Regional distribution of binding sites for the nitric oxide synthase inhibitor L-[3H]nitroarginine in rat brain

Neurochemical Research

Volumn 21, Issue 3, 1996, Pages 355-359

  Rao, V L Raghavendra ^a   Butterworth, R F ^a  

^a UNIVERSITY OF MONTREAL   (Canada)

Author keywords

in vitro ligand binding; N(G) Nitro L arginine binding; nitric oxide synthase; quantitative autoradiography; regional distribution

Indexed keywords

N(G) NITROARGININE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; TRITIUM;

ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BINDING SITE; BRAIN REGION; CONTROLLED STUDY; NEUROCHEMISTRY; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ASSAY; RAT; TISSUE DISTRIBUTION;

ANIMALS; AUTORADIOGRAPHY; BINDING SITES; BRAIN; CYTOSOL; KINETICS; NEURONS; NITRIC OXIDE SYNTHASE; NITROARGININE; RATS; TISSUE DISTRIBUTION; TRITIUM;

ANIMALIA; TRITIUM;

EID: 0029911767     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02531652     Document Type: Article

References (20)

1. Dawson, T. M., and Snyder, S. H. 1994. Gases as biological messengers: Nitric oxide and carbon monoxide in the brain. J. Neurosci. 14:5147-5159.
2. Garthwaite, J. 1995. Neural nitric oxide signalling. Trends Neurosci. 18:51-52.
3. Hecker, M., Mülsch, A., and Busse, R. 1994. Subcellular localization and characterization of neuronal nitric oxide synthase. J. Neurochem. 62:1524-1529.
4. Murphy, S., Simmons, M. L., Agullo, L., Garcia, A., Feinstein, D. L., Galea, E., Reis, D. J., Minc-Golomb, D., and Schwartz, J. P. 1993. Synthesis of nitric oxide in CNS glial cells. Trends Neurosci. 16:323-328.
5. Thomas, E., and Pearse, A. G. E. 1961. The fine localization of dehydrogenases in the nervous system. Histochemie 2:262-282.
6. Dawson, T. M., Bredt, D. S., Fotuhi, M., Hwang, P. M., and Snyder, S. H. 1991. Nitric oxide synthase and neuronal NADPH-diaphorase are identical in brain and peripheral tissues. Proc. Natl. Acad. Sci. USA 88:7797-7801.
7. Vincent, S. R., and Kimura, H. 1992. Histochemical mapping of nitric oxide synthase in the rat brain. Neuroscience 46:755-784.
8. Tracey, W. R., Nakane, M., Pollock, J. S., and Förstermann, U. 1993. Nitric oxide synthases in neuronal cells, macrophages and endothelium are NADPH diaphoreses, but represents only a fraction of total cellular NADPH diaphorase activity. Biochem. Biophys. Res. Commun. 195:1035-1040.
9. Matsumoto, T., Nakane, M., Pollock, J. S., Kuk, J. E., and Förstermann, U. 1993. A correlation between soluble brain nitric oxide synthase and NADPH-diaphorase activity is only seen after exposure of the tissue to fixative. Neurosci. Lett. 155:61-64.
10. Bredt, D. S., Hwang, P. M., and Snyder, S. H. 1990. Localization of nitric oxide synthase indicating a neural role for nitric oxide. Nature 347:768-770.
11. Kishimoto, J., Keverne, E. B., Hardwick, J., and Emson, P. C. 1993. Localization of nitric oxide synthase in the mouse olfactory and vomeronasal system: a histochemical, immunological and in situ hybridization study. Eur. J. Neurosci. 5:1684-1694.
12. Schmidt, H. H. H. W., Gagne, G. D., Nakane, M., Pollock, J. S., Miller, M. F., and Murad, F. 1992. Mapping of neural nitric oxide synthase in the rat suggests frequent co-localization with NADPH diaphorase but not with soluble guanylyl cyclase, and novel paraneural functions for nitrinergic signal transduction. J. Histochem. Cytochem. 40:1439-1456.
13. G-nitro-arginine binding in rat brain. Neuropharmacol. 34:63-73.
14. 3H]nitroarginine binding sites in rat cerebellum. J. Neurochem. 66:701-709.
15. G-nitro-arginine in rat brain. Br. J. Pharmacol. 109:287-288.
16. Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J. 1951. Protein measurements with Folin-phenol reagent. J. Biol. Chem. 193:265-275.
17. Paxinos, G., and Watson, C. 1982. The Rat Brain: in Stereotaxic Coordinates. Academic Press, NY, USA.
18. Bredt, D. S., and Snyder, S. H. 1989. Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum. Proc. Natl. Acad. Sci. USA 86:9030-9033.
19. 3H]arginine uptake in brain following portacaval anastomosis. J. Neurochem. 65:677-681.
20. Brüning, G. 1993. NADPH-diaphorase histochemistry in the postnatal mouse cerebellum suggests specific developmental functions for nitric oxide. J. Neurosci. Res. 36:580-587.