In vivo selection of HIV-1 variants with reduced susceptibility to the protease inhibitor L-735,524 and related compounds

Advances in Experimental Medicine and Biology

Volumn 394, Issue , 1996, Pages 327-331

  Emini, Emilio A ^b   Schleif, William A ^b   Deutsch, Paul ^b   Condra, Jon H ^b  

^a MERCK RESEARCH LABORATORIES   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

INDINAVIR; PROTEINASE INHIBITOR;

AMINO ACID SUBSTITUTION; CONFERENCE PAPER; CROSS RESISTANCE; ENZYME ACTIVITY; GENOTYPE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; PRIORITY JOURNAL; PROTEINASE INHIBITION; VIRUS PARTICLE;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0029911807     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4757-9209-6_30     Document Type: Conference Paper

References (8)

1. Kohl NE, Emini EA, Schleif WA et al. Active human immunodeficiency virus protease is required for viral infectivity. Proc Natl Acad Sci USA, 1988;85:4686-4690.
2. Toh H, Ono M, Saigo K et al. Retroviral protease-like sequence in the yeast transposon Tyl. Nature, 1985;315: 691-692.
3. Pearl LH and Taylor WR A structural model for the retroviral proteases. Nature, 1987;329:351-354.
4. Darke PL, Nutt RF, Brady SF et al. HIV-1 protease specificity of peptide cleavage is sufficient for processing of gag and pol polyproteins. Biochem. Biophys. Res. Commun., 1988;156:297-303.
5. Kotler M, Katz RA, Danho W et al. Synthetic peptides as substrates and inhibitors of a retroviral protease. Proc Natl Acad Sci USA, 1988;85:4185-4189.
6. Lillehoj EP, Salazar FHR, Mervis RJ et al. Purification and structural characterization of the putative gag-poi protease of human immunodeficiency virus. J Virol, 1988;62:3053-3058.
7. Huff JR HIV protease: A novel chemotherapeutic target for AIDS. J Med Chem, 1991;34:2305-2314.
8. Vacca JP, Dorsey BD, Schleif WA et al. L-735,524, an orally bioavailable HIV-1 protease inhibitor. Proc Natl Acad.Sci USA., 1994;91:4096-4100.