expression in endothelial cells of an IκBα-like gene is regulated by NF-κB. EMBO J 1993: 12: 2773.
13. WRIGHTON C, et al. Adenoviral-mediated ectopic expression of IκBα: a selective tool for interference with NF-κB-dependent gene induction in cytokine-treated endothelial cells. Transplant Proc 1995 (in press).
14. NAWROTH PP, et al. Modulation of endothelial hemostatic properties by tumor necrosis factor. J Exp Med 1986: 163: 740.
15. TSUCHIDA A, et al. Tumor necrosis factor production during human renal allograft rejection is associated with depression of plasma protein C and free protein S levels and decreased intragraft thrombomodulin expression. J Exp Med 1992: 175: 81.
16. ESMON CT. The regulation of natural anticoagulant pathways. Science 1987: 235: 1348.
17. GREY S, et al. Selective inhibitory effects of the anticoagulant activated protein C on the responses of human mononuclear phagocytes to LPS, IFN-γ or phorbol ester. J Immunol 1994: 153: 3664.
18. HANCOCK WW, et al. Binding of activated protein C to a specific receptor on human mononuclear phagocytes inhibits intracellular calcium signalling and monocyte-dependent proliferative responses. Transplantation 1995 (in press).
19. WRIGHTON C, et al. High-level expression of functional human thrombomodulin m cultured porcine aortic endothelial cells. Transplant Proc 1995: 27: 288.